2. Apoptosis Immunology/Inflammation
  3. Apoptosis Pyroptosis
  4. Ardisianone

Ardisianone is a component with an alkyl benzoquinone structure that can be isolated from Ardisia virens Kurz and Ardisia compressa tea extract. Ardisianone exhibits potent antileukemic activity, particularly against HL-60 cells, with IC50 values of 1.87 μM (24 h) and 1.67 μM (48 h). Ardisianone induces caspase-dependent apoptosis and triggers pyroptosis. Ardisianone can be used for the study of acute myeloid leukemia (AML).

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Ardisianone

Ardisianone Chemical Structure

CAS No. : 66398-68-3

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Ardisianone Related Antibodies

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Description

Ardisianone is a component with an alkyl benzoquinone structure that can be isolated from Ardisia virens Kurz and Ardisia compressa tea extract. Ardisianone exhibits potent antileukemic activity, particularly against HL-60 cells, with IC50 values of 1.87 μM (24 h) and 1.67 μM (48 h). Ardisianone induces caspase-dependent apoptosis and triggers pyroptosis. Ardisianone can be used for the study of acute myeloid leukemia (AML)[1].

In Vitro

Ardisianone (1-5 μM, 24-48 h) induces apoptosis and shows potent cytotoxic activity against HL-60 cells, with IC50 values of 1.87 μM (24 h) and 1.67 μM (48 h)[1].
Ardisianone (2-5 μM, 24 h) exerts pyroptosis-inducing activity in HL-60 cells[1].
Ardisianone (0.5-2 μM, 72 h) significantly increases CD11b expression and CD68 expression, and induces differentiation into monocyte-like and macrophage-like morphologies in HL-60 cells[1].
Ardisianone (2 μM) shows DNA damage-inducing activity in HL-60 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ardisianone Related Antibodies

Apoptosis Analysis[1]

Cell Line: HL-60 cells
Concentration: 1, 2, 3, 4, 5 μM
Incubation Time: 3, 6, 9, 12, 15, 24 h
Result: Induced apoptosis in HL-60 cells and concentration-dependent elevation of sub-G1 apoptotic population.
Induced profound degradation of DFF45/ICAD.
Upregulated death receptors (especially TNFR2).
Downregulated IAPs (cIAP1, cIAP2, survivin).
Promoted time-dependent activation of caspase-8/-3 and degradation of Bid.
Molecular Weight

406.56

Formula

C24H38O5
CAS No.
SMILES

CCCCCCCCCCCCC[C@@H](OC(C)=O)CC(C(C(OC)=C1)=O)=CC1=O
Structure Classification
Initial Source
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ardisianone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ardisianone66398-68-3ApoptosisPyroptosisacute myeloid leukemiaHL-60 cellsapoptosispyroptosisInhibitorinhibitorinhibit

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