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anti-HIV effects

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HIV (18) HIV Protease (1) Apoptosis (1) Autophagy (2) Bacterial (4) Biochemical Assay Reagents (3) CCR (3) Drug Isomer (1) Endogenous Metabolite (2) IKK (2) Influenza Virus (2) Interleukin Related (1) Isotope-Labeled Compounds (1) Mitochondrial Metabolism (1) NF-κB (1) Oxidative Phosphorylation (1) Parasite (3) TNF Receptor (1)
By Research Areas:	Cancer (11) Infection (17) Inflammation/Immunology (6) Metabolic Disease (2) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: HIV HIV Integrase HIV Protease

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N3506

Wilfortrine	HIV	Infection Inflammation/Immunology Cancer
Wilfortrine is a bioactive sesquiterpene alkaloid. Wilfortrine exhibits immunosuppresive effects. Wilfortrine also can inhibit leukaemia cell growth in mice and shows anti-HIV activity .

HY-119500

Ilimaquinone	HIV Bacterial	Infection Inflammation/Immunology Cancer
Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus . Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects .

HY-B1637

Ditiocarb sodium 3 Publications Verification Sodium diethyldithiocarbamate	HIV Biochemical Assay Reagents	Infection Inflammation/Immunology Cancer
Ditiocarb sodium (Sodium diethyldithiocarbamate) is an orally active copper reagent. Ditiocarb sodium exhibits activities such as antioxidation, chelation, anti-tumor effects, immunomodulation, and anti-HIV properties. Ditiocarb sodium can be used in the research of tumors, inflammatory, and immune-related diseases .

HY-N7543

Schisantherin D	HIV	Infection
Schisantherin D is a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera. Schisantherin D shows anti-HIV replication activities with an EC₅₀ of 0.5 μg/mL. Schisantherin D inhibits endothelin receptor B (ETBR) and has hepatoprotective effects .

HY-N6980

Licorice glycoside C2 1 Publications Verification	HIV	Infection Cancer
Licorice glycoside C2 is a oleanane-type triterpene oligoglycoside isolated from Glycyrrhiza uralensis. Various biological activities are associated with licorice extracts, such as anti-viral, anti-microbial, antioxidant, anti-inflammatory, anti-ulcer, anti-cancer and anti-HIV effects .

HY-121370

a-D-Galactose	HIV Endogenous Metabolite	Others
α-D-Galactose is a non-starch polysaccharide isolated from the bulb tissues of Lilium davidii var. unicolor Salisb. α-D-Galactose has anti-oxidation properties, anti-tumour activities, immunomodulatory effects and anti-HIV functions .

HY-111321

Fuscin	Oxidative Phosphorylation CCR HIV Bacterial Mitochondrial Metabolism Endogenous Metabolite	Infection Metabolic Disease
Fuscin, a fungal metabolite, CCR5 receptor antagonist with anti-HIV effects. Fuscin is a respiration and oxidative phosphorylation inhibitor, and also a mitochondrial SH-dependent transport-linked functions inhibitor .

HY-14388

PF-232798	CCR HIV	Infection
PF-232798 is an orally active CCR5 antagonist with anti-HIV effects .

HY-118747

Scirpusin A	HIV	Infection
Scirpusin A is a naturally occurring compound extracted from the legume plant Caragana rosea Turcz, exhibiting anti-HIV activity. Scirpusin A demonstrates significant inhibitory effects against HIV-1 (EC₅₀=7 μg/mL). Scirpusin A is utilized in research towards the development of anti-HIV therapeutics .

HY-12944

GSK163929	HIV CCR	Infection
GSK163929 (compound 122) is an orally active, anti-HIV CCR5 antagonist with low inhibitory potency against hEGR. GSK163929 had no adverse effects in rats at 2000 mg/kg/day (i.v., 7 d) and in dogs at 250 mg/kg/day (i.v., 7 d) .

HY-19149

Ro24-7429	HIV Apoptosis	Infection Inflammation/Immunology Cancer
Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects .

HY-B1637A

Ditiocarb sodium,98% 3 Publications Verification Sodium diethyldithiocarbamate,98%	HIV Biochemical Assay Reagents	Infection Inflammation/Immunology Cancer
Ditiocarb sodium,98% (Sodium diethyldithiocarbamate,98%) is an orally active copper reagent. Ditiocarb sodium,98% exhibits activities such as antioxidation, chelation, anti-tumor effects, immunomodulation, and anti-HIV properties. Ditiocarb sodium,98% can be used in the research of tumors, inflammatory, and immune-related diseases .

HY-B1637S

Ditiocarb-d10 sodium Sodium diethyldithiocarbamate-d₁₀ sodium	Isotope-Labeled Compounds HIV Biochemical Assay Reagents	Infection Inflammation/Immunology Cancer
Ditiocarb-d₁₀ sodium (Sodium diethyldithiocarbamate-d₁₀) is the deuterium labeled Ditiocarb sodium (HY-B1637). Ditiocarb sodium (Sodium diethyldithiocarbamate) is an orally active copper reagent. Ditiocarb sodium exhibits activities such as antioxidation, chelation, anti-tumor effects, immunomodulation, and anti-HIV properties. Ditiocarb sodium can be used in the research of tumors, inflammatory, and immune-related diseases .

HY-N2996

Ganodermanondiol	HIV Protease	Infection
Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum .Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity . Ganodermanondiol shows significant anti-HIV-1 protease activity with an IC₅₀ of 90 μM . Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC₅₀ of 41.7μM .

HY-N6924

Zingibroside R1	HIV	Infection Metabolic Disease Cancer
Zingibroside R1 is dammaranae-type triterpenoid saponin, isolated from rhizomes, taproots, and lateral roots of Panax japonicas C. A. Meyer, shows excellent anti-tumor effects as well as anti-angiogenic activity . Zingibroside R1 possesses some anti-HIV-1 activity. Zingibroside R1 has inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells (IC₅₀=91.3 μM) .

HY-W012732

Isoquinoline 2 Publications Verification	Drug Isomer HIV Parasite Interleukin Related NF-κB TNF Receptor	Neurological Disease Cancer
Isoquinoline is an analog of pyridine. Isoquinoline-based alkaloids, such as p-tolyl bisisoquinoline, phthaloyl isoquinoline, and naphthyl isoquinoline, exhibit anticancer activity. Berberine, an isoquinoline alkaloid, exerts anti-inflammatory effects in diabetic mice by downregulating the gene expression ratios of pro-/anti-inflammatory and Th1/Th2 cytokines. Additionally, some isoquinoline-based compounds also possess antidepressant, antibacterial, antimalarial, and anti-HIV activities .

HY-12687

Tizoxanide Maximum Cited Publications 11 Publications Verification TIZ	Bacterial HIV Autophagy Parasite IKK Influenza Virus	Infection Cancer
Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide *anti-infective* compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has *anti-HIV-1* activities and potent inhibition of both HBV and HCV replication with values EC₅₀ of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells .

HY-116240

2′,3′-Dideoxy-5-ethyluridine ddEtUrd	HIV	Infection
2′,3′-Dideoxy-5-ethyluridine (ddEtUrd) is an antiretroviral compound with weak anti-HIV activity. The 3'-substituted derivatives of 2′,3′-Dideoxy-5-ethyluridine did not show significant antiviral effects. 2′,3′-Dideoxy-5-ethyluridine was less potent in inhibiting HIV replication in human MT4 lymphocytes. Although phosphorylation induced by 2′,3′-Dideoxy-5-ethyluridine is essential for antiviral activity, there is no strong correlation between its affinity for human dThd kinase or dCyd kinase .

HY-12687R

Tizoxanide (Standard) TIZ (Standard)	Bacterial HIV Autophagy Parasite IKK Influenza Virus	Infection Cancer
Tizoxanide (Standard) is the analytical standard of Tizoxanide. This product is intended for research and analytical applications. Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide *anti-infective* compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has *anti-HIV-1* activities and potent inhibition of both HBV and HCV replication with values EC₅₀ of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3506

Wilfortrine	Infection Alkaloids Classification of Application Fields Source classification Celastraceae Pyridine Alkaloids Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology	HIV
Wilfortrine is a bioactive sesquiterpene alkaloid. Wilfortrine exhibits immunosuppresive effects. Wilfortrine also can inhibit leukaemia cell growth in mice and shows anti-HIV activity .

HY-119500

Ilimaquinone	Infection Quinones Classification of Application Fields Animals Marine natural products Benzene Quinones Sponge Inflammation/Immunology Disease Research Fields Cancer	HIV Bacterial
Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus . Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects .

HY-N7543

Schisantherin D	Infection Schisandra sphenanthera Rehd. et Wils Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields	HIV
Schisantherin D is a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera. Schisantherin D shows anti-HIV replication activities with an EC₅₀ of 0.5 μg/mL. Schisantherin D inhibits endothelin receptor B (ETBR) and has hepatoprotective effects .

HY-N6980

Licorice glycoside C2 1 Publications Verification	Infection Structural Classification Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch.	HIV
Licorice glycoside C2 is a oleanane-type triterpene oligoglycoside isolated from Glycyrrhiza uralensis. Various biological activities are associated with licorice extracts, such as anti-viral, anti-microbial, antioxidant, anti-inflammatory, anti-ulcer, anti-cancer and anti-HIV effects .

HY-121370

a-D-Galactose	Structural Classification Human Gut Microbiota Metabolites Microorganisms Liliaceae Source classification Plants Endogenous metabolite Lilium davidii Duchartre ex Elwes Saccharides Monosaccharides	HIV Endogenous Metabolite
α-D-Galactose is a non-starch polysaccharide isolated from the bulb tissues of Lilium davidii var. unicolor Salisb. α-D-Galactose has anti-oxidation properties, anti-tumour activities, immunomodulatory effects and anti-HIV functions .

HY-N2996

Ganodermanondiol	Infection Triterpenes Structural Classification Microorganisms Classification of Application Fields Terpenoids Polyporaceae Source classification Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields	HIV Protease
Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum .Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity . Ganodermanondiol shows significant anti-HIV-1 protease activity with an IC₅₀ of 90 μM . Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC₅₀ of 41.7μM .

HY-N6924

Zingibroside R1	Infection Structural Classification Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Classification of Application Fields Panax japonicas C. A. Mey. Source classification Metabolic Disease Plants Disease Research Fields Saccharides Araliaceae	HIV
Zingibroside R1 is dammaranae-type triterpenoid saponin, isolated from rhizomes, taproots, and lateral roots of Panax japonicas C. A. Meyer, shows excellent anti-tumor effects as well as anti-angiogenic activity . Zingibroside R1 possesses some anti-HIV-1 activity. Zingibroside R1 has inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells (IC₅₀=91.3 μM) .

HY-111321

Fuscin	Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Naphthalene Quinones Disease Research Fields	Oxidative Phosphorylation CCR HIV Bacterial Mitochondrial Metabolism Endogenous Metabolite
Fuscin, a fungal metabolite, CCR5 receptor antagonist with anti-HIV effects. Fuscin is a respiration and oxidative phosphorylation inhibitor, and also a mitochondrial SH-dependent transport-linked functions inhibitor .

HY-118747

Scirpusin A	Structural Classification Caragana rosea Turcz. ex Maxim. Source classification Phenols Polyphenols Plants Fabaceae	HIV
Scirpusin A is a naturally occurring compound extracted from the legume plant Caragana rosea Turcz, exhibiting anti-HIV activity. Scirpusin A demonstrates significant inhibitory effects against HIV-1 (EC₅₀=7 μg/mL). Scirpusin A is utilized in research towards the development of anti-HIV therapeutics .

Cat. No.	Product Name	Chemical Structure

HY-B1637S

Ditiocarb-d10 sodium
Ditiocarb-d₁₀ sodium (Sodium diethyldithiocarbamate-d₁₀) is the deuterium labeled Ditiocarb sodium (HY-B1637). Ditiocarb sodium (Sodium diethyldithiocarbamate) is an orally active copper reagent. Ditiocarb sodium exhibits activities such as antioxidation, chelation, anti-tumor effects, immunomodulation, and anti-HIV properties. Ditiocarb sodium can be used in the research of tumors, inflammatory, and immune-related diseases .

Ditiocarb-d10 sodium

Ditiocarb-d₁₀ sodium (Sodium diethyldithiocarbamate-d₁₀) is the deuterium labeled Ditiocarb sodium (HY-B1637). Ditiocarb sodium (Sodium diethyldithiocarbamate) is an orally active copper reagent. Ditiocarb sodium exhibits activities such as antioxidation, chelation, anti-tumor effects, immunomodulation, and anti-HIV properties. Ditiocarb sodium can be used in the research of tumors, inflammatory, and immune-related diseases .

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anti-HIV effects

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products