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Results for "

anti-HIV agent

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HIV (31) HIV Integrase (1) HIV Protease (1) Bcl-2 Family (1) Biochemical Assay Reagents (2) CXCR (2) DNA/RNA Synthesis (1) EBV (1) Fungal (1) HCV (1) HSV (1) Microtubule/Tubulin (1) NOD-like Receptor (NLR) (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) Reverse Transcriptase (3) ULK (1)
By Research Areas:	Cancer (3) Infection (32) Inflammation/Immunology (3) Metabolic Disease (1)
Click Chemistry:	Azide (1) Alkynes (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Click Chemistry

Targets Recommended: HIV HIV Integrase HIV Protease

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-106859

Letrazuril	HIV	Infection
Letrazuril is an *anti-HIV* agent.

HY-164122

Antiviral agent 56	HIV	Infection
Antiviral agent 56 (Compound 4) is an antiviral agent that has anti-HIV activity .

HY-109056

Elsulfavirine 1 Publications Verification R-1206	HIV	Infection
Elsulfavirine is a reverse transcriptase inhibitors for HIV-1 infection and is a new anti-HIV agent .

HY-N1529

Gomisin M1 (±)-Gomisin M1	HIV	Infection
Gomisin M1 ((±)-Gomisin M1) is a potent anti-HIV agent with an EC₅₀ of <0.65 μM .

HY-16451

SC-49483 NSC 670880	HIV	Infection
SC-49483 (NSC 670880), an O-butanoylated ester of Miglustat (HY-17020), is an anti-HIV agent. SC-49483 can be used for the study of HIV infection .

HY-N6849

InteriotherinA	HIV	Infection Metabolic Disease
Interiotherin A is a lignan with a dibenzocyclooctadiene skeleton isolated from Kadsura interior. Interiotherin A inhibits HIV replication to exhibit anti-HIV activity, it has a role as a metabolite and an anti-HIV agent .

HY-N4004

Isoapetalic acid	HIV	Infection
Isoapetalic acid (compound 4) is a potent anti-HIV agent .

HY-10892

HEPT	HIV	Infection
HEPT is a potent and selective anti-HIV-1 agent .

HY-120132

KNI-102	HIV	Infection
KNI-102 is a potent anti-HIV agent with an IC₅₀ value of 100 nM for HIV protease .

HY-158419

PB(OH)3	HIV	Infection
PB(OH)3 is an anti-HIV-1 agent that can be used in antiviral research .

HY-N10958

Wikstrol A	Fungal HIV Microtubule/Tubulin	Infection
Wikstrol A is a potent antifungal, antimitotic and anti-HIV-1 Agent. Wikstrol A induces morphological deformation of P. oryzae mycelia with an MMDC value of 70.1 µM. Wikstrol A shows activity against microtubule polymerization with an IC₅₀ value of 131 µM. Wikstrol A shows anti-HIV-1 activity with an IC₅₀ value of 67.8 µM .

HY-116469

ZP7	HIV	Infection
ZP7 (compound 7c) is a potent anti-HIV-1 agent with an EC₅₀ of 36.4nM. ZP7 can be utilized in HIV-1 research .

HY-161924

HIV-1 inhibitor-73	HIV	Infection
HIV-1 inhibitor-73 (compound 13c) is a potent anti-HIV-1 agent, against the whole tested viral panel with EC50 ranging from 4.68 to 229 nM .

HY-100870

Obefazimod ABX464	HIV	Infection
Obefazimod (ABX464) is a potent *anti-HIV* agent. Obefazimod inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) with an IC₅₀ ranging between 0.1 μM and 0.5 μM.

HY-A0203A

Pentosan Polysulfate (Sodium) (W/W 43%) 1 Publications Verification	HIV	Infection Inflammation/Immunology Cancer
Pentosan Polysulfate Sodium is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate Sodium also is a potent and selective anti-HIV agent. Pentosan Polysulfate Sodium is used for the treatment of interstitial cystitis .

HY-N3242

Moronic acid (+)-Moronic acid	HIV Reactive Oxygen Species (ROS) NOD-like Receptor (NLR)	Infection Inflammation/Immunology
Moronic Acid is a triterpenoid compound, which is an orally available anti-HIV agent with anti-inflammatory activity. Moronic Acid can inhibit viral replication, with an EC₅₀ value of <1 μg/mL. Moronic Acid can be isolated from Brazilian propolis .

HY-W127423

Methyl 2-hydroxyoctadecanoate	Biochemical Assay Reagents	Others
Methyl (+/-)-2-hydroxystearateis a hydroxylated fatty acid methyl ester that broadens phase transitions in dimyristoylphosphatidylcholine (DMPC) lipid membranes. It has been used in the synthesis of lipid-nucleotide conjugated anti-HIV agents to increase the cleavage of phosphodiester bonds and the number of released intracellular nucleotides.

HY-N10801

Salvianan A	HIV	Infection
1,6,11-Trimethyl-1,2-dihydrofuro[2',3':1,2]phenanthro[4,3-d]oxazole (compound 1) is a potent *anti-HIV-1* agent .

HY-167945

AMD-3329	HIV CXCR	Infection
AMD-3329 is a potent and selective anti-HIV-1 and HIV-2 agent, exhibiting activity by inhibiting virus replication through binding to the chemokine receptor CXCR4, which serves as a co-receptor for the entry of X4 viruses.

HY-B1285

Dimercaprol 2,3-Dimercapto-1-propanol; Dithioglycerol	HIV	Infection
Dimercaprol (2,3-Dimercapto-1-propanol) is an anti-heavy metal-poisoning agent, which exhibits anti-HIV activity. Dimercaprol can be used for the study for arsenic, mercury, gold, lead, antimony, and other toxic metal poisoning .

HY-B1285R

Dimercaprol (Standard) 2,3-Dimercapto-1-propanol (Standard); Dithioglycerol (Standard)	Reference Standards HIV	Infection
Dimercaprol (Standard) is the analytical standard of Dimercaprol. This product is intended for research and analytical applications. Dimercaprol (2,3-Dimercapto-1-propanol) is an anti-heavy metal-poisoning agent, which exhibits anti-HIV activity. Dimercaprol can be used for the study for arsenic, mercury, gold, lead, antimony, and other toxic metal poisoning .

HY-P10653

C5A	HCV HIV	Infection
C5A is a microbicidal peptide, anti-hepatitis C virus (HCV), and anti-HIV agent. C5A disrupts the membrane integrity of the HIV virion as well as the integrity of the conical capsid core that surrounds the viral genome. C5A inhibits in vitro infectivity of a broad range of primary HIV isolates in various primary target cells. C5A protects mice against vaginal and rectal HIV challenges .

HY-N0867

13-Oxyingenol-13-dodecanoate	HIV ULK Bcl-2 Family	Infection Cancer
13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC₅₀ value of 33.7 nM .13-Oxyingenol-dodecanoate can induce the expression of ULK1 to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of BCL-2 to effect apoptosis .

HY-116528

GCA-186	HIV	Infection
GCA-186 is a potent *anti-HIV-1* agent. GCA-186 is highly active against both wild type and mutated HIV-1 strains with EC₅₀s of 1, 180, 1, and 40 nM for III_B, III_B-R(Y181C), NL4-3 and NL4-3_K103N of HIV-1 strains, respectively .

HY-104012

Islatravir 2 Publications Verification MK-8591	HIV Reverse Transcriptase	Infection
Islatravir (MK-8591) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC₅₀s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively. Islatravir is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-118711

HI-346	HIV Reverse Transcriptase	Infection
HI-346 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) for HIV-1 with an IC₅₀ value against the HIV-1 virus strain (HTLV-IIIB) of 3 nM. HI-346 is a vaginal bactericidal contraceptive agent, with its sperm-killing activity having an EC₅₀ value of 42 μM. HI-346 shows no cytotoxicity to normal cells at effective concentrations. HI-346 can be used in anti-HIV-1 and contraceptive research .

HY-125810

4'-Ethynyl-2'-deoxyadenosine	HIV Reverse Transcriptase	Infection Inflammation/Immunology
4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC₅₀ of 98 nM in MT-4 cells for anti-HIV-1 activity . 4'-Ethynyl-2'-deoxyadenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N15327

Hyrtiosal	HIV HIV Integrase	Infection
Hyrtiosal, found in the marine sponge Hyrtios erectus, is an inhibitor of the N-terminal domain (NTD) of HIV-1 integrase (HIV-1 IN) with an IC₅₀ value of 9.60-0.86 μM. Hyrtiosal binds to the Ser17, Trp19, and Lys34 sites on the NTD of HIV-1 IN, inhibiting the binding of HIV-1 viral DNA to integrase and interfering with the formation of the pre-integrated complex of HIV-1. Hyrtiosal is promising for research of anti-HIV agents .

HY-134809A

Cyclotriazadisulfonamide hydrochloride CADA hydrochloride	HIV	Infection
Cyclotriazadisulfonamide (CADA) hydrochloride is a specific CD4-targeted HIV entry inhibitor with activity against HIV-1 replication. Cyclotriazadisulfonamide hydrochloride can specifically downregulate the expression of CD4 receptors on the cell surface, effectively inhibiting HIV transmission. Cyclotriazadisulfonamide hydrochloride can inhibit HIV-1(NL4.3) and SIV(mac251), and has a synergistic effect when used in combination with cellulose acetate (CAP). Cyclotriazadisulfonamide hydrochloride can also be used as a microbial gel formulation to maintain CD4 downregulation and antiviral activity, and is a broad-spectrum anti-HIV agent.

HY-W009722A

Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% Ditiocarb sodium trihydrate, ACS, 99.0%	HIV Biochemical Assay Reagents	Infection
Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% (Ditiocarb sodium trihydrate, ACS, 99.0%) is a copper reagent. The reaction with Cu ²⁺ solution resulted in the formation of a complex, which increased the copper displacement precipitation rate. Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% can reduce HIV infection and can be used in adjuvant immune research of high-risk breast cancer .

HY-126781

Fozivudine tidoxil BM-211290	HIV DNA/RNA Synthesis	Infection
Fozivudine tidoxil (BM-211290) is an orally active thioether lipid-zidovudine (ZDV) conjugate with *anti-HIV* activity. Fozivudine tidoxil, a member of the NRTI family of agent, is incorporated into the newly synthesized strand of DNA during intracellular viral replication and irreversibly binds viral RT which disrupts viral reverse-transcription . Fozivudine tidoxil is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-111224

GSK812397	HIV CXCR	Infection
GSK812397 is a CXCR4 antagonist with potential for the treatment of HIV infection. To evaluate the clinical potential of GSK812397, kilogram-scale agent candidates are needed. Here, an improved, scalable synthetic route for the CXCR4 antagonist GSK812397 is described. This new route has been scaled up in a 50-liter stationary facility to obtain 1.2 kg of agent substance in 20% overall yield and >99% chemical and enantiomeric purity in five steps. CXC chemokine receptor 4 (CXCR4) is a 7-transmembrane protein that functions in part as a host co-receptor for multiple strains of HIV-1. It is thought that targeting CXCR4 will help inhibit the replication of several late cytopathic viruses; therefore, CXCR4 antagonists are one of the most promising new classes of experimental anti-HIV agents. GSK812397 is a potent CXCR4 antagonist and is therefore a candidate for investigation for the treatment of HIV infection.

HY-N4155

2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid	EBV HIV Protease HSV	Infection Cancer
2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid, a natural ursane-type triterpene, is a potent inhibitor of HIV protease (HIV Protease). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid is also an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid displays an inhibitory activity against nitric oxide production in Lipopolysaccharide (Lipopolysaccharides)-activated RAW 264.7 cells .

Cat. No.	Product Name	Type

HY-W127423

Methyl 2-hydroxyoctadecanoate	Biochemical Assay Reagents
Methyl (+/-)-2-hydroxystearateis a hydroxylated fatty acid methyl ester that broadens phase transitions in dimyristoylphosphatidylcholine (DMPC) lipid membranes. It has been used in the synthesis of lipid-nucleotide conjugated anti-HIV agents to increase the cleavage of phosphodiester bonds and the number of released intracellular nucleotides.

HY-W009722A

Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% Ditiocarb sodium trihydrate, ACS, 99.0%	Chelators
Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% (Ditiocarb sodium trihydrate, ACS, 99.0%) is a copper reagent. The reaction with Cu ²⁺ solution resulted in the formation of a complex, which increased the copper displacement precipitation rate. Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% can reduce HIV infection and can be used in adjuvant immune research of high-risk breast cancer .

Sodium diethylcarbamodithioate trihydrate, ACS, 99.0%

Ditiocarb sodium trihydrate, ACS, 99.0%

Chelators

Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% (Ditiocarb sodium trihydrate, ACS, 99.0%) is a copper reagent. The reaction with Cu ²⁺ solution resulted in the formation of a complex, which increased the copper displacement precipitation rate. Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% can reduce HIV infection and can be used in adjuvant immune research of high-risk breast cancer .

Cat. No.	Product Name	Target	Research Area