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Pathways Recommended:	Cytoskeleton

Results for "

actin cytoskeleton

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Arp2/3 Complex (1) Akt (1) AMPK (1) Antibiotic (1) Apoptosis (1) Bacterial (1) Bcl-2 Family (1) Biochemical Assay Reagents (1) Dynamin (1) Endogenous Metabolite (1) ERK (2) FAK (1) Fluorescent Dye (2) Fungal (2) HIV Integrase (1) Integrin (1) Isotope-Labeled Compounds (1) LIM Kinase (LIMK) (3) Liposome (1) mRNA (1) mTOR (1) NF-κB (2) Oxidative Phosphorylation (1) p38 MAPK (1) PKA (1) Ras (2) Reactive Oxygen Species (ROS) (1) ROCK (1) Src (1)
By Research Areas:	Cancer (12) Infection (3) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (3)
Oligonucleotides:	mRNA (1) Phospholipids (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

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Products

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Arp2/3 Complex

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111009

Swinholide A	Fungal	Infection
Swinholide A is the *actin*-binding marine polyketide and dimerizes actin with the K_d of ~ 50 nM . Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity .

HY-16931

SMIFH2 5+ Cited Publications	Arp2/3 Complex	Cancer
SMIFH2 is a formin specific inhibitor. SMIFH2 inhibits actin polymerization by Formins and affects the actin cytoskeleton .

HY-P0028

Phalloidin 20+ Cited Publications	Fluorescent Dye	Others
Phalloidin is a mushroom-derived toxin which can be used to label F-actin of the cytoskeleton with fluorochrome .

HY-136808

Pfn1-IN-1	Others	Cancer
Pfn1-IN-1 (compound C1) is a Pfn1 inhibitor that inhibits the angiogenic capacity of endothelial cells (EC). Pfn1 is a regulator of the actin cytoskeleton, inducing actin polymerization and essential cellular activities. Pfn1-IN-1 inhibits Pfn1-Actin interaction and Actin polymerization.

HY-117149

MLS000532223	Ras	Cancer
MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases, with EC₅₀ values ranging from 16 μM to 120 μM. MLS000532223 prevents GTP binding to several GTPases .

HY-162798

ROCK2-IN-9	ROCK	Cancer
ROCK2-IN-9 (compound 7u) is a selective ROCK2 inhibitor (IC₅₀=36.8 nM) with anticancer activity. ROCK2-IN-9 inhibits cancer cell migration and invasion by regulating multiple cellular activities of the actin cytoskeleton. ROCK2-IN-9 can be used in breast cancer research .

HY-E70841

LIMK2 Recombinant Human Active Protein Kinase	LIM Kinase (LIMK)	Cancer
LIM kinase 2 (LIMK2) is a serine/threonine and tyrosine kinases. LIMK2 plays a crucial role in the regulation of cytoskeleton dynamics by controlling actin filaments and microtubule turnover, especially through the phosphorylation of cofilin, an actin depolymerising factor. LIMK2 Recombinant Human Active Protein Kinase is a recombinant LIMK2 protein that can be used to study LIMK2-related functions .

HY-174548

Human PDGFRB mRNA	mRNA	Cancer
Human PDGFRB mRNA encodes the human platelet derived growth factor receptor beta (PDGFRB) protein, a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. PDGFRB is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton.

HY-P3828

Biotin-myelin basic protein (94-102)	Fluorescent Dye	Neurological Disease
Biotin-myelin basic protein (94-102) is a peptide fragemt. Myelin basic protein is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin, it plays an important role in the process of myelination of nerves in the nervous system. Myelin basic protein also acts as a membrane actin-binding protein, which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin .

HY-174229

SM311	LIM Kinase (LIMK)	Neurological Disease Cancer
SM311 (Compound 10), a chemical probe, is a potent selective irreversible LIMK1 inhibitor (EC₅₀=0.045 μM, >30-fold selective over LIMK2). SM311 blocks cofilin phosphorylation and actin cytoskeleton regulation. SM311 is promising for research of neurodegenerative diseases like Fragile X syndrome (FXS) and Alzheimer’s disease, as well as tumor invasion .

HY-P5455

S3 Fragment	LIM Kinase (LIMK)	Others
S3 Fragment is a biological active peptide. (This peptide contains the unique amino-terminal phosphorylation site of Xenopus ADF/cofilin, the LIM kinase (LIMK) phosphorylation site. LIMK1 is a key regulator of the actin cytoskeleton through its phosphorylation of ADF/cofilin at serine-3 for inactivation. This peptide is a fragment of the S3 peptide containing the serine-3 sequence of ADF/cofilin that has been widely used as an effective competitive inhibitor of LIMK1.)

HY-P10993

CT20p	Bcl-2 Family	Cancer
CT20p is an anticancer peptide based on the C hydrophobic terminus of Bax. CT20p has a unique cytotoxic effect independent of full-length Bax, and can act on mitochondria, leading to fusion-like aggregation and mitochondrial membrane hyperpolarization. CT20p can reduce α5β1 integrin levels and inhibit *F-actin* polymerization, thereby destroying the cytoskeleton and preventing cell attachment. CT20p can be used in the study of breast cancer .

HY-148385

Ganglioside GM2	Endogenous Metabolite Integrin FAK Src ERK p38 MAPK	Neurological Disease Cancer
Ganglioside GM2 is a human tumor antigen predominantly found in human tumor cells and fetal brain tissue. As a sialylated glycosphingolipid, Ganglioside GM2 is involved in processes such as cell signaling, adhesion, and motility. Ganglioside GM2 abnormal expression and accumulation are associated with tumors and neurodegenerative disorders. Ganglioside GM2 promotes tumor cell migration and invasion by directly binding to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, and inducing actin cytoskeleton remodeling .

HY-N6727

Gliotoxin Aspergillin	Apoptosis PKA NF-κB Bacterial Fungal Antibiotic	Infection Inflammation/Immunology Cancer
Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells . Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis . Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells . Gliotoxin is a potent NOTCH2 transactivation inhibitor, can effectively induce apoptosis of chronic lymphocytic leukemia (CLL) cells .

HY-N6588

3,4,5-Tricaffeoylquinic acid 3,4,5-triCQA	Akt NF-κB	Inflammation/Immunology Cancer
3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. 3,4,5-Tricaffeoylquinic acid induces cell cycle arrest at G0/G1, actin cytoskeleton organization, chromatin remodeling, neuronal differentiation, and bone morphogenetic protein signaling in human neural stem cells. 3,4,5-Tricaffeoylquinic acid has the potential for the research of aging-associated diseases .

HY-152003S

Ganglioside GM2-d3 ammonium	Isotope-Labeled Compounds	Others
Ganglioside GM2-d₃ (ammonium) is the deuterium labeled Ganglioside GM2 (HY-148385). Ganglioside GM2 is a human tumor antigen predominantly found in human tumor cells and fetal brain tissue. As a sialylated glycosphingolipid, Ganglioside GM2 is involved in processes such as cell signaling, adhesion, and motility. Ganglioside GM2 abnormal expression and accumulation are associated with tumors and neurodegenerative disorders. Ganglioside GM2 promotes tumor cell migration and invasion by directly binding to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, and inducing actin cytoskeleton remodeling .

HY-157699

1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium	Liposome Biochemical Assay Reagents
1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium is a membrane-bound signaling molecule with intracellular activity in regulating membrane trafficking and signal transduction. 1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium can be used in the preparation of liposomes to enhance the efficiency of compound delivery. 1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium can also act as a coordinator of the actin cytoskeleton and participate in the regulation of cell morphology and motility.

HY-123572

Bis-T-23 AG1717	Dynamin HIV Integrase	Infection Metabolic Disease Inflammation/Immunology
Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. Bis-T-23 can promote actin-dependent dynamin oligomerization. Bis-T-23 can be used for the research of HIV and chronic kidney diseases (CKD) .

HY-115507

NMac1	AMPK mTOR ERK Oxidative Phosphorylation Reactive Oxygen Species (ROS) Ras	Cancer
NMac1 is an orally active Nm23/NDPK activator. NMac1 directly binds to Nm23-H1 and activates the NDPK activity of recombinant Nm23-H1 with an EC₅₀ of 10.7 uM. NMac1 induces AMPK activation and inhibits mTOR and ERK, leading to mitochondrial OXPHOS dysregulation and suppressing mitochondrial ROS production, which in turn induces mitochondrial dysfunction in MDA-MB-231 cells. NMac1 inhibits Complex I activity and suppresses changes in morphology and actin cytoskeleton organization following Rac1 activation in MDA-MB-231 cells. NMac1 inhibits tumor invasion, migration and metastasis. NMac1 is useful for studying metastatic tumors, such as breast cancer. NMac1 can be isolated from the ginger cassumunar Roxb .

Cat. No.	Product Name

HY-L060

Cytoskeleton Compound Library	1,859 compounds
The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases. MCE designs a unique collection of 1,859 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

Cytoskeleton Compound Library

1,859 compounds

The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases.

MCE designs a unique collection of 1,859 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

Cat. No.	Product Name	Type

HY-157699

1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium	Drug Delivery
1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium is a membrane-bound signaling molecule with intracellular activity in regulating membrane trafficking and signal transduction. 1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium can be used in the preparation of liposomes to enhance the efficiency of compound delivery. 1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium can also act as a coordinator of the actin cytoskeleton and participate in the regulation of cell morphology and motility.

1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium

Drug Delivery

1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium is a membrane-bound signaling molecule with intracellular activity in regulating membrane trafficking and signal transduction. 1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium can be used in the preparation of liposomes to enhance the efficiency of compound delivery. 1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium can also act as a coordinator of the actin cytoskeleton and participate in the regulation of cell morphology and motility.

Cat. No.	Product Name	Target	Research Area

HY-P0028

Phalloidin 20+ Cited Publications	Fluorescent Dye	Others
Phalloidin is a mushroom-derived toxin which can be used to label F-actin of the cytoskeleton with fluorochrome .

HY-P5455

S3 Fragment	LIM Kinase (LIMK)	Others
S3 Fragment is a biological active peptide. (This peptide contains the unique amino-terminal phosphorylation site of Xenopus ADF/cofilin, the LIM kinase (LIMK) phosphorylation site. LIMK1 is a key regulator of the actin cytoskeleton through its phosphorylation of ADF/cofilin at serine-3 for inactivation. This peptide is a fragment of the S3 peptide containing the serine-3 sequence of ADF/cofilin that has been widely used as an effective competitive inhibitor of LIMK1.)

HY-P3828

Biotin-myelin basic protein (94-102)	Fluorescent Dye	Neurological Disease
Biotin-myelin basic protein (94-102) is a peptide fragemt. Myelin basic protein is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin, it plays an important role in the process of myelination of nerves in the nervous system. Myelin basic protein also acts as a membrane actin-binding protein, which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin .

HY-P10993

CT20p	Bcl-2 Family	Cancer
CT20p is an anticancer peptide based on the C hydrophobic terminus of Bax. CT20p has a unique cytotoxic effect independent of full-length Bax, and can act on mitochondria, leading to fusion-like aggregation and mitochondrial membrane hyperpolarization. CT20p can reduce α5β1 integrin levels and inhibit *F-actin* polymerization, thereby destroying the cytoskeleton and preventing cell attachment. CT20p can be used in the study of breast cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-111009

Swinholide A	Infection Natural Products Classification of Application Fields Animals Source classification Marine natural products Sponge Disease Research Fields	Fungal
Swinholide A is the *actin*-binding marine polyketide and dimerizes actin with the K_d of ~ 50 nM . Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity .

HY-N6727

Gliotoxin Aspergillin	Anti-inflammation/Immunoregulatory Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Biological Pesticide Research Agricultural Research Infection Microorganisms Antibiotics Inflammation/Immunology Disease Research Fields	Apoptosis PKA NF-κB Bacterial Fungal Antibiotic
Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells . Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis . Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells . Gliotoxin is a potent NOTCH2 transactivation inhibitor, can effectively induce apoptosis of chronic lymphocytic leukemia (CLL) cells .

HY-N6588

3,4,5-Tricaffeoylquinic acid 3,4,5-triCQA	Classification of Application Fields Simple Phenylpropanols Source classification Phenols Polyphenols Phenylpropanoids Plants Convolvulaceae Inflammation/Immunology Disease Research Fields Ipomoea batatas (Linn.) Lamarck	Akt NF-κB
3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. 3,4,5-Tricaffeoylquinic acid induces cell cycle arrest at G0/G1, actin cytoskeleton organization, chromatin remodeling, neuronal differentiation, and bone morphogenetic protein signaling in human neural stem cells. 3,4,5-Tricaffeoylquinic acid has the potential for the research of aging-associated diseases .

Cat. No.	Product Name	Chemical Structure

HY-152003S

Ganglioside GM2-d3 ammonium
Ganglioside GM2-d₃ (ammonium) is the deuterium labeled Ganglioside GM2 (HY-148385). Ganglioside GM2 is a human tumor antigen predominantly found in human tumor cells and fetal brain tissue. As a sialylated glycosphingolipid, Ganglioside GM2 is involved in processes such as cell signaling, adhesion, and motility. Ganglioside GM2 abnormal expression and accumulation are associated with tumors and neurodegenerative disorders. Ganglioside GM2 promotes tumor cell migration and invasion by directly binding to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, and inducing actin cytoskeleton remodeling .

Ganglioside GM2-d3 ammonium

Ganglioside GM2-d₃ (ammonium) is the deuterium labeled Ganglioside GM2 (HY-148385). Ganglioside GM2 is a human tumor antigen predominantly found in human tumor cells and fetal brain tissue. As a sialylated glycosphingolipid, Ganglioside GM2 is involved in processes such as cell signaling, adhesion, and motility. Ganglioside GM2 abnormal expression and accumulation are associated with tumors and neurodegenerative disorders. Ganglioside GM2 promotes tumor cell migration and invasion by directly binding to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, and inducing actin cytoskeleton remodeling .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P85576

	Phostensin Antibody (YA5268) HKMT1098; KIAA1949; Protein phosphatase 1 F actin cytoskeleton targeting subunit.	WB	Human
	Phostensin Antibody (YA5268) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Phostensin.

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Cat. No.	Product Name		Classification

HY-174548

Human PDGFRB mRNA		mRNA
Human PDGFRB mRNA encodes the human platelet derived growth factor receptor beta (PDGFRB) protein, a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. PDGFRB is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton.

HY-157699

1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium		Phospholipids
1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium is a membrane-bound signaling molecule with intracellular activity in regulating membrane trafficking and signal transduction. 1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium can be used in the preparation of liposomes to enhance the efficiency of compound delivery. 1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium can also act as a coordinator of the actin cytoskeleton and participate in the regulation of cell morphology and motility.

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actin cytoskeleton

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Natural
Products