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acquisition

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11

Inhibitors & Agonists

1

Biochemical Assay Reagents

1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10932
    Aniracetam
    1 Publications Verification

    Ro 13-5057

    		 nAChR iGluR Neurological Disease
    Aniracetam (Ro 13-5057) is an orally active neuroprotective agent, possessing nootropics effects. Aniracetam potentiates the ionotropic quisqualate (iQA) responses in the CA1 region of rat hippocampal slices. Aniracetam also potentiates the excitatory post synaptic potentials (EPSPs) in Schaffer collateral-commissural synapses. Aniracetam can prevents the CO2-induced impairment of acquisition in hypercapnia model rats. Aniracetam can be used to research cerebral dysfunctional disorders .
    Aniracetam
  • HY-W354203
    N'-Isonicotinoylisonicotinohydrazide

    1,2-Diisonicotinoylhydrazine

    		 Reactive Oxygen Species (ROS) Bacterial Infection
    N'-Isonicotinoylisonicotinohydrazide (Compound 7, 1,2-Diisonicotinoylhydrazine) is a competitive inhibitor (IC50=5-30 μM) of bacterial heme oxygenase (HO). N'-Isonicotinoylisonicotinohydrazide inhibits iron release and bacterial iron acquisition. N'-Isonicotinoylisonicotinohydrazide exhibits selective activity against HO enzymes from Pseudomonas aeruginosa and Neisseria meningitidis. N'-Isonicotinoylisonicotinohydrazide is promising for research of multidrug-resistant Gram-negative bacterial infections .
    N'-Isonicotinoylisonicotinohydrazide
  • HY-77957
    1-O-Methyl-2-deoxy-D-ribose

    		Biochemical Assay Reagents Others
    1-O-Methyl-2-deoxy-D-ribose is a ribose derivative that can be more conveniently obtained through a one-step reaction by introducing a methoxy protective group at the anomeric carbon position under acidic conditions. This facilitates the acquisition of 2-deoxy-D-ribose. 1-O-Methyl-2-deoxy-D-ribose can be utilized in research on the synthesis of chemical materials .
    1-O-Methyl-2-deoxy-D-ribose
  • HY-128200
    Pseudomonas quinolone signal
    1 Publications Verification

    PQS

    		 Bacterial Infection Inflammation/Immunology
    Pseudomonas quinolone signal (PQS) is a quorum-sensing signaling molecule produced by Pseudomonas aeruginosa. The synthesis of Pseudomonas quinolone signal relies on the las quorum-sensing system, and its biological activity is associated with the rhl system. Pseudomonas quinolone signal regulates the expression of the virulence gene lasB. Additionally, Pseudomonas quinolone signal plays roles in iron acquisition, cytotoxicity, outer-membrane vesicle biogenesis, and host immune modulation .
    Pseudomonas quinolone signal
  • HY-10895
    SB-334867
    Maximum Cited Publications
    8 Publications Verification

    SB 334867A

    		 Orexin Receptor (OX Receptor) Neurological Disease Endocrinology
    SB-334867 (SB 334867A) is an excellent,selective and blood-brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pKb=7.4), 100-fold over 5-HT2B, 5-HT2C with pKi values of 5.4 and 5.3, respectively . SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo .
    SB-334867
  • HY-10895A
    SB-334867 free base
    Maximum Cited Publications
    8 Publications Verification

    SB334867A free base

    		 Orexin Receptor (OX Receptor) Neurological Disease Endocrinology
    SB-334867 free base (SB334867A free base) is an excellent, selective and blood–brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pKb=7.4), 100-fold over 5-HT2B, 5-HT2C with pKi values of 5.4 and 5.3, respectively . SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo .
    SB-334867 free base
  • HY-10932R
    Aniracetam (Standard)

    Ro 13-5057 (Standard)

    		 Reference Standards nAChR iGluR Neurological Disease
    Aniracetam (Standard) is the analytical standard of Aniracetam. This product is intended for research and analytical applications. Aniracetam (Ro 13-5057) is an orally active neuroprotective agent, possessing nootropics effects. Aniracetam potentiates the ionotropic quisqualate (iQA) responses in the CA1 region of rat hippocampal slices. Aniracetam also potentiates the excitatory post synaptic potentials (EPSPs) in Schaffer collateral-commissural synapses. Aniracetam can prevents the CO2-induced impairment of acquisition in hypercapnia model rats. Aniracetam can be used to research cerebral dysfunctional disorders .
    Aniracetam (Standard)
  • HY-114992
    2-Propyl-2-pentenoic acid

    		Drug Metabolite Neurological Disease
    2-Propyl-2-pentenoic acid is a metabolite of Valproic acid (HY-10585). 2-Propyl-2-pentenoic acid has a facilitating action on the acquisition of conditioned behavior with negative reinforcement in mice .
    2-Propyl-2-pentenoic acid
  • HY-N14351
    Ferrocin A

    		SARS-CoV Bacterial Antibiotic Infection
    Ferrocin A is a lipopeptide compound that targets the SARS-CoV-2 RNA-dependent RNA polymerase (nsp12). Ferrocin A can stably bind to nsp12, and as an iron-chelating peptide, it reduces the concentration of free iron in the environment via complexation, thereby inhibiting bacterial growth by repressing the acquisition of essential metal cations. As an iron-chelating antiviral molecule, Ferrocin A may be used in studies related to COVID-19 and bacterial infections .
    Ferrocin A
  • HY-175254
    Antibiofilm agent-17

    		Bacterial Infection
    Antibiofilm agent-17 is a dual-action biofilm inhibitor against Pseudomonas aeruginosa (IC50 = 0.33 μM). Antibiofilm agent-17 inhibits biofilm growth by reducing quorum sensing-mediated virulence production and iron ion acquisition. Antibiofilm agent-17 exhibits synergistic antimicrobial effects in a mouse wound infection model. Antibiofilm agent-17 can be used in research on combating Pseudomonas aeruginosa infections .
    Antibiofilm agent-17
  • HY-10895R
    SB-334867 (Standard)

    		Orexin Receptor (OX Receptor) Neurological Disease Endocrinology
    SB-334867 (Standard) is the analytical standard of SB-334867. This product is intended for research and analytical applications. SB-334867 (SB 334867A) is an excellent,selective and blood-brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pKb=7.4), 100-fold over 5-HT2B, 5-HT2C with pKi values of 5.4 and 5.3, respectively . SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo .
    SB-334867 (Standard)

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