Search Result

Results for "

YTHDF

" in MedChemExpress (MCE) Product Catalog:

By Targets:	YTHDF (9) Apoptosis (4) Autophagy (2) Endogenous Metabolite (1) Epigenetic Reader Domain (1) Ferroptosis (2) FOXO (1) Glutathione Peroxidase (2) Heme Oxygenase (HO) (2) Indoleamine 2,3-Dioxygenase (IDO) (2) Influenza Virus (1) Interleukin Related (1) Keap1-Nrf2 (2) MMP (1) PROTACs (1) Pyroptosis (1) Reactive Oxygen Species (ROS) (2) Reference Standards (2) Small Interfering RNA (siRNA) (9) TGF-β Receptor (2)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Endocrinology (1) Infection (1) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (3) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (3) siRNAs (9)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: YTHDF

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-173008

YTHDF2-IN-1	Apoptosis YTHDF	Cancer
YTHDF2-IN-1 (Compound CK-75) is the inhibitor for YT521-B homology domain family 2 *YTHDF2* (K_d=26.2 μM), that blocks the interaction between YTHDF2 and m6A RNA. YTHDF2-IN-1 inhibits the colony formation of JAR cells, exhibits antiproliferative activity in a variety of cancer cells (IC₅₀ in micromolar levels), arrests the cell cycle at G0/G1 phase, induces apoptosis in K562 .

HY-174982

YTHDF2 ligand-1	YTHDF	Cancer
YTHDF2 ligand-1 (Compound 23) is a selective and high-affinity *YTHDF2* ligand with a K_d of 1.3 μM (FP assay) and an IC₅₀ of 11 μM (HTRF assay) . YTHDF2 ligand-1 can be used in the study of cancer .

HY-RS15939

YTHDF3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) YTHDF	Others
YTHDF3 Human Pre-designed siRNA Set A contains three designed siRNAs for YTHDF3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

YTHDF3 Human Pre-designed siRNA Set A YTHDF3 Human Pre-designed siRNA Set A

HY-RS15937

YTHDF1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) YTHDF	Others
YTHDF1 Human Pre-designed siRNA Set A contains three designed siRNAs for YTHDF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

YTHDF1 Human Pre-designed siRNA Set A YTHDF1 Human Pre-designed siRNA Set A

HY-RS23691

Ythdf1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ythdf1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ythdf1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ythdf1 Rat Pre-designed siRNA Set A Ythdf1 Rat Pre-designed siRNA Set A

HY-RS17237

Ythdf1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ythdf1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ythdf1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ythdf1 Mouse Pre-designed siRNA Set A Ythdf1 Mouse Pre-designed siRNA Set A

HY-RS15938

YTHDF2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) YTHDF	Others
YTHDF2 Human Pre-designed siRNA Set A contains three designed siRNAs for YTHDF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

YTHDF2 Human Pre-designed siRNA Set A YTHDF2 Human Pre-designed siRNA Set A

HY-RS26325

Ythdf3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ythdf3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ythdf3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ythdf3 Rat Pre-designed siRNA Set A Ythdf3 Rat Pre-designed siRNA Set A

HY-RS19828

Ythdf3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ythdf3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ythdf3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ythdf3 Mouse Pre-designed siRNA Set A Ythdf3 Mouse Pre-designed siRNA Set A

HY-RS23390

Ythdf2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ythdf2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ythdf2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ythdf2 Rat Pre-designed siRNA Set A Ythdf2 Rat Pre-designed siRNA Set A

HY-RS16947

Ythdf2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ythdf2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ythdf2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ythdf2 Mouse Pre-designed siRNA Set A Ythdf2 Mouse Pre-designed siRNA Set A

HY-168610

YTH-IN-1	Epigenetic Reader Domain YTHDF	Cancer
YTH-IN-1 (compound N-7) is a pan-YTH domain inhibitor with the IC₅₀ values of 39 μM, 34 μM, 35 μM, 48 μM and 30 μM for human YTH ^YTHDF1, YTH ^YTHDF2, YTH ^YTHDF3, YTH ^YTHDC1, and YTH ^YTHDC2, respectively .

HY-176848

SKLB-Y13	YTHDF Apoptosis	Cancer
SKLB-Y13 is a selective *YTHDF1* inhibitor with an IC₅₀ of 0.76  μM. SKLB-Y13 binds to the m ⁶A recognition pocket and disrupts m ⁶A-dependent YTHDF1-PRPF6 mRNA interaction, impairing the translation of PRPF6 and inhibiting breast cancer proliferation while promoting apoptosis. SKLB-Y13 has antitumor activity, promising for cancers therapies targeting RNA epigenetic Readers .

HY-154919

DC-Y13-27 4 Publications Verification	YTHDF FOXO MMP Pyroptosis Interleukin Related	Endocrinology Cancer
DC-Y13-27 is a DC-Y13 derivative and *YTHDF2* inhibitor (K_D: 37.9 μM). DC-Y13-27 inhibits *YTHDF2, restores FOXO3* and TIMP1 protein levels, and reduces MMP1/3/7/9 expression. DC-Y13-27 induces Pyroptosis and increases IL-1β secretion. DC-Y13-27 reduces intervertebral disc degeneration and enhances the response to radiotherapy in colon cancer and melanoma. DC-Y13-27 has antitumor activity against breast cancer .

HY-N0086R

N6-Methyladenosine (Standard) 6-Methyladenosine (Standard); N-Methyladenosine (Standard)	Endogenous Metabolite Influenza Virus Reference Standards	Infection
N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion . N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits .

HY-137341

SK-3-91	PROTACs YTHDF	Cancer
SK-3-91 is a PROTAC-type multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases). SK-3-91 induces protein degradation through the ubiquitin biotinylation (E-STUB) pathway. SK-3-91 degrades *YTHDF2*. SK-3-91 inhibits cell proliferation and induces morphological changes. (Pink: TAE648 ligand (HY-169396); Blue: E3 ligase ligand (HY-131717); Black: Linker (HY-140819). The E3 ligase ligand and linker can form a conjugate (HY-169397)) .

HY-N0353R

Curdione (Standard) (+)-Curdione (Standard)	Reference Standards Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) TGF-β Receptor Indoleamine 2,3-Dioxygenase (IDO)	Others
Curdione (Standard) is the analytical standard of Curdione. This product is intended for research and analytical applications. Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2. Curdione inhibits ferroptosis in Isoproterenol (HY-B0468)-induced myocardial infarction by regulating the Keap1/Trx1/GPX4 signaling pathway, suppressing oxidative stress (ROS) and apoptosis. Curdione ameliorates Doxorubicin (HY-15142)-induced cardiotoxicity by inhibiting oxidative stress (ROS) and activating the Nrf2/HO-1 pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin (HY-17565A)-induced pulmonary fibrosis by inhibiting TGF-β-induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting IDO1. Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated ERBB4 promoter methylation. Curdione inhibits inducible prostaglandin E2 production (IC₅₀ = 1.1 μM) and cyclooxygenase 2 expression .

HY-N0353

Curdione 1 Publications Verification (+)-Curdione	Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) TGF-β Receptor Indoleamine 2,3-Dioxygenase (IDO)	Cardiovascular Disease Neurological Disease Cancer
Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2. Curdione inhibits ferroptosis in Isoproterenol (HY-B0468)-induced myocardial infarction by regulating the Keap1/Trx1/GPX4 signaling pathway, suppressing oxidative stress (ROS) and apoptosis. Curdione ameliorates Doxorubicin (HY-15142)-induced cardiotoxicity by inhibiting oxidative stress (ROS) and activating the Nrf2/HO-1 pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin (HY-17565A)-induced pulmonary fibrosis by inhibiting TGF-β-induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting IDO1. Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated ERBB4 promoter methylation. Curdione inhibits inducible prostaglandin E2 production (IC₅₀ = 1.1 μM) and cyclooxygenase 2 expression .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0086R

N6-Methyladenosine (Standard) 6-Methyladenosine (Standard); N-Methyladenosine (Standard)	Structural Classification Natural Products Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite Influenza Virus Reference Standards
N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion . N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits .

HY-N0353

Curdione 1 Publications Verification (+)-Curdione	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Other Diseases Curcuma phaeocaulis Valeton Plants Disease Research Fields Zingiberaceae	Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) TGF-β Receptor Indoleamine 2,3-Dioxygenase (IDO)
Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2. Curdione inhibits ferroptosis in Isoproterenol (HY-B0468)-induced myocardial infarction by regulating the Keap1/Trx1/GPX4 signaling pathway, suppressing oxidative stress (ROS) and apoptosis. Curdione ameliorates Doxorubicin (HY-15142)-induced cardiotoxicity by inhibiting oxidative stress (ROS) and activating the Nrf2/HO-1 pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin (HY-17565A)-induced pulmonary fibrosis by inhibiting TGF-β-induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting IDO1. Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated ERBB4 promoter methylation. Curdione inhibits inducible prostaglandin E2 production (IC₅₀ = 1.1 μM) and cyclooxygenase 2 expression .

HY-N0353R

Curdione (Standard) (+)-Curdione (Standard)	Structural Classification Terpenoids Sesquiterpenes Source classification Curcuma phaeocaulis Valeton Plants Zingiberaceae	Reference Standards Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) TGF-β Receptor Indoleamine 2,3-Dioxygenase (IDO)
Curdione (Standard) is the analytical standard of Curdione. This product is intended for research and analytical applications. Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2. Curdione inhibits ferroptosis in Isoproterenol (HY-B0468)-induced myocardial infarction by regulating the Keap1/Trx1/GPX4 signaling pathway, suppressing oxidative stress (ROS) and apoptosis. Curdione ameliorates Doxorubicin (HY-15142)-induced cardiotoxicity by inhibiting oxidative stress (ROS) and activating the Nrf2/HO-1 pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin (HY-17565A)-induced pulmonary fibrosis by inhibiting TGF-β-induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting IDO1. Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated ERBB4 promoter methylation. Curdione inhibits inducible prostaglandin E2 production (IC₅₀ = 1.1 μM) and cyclooxygenase 2 expression .

Cat. No.	Compare	Product Name	Species	Source

HY-P702576

	YTHDF2 Protein, Human (His) DF2; CLL-associated antigen KW-14; High-glucose-regulated protein 8; Renal carcinoma antigen NY-REN-2	Human	E. coli
	YTHDF2 Protein, Human (His) is the recombinant human-derived YTHDF2, expressed by E. coli , with C-6*His labeled tag. ,

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81684

	YTHDF1 Antibody (YA1429) C20orf21; DF1	WB, IP	Human, Hamster
	YTHDF1 Antibody (YA1429) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to YTHDF1.

HY-P86454

	YTHDF2 Antibody (YA6146)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	YTHDF2 Antibody (YA6146) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to YTHDF2.

HY-P86545

	YTHDF1 Antibody (YA6237) C20orf21; DACA 1; DACA-1; Dermatomyositis associated with cancer putative autoantigen 1; YTH domain family 1; YTH domain family member 1; YTH domain family protein 1; YTHD1; YTHD1_HUMAN; YTHDF1;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	YTHDF1 Antibody (YA6237) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to YTHDF1.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

YTHDF3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
YTHDF3 Human Pre-designed siRNA Set A contains three designed siRNAs for YTHDF3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

YTHDF1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
YTHDF1 Human Pre-designed siRNA Set A contains three designed siRNAs for YTHDF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ythdf1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ythdf1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ythdf1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ythdf1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ythdf1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ythdf1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

YTHDF2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
YTHDF2 Human Pre-designed siRNA Set A contains three designed siRNAs for YTHDF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ythdf3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ythdf3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ythdf3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ythdf3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ythdf3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ythdf3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ythdf2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ythdf2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ythdf2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ythdf2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ythdf2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ythdf2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks