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Voltage-dependent Ca2 channel

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By Targets:	Calcium Channel (11) Potassium Channel (3) Sodium Channel (2) Androgen Receptor (1) Apoptosis (1) Autophagy (1) Bacterial (1) Endogenous Metabolite (1) Enterovirus (1) ERK (1) GABA Receptor (2) Guanylate Cyclase (1) iGluR (1) Isotope-Labeled Compounds (1) Mineralocorticoid Receptor (1) NF-κB (1) Reference Standards (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (7) Endocrinology (1) Infection (2) Inflammation/Immunology (4) Metabolic Disease (5) Neurological Disease (3)

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Targets Recommended: CRAC Channel VDAC Apical Sodium-Dependent Bile Acid Transporter CaMK CDK PKG SNIPERs DNA-PK Chloride Channel Calcium Channel HCN Channel TRP Channel Sodium Channel Potassium Channel Piezo Channel SGLT CDKL PDK-1 Pyruvate Oxidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Q40876

BBT	Calcium Channel	Metabolic Disease
BBT is an enhancer of impaired glucose-stimulated insulin secretion (GSIS). BBT exhibits anti-hyperglycemia activity, and protects β-cells from cytokine- or streptozotocin (STZ (HY-13753))-induced cell death in type 2 diabetes models. BBT acts function via cAMP/PKA and long-lasting (L-type) voltage-dependent Ca2+ channel/CaMK2 pathway .

HY-N0215S14

L-Phenylalanine-15N,d8 (S)-2-Amino-3-phenylpropionic acid-¹⁵N,d₈	Isotope-Labeled Compounds Calcium Channel iGluR Endogenous Metabolite	Metabolic Disease
L-Phenylalanine- ¹⁵N,d₈ is the deuterium and ¹⁵N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a K_i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .

HY-N2060

Evocarpine	Apoptosis Bacterial	Infection Inflammation/Immunology Cancer
Evocarpine, a quinolone alkaloid that could be isolated from Evodiae fructus, inhibitss Ca ²⁺ influx through voltage-dependent calcium channels. Antimycobacterial activity .

HY-P0190A

Iberiotoxin TFA 1 Publications Verification	Potassium Channel	Others
Iberiotoxin (TFA) is a selective high conductance high conductance **Ca ²⁺-activated K ⁺ channel inhibitor with a K_d** of ~1 nM. Iberiotoxin (TFA) does not block other types of voltage-dependent ion channels .

HY-P0190

Iberiotoxin 1 Publications Verification	Potassium Channel	Cardiovascular Disease
Iberiotoxin is a toxin isolated from Buthus tamulus scorpion venom. Iberiotoxin is a selective high conductance high conductance **Ca ²⁺-activated K ⁺ channel inhibitor with a K_d** of ~1 nM. Iberiotoxin does not block other types of voltage-dependent ion channels .

HY-169115A

(Rac)-PD0299685	Calcium Channel	Inflammation/Immunology
(Rac)-PD0299685 is a Ca(2+) channel α2δ ligand that was investigated for relieving interstitial cystitis pain in a randomized, double-blind, placebo-controlled phase IIa study. (Rac)-PD0299685 demonstrated a clinically significant reduction in daily worst pain severity scores at the 60 mg dose compared to placebo. (Rac)-PD0299685 is also a potent voltage-dependent calcium channel inhibitor for the study of retina-related diseases.

HY-B1671R

(+)-Kavain (Standard)	Reference Standards GABA Receptor Sodium Channel Calcium Channel	Neurological Disease Metabolic Disease
(+)-Kavain (Standard) is the analytical standard of (+)-Kavain. This product is intended for research and analytical applications. (+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels . (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy . (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied .

HY-N15737

Fukinolic acid	Calcium Channel Enterovirus	Infection Cardiovascular Disease
Fukinolic acid is a benzyltartaric acid ester, is a vasodilator with antiviral activity against enterovirus A71 (EV-A71) replication. Fukinolic acid is a *receptor-operated Ca ²⁺* channels (ROC)** inhibitor, suppressing extracellular Ca ²⁺ influx through ROC activated by Norepinephrine (HY-13715) without affecting voltage-dependent Ca ²⁺ channels .

HY-142050

(R)-IDHP	Calcium Channel	Cardiovascular Disease
(R)-IDHP is an isomer of IDHP, a salvia metabolite that exerts vasorelaxant effects by inhibiting Ca ²⁺ release and Ca ²⁺ inward flow in voltage-dependent and receptor-operated calcium channels in vascular smooth muscle cells. IDHP is used in studies of cardiovascular disease .

HY-N15735

Cimicifugic acid D 2-Caffeoylpiscidic acid	Calcium Channel	Cardiovascular Disease
Cimicifugic acid D (2-Caffeoylpiscidic acid) is a benzyltartaric acid ester that induces vasodilation of precontracted rat aortic strips and endothelium-independent relaxation mechanism. Cimicifugic acid D inhibits extracellular Ca ²⁺ influx through *receptor-operated Ca ²⁺* channels (ROC)** in Norepinephrine (HY-13715)-induced contraction of rat aortic strips, without affecting voltage-dependent Ca ²⁺ channels (VDC) or K ⁺-induced contractions .

HY-147377

N-Salicyloyltryptamine	Calcium Channel ERK Potassium Channel Guanylate Cyclase NF-κB	Cardiovascular Disease Neurological Disease Inflammation/Immunology
N-Salicyloyltryptamine acts on voltage-dependent Na ⁺, Ca ²⁺, and K ⁺ ion channels inhibitor. N-Salicyloyltryptamine inhibits K ⁺ currents with an IC₅₀ value of 34.6 μM (I_to). N-Salicyloyltryptamine also exhibits anticonvulsant, anti-inflammatory, analgesic, and vasorelaxation effect ^- .

HY-B1671

(+)-Kavain	GABA Receptor Sodium Channel Calcium Channel	Neurological Disease Metabolic Disease
(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na ⁺ and Ca ²⁺ channels . (+)-Kavain is shown to bind at the α4β2δ GABA_A receptor and potentiate GABA efficacy . (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied .

HY-13764A

dl-Tetrandrine	Calcium Channel	Cardiovascular Disease Inflammation/Immunology Cancer
dl-Tetrandrine is an orally active and brain-penetrant calcium channel blocker that inhibits voltage-dependent calcium channels. dl-Tetrandrine selectively blocks Ca ²⁺ influx with an IC₅₀ value of approximately 1-10 μM. dl-Tetrandrine exerts anti-inflammatory, immunosuppressive, and anti-arrhythmic activities by inhibiting intracellular calcium overload, and can reverse multidrug resistance in tumor cells. dl-Tetrandrine is promising for research of autoimmune diseases (such as rheumatoid arthritis), cardiovascular diseases, and tumor drug resistance reversal .

HY-B0561

Spironolactone 5 Publications Verification SC9420	Mineralocorticoid Receptor Androgen Receptor Autophagy Calcium Channel	Cardiovascular Disease Metabolic Disease Endocrinology Cancer
Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC₅₀=24 nM) and androgen receptor (IC₅₀=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent *Ca ²⁺* channels to exert antihypertensive effects .

Cat. No.	Product Name	Target	Research Area

HY-P0190A

Iberiotoxin TFA 1 Publications Verification	Potassium Channel	Others
Iberiotoxin (TFA) is a selective high conductance high conductance **Ca ²⁺-activated K ⁺ channel inhibitor with a K_d** of ~1 nM. Iberiotoxin (TFA) does not block other types of voltage-dependent ion channels .

HY-P0190

Iberiotoxin 1 Publications Verification	Potassium Channel	Cardiovascular Disease
Iberiotoxin is a toxin isolated from Buthus tamulus scorpion venom. Iberiotoxin is a selective high conductance high conductance **Ca ²⁺-activated K ⁺ channel inhibitor with a K_d** of ~1 nM. Iberiotoxin does not block other types of voltage-dependent ion channels .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2060

Evocarpine	Infection Alkaloids Structural Classification Classification of Application Fields Evodia rutaecarpa (Juss.) Benth. Source classification Rutaceae Quinoline Alkaloids Plants Inflammation/Immunology Disease Research Fields	Apoptosis Bacterial
Evocarpine, a quinolone alkaloid that could be isolated from Evodiae fructus, inhibitss Ca ²⁺ influx through voltage-dependent calcium channels. Antimycobacterial activity .

HY-P0190

Iberiotoxin 1 Publications Verification	Cardiovascular Disease Structural Classification Natural Products Animals Classification of Application Fields Source classification Disease Research Fields	Potassium Channel
Iberiotoxin is a toxin isolated from Buthus tamulus scorpion venom. Iberiotoxin is a selective high conductance high conductance **Ca ²⁺-activated K ⁺ channel inhibitor with a K_d** of ~1 nM. Iberiotoxin does not block other types of voltage-dependent ion channels .

HY-B1671

(+)-Kavain	Structural Classification Source classification Other Phenylpropanoids Piper methysticum G.Forst. Piperaceae Phenylpropanoids Plants	GABA Receptor Sodium Channel Calcium Channel
(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na ⁺ and Ca ²⁺ channels . (+)-Kavain is shown to bind at the α4β2δ GABA_A receptor and potentiate GABA efficacy . (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied .

HY-B1671R

(+)-Kavain (Standard)	Structural Classification Source classification Other Phenylpropanoids Piper methysticum G.Forst. Piperaceae Phenylpropanoids Plants	Reference Standards GABA Receptor Sodium Channel Calcium Channel
(+)-Kavain (Standard) is the analytical standard of (+)-Kavain. This product is intended for research and analytical applications. (+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels . (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy . (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied .

HY-N15737

Fukinolic acid	Structural Classification Ranunculaceae Source classification Phenols Polyphenols Plants Cimicifuga racemosa (L.) Nutt.	Calcium Channel Enterovirus
Fukinolic acid is a benzyltartaric acid ester, is a vasodilator with antiviral activity against enterovirus A71 (EV-A71) replication. Fukinolic acid is a *receptor-operated Ca ²⁺* channels (ROC)** inhibitor, suppressing extracellular Ca ²⁺ influx through ROC activated by Norepinephrine (HY-13715) without affecting voltage-dependent Ca ²⁺ channels .

HY-142050

(R)-IDHP	Structural Classification Labiatae Source classification Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants	Calcium Channel
(R)-IDHP is an isomer of IDHP, a salvia metabolite that exerts vasorelaxant effects by inhibiting Ca ²⁺ release and Ca ²⁺ inward flow in voltage-dependent and receptor-operated calcium channels in vascular smooth muscle cells. IDHP is used in studies of cardiovascular disease .

HY-N15735

Cimicifugic acid D 2-Caffeoylpiscidic acid	Structural Classification Ranunculaceae Source classification Phenols Polyphenols Plants Cimicifuga racemosa (L.) Nutt.	Calcium Channel
Cimicifugic acid D (2-Caffeoylpiscidic acid) is a benzyltartaric acid ester that induces vasodilation of precontracted rat aortic strips and endothelium-independent relaxation mechanism. Cimicifugic acid D inhibits extracellular Ca ²⁺ influx through *receptor-operated Ca ²⁺* channels (ROC)** in Norepinephrine (HY-13715)-induced contraction of rat aortic strips, without affecting voltage-dependent Ca ²⁺ channels (VDC) or K ⁺-induced contractions .

HY-13764A

dl-Tetrandrine	Structural Classification Alkaloids Source classification Stephania japonica var. discolor (Blume) Forman Plants Menispermaceae Alkaloid Dimers	Calcium Channel
dl-Tetrandrine is an orally active and brain-penetrant calcium channel blocker that inhibits voltage-dependent calcium channels. dl-Tetrandrine selectively blocks Ca ²⁺ influx with an IC₅₀ value of approximately 1-10 μM. dl-Tetrandrine exerts anti-inflammatory, immunosuppressive, and anti-arrhythmic activities by inhibiting intracellular calcium overload, and can reverse multidrug resistance in tumor cells. dl-Tetrandrine is promising for research of autoimmune diseases (such as rheumatoid arthritis), cardiovascular diseases, and tumor drug resistance reversal .

Cat. No.	Compare	Product Name	Species	Source

HY-P72109

	CACNA2D1 Protein, Human (His-SUMO) Ca2D1_HUMAN; CaCN A2; CaCNA2; Cacna2d1; CaCNL2A; Calcium channel L type alpha 2 polypeptide; Calcium channel Voltage dependent alpha 2/delta subunit 1; CCHL2A; Dihydropyridine receptor alpha 2 subunit; Dihydropyridine sensitive L type Calcium channel alpha 2/delta subunit; Dihydropyridine sensitive L type Calcium channel subunits alpha 2/delta; L type Calcium channel subunit alpha 2; MHS 3; MHS3; Voltage dependent Calcium channel subunit alpha 2/delta 1; Voltage gated Calcium channel subunit alpha 2/delta 1; Voltage-dependent Calcium channel subunit delta-1; Voltage-gated Calcium channel subunit alpha-2/delta-1	Human	E. coli
	The CACNA2D1 protein, particularly its α-2/δ subunit, plays a key role in regulating calcium current density and activation/deactivation kinetics of voltage-dependent calcium channels. It contributes to excitation-contraction coupling, coordinating cellular processes. CACNA2D1 Protein, Human (His-SUMO) is the recombinant human-derived CACNA2D1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-N0215S14

L-Phenylalanine-15N,d8
L-Phenylalanine- ¹⁵N,d₈ is the deuterium and ¹⁵N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a K_i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .

L-Phenylalanine-15N,d8

L-Phenylalanine- ¹⁵N,d₈ is the deuterium and ¹⁵N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a K_i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .

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Voltage-dependent Ca2 channel

Inhibitors & Agonists

Peptides

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

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