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Results for "

Type I/II inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5 alpha Reductase (5) Androgen Receptor (1) Angiotensin Receptor (6) Angiotensin-converting Enzyme (ACE) (3) Antibiotic (1) Apoptosis (2) Autophagy (10) Bacterial (3) Bcr-Abl (2) c-Kit (1) Calcium Channel (1) Endogenous Metabolite (2) Fluorescent Dye (1) HIF/HIF Prolyl-Hydroxylase (2) HIV (1) Influenza Virus (1) Interleukin Related (3) Isotope-Labeled Compounds (5) JAK (1) MHC (5) Mitochondrial Metabolism (1) MMP (3) NF-κB (2) p97 (1) PDGFR (1) PKC (1) Potassium Channel (1) Reference Standards (3) SOD (2) Sodium Channel (1) Src (1) TGF-β Receptor (2)
By Research Areas:	Cancer (19) Cardiovascular Disease (9) Endocrinology (8) Infection (3) Inflammation/Immunology (7) Metabolic Disease (3) Neurological Disease (1)

By Targets:

5 alpha Reductase (5)

Androgen Receptor (1)

Angiotensin Receptor (6)

Angiotensin-converting Enzyme (ACE) (3)

Antibiotic (1)

Apoptosis (2)

Autophagy (10)

Bacterial (3)

Bcr-Abl (2)

c-Kit (1)

Calcium Channel (1)

Endogenous Metabolite (2)

Fluorescent Dye (1)

HIF/HIF Prolyl-Hydroxylase (2)

HIV (1)

Influenza Virus (1)

Interleukin Related (3)

Isotope-Labeled Compounds (5)

JAK (1)

MHC (5)

Mitochondrial Metabolism (1)

MMP (3)

NF-κB (2)

p97 (1)

PDGFR (1)

PKC (1)

Potassium Channel (1)

Reference Standards (3)

SOD (2)

Sodium Channel (1)

Src (1)

TGF-β Receptor (2)

By Research Areas:

Cancer (19)

Cardiovascular Disease (9)

Endocrinology (8)

Infection (3)

Inflammation/Immunology (7)

Metabolic Disease (3)

Neurological Disease (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Photosystem II C-type Lectin-like Receptors (CTLRs) Scavenger Receptor Class B type I (SR-BI） PCSK9 CD74

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12075

LY2109761 Maximum Cited Publications 59 Publications Verification	TGF-β Receptor Autophagy	Cancer
LY2109761 is an orally active, selective TGF-β receptor type I/II inhibitor with K_is of 38 nM and 300 nM, respectively.

HY-B0199A

Mycophenolate mofetil hydrochloride 5+ Cited Publications RS 61443 hydrochloride; TM-MMF hydrochloride	Endogenous Metabolite Bacterial	Cancer
Mycophenolate mofetil (RS 61443) hydrochloride is a immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPD) type I/II with IC₅₀s of 39 nM and 27 nM, respectively.

HY-13635

Finasteride 4 Publications Verification MK-906	5 alpha Reductase	Cancer
Finasteride (MK-906) is an orally active and competitive 5α-reductase inhibitor, with an IC₅₀ of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia .

HY-13955

Telmisartan 10+ Cited Publications BIBR 277	Angiotensin Receptor Autophagy	Cardiovascular Disease Endocrinology Cancer
Telmisartan is a potent, long lasting antagonist of *angiotensin II type* 1 receptor (AT1)*, selectively inhibiting* the binding of ¹²⁵I-AngII to AT1 receptors with IC₅₀ of 9.2 nM.

HY-P990188

Anti-Mouse MHC class II (I-A) Antibody (Y-3P)	MHC	Inflammation/Immunology
Anti-Mouse MHC class II (I-A) Antibody (Y-3P) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC class II. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) reacts with mouse MHC Class II haplotypes I-Ab, I-Af, I-Ap, I-Aq, I-Ar, I-As, I-Au, I-Av, and weakly with I-Ak. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) blocks MHC class II and inhibits expansion of regulate T cells. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) can be used for the immunology research .

HY-P990187

Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114)	MHC Influenza Virus	Infection Inflammation/Immunology
Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse MHC Class II. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) reacts with mouse MHC Class II haplotypes I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) does not react with I-Af, I-Ak, or I-As haplotypes. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) blocks MHC Class II and inhibit T cell generation. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) can be used for the researches of infection and immunology, such as influenza A virus (IAV) infection .

HY-P990184

Anti-Mouse MHC Class II (βchain) Antibody (KL277)	MHC	Others
Anti-Mouse MHC Class II (βchain) Antibody (KL277) is a hamster/mouse-derived IgG type antibody inhibitor, targeting to mouse MHC Class II. Anti-Mouse MHC Class II (βchain) Antibody (KL277) reacts with mouse MHC Class II haplotypes I-Ab, I-Ad, I-Ap, I-Aq, I-Abu, and I-Abw. Anti-Mouse MHC Class II (βchain) Antibody (KL277) does not react with I-Aa, I-Ak, I-Af, I-Aj, I-As, or I-Atl haplotypes. Anti-Mouse MHC Class II (βchain) Antibody (KL277) can be used for western blot experiments .

HY-P990186

Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2)	MHC	Others
Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) is a mouse-derived IgG2c κ type antibody inhibitor, targeting to mouse MHC Class II. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) reacts with mouse MHC Class II haplotypes I-Ak, I-Ar, I-Af, I-As, and I-Ag7. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) does not react with I-Ab, I-Ad, I-Ap, or I-Aq haplotypes. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) blocks MHC Class II and inhibits antigen proliferation responses. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) can be used for the research of immunology .

HY-13635A

Finasteride acetate MK-906 acetate	5 alpha Reductase	Cancer
Finasteride (MK-906) acetate is a potent and competitive 5α-reductase inhibitor, with an IC₅₀ of 4.2 nM for type II 5α-reductase. Finasteride acetate has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride acetate can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia .

HY-P990185

Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S)	MHC	Inflammation/Immunology Cancer
Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse/rat MHC Class II. Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) reacts with mouse MHC Class II alloantigen I-Ek and the rat MHC class II alloantigen RT1D. Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) blocks antigen presentation. Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) can be used for the research of immunology and cancer .

HY-103245

Cl-4AS-1	Androgen Receptor	Cancer
Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC₅₀ = 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively) .

HY-13635S

Finasteride-d9 MK-906-d₉	Isotope-Labeled Compounds 5 alpha Reductase	Cancer
Finasteride-d₉ is deuterium labeled Finasteride. Finasteride (MK-906) is a potent and competitive 5α-reductase inhibitor, with an IC₅₀ of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia .

HY-13635R

Finasteride (Standard) MK-906 (Standard)	Reference Standards 5 alpha Reductase	Cancer
Finasteride (Standard) is the analytical standard of Finasteride. This product is intended for research and analytical applications. Finasteride (MK-906) is a potent and competitive 5α-reductase inhibitor, with an IC₅₀ of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia .

HY-12075R

LY2109761 (Standard)	TGF-β Receptor Autophagy	Cancer
LY2109761 (Standard) is the analytical standard of LY2109761. This product is intended for research and analytical applications. LY2109761 is an orally active, selective TGF-β receptor type I/II inhibitor with Kis of 38 nM and 300 nM, respectively.

HY-119370

CHMFL-ABL-121	Bcr-Abl Apoptosis	Cancer
CHMFL-ABL-121 is a highly potent type II ABL kinase inhibitor with IC₅₀s of 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein, respectively .

HY-108355

R59949 1 Publications Verification	PKC	Cancer
R59949 is a pan diacylglycerol kinase (DGK) inhibitor with an IC₅₀ of 300 nM. R59949 strongly inhibits the activity of type I DGK α and γ and moderately attenuates the activity of type II DGK θ and κ. R59949 activates protein kinase C (PKC) by enhancing the levels of the endogenous ligand diacyl glycerol .

HY-155003

TPEQM-DMA	Fluorescent Dye	Cancer
TPEQM-DMA is a NIR-II photosensitizer. TPEQM-DMA accumulates in cancerous mitochondria, and inhibits cancer cell growth. TPEQM-DMA has potent type-I phototherapeutic efficacy to overcome the intrinsic pitfalls of PDT in combating hypoxic tumors .

HY-106129

Izonsteride LY 320236	5 alpha Reductase	Endocrinology Cancer
Izonsteride (Compound LY320236) is an inhibitor of 5α-reductase (IC₅₀ = 11.6 nM for type I; 7.37 nM for type II). LY320236 inhibits the activity of steroid 5α-reductase, preventing the conversion of testosterone (T) to dihydrotestosterone (DHT). LY320236 can significantly inhibit the growth of LNCaP tumors in thymic mice without exhibiting obvious host toxicity .

HY-N0433

Astragaloside II 1 Publications Verification Astrasieversianin VIII	Autophagy Interleukin Related HIF/HIF Prolyl-Hydroxylase SOD NF-κB	Inflammation/Immunology Endocrinology Cancer
Astragaloside II is an orally active Cycloartane-type triterpene glycoside. Astragaloside II can be extracted from Astragalus membranaceus. Astragaloside II inhibits Autophagy, decreases pro-inflammatory cytokines (IL-6, IL-1β), HIF-α, p-p65, p-IκB and increases SOD. Astragaloside II regulates immunity and reduces inflammatory responses. Astragaloside II can be used in the research of diseases such as liver cancer, osteoporosis, immunosuppressive diseases, and ulcerative colitis .

HY-13955S1

Telmisartan-d4 BIBR 277-d₄	Isotope-Labeled Compounds Angiotensin Receptor Autophagy	Cardiovascular Disease Endocrinology
Telmisartan-d₄ is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC₅₀ of 9.2 nM .

HY-13955S

Telmisartan-d3	Angiotensin Receptor Autophagy	Cardiovascular Disease Endocrinology
Telmisartan-d₃ is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC₅₀ of 9.2 nM .

HY-13955R

Telmisartan (Standard) BIBR 277 (Standard)	Reference Standards Angiotensin Receptor Autophagy	Cardiovascular Disease Endocrinology
Telmisartan (Standard) is the analytical standard of Telmisartan. This product is intended for research and analytical applications. Telmisartan is a potent, long lasting antagonist of *angiotensin II type* 1 receptor (AT1)*, selectively inhibiting* the binding of ¹²⁵I-AngII to AT1 receptors with IC₅₀ of 9.2 nM.

HY-B0199AS

Mycophenolate Mofetil-d4 hydrochloride RS 61443-d₄ hydrochloride; TM-MMF-d₄ hydrochloride	Bacterial Endogenous Metabolite Isotope-Labeled Compounds	Cancer
Mycophenolate Mofetil-d₄ hydrochloride is deuterated labeled Mycophenolate mofetil hydrochloride (HY-B0199A). Mycophenolate mofetil (RS 61443) hydrochloride is a immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPD) type I/II with IC₅₀s of 39 nM and 27 nM, respectively.

HY-N0433R

Astragaloside II (Standard) Astrasieversianin VIII (Standard)	Reference Standards Autophagy Interleukin Related HIF/HIF Prolyl-Hydroxylase SOD NF-κB	Inflammation/Immunology Endocrinology Cancer
Astragaloside II (Standard) is the analytical standard of Astragaloside II (HY-N0433). This product is intended for research and analytical applications. Astragaloside II is an orally active Cycloartane-type triterpene glycoside. Astragaloside II can be extracted from Astragalus membranaceus. Astragaloside II inhibits Autophagy, decreases pro-inflammatory cytokines (IL-6, IL-1β), HIF-α, p-p65, p-IκB and increases SOD. Astragaloside II regulates immunity and reduces inflammatory responses. Astragaloside II can be used in the research of diseases such as liver cancer, osteoporosis, immunosuppressive diseases, and ulcerative colitis .

HY-13955S2

Telmisartan-13C,d3 BIBR 277-¹³C,d₃	Isotope-Labeled Compounds Angiotensin Receptor Autophagy	Cardiovascular Disease Endocrinology
Telmisartan- ¹³C,d₃ is the ¹³C- and deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.

HY-155107

ND-011992	Mitochondrial Metabolism Bacterial	Infection
ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. ND-011992 inhibits respiratory complex I and bo₃ oxidase in addition to *bd-I* and bd-II oxidases in E. coli strain BL21Δcyo with the IC₅₀* of 0.12, 2.47, 0.63 and 1.3 μM, respectively. ND-011992 can be used for tuberculosis study .

HY-P2200

Siamycin I BMY-29304	HIV Antibiotic	Infection Inflammation/Immunology
Siamycin I (BMY-29304), a 21-residue tricyclic peptide, is a secondary metabolite in actinomycetes. Siamycin I is a HIV fusion inhibitor with ED₅₀s of 0.05 to 5.7 μM for acute HIV type 1 (HIV-1) and HIV-2 infections. Siamycin I inhibits the gelatinase and gelatinase biosynthesis-activating pheromone (GBAP) signaling via the FsrC-FsrA two-component regulatory system in a noncompetitive manner. Siamycin I suppresses the expression of both fsrBDC and gelE-sprE transcripts. Siamycin I, a lasso peptide, interacts with lipid II and inhibits cell wall biosynthesis. Siamycin I, an antibiotic, has the potential for enterococcal infections research .

HY-13955S3

Telmisartan-d7 BIBR 277-d₇	Isotope-Labeled Compounds Autophagy Angiotensin Receptor	Cardiovascular Disease
Telmisartan-d₇ (BIBR 277-d₇) is a deuterium labeled Telmisartan (HY-13955). Telmisartan is a potent, long lasting antagonist of *angiotensin II type* 1 receptor (AT1)*, selectively inhibiting* the binding of ¹²⁵I-AngII to AT1 receptors with IC₅₀ of 9.2 nM.

HY-B1451

Imidapril hydrochloride TA-6366	Angiotensin-converting Enzyme (ACE) MMP	Cardiovascular Disease Metabolic Disease
Imidapril hydrochloride (TA-6366) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. Imidapril hydrochloride suppresses the conversion of angiotensin I to angiotensin II and thereby reduces total peripheral resistance and systemic blood pressure. Imidapril hydrochloride can be used for hypertension, type 1 diabetic, nephropathy and chronic heart failure research .

HY-B1451A

Imidapril TA-6366 free base	Angiotensin-converting Enzyme (ACE) MMP	Cardiovascular Disease Metabolic Disease
Imidapril (TA-6366 free base) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. Imidapril suppresses the conversion of angiotensin I to angiotensin II and thereby reduces total peripheral resistance and systemic blood pressure. Imidapril can be used for hypertension, type 1 diabetic, nephropathy and chronic heart failure research .

HY-P1110

AF12198 4 Publications Verification	Interleukin Related	Inflammation/Immunology
AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC₅₀=8 nM) but not the human type II receptor (IC₅₀=6.7 µM) or the murine type I receptor (IC₅₀>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC₅₀=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC₅₀=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo .

HY-15814

HG-7-85-01	Bcr-Abl PDGFR c-Kit Src JAK Apoptosis	Cancer
HG-7-85-01 is a type II ATP competitive inhibitor of wild-type and gatekeeper mutations forms of Bcr-Abl, PDGFRα, Kit, and Src kinases. HG-7-85-01 inhibits T315I mutant Bcr-Abl kinase, KDR and RET with IC₅₀s of 3 nM, 20 nM and 30 nM, and is only weak or no inhibition of other kinases (IC₅₀>2 μM). HG-7-85-01 inhibits the cell proliferation, which is mediated by the induction of apoptosis, and inhibition of cell-cycle progression .

HY-123872

MSC1094308	p97	Cancer
MSC1094308 is a non-competitive and reversible VPS4B/p97 (VCP) (I/II type AAA ATPase) allosteric inhibitor, with IC₅₀ values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively . MSC1094308 inhibits the D2 ATPase activity by binding to a agentable hotspot of p97. MSC1094308 can be used in study of cancer .

HY-B1451R

Imidapril hydrochloride (Standard)	Angiotensin-converting Enzyme (ACE) MMP	Cardiovascular Disease Metabolic Disease
Imidapril (hydrochloride) (Standard) is the analytical standard of Imidapril (hydrochloride). This product is intended for research and analytical applications. Imidapril hydrochloride (TA-6366) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. Imidapril hydrochloride suppresses the conversion of angiotensin I to angiotensin II and thereby reduces total peripheral resistance and systemic blood pressure. Imidapril hydrochloride can be used for hypertension, type 1 diabetic, nephropathy and chronic heart failure research .

HY-12596

JNJ-26489112	Calcium Channel Sodium Channel Potassium Channel	Neurological Disease
JNJ-26489112, a CNS-active agent, exhibits broad-spectrum anticonvulsant activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures. JNJ-26489112 inhibits voltage-gated Na ⁺ channels and N-type Ca ²⁺ channels, and is effective as a K ⁺ channel opener. JNJ-26489112 has very weak inhibition of CA-II (IC₅₀=35 μM) and CA-I (18 μM) .

Cat. No.	Product Name	Target	Research Area

HY-P1110

AF12198 4 Publications Verification	Interleukin Related	Inflammation/Immunology
AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC₅₀=8 nM) but not the human type II receptor (IC₅₀=6.7 µM) or the murine type I receptor (IC₅₀>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC₅₀=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC₅₀=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo .

HY-P2200

Siamycin I BMY-29304	HIV Antibiotic	Infection Inflammation/Immunology
Siamycin I (BMY-29304), a 21-residue tricyclic peptide, is a secondary metabolite in actinomycetes. Siamycin I is a HIV fusion inhibitor with ED₅₀s of 0.05 to 5.7 μM for acute HIV type 1 (HIV-1) and HIV-2 infections. Siamycin I inhibits the gelatinase and gelatinase biosynthesis-activating pheromone (GBAP) signaling via the FsrC-FsrA two-component regulatory system in a noncompetitive manner. Siamycin I suppresses the expression of both fsrBDC and gelE-sprE transcripts. Siamycin I, a lasso peptide, interacts with lipid II and inhibits cell wall biosynthesis. Siamycin I, an antibiotic, has the potential for enterococcal infections research .

Cat. No.	Product Name	Target	Research Area

HY-P990188

Anti-Mouse MHC class II (I-A) Antibody (Y-3P)	MHC	Inflammation/Immunology
Anti-Mouse MHC class II (I-A) Antibody (Y-3P) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC class II. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) reacts with mouse MHC Class II haplotypes I-Ab, I-Af, I-Ap, I-Aq, I-Ar, I-As, I-Au, I-Av, and weakly with I-Ak. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) blocks MHC class II and inhibits expansion of regulate T cells. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) can be used for the immunology research .

HY-P990187

Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114)	MHC Influenza Virus	Infection Inflammation/Immunology
Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse MHC Class II. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) reacts with mouse MHC Class II haplotypes I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) does not react with I-Af, I-Ak, or I-As haplotypes. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) blocks MHC Class II and inhibit T cell generation. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) can be used for the researches of infection and immunology, such as influenza A virus (IAV) infection .

HY-P990184

Anti-Mouse MHC Class II (βchain) Antibody (KL277)	MHC	Others
Anti-Mouse MHC Class II (βchain) Antibody (KL277) is a hamster/mouse-derived IgG type antibody inhibitor, targeting to mouse MHC Class II. Anti-Mouse MHC Class II (βchain) Antibody (KL277) reacts with mouse MHC Class II haplotypes I-Ab, I-Ad, I-Ap, I-Aq, I-Abu, and I-Abw. Anti-Mouse MHC Class II (βchain) Antibody (KL277) does not react with I-Aa, I-Ak, I-Af, I-Aj, I-As, or I-Atl haplotypes. Anti-Mouse MHC Class II (βchain) Antibody (KL277) can be used for western blot experiments .

HY-P990186

Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2)	MHC	Others
Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) is a mouse-derived IgG2c κ type antibody inhibitor, targeting to mouse MHC Class II. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) reacts with mouse MHC Class II haplotypes I-Ak, I-Ar, I-Af, I-As, and I-Ag7. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) does not react with I-Ab, I-Ad, I-Ap, or I-Aq haplotypes. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) blocks MHC Class II and inhibits antigen proliferation responses. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) can be used for the research of immunology .

HY-P990185

Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S)	MHC	Inflammation/Immunology Cancer
Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse/rat MHC Class II. Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) reacts with mouse MHC Class II alloantigen I-Ek and the rat MHC class II alloantigen RT1D. Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) blocks antigen presentation. Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) can be used for the research of immunology and cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0199A

Mycophenolate mofetil hydrochloride 5+ Cited Publications RS 61443 hydrochloride; TM-MMF hydrochloride	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Bacterial
Mycophenolate mofetil (RS 61443) hydrochloride is a immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPD) type I/II with IC₅₀s of 39 nM and 27 nM, respectively.

HY-N0433

Astragaloside II 1 Publications Verification Astrasieversianin VIII	Triterpenes Structural Classification Classification of Application Fields Leguminosae Terpenoids Source classification Other Diseases Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields	Autophagy Interleukin Related HIF/HIF Prolyl-Hydroxylase SOD NF-κB
Astragaloside II is an orally active Cycloartane-type triterpene glycoside. Astragaloside II can be extracted from Astragalus membranaceus. Astragaloside II inhibits Autophagy, decreases pro-inflammatory cytokines (IL-6, IL-1β), HIF-α, p-p65, p-IκB and increases SOD. Astragaloside II regulates immunity and reduces inflammatory responses. Astragaloside II can be used in the research of diseases such as liver cancer, osteoporosis, immunosuppressive diseases, and ulcerative colitis .

HY-N0433R

Astragaloside II (Standard) Astrasieversianin VIII (Standard)	Triterpenes Structural Classification Leguminosae Terpenoids Source classification Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants	Reference Standards Autophagy Interleukin Related HIF/HIF Prolyl-Hydroxylase SOD NF-κB
Astragaloside II (Standard) is the analytical standard of Astragaloside II (HY-N0433). This product is intended for research and analytical applications. Astragaloside II is an orally active Cycloartane-type triterpene glycoside. Astragaloside II can be extracted from Astragalus membranaceus. Astragaloside II inhibits Autophagy, decreases pro-inflammatory cytokines (IL-6, IL-1β), HIF-α, p-p65, p-IκB and increases SOD. Astragaloside II regulates immunity and reduces inflammatory responses. Astragaloside II can be used in the research of diseases such as liver cancer, osteoporosis, immunosuppressive diseases, and ulcerative colitis .

Cat. No.	Product Name	Chemical Structure

HY-13635S

Finasteride-d9

Finasteride-d₉ is deuterium labeled Finasteride. Finasteride (MK-906) is a potent and competitive 5α-reductase inhibitor, with an IC₅₀ of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia .

HY-13955S

Telmisartan-d3
Telmisartan-d₃ is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC₅₀ of 9.2 nM .

HY-13955S3

Telmisartan-d7
Telmisartan-d₇ (BIBR 277-d₇) is a deuterium labeled Telmisartan (HY-13955). Telmisartan is a potent, long lasting antagonist of *angiotensin II type* 1 receptor (AT1)*, selectively inhibiting* the binding of ¹²⁵I-AngII to AT1 receptors with IC₅₀ of 9.2 nM.

HY-13955S1

Telmisartan-d4
Telmisartan-d₄ is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC₅₀ of 9.2 nM .

HY-B0199AS

Mycophenolate Mofetil-d4 hydrochloride
Mycophenolate Mofetil-d₄ hydrochloride is deuterated labeled Mycophenolate mofetil hydrochloride (HY-B0199A). Mycophenolate mofetil (RS 61443) hydrochloride is a immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPD) type I/II with IC₅₀s of 39 nM and 27 nM, respectively.

HY-13955S2

Telmisartan-13C,d3
Telmisartan- ¹³C,d₃ is the ¹³C- and deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.

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Type I/II inhibitor

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