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Results for "

TRAF2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (5) Autophagy (2) Beclin1 (1) Caspase (1) DAPK (1) Endogenous Metabolite (1) HIV (1) IAP (1) IRE1 (1) JNK (1) MAP4K (4) mRNA (1) Necroptosis (1) NF-κB (1) Nuclear Hormone Receptor 4A/NR4A (1) p62 (1) Reactive Oxygen Species (ROS) (1) RIP kinase (2) Ser/Thr Protease (4) Small Interfering RNA (siRNA) (4) TGF-beta/Smad (2) TNF Receptor (1) Wnt (3)
By Research Areas:	Cancer (9) Inflammation/Immunology (5) Metabolic Disease (1) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) mRNA (1) Human Pre-designed siRNA Sets (2) siRNAs (4)

Inhibitors & Agonists

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-117469

Triptohypol C	Nuclear Hormone Receptor 4A/NR4A p62	Inflammation/Immunology
Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an K_d value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1 .

HY-156818

TNIK-IN-7	Ser/Thr Protease	Cancer
TNIK-IN-7 (Compound 8) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK), with IC₅₀ of 11 nM, that has antitumor activity .

HY-124762

TNIK-IN-1	Ser/Thr Protease	Cancer
TNIK-IN-1 (Compound 1) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK), with IC₅₀ of 65 nM, that has antitumor activity .

HY-156817

TNIK-IN-6	TNF Receptor	Neurological Disease
TNIK-IN-6 (Compound 9) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK) and , with IC₅₀ of 0.93 μM, that plays important roles in neurological and psychiatric disorders ^[2].

HY-156502

TINK-IN-1	MAP4K	Cancer
TINK-IN-1 (Compound 9) is a potent and selective Traf2- and Nck-interacting kinase (TNIK) inhibitor with an IC₅₀ of 8 nM. TINK-IN-1 inhibits colorectal cancer cells viability .

HY-145292

TNIK-IN-2	Ser/Thr Protease	Cancer
TNIK-IN-2 is a Traf2- and Nck-interacting protein kinase (TNIK) inhibitor, with an IC₅₀ of 1.3337 μM. TNIK-IN-2 can be used for the study of colorectal cancer (CRC) .

HY-RS14968

TRAF2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TRAF2 Human Pre-designed siRNA Set A contains three designed siRNAs for TRAF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TRAF2 Human Pre-designed siRNA Set A TRAF2 Human Pre-designed siRNA Set A

HY-RS23300

Traf2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Traf2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Traf2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Traf2 Rat Pre-designed siRNA Set A Traf2 Rat Pre-designed siRNA Set A

HY-RS16859

Traf2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Traf2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Traf2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Traf2 Mouse Pre-designed siRNA Set A Traf2 Mouse Pre-designed siRNA Set A

HY-174514

Human TNFRSF4 mRNA	mRNA	Cancer
Human TNFRSF4 mRNA encodes the human TNF receptor superfamily member 4 (TNFRSF4) protein, a member of the TNF receptor superfamily. TNFRSF4 has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5.

HY-100830

NCB-0846 4 Publications Verification	Wnt MAP4K TGF-beta/Smad	Cancer
NCB-0846 is an orally active, selective inhibitor for Wnt, that inhibits Traf2- and Nck-interacting kinase (TNIK) with an IC₅₀ of 21 nM. NCB-0846 blocks TGF-β signaling pathway by inhibiting *SMAD2/3* phosphorylation and nuclear translocation ^[2].

HY-122805

PF-794	Ser/Thr Protease	Neurological Disease
PF-794 is a potent, selective and ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with an IC₅₀ of 39 nM. PF-794 shows selective for the TNIK family. PF-794 reduces endogenous p120-catenin phosphorylation in cells. PF-794 can be used for teh study of psychiatric disorders .

HY-16591

Birinapant 35+ Cited Publications TL32711	IAP Apoptosis HIV	Cancer
Birinapant (TL32711), a bivalent Smac mimetic, is a potent antagonist for XIAP and cIAP1 with K_ds of 45 nM and less than 1 nM, respectively. Birinapant (TL32711) induces the autoubiquitylation and proteasomal degradation of cIAP1 and cIAP2 in intact cells, which results in formation of a RIPK1: caspase-8 complex, caspase-8 activation, and induction of tumor cell death. Birinapant (TL32711) targets TRAF2-associated cIAPs and abrogates TNF-induced NF-κB activation.

HY-100830A

NCB-0970	Wnt MAP4K TGF-beta/Smad	Inflammation/Immunology
NCB-0970 is the negative control of NCB-0846 (HY-100830). NCB-0846 is an orally active, selective inhibitor for Wnt, that inhibits Traf2- and Nck-interacting kinase (TNIK) with an IC₅₀ of 21 nM. NCB-0846 blocks TGF-β signaling pathway by inhibiting *SMAD2/3* phosphorylation and nuclear translocation ^[2].

HY-138779

ICCB-19 hydrochloride 1 Publications Verification	Autophagy RIP kinase Apoptosis	Inflammation/Immunology
ICCB-19 hydrochloride is a TRADD (TNFRSF1A associated via death domain) inhibitor. ICCB-19 hydrochloride binds with N-terminal domain of TRADD (TRADD-N), disrupting its binding to both TRADD-C and TRAF2. ICCB-19 hydrochloride is indirect inhibitor of RIPK1 kinase activity. ICCB-19 hydrochloride effectively induces autophagy and the degradation of long-lived proteins .

HY-145293

TNIK-IN-3	DAPK	Cancer
TNIK-IN-3 is a potent, selective and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK), with an IC₅₀ of 0.026 μM. TNIK-IN-3 could also inhibit Flt4 (IC₅₀=0.030 μM), Flt1 (IC₅₀=0.191 μM) and DRAK1 (IC₅₀=0.411 μM). TNIK-IN-3 can be used for the research of colorectal cancer .

HY-134050

Apostatin-1 1 Publications Verification Apt-1	RIP kinase Autophagy Apoptosis Beclin1 Necroptosis	Inflammation/Immunology
Apostatin-1 (Apt-1) is a potent TRADD inhibitor. Apostatin-1 can bind with TRADD-N (K_D=2.17 μM), disrupting its binding to both TRADD-C and TRAF2. Apostatin-1 modulates the ubiquitination of RIPK1 and beclin 1. Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin .

HY-124745

KY-05009 1 Publications Verification	MAP4K Wnt Apoptosis	Cancer
KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a K_i of 100 nM. KY-05009 pharmacologically inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the protein expression of TNIK and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells. KY-05009 exerts anti-cancer activity .

HY-19696B

Tauroursodeoxycholate dihydrate Maximum Cited Publications 84 Publications Verification Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate	Caspase Apoptosis Endogenous Metabolite IRE1 NF-κB JNK Reactive Oxygen Species (ROS) Akt	Neurological Disease Metabolic Disease Inflammation/Immunology
Tauroursodeoxycholate dehydrate is an orally active taurine conjugate of Ursodeoxycholic acid (HY-13771). Tauroursodeoxycholate dehydrate inhibits caspase-3/7, Apoptosis, *IRE1α/TRAF2/NF-κB, prevents JNK* phosphorylation, inhibits ROS generation, and activates Akt signaling. Tauroursodeoxycholate dehydrate prevents cataract formation, reduces renal tubular damage in type 2 diabetic mice, reduces I/R injury in liver, and inhibits intestinal inflammation and barrier disruption in nonalcoholic fatty liver disease ^[2] .

HY-RS14197

TANK Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TANK Human Pre-designed siRNA Set A contains three designed siRNAs for TANK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TANK Human Pre-designed siRNA Set A TANK Human Pre-designed siRNA Set A

Triptohypol C	Triterpenes Structural Classification Ketones, Aldehydes, Acids Terpenoids Celastraceae Tripterygium wilfordii Hook. f. Plants	Nuclear Hormone Receptor 4A/NR4A p62
Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an K_d value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1 .

Tauroursodeoxycholate dihydrate 80+ Cited Publications Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Caspase Apoptosis Endogenous Metabolite IRE1 NF-κB JNK Reactive Oxygen Species (ROS) Akt
Tauroursodeoxycholate dehydrate is an orally active taurine conjugate of Ursodeoxycholic acid (HY-13771). Tauroursodeoxycholate dehydrate inhibits caspase-3/7, Apoptosis, *IRE1α/TRAF2/NF-κB, prevents JNK* phosphorylation, inhibits ROS generation, and activates Akt signaling. Tauroursodeoxycholate dehydrate prevents cataract formation, reduces renal tubular damage in type 2 diabetic mice, reduces I/R injury in liver, and inhibits intestinal inflammation and barrier disruption in nonalcoholic fatty liver disease ^[2] .

Species:	Human (3)
Tag:	His (1) Tag Free (1) GST (1)
Source:	Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P701646

	TNIK Protein, Human (sf9) TNIK; TRAF2 and NCK-interacting protein kinase	Human	Sf9 insect cells
	TNIK protein is a key activator of the Wnt signaling pathway and regulates gene expression by phosphorylating TCF4/TCF7L2 at the promoter of Wnt target genes. TNIK is located upstream of the JUN N-terminal pathway and contributes to the complex Wnt signaling cascade. TNIK Protein, Human (sf9) is the recombinant human-derived TNIK protein, expressed by sf9 insect cells , with tag free.

HY-P701645

	TNIK Protein, Human (sf9, His) TNIK; TRAF2 and NCK-interacting protein kinase	Human	Sf9 insect cells
	TNIK protein is a key activator of the Wnt signaling pathway and regulates gene expression by phosphorylating TCF4/TCF7L2 at the promoter of Wnt target genes. TNIK is located upstream of the JUN N-terminal pathway and contributes to the complex Wnt signaling cascade. TNIK Protein, Human (sf9, His) is the recombinant human-derived TNIK protein, expressed by sf9 insect cells , with N-8*His labeled tag.

HY-P702993

	TRAF2 Protein, Human (sf9, GST) TRAP3	Human	Sf9 insect cells
	TRAF2 Protein, Human (sf9, GST) is the recombinant human-derived TRAF2, expressed by Sf9 insect cells , with GST labeled tag. ,

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HY-P80357

	TRAF2 Antibody (YA032)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
	TRAF2 Antibody (YA032) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TRAF2.

HY-P84523

	TRAF2 Antibody (YA4220) TRAP; TRAP3; MGC:45012	WB, FC, ELISA	Human
	TRAF2 Antibody (YA4220) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TRAF2.

HY-P83080

	TRAF2 Antibody (YA2825) KIAA0057; TRAM like protein; Tram2; Translocating chain associating membrane protein 2; Translocation associated membrane protein 2	WB	Human, Mouse, Rat
	TRAF2 Antibody (YA2825) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TRAF2.

HY-P84522

	TRAF2 Antibody (YA4219) TRAP; TRAP3; MGC:45012	IHC-P, ICC/IF, FC, ELISA	Human
	TRAF2 Antibody (YA4219) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRAF2.

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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

TRAF2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TRAF2 Human Pre-designed siRNA Set A contains three designed siRNAs for TRAF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Traf2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Traf2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Traf2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Traf2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Traf2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Traf2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Human TNFRSF4 mRNA		mRNA
Human TNFRSF4 mRNA encodes the human TNF receptor superfamily member 4 (TNFRSF4) protein, a member of the TNF receptor superfamily. TNFRSF4 has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5.

TANK Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TANK Human Pre-designed siRNA Set A contains three designed siRNAs for TANK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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