TRAF2 Protein, Human (sf9, GST)

TRAF2 Protein, Human (sf9, GST) is the recombinant human-derived TRAF2, expressed by Sf9 insect cells , with GST labeled tag. ,

TRAF2 is an E3 ubiquitin-protein ligase that plays a central role in regulating NF-kappa-B and JNK activation, thereby influencing cell survival and apoptosis. It catalyzes 'Lys-63'-linked ubiquitination of target proteins such as BIRC3, IKBKE, MLST8, RIPK1, and TICAM1, and serves as an essential component of multiple E3 ubiquitin-protein ligase complexes, facilitating ubiquitination by bridging target proteins with other E3 ligases. TRAF2 regulates the protein levels of BIRC2 and BIRC3 by inhibiting their autoubiquitination and subsequent degradation, a process independent of its RING-type zinc finger domain. Additionally, TRAF2 mediates NF-kappa-B activation by EIF2AK2/PKR and, in complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE. In the mTOR pathway, TRAF2 modulates the assembly of mTORC1 and mTORC2 by mediating 'Lys-63'-linked ubiquitination of MLST8, inhibiting mTORC2 formation while promoting mTORC1 assembly. TRAF2 is also required for normal antibody isotype switching from IgM to IgG (by similar).

Human

Sf9 insect cells

GST

Q12933-1 (M1-L501)

7186

Full Length of Isoform-1

Greater than 90% as determined by reducing SDS-PAGE