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Results for "

Squalene Synthase (SQS)

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

1

Recombinant Proteins

1

Antibodies

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-178158
    SQS-IN-1

    		Farnesyl Transferase Apoptosis DNA/RNA Synthesis Cancer
    SQS-IN-1 is a squalene synthase (SQS) inhibitor. SQS-IN-1 exhibits potent and broad-spectrum anti-proliferative effects on both mouse and human lung cancer cell lines. SQS-IN-1 inhibits DNA replication and the cell cycle, causing mitochondrial hyperpolarization and inducing cell apoptosis. SQS-IN-1 inhibits cell migration and invasion. SQS-IN-1 can be used to the study of lung cancer .
    SQS-IN-1
  • HY-135625
    BPH-1218

    		Parasite Infection
    BPH-1218 is an inhibitor of squalene synthase (SQS), with the IC50 of 31 nM and 64 nM for TcSQS and HsSQS, respectively, that can be used as an anti-infective agent .
    BPH-1218
  • HY-100299A
    RPR107393

    		Farnesyl Transferase Cardiovascular Disease Metabolic Disease
    RPR107393 is an orally active potent selective squalene synthase (SQS) inhibitor. RPR107393 inhibits rat liver microsomal squalene synthase with an IC50 value of 0.8 nM. RPR107393 reduces triglyceride biosynthesis by suppressing fatty acid biosynthesis via an increase in intracellular farnesol and its derivatives. RPR107393 reduces plasma cholesterol in rats and marmosets. RPR107393 can be used for metabolic disease research, such as hypercholesterolemia, hypertriglyceridemia and atherosclerosis .
    RPR107393
  • HY-100299
    RPR107393 free base

    		Farnesyl Transferase Cardiovascular Disease Metabolic Disease
    RPR107393 free base is an orally active potent selective squalene synthase (SQS) inhibitor. RPR107393 free base inhibits rat liver microsomal squalene synthase with an IC50 value of 0.8 nM. RPR107393 free base reduces triglyceride biosynthesis by suppressing fatty acid biosynthesis via an increase in intracellular farnesol and its derivatives. RPR107393 free base reduces plasma cholesterol in rats and marmosets. RPR107393 free base can be used for metabolic disease research, such as hypercholesterolemia, hypertriglyceridemia and atherosclerosis [1][2].
    RPR107393 free base
  • HY-178088
    L-731120

    		Endogenous Metabolite Fungal Infection Metabolic Disease
    L-731120 is an alkyl citrate zargozaga acid A analogue, which is secondary metabolite produced by fungal fermentation. L-731120 shows inhibitory activity against squalene synthase (SQS) (IC50 = 260 nM). L-731120 can inhibit the synthesis of cholesterol in the liver. L-731120 can be used for the research of infection and metabolic disease, such as hypercholesterolemia .
    L-731120

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