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Results for "

Shelterin

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-153917
    CRT0063465

    		Phosphatase Metabolic Disease Cancer
    CRT0063465 is a Ligand of HumanPGK1andStress Sensor DJ1, with theKdof 24 μM ofPGK1. CRT0063465 modulates the shelterin complex composition and telomere Length .
    CRT0063465
  • HY-172662
    TRF1-TIN2 interaction-IN-1

    		Telomerase Cancer
    TRF1-TIN2 interaction-IN-1 (Compound 40) is a TRF1-TIN2 interaction inhibitor. TRF1-TIN2 interaction-IN-1 binds to the TRFH domain of TRF1 (KD = 29 μM) and competitively inhibits the binding of the TIN2 peptide (IC50 = 67 μM). TRF1-TIN2 interaction-IN-1 disrupts the interaction between TRF1 and TIN2 by occupying the hotspot region of the TRF1-TIN2 binding interface. TRF1-TIN2 interaction-IN-1 can expel TRF 1 from the shelterin complex and can be used to study shelterin-related cancers .
    TRF1-TIN2 interaction-IN-1

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