STAT4

By Targets:	Apoptosis (1) HDAC (1) JAK (1) PROTACs (3) Small Interfering RNA (siRNA) (3) STAT (5)
By Research Areas:	Cancer (3) Inflammation/Immunology (3) Metabolic Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-173236

STAT4-IN-1	STAT	Metabolic Disease Inflammation/Immunology
STAT4-IN-1 is an inhibitor of *STAT4* with a K_i of 0.35 μM. STAT4-IN-1 is expected to be used in the research of autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes .

HY-109854A

(R)-Lisofylline (R)-Lisophylline	STAT	Metabolic Disease Inflammation/Immunology
(R)-Lisofylline ((R)-Lisophylline) is a (R)-enantiomer of the metabolite of Pentoxifylline with anti-inflammatory properties. (R)-Lisofylline is a lysophosphatidic acid acyltransferase inhibitor with an IC₅₀ of 0.6 μM and interrupts IL-12 signaling-mediated *STAT4* activation. (R)-Lisofylline has the potential for type 1 diabetes, autoimmune disorders research .

HY-161464

Chlopynostat	HDAC Apoptosis	Cancer
Chlopynostat (Compound 6c) is a HDAC1 inhibitor with a IC₅₀ value of 67 nM. Chlopynostat reverses STAT4/p66Shc defects by inhibiting HDAC1-induced < b>Apoptosis .

HY-169360

SD-436	PROTACs STAT	Cancer
SD-436 is a highly selective and efficacious STAT3 PROTAC degrader (DC₅₀: 0.5 μM), with IC₅₀ of 19 nM (STAT3), 270 nM (STAT1), 360 nM (STAT4), >10 μM (STAT5) and >10 μM (STAT6). SD-436 promotes ubiquitination and degradation of STAT3, and induces tumor regression. SD-436 can be used for tumor research, such as leukemia and lymphoma (Pink: STAT3 ligand (HY-169361); Blue: E3 ligase ligand (HY-43722); Black: linker (HY-147052) .

HY-173357

TYD-68	PROTACs JAK STAT	Inflammation/Immunology
TYD-68 is a highly efficient and selective CRBN-recruited TYK2 PROTAC degrader with a DC₅₀ value of 0.42 nM. TYD-68 significantly inhibits IL-12 and IFN-α-induced *STAT4* and *STAT1* phosphorylation, thereby blocking TYK2-dependent signaling pathways. TYD-68 can be used in the study of psoriasis. (Pink: Target protein ligand (HY-173359); Black: Linker (HY-W007732B); Blue: E3 ligase ligand (HY-14658); E3 ligase ligand + Linker (HY-173358)) .

HY-RS17148

Stat4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Stat4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stat4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Stat4 Mouse Pre-designed siRNA Set A Stat4 Mouse Pre-designed siRNA Set A

HY-RS23597

Stat4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Stat4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Stat4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Stat4 Rat Pre-designed siRNA Set A Stat4 Rat Pre-designed siRNA Set A

HY-RS13891

STAT4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
STAT4 Human Pre-designed siRNA Set A contains three designed siRNAs for STAT4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

STAT4 Human Pre-designed siRNA Set A STAT4 Human Pre-designed siRNA Set A

HY-172946

SD-2301	PROTACs STAT	Cancer
SD-2301 is a selective STAT3 PROTAC degrader. SD-2301 induces *STAT3* degradation without affecting the protein levels of other STAT family members (STAT1, STAT2, STAT4, STAT5, STAT6). SD-2301 exerts anti-tumor effects in B16F10-bearing mice. SD-2301 can be used for the study of cancer. (Pink: STAT3 ligand (HY-172947), Blue: VHL Ligand (HY-172948), Black: Linker (HY-W577012), VHL ligand-linker conjugate (HY-172949)) .

Cat. No.	Product Name

HY-L008

*JAK/STAT* Compound Library**	612 compounds
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID). MCE provides 612 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

JAK/STAT Compound Library

612 compounds

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).

MCE provides 612 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

Cat. No.	Compare	Product Name	Species	Source

HY-P76664

	STAT4 Protein, Human (sf9, His) Signal transducer and activator of transcription 4; STAT4	Human	Sf9 insect cells
	The STAT4 protein is mainly expressed in hematopoietic cells and is critical for cell growth, differentiation and immune responses. It plays a key role in T helper 1 cell differentiation, interferon gamma production, and various neutrophil activities. STAT4 Protein, Human (sf9, His) is the recombinant human-derived STAT4 protein, expressed by Sf9 insect cells , with N-His labeled tag.

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HY-P80903

	STAT4 Antibody (YA055) STAT4; Signal transducer and activator of transcription 4	WB, IHC-P, IP	Human
	STAT4 Antibody (YA055) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STAT4.

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Cat. No.	Product Name		Classification

HY-RS17148

Stat4 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Stat4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stat4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23597

Stat4 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Stat4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Stat4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS13891

STAT4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
STAT4 Human Pre-designed siRNA Set A contains three designed siRNAs for STAT4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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