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Results for "

SIRS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (1) Fluorescent Dye (2) Fungal (1) HDAC (2) Keap1-Nrf2 (2) Mitochondrial Metabolism (1) Mixed Lineage Kinase (1) Necroptosis (7) Reference Standards (3) RIP kinase (6) SARS-CoV (2) Sirtuin (4) Virus Protease (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (3) Infection (2) Inflammation/Immunology (9) Metabolic Disease (1) Neurological Disease (2)
Click Chemistry:	Tetrazine (1)

Inhibitors & Agonists

Fluorescent Dye

Natural
Products

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-157456

RIPK1-IN-19	RIP kinase	Inflammation/Immunology
RIPK1-IN-19 is a selective RIPK1 inhibitor (IC₅₀=15 nM). RIPK1-IN-19 does not show obvious activity against RIPK2, RIPK3, and RIPK4. RIPK1-IN-19 displays potent protective activity in TNFα-induced systemic inflammatory response syndrome (SIRS) model and Imiquimod (IMQ)-induced psoriasis model. RIPK1-IN-19 can be used in research on inflammation and immune system diseases .

HY-100585

Splitomicin Splitomycin	HDAC	Cancer
Splitomicin (Splitomycin) is a selective *Sir2p* inhibitor. Splitomicin inhibits NAD ⁺-dependent HDAC activity of Sir2 protein. Splitomicin induces dose-dependent inhibition of HDAC in the yeast extract with an IC₅₀ of 60 μM .

HY-N2031

Parishin 2 Publications Verification	Others	Neurological Disease
Parishin is a phenolic glucoside isolated from Gastrodia elata. Parishin exhibits antiaging effects and extends the lifespan of yeast via regulation of *Sir2/Uth1/TOR* signaling pathway .

HY-133859

M084	Mitochondrial Metabolism	Metabolic Disease
M084 is a benzimidazole derivative. M084 inhibits the mitochondrial respiration, activate mitochondrial unfolded protein response and AMPK, recruites SIR-2.1 and SKN-1, and finally through the transcription factor DAF-16, delays the aging process of C. elegans .

HY-149052

SZM-1209	RIP kinase Mixed Lineage Kinase Necroptosis	Inflammation/Immunology
SZM-1209 is an orally active, potent and specific RIPK1 inhibitor, with a K_d of 85 nM. SZM-1209 exhibits high anti-necroptotic activity (EC₅₀=22.4 ± 8.1 nM). SZM-1209 shows anti-SIRS (systemic inflammatory response syndrome), and anti-ALI (acute lung injury) effects .

HY-W142410

2-Dodecanol	Fungal	Others
2-Dodecanol inhibits hyphal formation and *SIR2* expression in C. albicans .

HY-100585R

Splitomicin (Standard) Splitomycin (Standard)	Reference Standards HDAC	Cancer
Splitomicin (Standard) is the analytical standard of Splitomicin. This product is intended for research and analytical applications. Splitomicin (Splitomycin) is a selective Sir2p inhibitor. Splitomicin inhibits NAD+-dependent HDAC activity of Sir2 protein. Splitomicin induces dose-dependent inhibition of HDAC in the yeast extract with an IC50 of 60 μM .

HY-153435

RIP1 kinase inhibitor 5	RIP kinase Necroptosis	Cancer
RIP1 kinase inhibitor 5 (example 1) is a potent inhibitor of RIP1, which is used as a checkpoint kinase to control tumor immunity . RIP1 kinase inhibitor 5 is similar with SIR1-365 (compound 13), which inhibits necrosis and iron death activity .

HY-N2031R

Parishin (Standard)	Reference Standards Others	Neurological Disease
Parishin (Standard) is the analytical standard of Parishin. This product is intended for research and analytical applications. Parishin is a phenolic glucoside isolated from Gastrodia elata. Parishin exhibits antiaging effects and extends the lifespan of yeast via regulation of Sir2/Uth1/TOR signaling pathway .

HY-131041

Ned-K	Calcium Channel	Cardiovascular Disease
Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR)-induced Ca ²⁺ oscillations in cardiomyocytes .

HY-15452

Selisistat Maximum Cited Publications 244 Publications Verification EX-527	Sirtuin	Inflammation/Immunology Cancer
Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC₅₀ of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease .

HY-N1926

Dihydrocoumarin Hydrocoumarin; Chroman-2-one	Sirtuin	Cancer
Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC₅₀s of 208 μM and 295 μM, respectively .

HY-D2243

Cy3.5 tetrazine	Fluorescent Dye	Others
Cy3.5 tetrazineis a Tetrazine modified Cy3.5 fluorescent dye. SiR-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .

HY-15452R

Selisistat (Standard)	Sirtuin	Inflammation/Immunology Cancer
Selisistat (Standard) is the analytical standard of Selisistat. This product is intended for research and analytical applications. Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease .

HY-N1926R

Dihydrocoumarin (Standard) Hydrocoumarin (Standard); Chroman-2-one (Standard)	Reference Standards Sirtuin	Cancer
Dihydrocoumarin (Standard) is the analytical standard of Dihydrocoumarin. This product is intended for research and analytical applications. Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively .

HY-174820

AZ'320	Necroptosis RIP kinase	Inflammation/Immunology Cancer
AZ'320 is an ATP-competitive necroptosis (EC₅₀ of 4.9 μM) inhibitor and a RIPK1 (pK_D of 5.45) inhibitor. AZ'320 inhibits necroptosis by inhibiting RIPK1 phosphorylation. AZ’320 prevents mortality of the mice and rescues temperature and body weight in SIRS mice models. AZ'320 can be used for researches of cancer and inflammation .

HY-173185

RIP1-IN-1	RIP kinase Necroptosis	Inflammation/Immunology
RIP1-IN-1 is an orally active RIP1 inhibitor with strong RIP1 binding affinity (K_d: 110 nM). RIP1-IN-1 exhibits strong anti-necroptosis activity. RIP1-IN-1 effectively inhibits the formation of necrosomes by blocking the phosphorylation of RIP1, RIP3 and MLKL signaling pathways. RIP1-IN-1 inhibits necroptosis and can be used in the study of acute liver injury .

HY-163390

RIP1 kinase inhibitor 9	RIP kinase Necroptosis	Inflammation/Immunology Cancer
RIP1 kinase inhibitor 9 (compound SY-1) is a selective RIP kinase inhibitor. RIP1 kinase inhibitor 9 effectively suppresses the central inflammatory response induced by epilepsy. RIP1 kinase inhibitor 9 inhibits Z-VAD-FMK (HY-16658B)-induced necroptosis in HT-29 cells with an EC₅₀ of 7.04 nM .

HY-D1679

Phalloidin-f-HM-SiR	Fluorescent Dye	Others
Phalloidin-f-HM-SiR is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.

HY-14909

Bardoxolone 15+ Cited Publications CDDO; RTA 401	Keap1-Nrf2 Necroptosis SARS-CoV Virus Protease	Infection Cardiovascular Disease Inflammation/Immunology
Bardoxolone (RTA 401; CDDO) is an orally active activator of nuclear regulatory factor (NRf-2) and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone inhibits SARS-CoV-2 3CL protease with an EC₅₀ value of 0.43 μM in vero cells. Bardoxolone also inhibits necroptosis in HT-29 cells with an EC₅₀ value of 1.30 μM by blocking necrosome formation through inhibiting phosphorylation of RIPK1 and RIPK3. Bardoxolone can be used in research on COVID-19, TNF-induced systemic inflammatory response syndrome (SIRS), and cerebral ischemia-reperfusion injury .

HY-14909R

Bardoxolone (Standard) CDDO (Standard); RTA 401 (Standard)	Keap1-Nrf2 Necroptosis SARS-CoV Virus Protease	Infection Cardiovascular Disease Inflammation/Immunology
Bardoxolone (Standard) is the analytical standard of Bardoxolone (HY-14909). This product is intended for research and analytical applications. Bardoxolone is an orally active activator of nuclear regulatory factor (NRf-2) and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone inhibits SARS-CoV-2 3CL protease with an EC₅₀ value of 0.43 μM in vero cells. Bardoxolone also inhibits necroptosis in HT-29 cells with an EC₅₀ value of 1.30 μM by blocking necrosome formation through inhibiting phosphorylation of RIPK1 and RIPK3. Bardoxolone can be used in research on COVID-19, TNF-induced systemic inflammatory response syndrome (SIRS), and cerebral ischemia-reperfusion injury .

Cat. No.	Product Name	Type

HY-D2243

Cy3.5 tetrazine	Fluorescent Dyes/Probes
Cy3.5 tetrazineis a Tetrazine modified Cy3.5 fluorescent dye. SiR-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .

HY-D1679

Phalloidin-f-HM-SiR	Fluorescent Dyes/Probes
Phalloidin-f-HM-SiR is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.

Phalloidin-f-HM-SiR

Fluorescent Dyes/Probes

Phalloidin-f-HM-SiR is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.

Parishin 2 Publications Verification	Other Terpenoids Structural Classification Gastrodia elata Bl. Terpenoids Orchidaceae Source classification Plants	Others
Parishin is a phenolic glucoside isolated from Gastrodia elata. Parishin exhibits antiaging effects and extends the lifespan of yeast via regulation of *Sir2/Uth1/TOR* signaling pathway .

Dihydrocoumarin Hydrocoumarin; Chroman-2-one	Structural Classification other families Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Disease Research Fields Cancer	Sirtuin
Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC₅₀s of 208 μM and 295 μM, respectively .

Parishin (Standard)	Other Terpenoids Structural Classification Gastrodia elata Bl. Terpenoids Orchidaceae Source classification Plants	Reference Standards Others
Parishin (Standard) is the analytical standard of Parishin. This product is intended for research and analytical applications. Parishin is a phenolic glucoside isolated from Gastrodia elata. Parishin exhibits antiaging effects and extends the lifespan of yeast via regulation of Sir2/Uth1/TOR signaling pathway .

Dihydrocoumarin (Standard) Hydrocoumarin (Standard); Chroman-2-one (Standard)	Structural Classification other families Source classification Coumarins Phenylpropanoids Plants	Reference Standards Sirtuin
Dihydrocoumarin (Standard) is the analytical standard of Dihydrocoumarin. This product is intended for research and analytical applications. Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively .

Cat. No.	Product Name		Classification

HY-D2243

Cy3.5 tetrazine		Tetrazine
Cy3.5 tetrazineis a Tetrazine modified Cy3.5 fluorescent dye. SiR-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .

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SIRS

Inhibitors & Agonists

Fluorescent Dye

NaturalProducts

Click Chemistry

Natural
Products