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Results for "

Reverse transcriptase-IN-1

" in MedChemExpress (MCE) Product Catalog:

18

Inhibitors & Agonists

1

Natural
Products

1

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-130241
    Reverse transcriptase-IN-1

    		HIV Infection
    Reverse transcriptase-IN-1 (Compound 12z), a diarylbenzopyrimidine (DABP) analogue, is a potent, orally active HIV-1 nonnucleoside reverse transcriptase inhibitor. Reverse transcriptase-IN-1 has antiviral activity with EC50 values of 3.4 nM, 4.3 nM and 3.6 nM for HIV-1 IIIB, E138K and K103N mutants, respectively. Reverse transcriptase-IN-1 also has an IC50of 13.7 nM against HIV-1 reverse transcriptase enzyme .
    Reverse transcriptase-IN-1
  • HY-137453C
    (R,1R)-Tenofovir amibufenamide

    (R,1R)-HS-10234

    		 Drug Intermediate Others
    (R,1R)-Tenofovir amibufenamide ((R,1R)-HS-10234) can be used for the purifying a tenofovir prodrug. Tynofovir (tenofovir) is a nucleoside acids reverse transcriptase inhibitors .
    (R,1R)-Tenofovir amibufenamide
  • HY-105216
    L 697661

    		Reverse Transcriptase HIV Infection
    L 697661 is an orally active HIV-1 reverse transcriptase inhibitor .
    L 697661
  • HY-120737
    L-702007

    		HIV Infection
    L-702007 is a potent HIV-1 reverse transcriptase inhibitor .
    L-702007
  • HY-107003
    Opaviraline

    GW420867X

    		 HIV Protease Infection
    Opaviraline (GW420867X) is an anti-HIV-1 reverse transcriptase inhibitor .
    Opaviraline
  • HY-17423D
    ent-Abacavir

    		Drug Intermediate Others
    ent-Abacavir is an enantiomer of Abacavir. Abacavir is an orally active, competitive nucleoside reverse transcriptase inhibitor .
    ent-Abacavir
  • HY-169207
    NNRT-IN-5

    		Reverse Transcriptase Cancer
    NNRT-IN-5 (compund 10d) is an orally available non-nucleoside reverse transcriptase inhibitor .
    NNRT-IN-5
  • HY-131422
    (Rac)-8-Hydroxy-efavirenz

    		Drug Metabolite Infection
    (Rac)-8-Hydroxy-efavirenz is a metabolite of Efavirenz (HY-10572), a non-nucleoside HIV-1 reverse transcriptase inhibitor .
    (Rac)-8-Hydroxy-efavirenz
  • HY-129667
    BM 21.1298

    		Reverse Transcriptase HIV Infection
    BM 21.1298 is a selective and high specific nonnucleoside immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) inhibitor with antiviral activity .
    BM 21.1298
  • HY-118740
    L-708906

    		HIV Infection
    L-708906 is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an IC50 value of 12 μM. L-708906 inhibits HIV strains resistant to nonnucleoside or nucleoside reverse transcriptase inhibitors .
    L-708906
  • HY-137613C
    Rp-TTPαS tetrasodium

    		HIV Infection
    Rp-TTPαS (tetrasodium) is the Rp-isomer of TTPαS (tetrasodium). Rp-TTPαS (tetrasodium) incorporate with HIV-1 reverse transcriptase (HIV-1 RT) with HIV-1 RT with large phosphorothioate elemental effects .
    Rp-TTPαS tetrasodium
  • HY-15232S2
    Tenofovir alafenamide-d6

    GS-7340-d6

    		 Isotope-Labeled Compounds Reverse Transcriptase HIV Infection Cancer
    Tenofovir alafenamide-d6 (GS-7340-d6) is deuterium labeled Tenofovir alafenamide. Tenofovir alafenamide (GS-7340) is an investigational oral proagent of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor .
    Tenofovir alafenamide-d6
  • HY-19143
    L-697639

    		HIV Infection
    L-697639 is an inhibitor for HIV-1 reverse transcriptase (HIV-1 RT) with IC50 of 20-400 nM (in a template-primer-dependent manner). L-697639 exhibits antiviral activity, that inhibits 95% HIV-1 infection at concentrations of 12-200 nM in human T lymphocyte cultures .
    L-697639
  • HY-175363
    HIV-1-IN-84

    		HIV HIV Protease Infection
    HIV-1-IN-84 (Compound 9) is a potent HIV-1 non-nucleoside reverse transcriptase (HIV-1 RT) inhibitor (IC50=33.89 μM, EC50=540 nM). HIV-1-IN-84 is promising for research of HIV infections .
    HIV-1-IN-84
  • HY-172408
    NNRT-IN-6

    		Reverse Transcriptase HIV Infection
    NNRT-IN-6 (Compound 13a) is the non-nucleoside reverse transcriptase inhibitor (NNRT) for HIV-1 reverse transcriptase (HIV-1 RT) with IC50 of 0.41 μM. NNRT-IN-6 inhibits HIV-1 wildtype and mutant strains L100I, K103N, Y181C, Y188L, E138K, F227L/V106A and RES056 with EC50 of 6.2-250 nM .
    NNRT-IN-6
  • HY-175351
    HIV-1-IN-83

    		HIV Reverse Transcriptase Infection
    HIV-1-IN-83 (Compound 18E) is a HIV-1 non-nucleoside reverse transcriptase inhibitor with an IC50 of 0.45 μM for wild-type HIV-1 non-nucleoside reverse transcriptase. HIV-1-IN-83 has potent antiviral activity against both HIV-1 wild-type and mutant strains and improves antidrug resistance for Y188L and RES056 mutant strains. HIV-1-IN-83 has no significant toxicity up to 11.088 μM .
    HIV-1-IN-83
  • HY-W751002
    Orthosporin

    (+)-OrthosporIN

    		 Endogenous Metabolite Bacterial HIV Reverse Transcriptase Infection
    Orthosporin ((+)-Orthosporin), a phytotoxic isocoumarin compound, is a microbial secondary metabolite. Orthosporin can be isolated from the endophytic fungus Lasiodiplodia tbeobromae. Orthosporin has potent antibacterial activity against B. subtilis, E. coli and P. aeruginosa. Orthosporin also has antioxidant activity against DPPH radical and antiviral activities with inhibition of HIV-1 reverse transcriptase activity .
    Orthosporin
  • HY-117725
    S-2720

    		HIV Reverse Transcriptase Infection
    S-2720 is a potent inhibitor of both immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) and HIV-1 replication. The binding sites of S-2720 and the nonnucleoside compounds overlap. The small pocket in the p66 subunit-BI-RG-587 (HY-10570) complex is most likely the target of S-2720. S-2720 is a quinoxaline derivative, which is promising for research of HIV-1 infection .
    S-2720

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