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Pyk2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Pyk2 (9) Apoptosis (2) FAK (10) IGF-1R (2) Insulin Receptor (2) Small Interfering RNA (siRNA) (3) Syk (2)
By Research Areas:	Cancer (9) Endocrinology (2) Inflammation/Immunology (3) Metabolic Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: Pyk2

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-401485

Pyk2-IN-2	Pyk2 FAK	Cancer
Pyk2-IN-2 (compound 13j) is an inhibitor of *Pyk2* with an IC₅₀ of FAK kinase of 0.608 μM .

HY-18312

PF-4618433 3 Publications Verification	Pyk2	Metabolic Disease
PF-4618433 is a potent and selective *PYK2* inhibitor, with an IC₅₀ of 637 nM. PF-4618433 may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects and for targeted bone regeneration ^[2].

HY-109084

Conteltinib CT-707	FAK	Cancer
Conteltinib (CT-707) is a multi-kinase inhibitor targeting FAK, ALK, and Pyk2. Conteltinib exerts significant inhibitory effect on FAK with an IC₅₀ of 1.6 nM .

HY-10458

PF-562271 besylate Maximum Cited Publications 23 Publications Verification VS-6062 besylate	FAK Pyk2	Cancer
PF-562271 (VS-6062) besylate is a potent ATP-competitive, reversible inhibitor of FAK and *Pyk2* kinase, with an IC₅₀ of 1.5 nM and 13 nM, respectively .

HY-20403

PF-562271 hydrochloride 20+ Cited Publications VS-6062(hydrochloride)	FAK Pyk2	Cancer
PF-562271 (VS-6062) hydrochloride is a potent, ATP-competitive and reversible FAK and *Pyk2* kinase inhibitor with IC₅₀s of 1.5 nM and 13 nM, respectively .

HY-10459

PF-562271 Maximum Cited Publications 23 Publications Verification VS-6062	FAK Pyk2	Cancer
PF-562271 (VS-6062) is a potent, ATP-competitive and reversible FAK and *Pyk2* kinase inhibitor with IC₅₀s of 1.5 nM and 13 nM, respectively .

HY-10460

PF-431396 5+ Cited Publications	Pyk2 FAK	Cancer
PF-431396 is an orally active dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor, with IC₅₀ values of 2 nM and 11 nM, respectively ^[2] .

HY-15322

PRT062607 3 Publications Verification P505-15; PRT-2607; BIIB-057	Syk	Inflammation/Immunology
PRT062607(P505-15; PRT-2607; BIIB-057) is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM; >80-fold selective for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70.

HY-109084A

Conteltinib tetrahydrochloride CT-707 tetrahydrochloride	FAK	Cancer
Conteltinib tetrahydrochloride (CT-707 tetrahydrochloride) is the tetrahydrochloride salt form of Conteltinib (HY-109084). Conteltinib tetrahydrochloride is the inhibitor for FAK (IC₅₀=1.6 nM), ALK, and *Pyk2*. Conteltinib tetrahydrochloride exhibits a synergistic anti-tumor efficacy with Cabozantinib (HY-13016) .

HY-169953

BT-Amide	Pyk2	Metabolic Disease
BT-Amide is the orally active inhibitor for Pyk2 kinase with IC₅₀ of 44.69 nM. BT-Amide prevents glucocorticoid-induced bone loss, exhibits bone protective activity in C57BL/6 mouse .

HY-134570

ZINC40099027 2 Publications Verification	FAK	Metabolic Disease Inflammation/Immunology
ZINC40099027 is a selective FAK activator. ZINC40099027 promotes FAK phosphorylation, without activating its paralogs Pyk2 and Src. ZINC40099027 promotes the wound closure of human intestinal epithelial monolayers and the healing of mouse ulcers by activating FAK. ZINC40099027 can be used for diseases related to gastrointestinal mucosal injury research .

HY-13203

NVP-TAE 226 5+ Cited Publications TAE226	FAK Pyk2 IGF-1R Insulin Receptor Apoptosis	Endocrinology Cancer
NVP-TAE 226 (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC₅₀s of 5.5 nM and 140 nM, respectively. NVP-TAE 226 (TAE226) also effectively inhibits *Pyk2* and insulin receptor (InsR) with IC₅₀s of 3.5 nM and 44 nM, respectively ^[2].

HY-13203R

NVP-TAE 226 (Standard)	FAK Pyk2 IGF-1R Insulin Receptor Apoptosis	Endocrinology Cancer
NVP-TAE 226 (Standard) is the analytical standard of NVP-TAE 226. This product is intended for research and analytical applications. NVP-TAE 226 (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC50s of 5.5 nM and 140 nM, respectively. NVP-TAE 226 (TAE226) also effectively inhibits Pyk2 and insulin receptor (InsR) with IC50s of 3.5 nM and 44 nM, respectively ^[2].

HY-109082

Cevidoplenib SKI-O-703	Syk	Inflammation/Immunology
Cevidoplenib (SKI-O-703) is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities. Cevidoplenib is also the mesylate form of SKI-O-592. Cevidoplenib and SKI-O-592 inhibits BCR-mediated survival, proliferation, and differentiation of B cells. And SKI-O-592 potently inhibits multiple kinases with IC₅₀s of 6.2 nM (Syk), 1.859 μM (Jak2), 5.807 μM (Jak3), 0.412 μM (RET), 0.687 μM (KOR), 1.783 μM (FLT3), 16.96 μM (FGFR1), 5.662 μM (FGFR3), and 0.709 μM (Pyk2), respectively ^[2] .

HY-RS26981

Ptk2b Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ptk2b Rat Pre-designed siRNA Set A contains three designed siRNAs for Ptk2b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ptk2b Rat Pre-designed siRNA Set A Ptk2b Rat Pre-designed siRNA Set A

HY-RS20473

Ptk2b Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ptk2b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ptk2b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ptk2b Mouse Pre-designed siRNA Set A Ptk2b Mouse Pre-designed siRNA Set A

HY-RS11402

PTK2B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PTK2B Human Pre-designed siRNA Set A contains three designed siRNAs for PTK2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PTK2B Human Pre-designed siRNA Set A PTK2B Human Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

HY-P5527F

FAM-CSKtide	Peptides	Others
FAM-CSKtide is a biological active peptide. (This is a FAM labeled peptide substrate (Abs/Em = 494/521 nm) for C-terminal Src kinase (Csk) and many other kinases such as Axl, cKit, ERBB4, Fes, Flt3, IGF-1 R, MET, MUSK, PYK2, Ret, TIE2, TrkA, VEGF-R1 and VEGF-R2.)

Cat. No.	Compare	Product Name	Species	Source

HY-P702717

	PTK2B Protein, Human (sf9) PTK2B; PTK2B protein tyrosine kinase 2 beta; FAK2, protein tyrosine kinase 2 beta; protein-tyrosine kinase 2-beta; CADTK; CAKB; PTK; Pyk2; RAFTK; FADK 2; CAK-beta; protein kinase B; focal adhesion kinase 2; cell adhesion kinase beta; proline-rich tyrosine kinase 2; calcium-dependent tyrosine kinase; related adhesion focal tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase; PKB; FAK2; FADK2	Human	Sf9 insect cells
	PTK2B Protein, Human (sf9) is the recombinant human-derived PTK2B, expressed by Sf9 insect cells , with tag Free labeled tag. ,

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80290

	PYK2 Antibody (YA115)	WB, ICC/IF, IHC-P	Human, Mouse
	PYK2 Antibody (YA115) is a non-conjugated and Rabbit origined monoclonal antibody about 116 kDa, targeting to PYK2. It can be used for WB,ICC/IF,IHC-P assays with tag free, in the background of Human, Mouse.

HY-P80877

	PYK2 Antibody (YA682) PTK2B; FAK2; Pyk2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro	WB, IHC-P	Human
	PYK2 Antibody (YA682) is a non-conjugated and Mouse origined monoclonal antibody about 116 kDa, targeting to PYK2 (4B4). It can be used for WB,IHC-P assays with tag free, in the background of Human.

HY-P84568

	PYK2 Antibody (YA4265) PKB; PTK; CAKB; FAK2; FRNK; PTK2B	WB, IHC-P, ELISA	Human
	PYK2 Antibody (YA4265) is a mouse-derived and non-conjugated IgG2a antibody, targeting to PYK2. It can be applicated for WB, IHC-P, ELISA assays, in the background of human.

HY-P85341

	PYK2 Antibody (YA5033) PTK2B; FAK2; Pyk2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro	WB, IHC-P, ICC/IF, ELISA	Human
	PYK2 Antibody (YA5033) is a mouse-derived and non-conjugated monoclonal antibody, targeting to PYK2. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human.

HY-P85462

	PYK2 Antibody (YA5154) PTK2B; FAK2; Pyk2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro	WB	Human, Mouse, Dog, Pig, Rabbit
	PYK2 Antibody (YA5154) is a mouse-derived and non-conjugated monoclonal antibody, targeting to PYK2. It can be applicated for WB assays, in the background of human, mouse, dog, pig, rabbit.

HY-P86140

	PYK2 Antibody (YA5832) PTK2B; FAK2; Pyk2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	PYK2 Antibody (YA5832) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PYK2. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Ptk2b Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ptk2b Rat Pre-designed siRNA Set A contains three designed siRNAs for Ptk2b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ptk2b Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ptk2b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ptk2b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

PTK2B Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PTK2B Human Pre-designed siRNA Set A contains three designed siRNAs for PTK2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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