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Results for "

Papain inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Autophagy (3) Bacterial (3) Cathepsin (5) Deubiquitinase (3) DNA Methyltransferase (2) Elastase (2) Endogenous Metabolite (2) Factor Xa (4) Fluorescent Dye (2) Fungal (2) HIF/HIF Prolyl-Hydroxylase (2) Monocarboxylate Transporter (2) Reference Standards (1) SARS-CoV (32) Ser/Thr Protease (6) Thrombin (5) Virus Protease (9)
By Research Areas:	Cancer (7) Cardiovascular Disease (5) Infection (35) Inflammation/Immunology (6) Metabolic Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1315

**Papain inhibitor** Glycylglycyl-L-tyrosyl-L-arginine	Cathepsin	Others
Papain inhibitor (Glycylglycyl-L-tyrosyl-L-arginine) acts as an effective competitive inhibitor to *papain, with a K_i* of 9 μM at pH 6.2 .

HY-W790014

Z-FG-NHO-BzOME	Cathepsin	Infection
Z-FG-NHO-BzOME is a cysteine protease inhibitor that selectively inhibits cathepsin B, cathepsin L, cathepsin S, and papain .

HY-15282

E-64 Maximum Cited Publications 19 Publications Verification Proteinase inhibitor E 64	Cathepsin Autophagy Bacterial	Inflammation/Immunology Cancer
E-64 (Proteinase inhibitor E 64) is a potent irreversible inhibitor against general cysteine proteases with IC₅₀ of 9 nM for *papain*.

HY-150784

XR8-89	SARS-CoV	Infection
XR8-89 is a potent papain-like protease (PL ^pro) inhibitor with an IC₅₀ value of 0.1 μM. XR8-89 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. XR8-89 can be used for SARS-CoV-2 research .

HY-162981

PLpro-IN-7	SARS-CoV	Cancer
PLpro-IN-7 (compund 83) is a novel papain-like protease (PLpro) inhibitor with IC₅₀ of 3 nM .

HY-124556

Elasnin	Elastase	Inflammation/Immunology
Elasnin is a selective granulocyte elastase inhibitor. Elasnin is almost ineffective for pancreatic elastase, trypsin, chymotrypsin, thermolysin and papain .

HY-N5182

Chymostatin B	Others	Others
Chymostatin B is a subtype of chymostatin characterized by a valine residue. Chymostatin inhibits chymotrypsin, papain, and other serine/cysteine endopeptidases .

HY-N5180

Chymostatin A	Others	Others
Chymostatin A is a subtype of chymostatin characterized by a leucine residue. Chymostatin inhibits chymotrypsin, papain, and other serine/cysteine endopeptidases .

HY-N5183

Chymostatin C	Others	Others
Chymostatin C is a subtype of chymostatin characterized by a leucine residue. Chymostatin inhibits chymotrypsin, papain, and other serine/cysteine endopeptidases .

HY-150786

PLP_Snyder530	SARS-CoV	Infection
PLP_Snyder530 is a potent papain-like protease (PL ^pro) inhibitor with an IC₅₀ value of 6.4 μM. PLP_Snyder530 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. PLP_Snyder530 can be used for SARS-CoV-2 research .

HY-168584

SARS-CoV-2-IN-102	SARS-CoV	Infection
SARS-CoV-2-IN-102 (example 58) is a *SARS-CoV papain-like protease (PLpro)* inhibitor with an IC₅₀ <100 nM .

HY-150783

SARS-CoV-2-IN-24	SARS-CoV	Infection
SARS-CoV-2-IN-24 (compound 7) is a potent papain-like protease (PL ^pro) inhibitor. SARS-CoV-2-IN-24 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. SARS-CoV-2-IN-24 can be used for SARS-CoV-2 research .

HY-161365

PLpro-IN-2	SARS-CoV	Infection
PLpro-IN-2 (Compound 16) is an inhibitor for SARS-CoV-2 papain-like protease (PLpro), with an IC₅₀ of 0.25 μM .

HY-173305

Mpro/PLPro-IN-2	SARS-CoV Virus Protease	Infection
Mpro/PLPro-IN-2 (Compound 22l) is a non-covalent competitive dual inhibitor of the papain-like protease and main protease of SARS-CoV-2, with a K_i of 0.2 μM for the papain-like protease and a K_i of 1.1 μM for the main protease . Mpro/PLPro-IN-2 can be used in the research field of anti-SARS-CoV-2 .

HY-159655

PLpro-IN-6	SARS-CoV	Infection Inflammation/Immunology
PLpro-IN-6 (compound 6) is a papain-like protease (PLpro) inhibitor, with an IC₅₀ of 0.019 μM for SARS CoV2 PLpro enzyme .

HY-N13950

Bacithrocin A	Thrombin Factor Xa Ser/Thr Protease	Cardiovascular Disease
Bacithrocin A is a thrombin inhibitor that inhibits thrombin, factor Xa, trypsin and Papain with IC₅₀s of 48 μM, 13 μM, 0.65 μM, and 0.02 μM, respectively .

HY-N13957

Bacithrocin C	Thrombin Factor Xa Ser/Thr Protease	Cardiovascular Disease
Bacithrocin C is a thrombin inhibitor that inhibits thrombin, factor Xa, trypsin and Papain with IC₅₀s of 80 μM, 15 μM, 1.3 μM, and 0.02 μM, respectively .

HY-N13955

Bacithrocin B	Thrombin Factor Xa Ser/Thr Protease	Cardiovascular Disease
Bacithrocin B is a thrombin inhibitor that inhibits thrombin, factor Xa, trypsin and Papain with IC₅₀s of 84 μM, 17 μM, 1.7 μM, and 0.02 μM, respectively .

HY-N14193

Estatin B	Cathepsin	Inflammation/Immunology
Estatin B is a thiol protease inhibitor found by the Thermophilic Bacterium M4323, which is specific to thiol proteases such as papain, fig protease, and bromelain. Estatin B inhibits the production of IgE antibodies but not IgG in mice .

HY-17542

PLpro inhibitor 5+ Cited Publications	SARS-CoV	Infection
PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with an IC₅₀ of 2.6 µM . PLpro inhibitor inhibits SARS-CoV-2 PLpro with an IC₅₀ of 5.0 µM and an EC₅₀ of 21.0 µM .

HY-157439

SARS-CoV-2-IN-72	SARS-CoV	Infection
SARS-CoV-2-IN-72 (compound 12) is a potent allosteric inhibitor of the SARS-COV-2 papain-like protease domain that can trigger the degradation of NSP3 .

HY-150789

SARS-CoV-2-IN-23	SARS-CoV	Infection
SARS-CoV-2-IN-23 (compound GRL-0617) is a SARS-COV-2 papain-like protease (PLpro) inhibitor with an IC₅₀ value of 2.3 μM .

HY-158751

Jun9-72-2	SARS-CoV	Infection
Jun9-72-2 is a papain (Plpro) inhibitor of SARS-CoV-2 with an IC₅₀ value of 0.67 μM. Jun9-72-2 has antiviral activity .

HY-125528

Ro 09-1679	Thrombin	Cardiovascular Disease
Ro 09-1679 is a thrombin inhibitor, with an IC₅₀ of 33.6 μM. Ro 09-1679 inhibits the enzyme activities, with IC₅₀ values of 3.3, 0.04 and 0.0346 μM for factor Xa, trypsin and papain, respectively .

HY-N1910

4'-O-Methylbavachalcone 2 Publications Verification	SARS-CoV	Infection
4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC₅₀ of 10.1 μM .

HY-159985

Jun13728	SARS-CoV	Infection
Jun13728 is a potent and covalent *SARS-CoV-2 papain-like protease* inhibitor, with an IC₅₀ of 0.1 μM. Jun13728 can be used for SARS-CoV-2 antiviral research .

HY-N13896

Aureoquinone	Ser/Thr Protease	Infection
Aureoquinone is a broad-spectrum protease inhibitor. Aureoquinone inhibits trypsin, papain, thermophilic protease, collagenase and pound-protease, with IC₅₀ values of 11.4 μg/mL, 14.5 μg/mL, 17.8 μg/mL, 7.1 μg/mL, and 8.7 μg/mL, respectively .

HY-169419

SARS-CoV-2-IN-108	SARS-CoV Virus Protease	Infection
SARS-CoV-2-IN-108 (Compound 29) is an inhibitor for *SARSCoV-2 papain-like protease* with an IC₅₀ of 0.14 µM. SARS-CoV-2-IN-108 inhibits the virus replication with an EC₅₀ of 0.21 µM .

HY-N13960

Bacithrocin D Thiolstatin D	Thrombin Factor Xa	Cardiovascular Disease
Bacithrocin D (Thiolstatin D) inhibits multiple proteases and can prolong the clotting time. Bacithrocin D has IC₅₀ values of 124, 9, 0.85, and 0.01 μM for thrombin, factor Xa, trypsin, and papain, respectively .

HY-164868

SARS-CoV-2-IN-106	SARS-CoV	Infection
SARS-CoV-2-IN-106 (compound 19) is a *SARS-CoV-2 papain-like protease* inhibitor with the IC₅₀ values of 0.44 μM and 0.18 μM for PLpro enzymatic and viral replication ,respectively .

HY-126988

SP-Chymostatin B α-MAPI	Elastase	Others
SP-Chymostatin B (α-MAPI) is a strong inhibitor of many proteases, including chymotrypsin, papain, chymotrypsin-like serine proteinases, chymases, and lysosomal cysteine proteinases such as cathepsins A,B,C, H, and L. SP-Chymostatin B weakly inhibits human leucocyte elastase .

HY-N14772

Laccaridione A	Ser/Thr Protease	Infection
Laccaridione A can inhibit the activity of antiserine protease. Laccaridione A inhibits trypsin, papain, thermophilic protease, collagenase and zinc protease with IC₅₀s of 14.7 μg/mL, 2.5 μg/mL, 18.8 μg/mL, 7.2 μg/mL and 18.2 μg/mL, respectively .

HY-170504

ZHAWOC25153	SARS-CoV Virus Protease	Infection
ZHAWOC25153 (Compound 17o) is a SARS-CoV-2 papain-like cysteine protease (PLpro) inhibitor, with an IC₅₀ of 7 μM. ZHAWOC25153 exhibits antiviral activity and can be used in research within the field of anti-infection .

HY-161729

PLpro-IN-3	SARS-CoV	Infection
PLpro-IN-3 (compound 26R) is a potent Papain-like protease (PLpro) inhibitor with a IC₅₀ of 1.0μM. PLpro-IN-3 exhibits antiviral activity against SARS-CoV-2 with a EC₅₀ of 4.3 μM .

HY-120288

AM4299B	Cathepsin	Infection Metabolic Disease
AM4299B is an inhibitor for thiol protease. AM4299B inhibits bovine spleen cathepsin B, human kidney cathepsin L and *papain* with IC₅₀s of 0.7, 0.5 and 20 μM, respectively. AM4299B can be used in research in osteoporosis, and has potential to be used as an antiparasitic agent .

HY-157145

SARS-CoV-2-IN-69	SARS-CoV	Infection
SARS-CoV-2-IN-69 (Compound 7E) is a non-covalent SARS-CoV-2 inhibitor with an EC₅₀ value of 7.4 μM. SARS-CoV-2-IN-69 is a potent inhibitor of SARS-CoV-2 main protease (M ^pro) and a non-covalent inhibitor of papain (PL ^pro) .

HY-13765

6-Thioguanine 10+ Cited Publications Thioguanine; 2-Amino-6-purinethiol	SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite	Infection Inflammation/Immunology Cancer
6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

HY-117043

GRL0617 10+ Cited Publications	Deubiquitinase SARS-CoV	Infection
GRL0617 is a selective and competitive noncovalent inhibitor of *severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLpro), with an IC₅₀* of 0.6 μM and a Ki value of 0.49 μM. GRL0617 also inhibits SARS-CoV with an EC₅₀ of 14.5 μM. GRL0617 can be used for the research of severe acute respiratory syndrome .

HY-168259

PLpro-IN-8	SARS-CoV	Infection
PLpro-IN-8 (compound 1) is a *SARS-CoV papain-like protease (PLpro)* inhibitor with IC₅₀ values of 5.9 μM and 0.46 μM for SARS-CoV-2 PLpro and SARS -CoV-1 PLpro, respectively. PLpro-IN-8 inhibits Wuhan strain WK-521 of SARS-CoV-2 with an EC₅₀ of 2.7 μM .

HY-168917

9-AMN	SARS-CoV Virus Protease	Infection
9-AMN is the inhibitor for *SARS-CoV-2 papain-like protease* (SARS-CoV-2 PLpro), inhibits its deubiquitination (DUB) activity and protease activity with IC₅₀ of 4.55 µM and 4.15 µM. 9-AMN inhibits the SARS-CoV variants Delta and Omicron replication in Calu-3 cell with IC₅₀ of 1.04 µM and 2.35 µM .

HY-169092

PF-07957472	SARS-CoV Virus Protease	Infection
PF-07957472 (Compound 4) is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor. PF-07957472 shows cytopathic effect in SARS-CoV-2 infected NHBE cells (EC₅₀ = 13.9 nM). PF-07957472 shows antiviral effect in a mouse-adapted model of COVID-19 infection model .

HY-13765R

6-Thioguanine (Standard) Thioguanine (Standard); 2-Amino-6-purinethiol (Standard)	Reference Standards SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite	Infection Inflammation/Immunology Cancer
6-Thioguanine (Standard) is the analytical standard of 6-Thioguanine. This product is intended for research and analytical applications. 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

HY-168916

Jun13296	SARS-CoV Virus Protease
Jun13296 is an orally active quinoline *SARS-CoV-2 papain-like protease* inhibitor (IC₅₀ = 0.13 µM, K_i = 8.8 nM). Jun13296 exhibits potent inhibition against SARS-CoV-2 variants and Nirmatrelvir (HY-138687)-resistant mutants. Jun13296 improves lung viral titers, and prevents lung tissue damage in a SARS-CoV-2 infection model .

HY-100575

Acriflavine 5+ Cited Publications Acriflavinium chloride 3,6-Acridinediamine mix	Fluorescent Dye HIF/HIF Prolyl-Hydroxylase Bacterial SARS-CoV Monocarboxylate Transporter Fungal	Infection Cancer
Acriflavine (Acriflavinium chloride) is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine is an antiseptic agent. Acriflavine is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2 .

HY-W088075

Acriflavine hydrochloride 5+ Cited Publications Acriflavinium chloride hydrochloride	Fluorescent Dye HIF/HIF Prolyl-Hydroxylase Bacterial SARS-CoV Monocarboxylate Transporter Fungal	Infection Cancer
Acriflavine (Acriflavinium chloride) hydrochloride is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine hydrochloride is an antiseptic agent. Acriflavine hydrochloride is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine hydrochloride inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine hydrochloride is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine hydrochloride is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2 .

HY-N14773

Laccaridione B	Ser/Thr Protease	Infection Cancer
Laccaridione B can inhibit the activity of antiserine protease. Laccaridione B inhibits trypsin, papain, thermophilic protease, collagenase and zinc protease with IC₅₀s of 10.9 μg/mL, 5.1 μg/mL, 8.4 μg/mL, 5.7 μg/mL and 3.0 μg/mL, respectively. Laccaridione B also has a strong anti-proliferative activity against L-929, K-562 and HeLa cells with IC₅₀s of 2.4 μg/mL, 1.8 μg/mL and 13.9 μg/mL, respectively .

HY-172350

WEHI-P8	SARS-CoV	Infection
WEHI-P8 is an orally active inhibitor targeting the papain-like protease (PLpro) of coronaviruses. WEHI-P8 againsts SARS-CoV-2 PLpro with an IC₅₀ value of 12 nM. WEHI-P8 has good cellular activity with a EC₅₀ of 298 nM. WEHI-P8 protects mice from SARS-CoV-2 induced long-term symptoms in lung and brain. WEHI-P8 can be used for post-acute sequelae of COVID-19 study .

HY-178160

SARS-CoV-2 PLpro-IN-2	SARS-CoV Virus Protease	Infection
SARS-CoV-2 PLpro-IN-2 (Compound 12) is a highly selective SARS-CoV-2 papain-like protease (PLpro) inhibitor of (IC₅₀=0.06 μM). SARS-CoV-2 PLpro-IN-2 inhibits viral replication and immune evasion. SARS-CoV-2 PLpro-IN-2 exhibits antiviral efficacy in HeLa-ACE2 cells (EC₅₀=2.9 μM). SARS-CoV-2 PLpro-IN-2 is promising for research of COVID-19 .

HY-157403

Jun12682 1 Publications Verification	Virus Protease SARS-CoV	Infection
Jun12682 is an orally active SARS-CoV-2 papain-like protease (PL ^pro) inhibitor, with a K_i value of 37.7 nM and an EC₅₀ value of 1.1 μM in the FlipGFP PL ^pro assay. Jun12682 has efficacy in hindering PL ^pro both deubiquitination and deISGylation, with K_i values of 63.5 and 38.5 nM, respectively. Jun12682 exhibits resistance in multiple PL ^pro mutant strains, and its enzymatic activity is comparable to that of the wild-type. Jun12682 can be used for the study of the SARS-CoV-2 .

HY-162484

GZNL-P36	SARS-CoV Virus Protease	Infection
GZNL-P36 is an orally active inhibitor for SARS-CoV-2 papain-like protease (PL ^pro), with an IC₅₀ of 6.45 nM. GZNL-P36 inhibits SARS-CoV and its variants with EC₅₀ range from 58.2 nM to 2.66 μM. GZNL-P36 exhibits a peak plasma concentration C_max of 549 ng/mL, a half-life T_1/2 of 1.45 h and a bioavailability of 74.7% in CD-1 mouse. GZNL-P36 exhibits antiviral activity in SARS-CoV-2 XXB.1 infection in mouse .

Cat. No.	Product Name	Type

HY-100575

Acriflavine

5+ Cited Publications

Acriflavinium chloride 3,6-Acridinediamine mix

Fluorescent Dyes/Probes

Acriflavine (Acriflavinium chloride) is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine is an antiseptic agent. Acriflavine is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2 .

Cat. No.	Product Name	Target	Research Area

HY-P1315

**Papain inhibitor** Glycylglycyl-L-tyrosyl-L-arginine	Cathepsin	Others
Papain inhibitor (Glycylglycyl-L-tyrosyl-L-arginine) acts as an effective competitive inhibitor to *papain, with a K_i* of 9 μM at pH 6.2 .

HY-W790014

Z-FG-NHO-BzOME	Cathepsin	Infection
Z-FG-NHO-BzOME is a cysteine protease inhibitor that selectively inhibits cathepsin B, cathepsin L, cathepsin S, and papain .

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