Search Result

Isoforms Recommended:	PIM1

Results for "

PIM1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Anaplastic lymphoma kinase (ALK) (1) Apoptosis (19) Autophagy (4) c-Kit (1) Casein Kinase (4) Caspase (2) CDK (10) Checkpoint Kinase (Chk) (1) DAPK (1) DYRK (3) EGFR (1) ERK (1) FLT3 (1) GSK-3 (4) HDAC (2) Interleukin Related (1) IRAK (1) MELK (2) mTOR (2) NF-κB (1) PARP (1) Pim (66) Reference Standards (2) Ribosomal S6 Kinase (RSK) (2) RIP kinase (2) Small Interfering RNA (siRNA) (4) Src (2) Trk Receptor (2)
By Research Areas:	Cancer (66) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (7) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (4)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-162006

Pim-1 kinase inhibitor 8	Pim Apoptosis Autophagy	Cancer
Pim-1 kinase inhibitor 8 is a potent *PIM-1* inhibitor with an IC₅₀ value of 14.3 nM. Pim-1 kinase inhibitor 8 impedes cell proliferation and migration through PIM-1 inhibition and the induction of both apoptosis and autophagy. Pim-1 kinase inhibitor 8 inhibits solid tumor growth in Solid Ehrlich Carcinoma (SEC)-bearing mice. Pim-1 kinase inhibitor 8 can be used for breast and liver cancer research ^[1].

HY-RS10548

Pim1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pim1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pim1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pim1 Mouse Pre-designed siRNA Set A Pim1 Mouse Pre-designed siRNA Set A

HY-178443

Pim-1 kinase-IN-15	Pim	Cancer
Pim-1 kinase-IN-15 (Compound 15) is a highly potent and selective Pim-1 kinase inhibitor (IC₅₀=0.212 μM). Pim-1 kinase-IN-15 induces tumor cell apoptosis and suppress cell migration. Pim-1 kinase-IN-15 is promising for research of oncology, such as breast cancer ^[1].

HY-178133

Pim-1 kinase-IN-14	Pim Apoptosis Caspase	Cancer
Pim-1 kinase-IN-14 is a *PIM-1* kinase inhibitor with an IC₅₀ value of 94 nM. Pim-1 kinase-IN-14 shows broad-spectrum and high-efficiency anticancer activity against multiple human cancer cell lines, including liver cancer (HepG-2), colon cancer (Caco-2), myeloid leukemia (NFS-60), and prostate cancer (PC-3) cells. Pim-1 kinase-IN-14exerts its anticancer effects by inducing apoptosis and activating caspase 3/7. Pim-1 kinase-IN-14 can be used for the study of cancers associated with PIM-1 kinase overexpression ^[1].

HY-RS10549

Pim1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pim1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pim1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pim1 Rat Pre-designed siRNA Set A Pim1 Rat Pre-designed siRNA Set A

HY-RS10547

PIM1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PIM1 Human Pre-designed siRNA Set A contains three designed siRNAs for PIM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PIM1 Human Pre-designed siRNA Set A PIM1 Human Pre-designed siRNA Set A

HY-147785

Pim-1 kinase inhibitor 2	Pim Apoptosis	Cancer
Pim-1 kinase inhibitor 2 (Compound 13) is a potent inhibitor of Pim-1 kinase. Pim-1 kinase inhibitor 2 induces apoptosis. Pim-1 kinase inhibitor 2 has the potential for the research of cancer diseases ^[1].

HY-143295

Pim-1 kinase inhibitor 1	Pim Apoptosis	Cancer
Pim-1 kinase inhibitor 1 is a *Pim-1* kinase inhibitor with an IC₅₀ of 0.11 μM for Pim-1 kinase. Pim-1 kinase inhibitor 1 shows anticancer activity to several cancer cell lines by promotes cell apoptosis. Pim-1 kinase inhibitor 1 can be used for the research of cancer ^[1].

HY-168071

Pim-1 kinase inhibitor 11	Pim	Cancer
Pim-1 kinase inhibitor 11 (10f) is a *PIM-1* inhibitor, with an IC₅₀ of 0.18 μM. Pim-1 kinase inhibitor 11 (10f) exhibits anticancer activity. Pim-1 kinase inhibitor 11 (10f) induces apoptosis and arrests cell cycle progression ^[1].

HY-156915

Pim-1 kinase inhibitor 13	Pim	Inflammation/Immunology Cancer
Pim-1 Kinase Inhibitor 13 (compound 10) is a Pim-1 kinase inhibitor with an IC₅₀ of 4.41 μM. Pim-1 Kinase Inhibitor 13 can be utilized in immunology or cancer research ^[1].

HY-163119

Pim-1 kinase inhibitor 9	Pim	Cancer
Pim-1 kinase inhibitor 9 (compound 8b) is a selective inhibitor against Pim-1 kinase with IC₅₀ value of 0.24 µM. Pim-1 kinase inhibitor 9 inhibits cell cycle of T47D at S phase. Pim-1 kinase inhibitor 9 reveals antitumor activity ^[1].

HY-149976

Pim-1 kinase inhibitor 4	Pim	Cancer
Pim-1 kinase inhibitor 4 (Compound 10f) is a Pim-1 kinase inhibitor (IC₅₀: 17.01 nM). Pim-1 kinase inhibitor 4 also has antioxidant activity and inhibits DPPH. Pim-1 kinase inhibitor 4 induces apoptosis in PC-3 cell, and inhibits PC-3 cell growth with an IC₅₀ of 16 nM. Pim-1 kinase inhibitor 4 can be used for research of prostate cancer ^[1].

HY-150731

Pim-1 kinase inhibitor 3	Pim	Cancer
Pim-1 kinase inhibitor 3 (Compound H5) is a potent *Pim-1* kinase inhibitor with an IC₅₀ of 35.13 nM ^[1].

HY-162059

Pim-1 kinase inhibitor 10	Pim Apoptosis Caspase	Cancer
Pim-1 kinase inhibitor 10 (compound 13a) is a both competitive and non-competitive inhibitor of PIM-1/2 kinase. Pim-1 kinase inhibitor 10 can induce cell apoptosis and exhibits anticancer activity. Pim-1 kinase inhibitor 10 also induces caspase 3/7 activation ^[1].

HY-149996

Pim-1 kinase inhibitor 6	Pim	Cancer
Pim-1 kinase inhibitor 6 (Compound 4d) is a potent Pim-1 kinase inhibitor with IC₅₀ value of 0.46 μM, and has significant cytotoxic effect on cancer cells ^[1].

HY-149995

Pim-1 kinase inhibitor 5	Pim	Cancer
Pim-1 kinase inhibitor 5 (Compound 4c) is a Pim-1 kinase inhibitor (IC₅₀: 0.61 μM). Pim-1 kinase inhibitor 5 shows cytotoxicity against cancer cells, with IC₅₀s of 6.95-20.19 μM for HepG2, MCF-7, PC3, and HCT-116 cells ^[1].

HY-143897

PIM1-IN-3	Pim Apoptosis	Cancer
PIM1-IN-3 (Compound HL8) is a potent inhibitor of *PIM1. PIM1-IN-3* shows selective inhibition for the PIM-1 enzyme. PIM1-IN-3 induces apoptosis efficiently in Colo320 cells. PIM1-IN-3 has the potential for the research of cancer diseases ^[1].

HY-143898

PIM1-IN-4	Pim	Cancer
PIM1-IN-4 (Compound 8) is a potent inhibitor of *PIM1. PIM1-IN-4* reveals strong inhibition of five other enzymes, i.e., SGK-1, PKA, CaMK-1, GSK3β, and MSK1. PIM1-IN-4 has the potential for the research of cancer diseases ^[1].

HY-175277

PIM1-IN-8	Pim NF-κB Interleukin Related	Inflammation/Immunology
PIM1-IN-8 is a *PIM1/p65* pathway inhibitor. PIM1-IN-8 suppresses the expression of α-SMA and collagen I in activated fibroblasts and blocks TGF-β induced migration. PIM1-IN-8 alleviates pulmonary fibrosis in a Bleomycin (BLM) (HY-17565A)-induced pulmonary fibrosis mice model. PIM1-IN-8 can be used for the study of idiopathic pulmonary fibrosis (IPF) ^[1].

HY-108605

PIM1-IN-2	Pim	Cancer
PIM1-IN-2 is a potent and ATP competitive *Pim-1* inhibitor with a K_i of 91 nM. PIM1-IN-2 targets the ATP-binding kinase hinge region not by forming classical hydrogen bonds ^[1].

HY-111552

PIM1-IN-1	Pim	Cancer
PIM1-IN-1 is a potent and highly selective *PIM1/3* inhibitor, with IC₅₀s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC₅₀ of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity ^[1].

HY-147921

PIM1-IN-7	Pim	Cancer
PIM1-IN-7 (compound 6c) is a potent *PIM-1* inhibitor, with an IC₅₀ of 0.67 μM. PIM1-IN-7 shows the high cytotoxicity activity against HCT-116 and MCF-7 cells, with IC₅₀ values of 42.9 and 7.68 μM, respectively ^[1].

HY-147920

PIM1-IN-6	Pim	Cancer
PIM1-IN-6 (compound 5h) is a potent *PIM-1* inhibitor, with an IC₅₀ of 0.60 μM. PIM1-IN-6 shows the high cytotoxicity activity against HCT-116 and MCF-7 cells, with IC₅₀ values of 1.51 and 15.2 μM, respectively ^[1].

HY-10371

Pim1/AKK1-IN-1 Maximum Cited Publications 10 Publications Verification LKB1/AAK1 dual inhibitor	Pim	Cancer
Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with K_d values of 35 nM/53 nM/75 nM/380 nM for *Pim1/AKK1/MST2/LKB1* respectively, and also inhibits MPSK1 and TNIK.

HY-101947

SMI-16a 5+ Cited Publications PIM1/2 Kinase Inhibitor VI	Pim	Cancer
SMI-16a is a selective *Pim* kinase inhibitor with IC₅₀ values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively.

HY-143233

PIM-1/HDAC-IN-1	Pim HDAC Apoptosis	Cancer
PIM-1/HDAC-IN-1 (compound 4d) is a *PIM-1* inhibitor, with an IC₅₀ of 343.87 nM. PIM-1/HDAC-IN-1 has strong inhibitory activity and selectivity against HDAC 1 and HDAC 6, with IC₅₀ values of 63.65 and 62.39 nM, respectively. PIM-1/HDAC-IN-1 exhibits apoptosis inducing potential in MCF-7 cell lines. PIM-1/HDAC-IN-1 shows pre-G1 apoptosis and cell cycle arrest at G2/M phase ^[1].

HY-174302

PIM-1/HDAC-IN-2	Pim HDAC PARP Apoptosis	Cancer
PIM-1/HDAC-IN-2 is a robust *PIM/HDAC* inhibitor (IC₅₀ = 0.11 μM in MV4-11cells), which exerts a synergistic antiproliferative effect through a dual mechanism of inhibiting *PIM1* kinase and selectively inhibiting HDAC6. PIM-1/HDAC-IN-2 induces cell apoptosis. PIM-1/HDAC-IN-2 remarkably induces the cleavage of PARP, thereby initiating the arrest of the cell cycle in G1 phase and a reduction in S phase. PIM-1/HDAC-IN-2 demonstrates significant anticancer efficacyin the MV4-11 xenograft model without notable toxicity^[1]_.

HY-157404

Pim-1/2 kinase inhibitor 2	Pim	Cancer
Pim-1/2 kinase inhibitor 2 (compound 5b) is a competitive *PIM-1* and PIM-2 kinase inhibitor with IC₅₀s of 1.31 μM and 0.67 μM, respectively. Pim-1/2 kinase inhibitor 2 shows in-vitro low cytotoxicity against normal human lung fibroblast Wi-38 cell line and potent in-vitro anticancer activity against myeloid leukaemia (NFS-60), liver (HepG-2), prostate (PC-3), and colon (Caco-2) cancer cell lines ^[1].

HY-168517

PIM-1/CK2-IN-2	Pim Casein Kinase Apoptosis	Cancer
PIM-1/CK2-IN-2 (compound 3aA) is a *PIM-1/CK2* inhibitor. PIM-1/CK2-IN-2 can induce the mitochondrial apoptotic pathway in CCRF-CEM cells. PIM-1/CK2-IN-2 can be used in cancer research ^[1].

HY-W412264

Pim-1/2 kinase inhibitor 1	Pim	Cancer
Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of *4E-BP1* and p27 ^Kip1. Pim-1/2 kinase inhibitor 1 can be used in study of cancer, especially prostate cancer ^[1].

HY-18086

*TCS PIM-1* 1** 4 Publications Verification SC 204330	Pim	Cancer
TCS PIM-1 1 (SC 204330) is a potent, selective and ATP-competitive *Pim-1* kianse inhibitor with an IC₅₀ of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2 (IC₅₀s >20000 nM) ^[1].

HY-135816

*CK2/PIM1-IN-1*	Casein Kinase Pim	Inflammation/Immunology Cancer
CK2/PIM1-IN-1 is an inhibitor of CK2 and *PIM1, with IC₅₀s of 3.787 μM and 4.327 μM for CK2 and PIM1, respectively. CK2/PIM1-IN-1* is developed for the research of proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, vascular disorders, pathogenic infections and certain immunological disorders ^[1].

HY-173224

*CDK2/PIM1-IN-1*	CDK Pim	Cancer
CDK2/PIM1-IN-1 is an inhibitor of CDK2 (IC₅₀: 0.27 μM) and *PIM1* (IC₅₀: 0.67 μM) kinases. CDK2/PIM1-IN-1 induces apoptosis and reduces tumor-promoting TNF-α expression. CDK2/PIM1-IN-1 has antitumor activity ^[1].

HY-142696

*CDK6/PIM1-IN-1*	CDK Pim Apoptosis	Cancer
CDK6/PIM1-IN-1 is a potent and balanced dual *CDK6/PIM1* inhibitor with IC₅₀ values of 39 and 88 nM, respectively. CDK6/PIM1-IN-1 inhibits CDK4 (IC₅₀=3.6 nM). CDK6/PIM1-IN-1 significantly inhibits acute myeloid leukemia (AML) cell proliferation, arrest cell cycle at the G1 phase, and promote cell apoptosis. CDK6/PIM1-IN-1 exhibits potent anti-AML activity ^[1].

HY-142696A

*CDK6/PIM1-IN-1 hydrochloride*	CDK Pim Apoptosis	Cancer
CDK6/PIM1-IN-1 (Compound 51) hydrochloride is an orally active and potent dual *CDK6/PIM1* inhibitor with IC₅₀ values of 39 and 88 nM, respectively. CDK6/PIM1-IN-1 hydrochloride inhibits CDK4 (IC₅₀=3.6 nM). CDK6/PIM1-IN-1 hydrochloride significantly inhibits acute myeloid leukemia (AML) cell proliferation, arrest cell cycle at the G1 phase, and promote cell apoptosis. CDK6/PIM1-IN-1 exhibits potent anti-AML activity ^[1].

HY-16576A

SMI-4a 1 Publications Verification TCS-PIM-1-4a	Pim	Cancer
SMI-4a (TCS-PIM-1-4a) is a poten, selective, cell-permeable and ATP-competitive *Pim-1* inhibitor with an IC₅₀ of 24 μM and a K_i of 0.6 μM. SMI-4a also inhibits *Pim-2* (IC₅₀ of 100 μM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. SMI-4a has anticancer activity ^[1].

HY-N1950

Hispidulin 5 Publications Verification Dinatin	Pim	Cancer
Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC₅₀ of 2.71 μM.

HY-101126

TP-3654 3 Publications Verification	Pim	Cancer
TP-3654 is a second-generation *Pim* kinase inhibitor with K_i values of 5 and 42 nM for Pim-1 and Pim-3, respectively.

HY-13287

SGI-1776 free base Maximum Cited Publications 10 Publications Verification	Pim Autophagy Apoptosis	Cancer
SGI-1776 free base is an inhibitor of *Pim* kinases, with IC₅₀s of 7 nM, 363 nM, and 69 nM for Pim-1, -2 and -3, respectively.

HY-N4149

Quercetagetin 4 Publications Verification 6-Hydroxyquercetin	Pim	Inflammation/Immunology Cancer
Quercetagetin (6-Hydroxyquercetin) is a flavonoid ^[1]. Quercetagetin is a moderately potent and selective, cell-permeable *pim-1* kinase inhibitor (IC₅₀, 0.34 μM) . Anti-inflammatory and anticancer properties.

HY-N1950R

Hispidulin (Standard) Dinatin (Standard)	Reference Standards Pim	Cancer
Hispidulin (Standard) is the analytical standard of Hispidulin. This product is intended for research and analytical applications. Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC₅₀ of 2.71 μM.

HY-169670

Protein kinase inhibitor 13	Pim CDK GSK-3 Src	Cancer
Protein kinase inhibitor 13 (Compound I-90) is the inhibitor for protein kinase that exhibits inhibitory effects on kinases such as PIM-1, CDK-2, GSK-3 and SRC ^[1].

HY-13287A

SGI-1776	Pim Apoptosis Autophagy	Inflammation/Immunology Cancer
SGI-1776 is an inhibitor of Pim kinases, with IC₅₀s of 7 nM, 363 nM, and 69 nM for Pim-1, Pim-2 and Pim-3, respectively ^[1] .

HY-18095B

CX-6258 hydrochloride 2 Publications Verification	Pim	Cancer
CX-6258 hydrochloride is a potent and kinase selective *pan-Pim* kinases inhibitor, with IC₅₀*s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim*-3, respectively ^[1].

HY-18095A

CX-6258 hydrochloride hydrate 2 Publications Verification	Pim	Cancer
CX-6258 hydrochloride hydrate is a potent and kinase selective *pan-Pim* kinases inhibitor, with IC₅₀*s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim*-3, respectively ^[1].

HY-18095

CX-6258 2 Publications Verification	Pim	Cancer
CX-6258 is a potent and kinase selective *pan-Pim* kinases inhibitor, with IC₅₀*s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim*-3, respectively ^[1].

HY-12929

NSC756093 SU093	Pim	Cancer
NSC756093 is a potent inhibitor of the GBP1:PIM1 interaction. NSC756093 can potentially revert resistance to paclitaxel. NSC756093 can be used for ovarian cancer research ^[1].

HY-P1404

R8-T198wt	Pim	Cancer
R8-T198wt is a cell-permeable carboxyl-terminal p27 ^Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase ^[1].

HY-101783

GNE-955	Pim	Cancer
GNE-955 is a potent and orally active pan Pim kinase inhibitor with K_is of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively.

HY-N4149R

Quercetagetin (Standard) 6-Hydroxyquercetin (Standard)	Reference Standards Pim	Inflammation/Immunology Cancer
Quercetagetin (Standard) is the analytical standard of Quercetagetin. This product is intended for research and analytical applications. Quercetagetin (6-Hydroxyquercetin) is a flavonoid ^[1]. Quercetagetin is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50, 0.34 μM) . Anti-inflammatory and anticancer properties.

Cat. No.	Product Name	Target	Research Area

HY-P10042A

S6K Substrate acetate	Ribosomal S6 Kinase (RSK)	Others
S6K Substrate acetate is a substrate for active protein kinases, including CLK2, MRCKalpha, MRCKbeta, p70S6K, ROCK1, ROCK2, RSK1, RSK3, PIM1 ^[1].

HY-P1404

R8-T198wt	Pim	Cancer
R8-T198wt is a cell-permeable carboxyl-terminal p27 ^Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase ^[1].

HY-P10042

S6K Substrate	Ribosomal S6 Kinase (RSK)	Others
S6K Substrate is a substrate for active protein kinases, including CLK2, MRCKalpha, MRCKbeta, p70S6K, ROCK1, ROCK2, RSK1, RSK3, PIM1 ^[1].

Cat. No.	Compare	Product Name	Species	Source

HY-P701745

	PIM1 Protein, Human 1 Publications Verification PIM1; Serine/threonine-protein kinase PIM-1	Human	E. coli
	The PIM1 protein is a proto-oncogene with serine/threonine kinase activity that significantly promotes cell survival and proliferation, providing a selective advantage for tumorigenesis. It regulates MYC transcription, cell cycle progression, and inhibits pro-apoptotic proteins such as BAD, MAP3K5, and FOXO3 through phosphorylation. PIM1 Protein, Human is the recombinant human-derived PIM1 protein, expressed by E. coli , with tag free.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82757

	PIM1 Antibody (YA2502) PIM1; Serine/threonine-protein kinase PIM-1	WB, IHC-P	Human
	PIM1 Antibody (YA2502) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PIM1.