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Results for "

PFKFB3

" in MedChemExpress (MCE) Product Catalog:

14

Inhibitors & Agonists

2

Recombinant Proteins

1

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-RS10363
    PFKFB3 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PFKFB3 Human Pre-designed siRNA Set A contains three designed siRNAs for PFKFB3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PFKFB3 Human Pre-designed siRNA Set A
    PFKFB3 Human Pre-designed siRNA Set A
  • HY-153077
    PFKFB3-IN-2

    		Phosphatase Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    PFKFB3-IN-2 is a 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) inhibitor. PFKFB3-IN-2 has potential applications in cancer, neurodegenerative diseases, autoimmune diseases, inflammatory diseases, multiple sclerosis, metabolic diseases, angiogenesis inhibition and other diseases .
    PFKFB3-IN-2
  • HY-101971
    AZ PFKFB3 26
    1 Publications Verification

    		 Autophagy Cancer
    AZ PFKFB3 26 is a potent and selective PFKFB3 inhibitor with an IC50 of 23 nM. AZ PFKFB3 26 inhibits PFKFB1 and PFKFB2 with IC50s of 2.06 and 0.384 μM, respectively. AZ PFKFB3 26 can be used in the study of non-small cell lung cancer .
    AZ PFKFB3 26
  • HY-101972
    AZ-PFKFB3-67
    1 Publications Verification

    		 Phosphatase Bcl-2 Family Neurological Disease Metabolic Disease
    AZ-PFKFB3-67 is a potent and selective PFKFB3 kinase inhibitor with IC50s of 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1, respectively. AZ-PFKFB3-67 reduces MCL-1. AZ-PFKFB3-67 has neuroprotective activity [3].
    AZ-PFKFB3-67
  • HY-12204
    PFK-015
    3 Publications Verification

    		 Autophagy Metabolic Disease Inflammation/Immunology Cancer
    PFK-015, a derivative of 3PO, is a specific PFKFB3 inhibitor. PFK-015 inhibits recombinant PFKFB3 with an IC50 value of 110 nM and inhibits PFKFB3 activity in cancer cells with an IC50 value of 20 nM. PFK-015 can be used for the research of multiple cancers such as lung cancer, stomach cancer, colon cancer and esophageal squamous cell carcinoma (ESCC) .
    PFK-015
  • HY-112808
    KAN0438757
    4 Publications Verification

    		 Autophagy Cancer
    KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM .
    KAN0438757
  • HY-12203
    PFK-158
    10+ Cited Publications

    		 Autophagy Apoptosis Cancer
    PFK-158 is a potent and selective PFKFB3 inhibitor with an IC50 value 137 nM. PFK-158 reduces glucose uptake, ATP production, lactate release, and induces apoptosis and autophagy in cancer cells. PFK-158 has broad anti-tumor activity. PFK-158 can also enhance Colistin's resistance to bacteria [3].
    PFK-158
  • HY-RS16558
    Pfkfb3 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Pfkfb3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pfkfb3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Pfkfb3 Mouse Pre-designed siRNA Set A
    Pfkfb3 Mouse Pre-designed siRNA Set A
  • HY-RS22990
    Pfkfb3 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Pfkfb3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pfkfb3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Pfkfb3 Rat Pre-designed siRNA Set A
    Pfkfb3 Rat Pre-designed siRNA Set A
  • HY-101972A
    AZ-PFKFB3-67 quarterhydrate

    		Phosphatase Metabolic Disease
    AZ-PFKFB3-67 quarterhydrate is potent and selective metabolic kinase PFKFB3 inhibitor, with IC50s of 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1 respectively .
    AZ-PFKFB3-67 quarterhydrate
  • HY-110169
    (E/Z)-3PO

    		Phosphatase Cardiovascular Disease Cancer
    (E/Z)-3PO is a potent PFKFB3 inhibitor. (E/Z)-3PO can inhibit the glycolysis process, reduce the extracellular acidification rate, and inhibit the capillary tube formation, migration of endothelial cells, and the formation of aortic sprouts, thereby suppressing angiogenesis. (E/Z)-3PO is promising for research of diseases such as cancer, acute lung injury, pulmonary fibrosis, and atherosclerosis .
    (E/Z)-3PO
  • HY-110156
    YZ9

    		Phosphatase Cancer
    Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, and acts as a competitive inhibitor against Fru-6-P with a Ki value of 0.094 µM. Y29 exhibits antitumor effects against cervical cancer .
    YZ9
  • HY-19824
    3PO
    Maximum Cited Publications
    25 Publications Verification

    		 Autophagy Cancer
    3PO is an inhibitor of PFKFB3. 3PO attenuates the proliferation of several cancer cell lines with IC50s of 1.4-24 μmol/L. 3PO suppresses glucose uptake and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD + and NADH. 3PO can be used for the research of cancer .
    3PO
  • HY-123981
    5MPN

    		Phosphatase Cancer
    5MPN is a first-in-class, potent, orally active and selective 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) inhibitor. 5MPN appears to be a competitive inhibitor of the F6P binding site (Ki=8.6 μM). 5MPN does not inhibit PFK-1 or PFKFB3. 5MPN targets the sugar metabolism of tumors and suppresses proliferation of multiple human cancer cell lines .
    5MPN

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