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Results for "

P35

" in MedChemExpress (MCE) Product Catalog:

25

Inhibitors & Agonists

1

Inhibitory Antibodies

27

Recombinant Proteins

8

Antibodies

9

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-18299
    Purvalanol B
    1 Publications Verification

    NG 95

    CDK Parasite Infection Cancer
    Purvalanol B (NG 95) is a potent, selective, reversible and ATP-competitive inhibitor CDK, with IC50s of 6 nM, 6 nM, 9 nM, 6 nM for cdc2-cyclin B, CDK2-cyclin A, CDK2-cyclin E and CDK5-p35, respectively. Purvalanol B shows selectivity for CDK over a range of other protein kinases (IC50>1000 nM). Purvalanol B inhibits the growth a chloroquine-resistant strain of P. falciparum .
    Purvalanol B
  • HY-108359
    Alsterpaullone
    1 Publications Verification

    9-Nitropaullone; NSC 705701

    CDK GSK-3 Apoptosis Cancer
    Alsterpaullone (9-Nitropaullone) is a potent CDK inhibitor, with IC50s of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also competes with ATP for binding to GSK-3alpha/GSK-3beta with IC50s of both 4 nM. Alsterpaullone has antitumor activity, and possesses potential for the study in neurodegenerative and proliferative disorders . Alsterpaullone induces apoptosis in leukemia cell line .
    Alsterpaullone
  • HY-18299A
    Purvalanol A
    2 Publications Verification

    NG-60

    CDK Autophagy Apoptosis Cancer
    Purvalanol A is a potent CDK inhibitor, which inhibits cdc2-cyclin B, cdk2-cyclin A, cdk2-cyclin E, cdk4-cyclin D1, and cdk5-p35 with IC50s of 4, 70, 35, 850, 75 nM, resepctively.
    Purvalanol A
  • HY-136726

    CINK4

    CDK Cancer
    GP-82996 (CINK4) is a pharmacological inhibitor of CDK4/6. GP-82996 has IC50s of 1.5, 5.6 and 25 μM for CDK4/cyclin D1, CDK6/cyclin D1 and Cdk5/p35, respectively. GP-82996 induces the apoptosis of cancer cells U2OS. GP-82996 can be used in the research of cancer .
    CGP-82996
  • HY-P990226

    Interleukin Related Infection Inflammation/Immunology
    Anti-Mouse IL-12 p35 Antibody (C18.2) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-12 p35. Anti-Mouse IL-12 p35 Antibody (C18.2) can neutralize IL-12. Anti-Mouse IL-12 p35 Antibody (C18.2) can be used for the researches of infection, inflammation and immunology, such as airway inflammation and F. tularensis infection .
    Anti-Mouse IL-12 p35 Antibody (C18.2)
  • HY-18299AR

    CDK Autophagy Apoptosis Cancer
    Purvalanol A (Standard) is the analytical standard of Purvalanol A. This product is intended for research and analytical applications. Purvalanol A is a potent CDK inhibitor, which inhibits cdc2-cyclin B, cdk2-cyclin A, cdk2-cyclin E, cdk4-cyclin D1, and cdk5-p35 with IC50s of 4, 70, 35, 850, 75 nM, resepctively.
    Purvalanol A (Standard)
  • HY-173347

    CDK Neurological Disease
    BLINK11 is a BBB-penetrant CDK5 inhibitor. BLINK11 lowers CDK5 activity for both complexes CDK5/p35 (IC50 = 17.09 nM) and CDK5/p25 (IC50 = 14.69 nM). BLINK11 offers anti-diabetic and neuroprotective benefits. BLINK11 lowers blood glucose, enhances cognition, and reduces neurodegeneration in T2D mice .
    BLINK11
  • HY-173348

    CDK Neurological Disease
    BLINK15 is a BBB-penetrant CDK5 inhibitor. BLINK15 lowers CDK5 activity for both complexes CDK5/p35 (IC50 = 29.34 nM) and CDK5/p25 (IC50 = 12.08 nM). BLINK15 offers anti-diabetic and neuroprotective benefits. BLINK15 lowers blood glucose, enhances cognition, and reduces neurodegeneration in T2D mice .
    BLINK15
  • HY-111932

    CDK GSK-3 Cancer
    Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively . Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β .
    Indirubin-5-sulfonate
  • HY-119715

    CDK Apoptosis Cancer
    AG-012986 is a multitargeted CDK inhibitor. AG-012986 is active against CDK1/2/4/6/5/9, with Kis of 9.2 nM (CDK4/cyclin), 94 nM (CDK2/cyclin A), and 44 nM (CDK1/cyclin B), IC50s of 4 nM (CDK9/cyclin T) and 22 nM (CDK5/p35). AG-012986 has antiproliferative activities against cancer cells. AG-012986 induces cell cycle arrest, and apoptosis .
    AG-012986
  • HY-15504A
    RGB-286638 free base
    2 Publications Verification

    CDK GSK-3 MEK JAK Cancer
    RGB-286638 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.
    RGB-286638 free base
  • HY-15504
    RGB-286638
    2 Publications Verification

    CDK GSK-3 MEK JAK Cancer
    RGB-286638 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.
    RGB-286638
  • HY-176287

    Dopamine Receptor GSK-3 PKA Neurological Disease
    ARN25657 is a dual-acting D3R/GSK-3β modulator. ARN25657 has both partial D3R agonist activity (EC50 = 15.2 nM, Ki =1.5 nM) and potent GSK-3β inhibitor activity (IC50 = 19.3 nM). ARN25657 exhibits excellent GSK-3β selectivity over FYN, PKA, and CDK5/p35. ARN25657 inhibits P-gp-mediated acetoxymethyl calcein efflux and improves in vitro ADME properties while maintaining a balanced dual-target profile. ARN25657 is useful for studying bipolar disorder and related neuropsychiatric disorders .
    ARN25657
  • HY-W011428

    CDK Others Cancer
    Olomoucine is an ATP competitive inhibitor of CDKs. Olomoucine is a purine (HY-34431) derivative and inhibits CDC2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E (both IC50=7 μM), CDK/p35 kinase (IC50=3 μM) and ERK1/p44 MAP kinase (IC50=25 μM) . Olomoucine regulates cell cycle and shows anti-melanin tumor activity .
    Olomoucine
  • HY-112363

    RP107

    CDK GSK-3 ERK JNK CFTR Inflammation/Immunology Cancer
    Aloisine A (RP107) is a a potent cyclin-dependent kinase (CDK) inhibitor with IC50s of 0.15 μM, 0.12 μM, 0.4 μM, 0.16 μM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK5/p35, respectively. Aloisine A ininhibits GSK-3α (IC50=0.5 μM) and GSK-3β (IC50=1.5 μM). Aloisine A stimulates wild-type CFTR and mutated CFTR, with submicromolar affinity by a cAMP-independent mechanism. Aloisine A has the potential for CFTR-related diseases, including cystic fibrosis research .
    Aloisine A
  • HY-RS27045

    Small Interfering RNA (siRNA) Others

    Cdk5r1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cdk5r1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cdk5r1 Rat Pre-designed siRNA Set A
    Cdk5r1 Rat Pre-designed siRNA Set A
  • HY-RS23081

    Small Interfering RNA (siRNA) Others

    Anxa1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Anxa1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Anxa1 Rat Pre-designed siRNA Set A
    Anxa1 Rat Pre-designed siRNA Set A
  • HY-RS05328

    Small Interfering RNA (siRNA) Others

    GCHFR Human Pre-designed siRNA Set A contains three designed siRNAs for GCHFR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    GCHFR Human Pre-designed siRNA Set A
    GCHFR Human Pre-designed siRNA Set A
  • HY-RS15489

    Small Interfering RNA (siRNA) Others

    UPK3B Human Pre-designed siRNA Set A contains three designed siRNAs for UPK3B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    UPK3B Human Pre-designed siRNA Set A
    UPK3B Human Pre-designed siRNA Set A
  • HY-RS06678

    Small Interfering RNA (siRNA) Others

    Il12a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il12a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Il12a Mouse Pre-designed siRNA Set A
    Il12a Mouse Pre-designed siRNA Set A
  • HY-RS04840

    Small Interfering RNA (siRNA) Others

    FCN2 Human Pre-designed siRNA Set A contains three designed siRNAs for FCN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    FCN2 Human Pre-designed siRNA Set A
    FCN2 Human Pre-designed siRNA Set A
  • HY-RS20536

    Small Interfering RNA (siRNA) Others

    Cdk5r1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cdk5r1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cdk5r1 Mouse Pre-designed siRNA Set A
    Cdk5r1 Mouse Pre-designed siRNA Set A
  • HY-170522

    HIF/HIF Prolyl-Hydroxylase Inflammation/Immunology
    ISM012-042 is an orally active PHD1 and PHD2 inhibitor with IC50 values of 1.9 and 2.5 nM, respectively. ISM012-042 (2.5 μM) can protect Caco-2 cells from DSS-induced barrier disruption. In lipopolysaccharide (LPS)-induced mouse bone marrow-derived dendritic cells (BMDC), ISM012-042 has anti-inflammatory effects and can dose-dependently reduce the expression of IL-12 subunit IL-12p35 and TNF. ISM012-042 restores intestinal barrier function and alleviates intestinal inflammation in various experimental colitis models. ISM012-042 can be used for intestinal mucosal repair and research into immune diseases .
    ISM012-042
  • HY-RS06677

    Small Interfering RNA (siRNA) Others

    IL12A Human Pre-designed siRNA Set A contains three designed siRNAs for IL12A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    IL12A Human Pre-designed siRNA Set A
    IL12A Human Pre-designed siRNA Set A
  • HY-RS02387

    Small Interfering RNA (siRNA) Others

    CDK5R1 Human Pre-designed siRNA Set A contains three designed siRNAs for CDK5R1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CDK5R1 Human Pre-designed siRNA Set A
    CDK5R1 Human Pre-designed siRNA Set A

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