Oct4

By Targets:	Apoptosis (2) c-Myc (1) Isotope-Labeled Compounds (1) MDM-2/p53 (1) Oct3/4 (7) Reactive Oxygen Species (ROS) (1) Small Interfering RNA (siRNA) (2) STAT (1) TET Protein (1)
By Research Areas:	Cancer (4) Inflammation/Immunology (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119672

Oct4 inducer-1	Oct3/4	Others
Oct4 inducer-1 (compound OAC-3) is a potent *Oct4* activator. Oct4 inducer-1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. Oct4 inducer-1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time .

HY-12884

OAC2	Oct3/4	Others
OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.

HY-12303

OAC1 1 Publications Verification	Oct3/4 TET Protein	Cancer
OAC1 is a potent *Oct4* activator. OAC1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. OAC1 activates OCT4 through upregulation of HOXB4 expression. OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and TET1. OAC1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time .

HY-155528

O4I4	Others	Others
O4I4 (compound 23) is a OCT4-inducing compound with metabolical stability. O4I4 extends lifespan in Caenorhabditis elegans and Drosophila. O4I4 can be used for regenerative medicine and rejuvenation research .

HY-154951

Oct4 inducer-2	Oct3/4	Others
Oct4 inducer-2 is an *OCT4* inducer, which can maintain the formation of hiPSCs by promoting the expression of endogenous OCT4, which can be used in anti-aging research .

HY-119666

Rooperol	Apoptosis Reactive Oxygen Species (ROS) MDM-2/p53 Oct3/4	Inflammation/Immunology Cancer
Rooperol is a norlignan analog with antitumor, anti-inflammatory, and antioxidant activities. Rooperol induces apoptosis in CSCs through a mitochondrial-induced increase in ROS and a p53-dependent pathway, while also downregulating the expression of key stem cell regulatory factors, such as *Oct4, Nanog, and Sox2*, ultimately exerting its anticancer effects ^[4].

HY-N15201

Betavulgarin	STAT	Cancer
Betavulgarin is an anticancer agent. Betavulgarin can be isolated from Sugar Beet (Beta vulgaris). Betavulgarin suppresses the proliferation, migration, colony formation, and mammosphere formation of breast cancer cells, and reduces the size of the CD44 ⁺/CD24 ⁻ subpopulation and the expression of the self-renewal- related genes C-Myc, Nanog and Oct4. Betavulgarin promotes BCSCs death through the regulation of Stat3/Sox2 signaling .

HY-165606

SB-T-1214	Oct3/4 c-Myc Apoptosis	Cancer
SB-T-1214 (SBT) is a taxane. SB-T-1214 efficiently inhibits expression of stem cell-related genes (Oct4, Sox2, and c-Myc) and induces apoptosis of colon cancer spheroids with drug resistant tumorigenic CD133 ⁺/CD44 ^{+ ^{cells. SB-T-1214 strongly represses tumor growth in Pgp+ DLD-1 human colon tumor xenografts mice model. SB-T-1214 can be used for antitumor research, especially against tumors with drug resistance, such as colon, pancreatic and renal cancers .}}

HY-W777329

(4E)-4-Octenedioic acid-13C2 (E)-Oct-4-ene-1,8-dioic acid-¹³C₂	Isotope-Labeled Compounds	Others
(4E)-4-Octenedioic acid- ¹³C₂ ((E)-Oct-4-ene-1,8-dioic acid- ¹³C₂) is the ¹³C-labeled (4E)-4-Octenedioic acid (HY-W151203).

HY-RS10907

POU5F1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
POU5F1 Human Pre-designed siRNA Set A contains three designed siRNAs for POU5F1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

POU5F1 Human Pre-designed siRNA Set A POU5F1 Human Pre-designed siRNA Set A

HY-RS10908

Pou5f1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pou5f1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pou5f1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pou5f1 Mouse Pre-designed siRNA Set A Pou5f1 Mouse Pre-designed siRNA Set A

HY-18772

O4I2	Oct3/4	Others
O4I2 is a potent *Oct3/4* inducer. O4I2 induces the expression of pluripotent-associated genes Lin28, Sox2 and Nanog, and suppresses Rex1 .

Cat. No.	Product Name

HY-L039

Reprogramming Compound Library	2,568 compounds
Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since Yamanaka reprogrammed somatic cells to become induced pluripotent stem cells (iPSCs) using four transcription factors, OCT4, SOX2, KLF4, and c-MYC in 2006. Despite the development of efficient reprogramming methods, most methods are inappropriate for clinical applications because they carry the risk of integrating exogenous genetic factors or use oncogenes. Alternative approaches, such as those based on miRNA, non-viral genes, non-integrative vectors, and small molecules, have been studied as possible solutions to the problems. Among these alternatives, small molecules are attractive options for clinical applications. Reprogramming using small molecules is inexpensive and easy to control in a concentration- and time-dependent manner. It offers a high level of cell permeability, ease of synthesis and standardization, and it is appropriate for mass-producing cells. MCE Reprogramming Compound Library contains a unique collection of 2,568 compounds that act on reprogramming signaling pathways. These compounds are potential stimulators for reprogramming. This library is a useful tool for researching reprogramming and regenerative medicine.

Reprogramming Compound Library

2,568 compounds

Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since Yamanaka reprogrammed somatic cells to become induced pluripotent stem cells (iPSCs) using four transcription factors, OCT4, SOX2, KLF4, and c-MYC in 2006. Despite the development of efficient reprogramming methods, most methods are inappropriate for clinical applications because they carry the risk of integrating exogenous genetic factors or use oncogenes. Alternative approaches, such as those based on miRNA, non-viral genes, non-integrative vectors, and small molecules, have been studied as possible solutions to the problems. Among these alternatives, small molecules are attractive options for clinical applications. Reprogramming using small molecules is inexpensive and easy to control in a concentration- and time-dependent manner. It offers a high level of cell permeability, ease of synthesis and standardization, and it is appropriate for mass-producing cells.

MCE Reprogramming Compound Library contains a unique collection of 2,568 compounds that act on reprogramming signaling pathways. These compounds are potential stimulators for reprogramming. This library is a useful tool for researching reprogramming and regenerative medicine.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N15201

Betavulgarin	Structural Classification Natural Products Terpenoids Source classification Diterpenoids Beta vulgaris Linn. Plants Chenopodiaceae	STAT
Betavulgarin is an anticancer agent. Betavulgarin can be isolated from Sugar Beet (Beta vulgaris). Betavulgarin suppresses the proliferation, migration, colony formation, and mammosphere formation of breast cancer cells, and reduces the size of the CD44 ⁺/CD24 ⁻ subpopulation and the expression of the self-renewal- related genes C-Myc, Nanog and Oct4. Betavulgarin promotes BCSCs death through the regulation of Stat3/Sox2 signaling .

Cat. No.	Product Name	Chemical Structure

HY-W777329

(4E)-4-Octenedioic acid-13C2
(4E)-4-Octenedioic acid- ¹³C₂ ((E)-Oct-4-ene-1,8-dioic acid- ¹³C₂) is the ¹³C-labeled (4E)-4-Octenedioic acid (HY-W151203).

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80440

	Oct-4 Antibody (YA837) MGC22487; Oct 3; Oct 4; Oct-3; Oct-4; Oct3; Oct4; Octamer binding protein 3; Octamer binding protein 4; Octamer binding transcription factor 3; Octamer-binding protein 3; Octamer-binding protein 4; Octamer-binding transcription factor 3; OTF 3; OTF 4; OTF	WB, ICC/IF	Human, Mouse
	Oct-4 Antibody is a non-conjugated and Mouse origined monoclonal antibody about 39 kDa, targeting to POU5F1. It can be used for WB,ICC assays with tag free, in the background of Human, Mouse.

HY-P80770

	Oct-4 Antibody MGC22487; Oct 3; Oct 4; Oct-3; Oct-4; Oct3; Oct4; Octamer binding protein 3; Octamer binding protein 4; Octamer binding transcription factor 3; Octamer-binding protein 3; Octamer-binding protein 4; Octamer-binding transcription factor 3; OTF 3; OTF 4; OTF	WB, IHC-P, ICC/IF, IP, ChIP	Human, Mouse
	Oct-4 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 39 kDa, targeting to POU5F1. It can be used for WB,IHC-P,ICC/IF,IP,ChIP assays with tag free, in the background of Human, Mouse.

HY-P84462

	OCT4 Antibody (YA4159) Oct3; Oct4; OTF3; OTF4; OTF-3; Oct-3; Oct-4; MGC22487; POU5F1	WB, ICC/IF, FC, ELISA	Human
	OCT4 Antibody (YA4159) is a mouse-derived and non-conjugated IgG1 antibody, targeting to OCT4. It can be applicated for WB, ICC/IF, FC, ELISA assays, in the background of human.

HY-P84463

	POU5F1 Antibody (YA4160) Oct3; Oct4; OTF3; OTF4; OTF-3; Oct-3; Oct-4	IHC-P, FC, ELISA	Human
	POU5F1 Antibody (YA4160) is a mouse-derived and non-conjugated IgG1 antibody, targeting to POU5F1. It can be applicated for IHC-P, FC, ELISA assays, in the background of human.

HY-P85304

	Oct-3/4 Antibody (YA4996) POU5F1; Oct3; Oct4; OTF3; POU domain; class 5, transcription factor 1; Octamer-binding protein 3; Oct-3; Octamer-binding protein 4; Oct-4; Octamer-binding transcription factor 3; OTF-3	WB, ICC/IF, FC, ELISA	Human
	Oct-3/4 Antibody (YA4996) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Oct-3/4. It can be applicated for WB, ICC/IF, FC, ELISA assays, in the background of human.

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Cat. No.	Product Name		Classification

HY-RS10907

POU5F1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
POU5F1 Human Pre-designed siRNA Set A contains three designed siRNAs for POU5F1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS10908

Pou5f1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Pou5f1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pou5f1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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