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OBI

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By Targets:	17β-HSD (1) DNA Alkylator/Crosslinker (1) Drug-Linker Conjugates for ADC (1) Fluorescent Dye (1) Nucleoside Antimetabolite/Analog (5) Ser/Thr Protease (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (9)
Click Chemistry:	Azide (1)
Oligonucleotides:	A (2) Nucleosides and their Analogs (5) C (1) U (2) Human Pre-designed siRNA Sets (1) siRNAs (1)

12

Inhibitors & Agonists

1

Click Chemistry

6

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

OBI-992 drug-linker	Drug-Linker Conjugates for ADC	Cancer
OBI-992 drug-linker is a drug-linker conjugate composed of a TOP I inhibitor Exatecan (HY-13631) and a linker. OBI-992 drug-linker exhibits antitumor property in mouse models and can be used for synthesis of ADC OBI-992 .

(R)-Odafosfamide OBI-3424; TH-3424; (R)-AST-3424	DNA Alkylator/Crosslinker	Cancer
(R)-Odafosfamide (OBI-3424) is a proagent that is selectively converted by AKR1C3 (aldo-keto reductase 1C3) to a potent DNA-alkylating agent. (R)-Odafosfamide can be used for hepatocellular carcinoma, castrate-resistant prostate cancer, and acute lymphoblastic leukemia (ALL) research .

*OBI*	Fluorescent Dye	Others Cancer
OBI is a Red Broccoli probe with red fluorescence. OBI enables Red Broccoli to be easily detected in living mammalian cells. OBI can be used to monitor intracellular metabolites .

OBI1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
OBI1 Human Pre-designed siRNA Set A contains three designed siRNAs for OBI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

OBI1 Human Pre-designed siRNA Set A OBI1 Human Pre-designed siRNA Set A

Odafosfamide (S)-OBI-3424; (S)-TH-3424; AST-3424	17β-HSD	Cancer
Odafosfamide ((S)-OBI-3424) is a highly selective prodrug bis-alkylating agent activated by aldehyde-keto reductase 1C3 (AKR1C3). Odafosfamide is highly cytotoxic to cell lines with high AKR1C3 expression. Odafosfamide exhibits antitumor activity in a variety of tumors with high AKR1C3 expression (such as liver cancer, non-small cell lung cancer, and leukemia). Odafosfamide can be used in cancer research .

6-O-Bis-(4,5-dimethoxy-2-nitrobenzyloxyphosphoryl)-D-trehalose	Others	Others
6-O-Bis-(4,5-dimethoxy-2-nitrobenzyloxyphosphoryl)-D-trehalose is a synthetic compound that interferes with plant sugar signaling. After being absorbed by plants, 6-O-Bis-(4,5-dimethoxy-2-nitrobenzyloxyphosphoryl)-D-trehalose can trigger the release of T6P by light exposure, thereby activating the signaling pathway inside the plant. 6-O-Bis-(4,5-dimethoxy-2-nitrobenzyloxyphosphoryl)-D-trehalose can be used to study plant biosynthesis .

6-O-Bis[1-(2-nitrophenyl)-ethoxyphosphoryl]-D-trehalose	Ser/Thr Protease	Others
6-O-Bis[1-(2-nitrophenyl)-ethoxyphosphoryl]-D-trehalose is an important signaling molecule that regulates carbon utilization and growth in plants. 6-O-Bis[1-(2-nitrophenyl)-ethoxyphosphoryl]-D-trehalose releases T6P through light activation, which can stimulate starch synthesis and promote plant growth by inhibiting SnRK1, a protein kinase involved in energy conservation and survival. 6-O-Bis[1-(2-nitrophenyl)-ethoxyphosphoryl]-D-trehalose can be used to study plant growth and metabolism .

5′-O-[Bis(4-methoxyphenyl)phenylmethyl]cytidine	Nucleoside Antimetabolite/Analog	Cancer
5′-O-[Bis(4-methoxyphenyl)phenylmethyl]cytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine	Nucleoside Antimetabolite/Analog	Cancer
2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc . 2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

N-Benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-3′-deoxyadenosine	Nucleoside Antimetabolite/Analog	Cancer
N-Benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-3′-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

2′-Amino-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine	Nucleoside Antimetabolite/Analog	Cancer
2′-Amino-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-adenosine 5'-O-(4,4'-DIMETHOXYTRITYL)ADENOSINE	Nucleoside Antimetabolite/Analog	Cancer
5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .

Cat. No.	Product Name		Classification

2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine		Azide
2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc . 2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-adenosine 5'-O-(4,4'-DIMETHOXYTRITYL)ADENOSINE		Nucleosides and their Analogs A
5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .

OBI1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
OBI1 Human Pre-designed siRNA Set A contains three designed siRNAs for OBI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

5′-O-[Bis(4-methoxyphenyl)phenylmethyl]cytidine		Nucleosides and their Analogs C
5′-O-[Bis(4-methoxyphenyl)phenylmethyl]cytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine		Nucleosides and their Analogs U
2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc . 2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

N-Benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-3′-deoxyadenosine		Nucleosides and their Analogs A
N-Benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-3′-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

2′-Amino-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine		Nucleosides and their Analogs U
2′-Amino-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

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