O2- generation

By Targets:	Apoptosis (2) Fluorescent Dye (2) Huntingtin (3) NADPH Oxidase (1) Reactive Oxygen Species (ROS) (6) Reference Standards (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Inflammation/Immunology (5) Neurological Disease (4)
Oligonucleotides:	Antisense Oligonucleotides (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1458

Peroxyfluor 1	Fluorescent Dye	Cardiovascular Disease Neurological Disease Cancer
Peroxyfluor 1 is a cell-permeable probe for H₂O₂. Peroxyfluor 1 represents a first-generation, green-fluorescent probe .

HY-132579A

Tominersen sodium RG6042 sodium; IONIS-HTTRx sodium	Huntingtin	Neurological Disease
Tominersen sodium is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen sodium can be used for the research of Huntington’s disease (HD) .

HY-132579

Tominersen RG6042; IONIS-HTTRx	Huntingtin	Neurological Disease
Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD) .

HY-N2410

N-trans-Feruloyltyramine N-feruloyltyramine; Moupinamide	Reactive Oxygen Species (ROS) Apoptosis	Inflammation/Immunology
N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H₂O₂-induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research .

HY-150236

FITC-labeled Tominersen sodium	Huntingtin	Neurological Disease
FITC-labeled Tominersen (sodium) is the Tominersen labeled with FITC. Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD).

HY-114809

AL-1	Reactive Oxygen Species (ROS) NADPH Oxidase	Inflammation/Immunology Cancer
AL-1 is a potent O2 ^- generation inhibitor (IC₅₀ = 7.6 μM) through the inhibition of leukocytic NADPH oxidase. AL-1 inhibits 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced H₂O₂ production. AL-1 reduces tumor incidence in ICR mouse skin. AL-1 can be used for research on oxidative stress-related diseases including cancer .

HY-B0464A

Hydralazine	Reactive Oxygen Species (ROS)	Cardiovascular Disease Inflammation/Immunology Cancer
Hydralazine is a orally active antihypertensive agent, reduces peripheral resistance directly by relaxing the smooth muscle cell layer in arterial vessel. Hydralazine has antioxidant activity, as well as inhibits reactive oxygen species (ROS) release and O₂ ^·- generation with an IC₅₀ value of 9.53 mM and 1.19 mM, respectively .

HY-N4278

Huangjiangsu A	Reactive Oxygen Species (ROS)	Inflammation/Immunology
Huangjiangsu A, pseudoprotodioscin, methyl protobioside, protodioscin, and protodeltonin, isolated from D. villosa. Huangjiangsu A has hepatoprotective potential against H2O2-induced cytotoxicity and ROS generation and could be promising as potential therapeutic agents for liver diseases .

HY-116730

CHS-111	Reactive Oxygen Species (ROS)	Others
CHS-111 is a benzyl indazole inhibitor of superoxide anion O ^2- generation. CHS-111 inhibits the cell migration, and reduces the formyl-Met-Leu-Phe- but not phorbol ester-stimulated phospholipase D activity, with the IC₅₀ of 3.9 μM .

HY-N2410R

N-trans-Feruloyltyramine (Standard) N-feruloyltyramine (Standard); Moupinamide (Standard)	Reference Standards Reactive Oxygen Species (ROS) Apoptosis	Inflammation/Immunology
N-trans-Feruloyltyramine (Standard) is the analytical standard of N-trans-Feruloyltyramine. This product is intended for research and analytical applications. N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H2O2-induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research .

HY-N9676

Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside	Others	Others
Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside is a flavonoid compound that can be isolated from Quercus dentata. Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside suppresses the superoxide generation induced by arachidonic acid .

HY-15914

DHBS DCHBS	Fluorescent Dye	Others
DHBS (3, 5-dichloro-2-hydroxybenzenesulfonate) is used in conjunction with 4-aminoantipyrine (4-AAP) (HY-W100990) and hydrogen peroxide (H₂O₂) for chromogenic quantitation of peroxidase in coupled enzymatic reactions. Component of Trinder reagent for use with peroxidase to measure generation of hydrogen peroxide in automated systems .

Cat. No.	Product Name	Type

HY-D1458

Peroxyfluor 1	Fluorescent Dye
Peroxyfluor 1 is a cell-permeable probe for H₂O₂. Peroxyfluor 1 represents a first-generation, green-fluorescent probe .

HY-150236

FITC-labeled Tominersen sodium	Fluorescent Dye
FITC-labeled Tominersen (sodium) is the Tominersen labeled with FITC. Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD).

HY-15914

DHBS DCHBS	Fluorescent Dye
DHBS (3, 5-dichloro-2-hydroxybenzenesulfonate) is used in conjunction with 4-aminoantipyrine (4-AAP) (HY-W100990) and hydrogen peroxide (H₂O₂) for chromogenic quantitation of peroxidase in coupled enzymatic reactions. Component of Trinder reagent for use with peroxidase to measure generation of hydrogen peroxide in automated systems .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2410

N-trans-Feruloyltyramine N-feruloyltyramine; Moupinamide	Alkaloids Classification of Application Fields Other Alkaloids Source classification Phenols Polyphenols Piperaceae Plants Inflammation/Immunology Disease Research Fields Piper nigrum Linn.	Reactive Oxygen Species (ROS) Apoptosis
N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H₂O₂-induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research .

HY-N2410R

N-trans-Feruloyltyramine (Standard) N-feruloyltyramine (Standard); Moupinamide (Standard)	Alkaloids Other Alkaloids Source classification Phenols Polyphenols Piperaceae Plants Piper nigrum Linn.	Reference Standards Reactive Oxygen Species (ROS) Apoptosis
N-trans-Feruloyltyramine (Standard) is the analytical standard of N-trans-Feruloyltyramine. This product is intended for research and analytical applications. N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H2O2-induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research .

HY-N9676

Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside	Flavonoids Flavones Source classification Quercus dentata Thunb. Plants Fagaceae	Others
Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside is a flavonoid compound that can be isolated from Quercus dentata. Kaempferol 3-O-(2'',4''-di-acetyl-3''-cis-p-coumaroyl-6''-trans-p-coumaroyl)-β-D-glucopyranoside suppresses the superoxide generation induced by arachidonic acid .

Cat. No.	Product Name		Classification

HY-132579A

Tominersen sodium RG6042 sodium; IONIS-HTTRx sodium		Antisense Oligonucleotides
Tominersen sodium is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen sodium can be used for the research of Huntington’s disease (HD) .

HY-132579

Tominersen RG6042; IONIS-HTTRx		Antisense Oligonucleotides
Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD) .

HY-150236

FITC-labeled Tominersen sodium		Antisense Oligonucleotides
FITC-labeled Tominersen (sodium) is the Tominersen labeled with FITC. Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD).

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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O2- generation

Inhibitors & Agonists

Fluorescent Dye

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Oligonucleotides

Natural
Products