O-acyltransferase

By Targets:	Acyltransferase (10) Apoptosis (3) Biochemical Assay Reagents (2) Casein Kinase (1) Drug Intermediate (1) Endogenous Metabolite (1) Porcupine (2) Reference Standards (1) Wnt (3)
By Research Areas:	Cancer (9) Cardiovascular Disease (4) Infection (1) Inflammation/Immunology (1) Metabolic Disease (3) Neurological Disease (1)

Targets Recommended: Acyltransferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100399A

Nevanimibe hydrochloride 3 Publications Verification PD-132301 hydrochloride; ATR101 hydrochloride	Acyltransferase Apoptosis	Cancer
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC₅₀ of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC₅₀ of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer .

HY-16437

RP-64477	Acyltransferase	Cardiovascular Disease
RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT).

HY-19286

Eflucimibe F 12511	Acyltransferase	Cancer
Eflucimibe (F 12511) is a new acyl-coenzyme *A cholesterol O-acyltransferase* (ACAT)** inhibitor. Eflucimibe can be used in the research of atherosclerosis .

HY-160804

Desmethyl nevanimibe	Drug Intermediate	Cancer
Desmethyl nevanimibe (Compound 5) is the demethyl precursor of the *sterol O-acyltransferase* 1 (SOAT1**) inhibitor Nevanimibe (PD-132301) .

HY-153855

Zamaporvint RXC004	Wnt Acyltransferase Porcupine	Cancer
Zamaporvint (RXC004) is an orally active and selective inhibitor of Wnt. Zamaporvint targete membrane-bound o-acyltransferase Porcupine and inhibited Wnt ligand palmitoylation, secretion, and pathway activation. Zamaporvint displays a favorable pharmacokinetic profile and shows potent antiproliferative effects in Wnt ligand-dependent colorectal and pancreatic cell lines. Zamaporvint possesses multiple antitumor mechanisms and can be used in cancer research .

HY-100399

Nevanimibe PD-132301; ATR-101	Acyltransferase Apoptosis	Cancer
Nevanimibe (PD-132301) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC₅₀ of 9 nM. Nevanimibe inhibits ACAT2 with an EC₅₀ of 368 nM. Nevanimibe induces cell apoptosis and has the potential for adrenocortical cancer .

HY-100399AR

Nevanimibe hydrochloride (Standard) PD-132301 hydrochloride (Standard); ATR101 hydrochloride (Standard)	Reference Standards Acyltransferase Apoptosis	Cancer
Nevanimibe hydrochloride (Standard) is the analytical standard of Nevanimibe hydrochloride. This product is intended for research and analytical applications. Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer .

HY-122078

FR-190809	Acyltransferase	Metabolic Disease
FR-190809 is a potent, nonadrenotoxic, orally efficacious acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibitor, with an IC₅₀ of 45 nM .

HY-148869A

Hexanoyl-coenzyme A triammonium 06:0 Coenzyme A triammonium	Biochemical Assay Reagents	Metabolic Disease
Hexanoyl-Coenzyme A triammonium (06:0 Coenzyme A) is a medium-chain fatty acyl CoA that is an acyl donor substrate for ghrelin O-acyltransferase (GOAT) .

HY-169813

Yakuchinone B	Acyltransferase	Cardiovascular Disease
Yakuchinone B is an Acyl-CoA: cholesterol O-acyltransferase (ACAT) inhibitor with hypocholesterolemic activity, which is found in the seeds of Zingiberaceae. Yakuchinone B inhibits rat hepatic ACAT with an IC₅₀ value of 20.6 μM. Yakuchinone B is promising for research of hypercholesterolemia and atherosclerosis .

HY-117832

Pyripyropene A 1 Publications Verification	Acyltransferase	Infection Cardiovascular Disease Inflammation/Immunology
Pyripyropene A is an orally active, potent and selective *sterol O-acyltransferase* 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) inhibitor, with an IC₅₀** of 0.07 µM. Pyripyropene A attenuates hypercholesterolemia and atherosclerosis in vivo .

HY-103479

GOAT-IN-1	Acyltransferase	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
GOAT-IN-1 is an inhibitor of *ghrelin O-acyltransferase* (GOAT)**, which could be useful for the prophylaxis or treatment of obesity, diabetes, hyperlipidemia, metabolic, non-alcoholic fatty liver, steatohepatitis, sarcopenia, appetite control, alcohol/narcotic dependence, Alzheimer’s disease, Parkinson’s disease, cerebrovascular dementia, cerebral apoplexy, cerebral infarction, cardic disease, some kind of tumors.

HY-13912

IWP-2 Maximum Cited Publications 24 Publications Verification	Wnt Porcupine Casein Kinase	Cancer
IWP-2 is an inhibitor of Wnt processing and secretion with an IC₅₀ of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC₅₀ of 40 nM for the gatekeeper mutant ^M82FCK1δ .

HY-13912G

IWP-2 1 Publications Verification	Wnt	Cancer
IWP-2 (GMP) is IWP-2 (HY-13912) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. IWP-2 is an inhibitor of Wnt processing and secretion with an IC₅₀ of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and blocks Wnt ligand palmitoylation .

HY-141572

1,2-Dioleoyl-sn-glycerol sn-1,2-Dioleoylglycerol	Biochemical Assay Reagents	Others
ALN29882 is a glycerolipid located on the plasma membrane. It consists of two fatty acid chains covalently linked to a single glycerol molecule by means of an ester bond. 18:1 DG has been used as a source of diacylglycerol in the diacylglycerol O-acyltransferase 1 (DGAT1) assay. It is also used as a substrate in the DGAT-1 enzyme assay to evaluate compounds as potential inhibitors of DGAT-1. Suitable for lipoprotein overlay screening assays with the recombinant protein His-AtROP6.

HY-E70255

26:0 Coenzyme A Hexacosanoyl coenzyme A triammonium	Endogenous Metabolite	Others
26:0 Coenzyme A (Hexacosanoyl coenzyme A triammonium) is a type of coenzyme A that can serve as a substrate for 1-acylglycerol-3-phosphate-O-acyltransferase isoform 11 (AGPAT11) .

Cat. No.	Product Name	Type

HY-13912G

IWP-2 (GMP) 1 Publications Verification	Fluorescent Dye
IWP-2 (GMP) is IWP-2 (HY-13912) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. IWP-2 is an inhibitor of Wnt processing and secretion with an IC₅₀ of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and blocks Wnt ligand palmitoylation .

Cat. No.	Product Name	Type

HY-13912G

IWP-2 (GMP) 1 Publications Verification	Biochemical Assay Reagents
IWP-2 (GMP) is IWP-2 (HY-13912) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. IWP-2 is an inhibitor of Wnt processing and secretion with an IC₅₀ of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and blocks Wnt ligand palmitoylation .

HY-141572

1,2-Dioleoyl-sn-glycerol sn-1,2-Dioleoylglycerol	Drug Delivery
ALN29882 is a glycerolipid located on the plasma membrane. It consists of two fatty acid chains covalently linked to a single glycerol molecule by means of an ester bond. 18:1 DG has been used as a source of diacylglycerol in the diacylglycerol O-acyltransferase 1 (DGAT1) assay. It is also used as a substrate in the DGAT-1 enzyme assay to evaluate compounds as potential inhibitors of DGAT-1. Suitable for lipoprotein overlay screening assays with the recombinant protein His-AtROP6.

1,2-Dioleoyl-sn-glycerol

sn-1,2-Dioleoylglycerol

Drug Delivery

ALN29882 is a glycerolipid located on the plasma membrane. It consists of two fatty acid chains covalently linked to a single glycerol molecule by means of an ester bond. 18:1 DG has been used as a source of diacylglycerol in the diacylglycerol O-acyltransferase 1 (DGAT1) assay. It is also used as a substrate in the DGAT-1 enzyme assay to evaluate compounds as potential inhibitors of DGAT-1. Suitable for lipoprotein overlay screening assays with the recombinant protein His-AtROP6.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-117832

Pyripyropene A 1 Publications Verification	Cardiovascular Disease Structural Classification Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Inflammation/Immunology Disease Research Fields	Acyltransferase
Pyripyropene A is an orally active, potent and selective *sterol O-acyltransferase* 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) inhibitor, with an IC₅₀** of 0.07 µM. Pyripyropene A attenuates hypercholesterolemia and atherosclerosis in vivo .

HY-169813

Yakuchinone B	Structural Classification Monophenols Source classification Phenols Plants Alpinia oxyphylla Miq. Zingiberaceae	Acyltransferase
Yakuchinone B is an Acyl-CoA: cholesterol O-acyltransferase (ACAT) inhibitor with hypocholesterolemic activity, which is found in the seeds of Zingiberaceae. Yakuchinone B inhibits rat hepatic ACAT with an IC₅₀ value of 20.6 μM. Yakuchinone B is promising for research of hypercholesterolemia and atherosclerosis .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P86947

	LPCAT3 Antibody (YA6640) 1-acylglycerophosphocholine O-acyltransferase antibody; 1-acylglycerophosphoserine O-acyltransferase antibody; LPCAT antibody; Lpcat3 antibody; LPLAT 5 antibody; LPSAT antibody; Lyso-PC acyltransferase 3 antibody; Lyso-PC acyltransferase antibody; Lyso-PS acyltransferase antibody; Lysophosphatidylcholine acyltransferase 3 antibody; 1-acylglycerophosphocholine O-acyltransferase antibody; 1-acylglycerophosphoserine O-acyltransferase antibody; LPCAT antibody; Lpcat3 antibody; LPLAT 5 antibody; LPSAT antibody; Lyso-PC acyltransferase 3 antibody; Lyso-PC acyltransferase antibody; Lyso-PS acyltransferase antibody; Lysophosphatidylcholine acyltransferase 3 antibody; Lysophosphatidylcholine acyltransferase antibody; Lysophosphatidylserine acyltransferase antibody; Lysophospholipid acyltransferase 5 antibody; MBOA5 antibody; MBOA5_HUMAN antibody; Membrane-bound O-acyltransferase domain-containing protein 5 antibody; O-acyltransferase domain-containing protein 5 antibody	WB, ICC/IF	Human, Monkey

HY-P81246

	DGAT1 Antibody (YA3508) ACAT related gene product 1; ACAT-related gene product 1; Acyl coenzyme A:cholesterol acyltransferase related gene 1; Acyl-CoA retinol O-fatty-acyltransferase; Acyl-CoA:diacylglycerol acyltransferase; ARAT; ARGP1; C75990; D15Ertd23e; Dgat; DGAT1; DGAT1_HUMAN; Diacylglycerol O acyltransferase 1; Diacylglycerol O-acyltransferase 1; Diglyceride acyltransferase; EC 2.3.1.20; hCG_24006; MGC139064; Retinol O fatty acyltransferase.	WB, IHC-P, IHC-F, ICC/IF, ELISA	Human
	DGAT1 Antibody is a rabbit-derived non-conjugated IgG antibody, targeting DGAT1, with a predicted molecular weight of 55 kDa (observed band size: 55 kDa). DGAT1 Antibody can be used for WB,IHC-P,IP experiments in human backgrounds.

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O-acyltransferase

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