Search Result
        
        
            
                Results for "
NAFLD
" in MedChemExpress (MCE) Product Catalog:
            
         
        
        
            
                
            
            
                
            
            
            
                
                    1
Biochemical Assay Reagents
 
            
            
                
            
            
            
                
            
            
                
            
            
            
                
                    5
Isotope-Labeled Compounds
 
            
            
            
            
                
            
         
        
            
            
                
                    
                    
                        
                            | Cat. No. | Product Name | Target | Research Areas | Chemical Structure | 
                    
                    
                        
                            
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                                    - HY-137996
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                                                |  | Akt
                                                    
                                                        mTOR | Metabolic Disease |  
                                                | Dehydrovomifoliol is a AKT/mTOR dual inhibitor. Dehydrovomifoliol reduces lipid accumulation and lipogenesis by inhibiting the AKT/mTOR signaling pathway. Dehydrovomifoliol is used in nonalcoholic fatty liver disease research (NAFLD) . |  
 
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                                    - HY-111179
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                                                |  | Drug Derivative | Inflammation/Immunology |  
                                                | ML261 is a hepatic lipid droplets formation inhibitor with an IC50 value of 69.7 nM. ML261 can be used for the research of non-alcoholic fatty liver disease (NAFLD) and inflammation . |  
 
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                                    - HY-157632
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-13 (Compound 5) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of < 0.1 μM for estradiol. HSD17B13-IN-13 can be used in the research of liver diseases, such as NAFLD . |  
 
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                                    - HY-163886
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                                                |  | Ketohexokinase | Metabolic Disease |  
                                                | KHK-IN-5 (Compound 18) is a KHK inhibitor. KHK-IN-5 can be used for the research of nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and type 2 diabetes (T2DM) . |  
 
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                                    - HY-161979
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                                                |  | 17β-HSD | Cancer |  
                                                | HSD17B13-IN-103 (Compound 44) is a HSD17B13 inhibitor. HSD17B13-IN-103 can be used in the study of non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) . |  
 
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                                    - HY-149971
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                                                |  | FXR | Inflammation/Immunology |  
                                                | XJ02862-S2 shows potent FXR agonistic activity. XJ02862-S2 is a promising lead compound for the research of NAFLD . |  
 
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                                    - HY-138996
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                                                |  | GCGR | Metabolic Disease |  
                                                | GLP-1 receptor agonist 8 is a potent agonist of GLP-1 R. GLP-1 receptor agonist 8 has the potential for the research of diabetes, obesity, and nonalcoholic fatty liver disease (NAFLD) (extracted from patent WO2019239319A1, compound 17) . |  
 
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                                    - HY-163259
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-62 (141) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research . |  
 
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                                    - HY-163248
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-37 (78) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research . |  
 
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                                    - HY-163255
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-58 (96) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research . |  
 
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                                    - HY-163246
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-34 (75) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research . |  
 
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                                    - HY-162216
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-89 (206) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research . |  
 
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                                    - HY-163240
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-24 (41) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research . |  
 
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                                    - HY-162214
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-90 (4) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research . |  
 
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                                    - HY-161227
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-43 (11) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research . |  
 
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                                    - HY-161231
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-78 (22) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research . |  
 
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                                    - HY-162212
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-85 (186) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research . |  
 
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                                    - HY-162211
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-84 (182) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research . |  
 
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                                    - HY-162689
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                                                |  | Free Fatty Acid Receptor | Inflammation/Immunology |  
                                                | GprA is a new synthetic agonist of G-protein-coupled receptor 120/free fatty acid receptor 4 (GPR120/FFAR4), with an AC50 of 203 nM on human GPR120 full isoform. GprA can be used in the research for NAFLD . |  
 
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                                    - HY-157627
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-9 (252) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with an IC50 of 0.01 μM for 50 nM HSD17B13. Used in NAFLD (Nonalcoholic fatty liver diseases) research . |  
 
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                                    - HY-163263S
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-80-d3 (179) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research . |  
 
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                                    - HY-163259S
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-62-d3 (176) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research . |  
 
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                                    - HY-W018392
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                                                | MEHP;  Phthalic acid mono-2-ethylhexyl ester | Endogenous Metabolite | Metabolic Disease |  
                                                | Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD) . |  
 
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                                    - HY-133707
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                                                |  | Endogenous Metabolite | Metabolic Disease |  
                                                | β-Muricholic acid is a potent and orally active biliary cholesterol-desaturating agent. β-Muricholic acid prevents cholesterol gallstones. β-Muricholic acid inhibits lipid accumulation. β-Muricholic acid has the potential for the research of nonalcoholic fatty liver disease (NAFLD)  . |  
 
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                                    - HY-157665
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-39 (Compound A) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13). HSD17B13-IN-39 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH . |  
 
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                                    - HY-155538
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                                                |  | Mitophagy | Metabolic Disease |  
                                                | Cisd2 agonist 1 (Compound 4q) is a Cisd2 agonist (EC50: 34 nM). Cisd2 agonist 1 enhances the Cisd2 expression and improves the pathological changes in the fatty livers. Cisd2 agonist 1 has good metabolic stability. Cisd2 agonist 1 can be used for research of NAFLD . |  
 
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                                    - HY-157664
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-38 (Compound D) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13). HSD17B13-IN-38 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH . |  
 
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                                    - HY-128145
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-41 (Compound C) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13). HSD17B13-IN-41 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH . |  
 
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                                    - HY-N0723
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                                                |  | Others | Metabolic Disease |  
                                                | Neomangiferin is a natural C-glucosyl xanthone isolated from m the dried rhizome of Anemarrhena asphodeloides. Neomangiferin has significant therapeutic effects on high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) in rats . |  
 
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                                    - HY-161212
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                                                |  | 17β-HSD | Metabolic Disease
                                                    
                                                        Inflammation/Immunology |  
                                                | HSD17B13-IN-8 (1) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with IC50 values of <0.1 μM for Estradiol and <1 μM for LTB3. Used in NAFLD (Nonalcoholic fatty liver diseases) research . |  
 
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                                    - HY-139230
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                                                |  | Cannabinoid Receptor
                                                    
                                                        PPAR | Metabolic Disease |  
                                                | OLHHA is a dual CB1 receptor antagonist and PPARα agonist. OLHHA also is a alcohol intake inhibitor with an EC50 value of 0.2 mg/kg. OLHHA  reduces both hepatic lipid accumulation and circulating triglyceride levels. OLHHA shows anti-steatotic activity and has the potential for the research of non-alcoholic fatty liver disease (NAFLD)  . |  
 
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                                    - HY-W018392S
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                                                | MEHP-d4;  Phthalic acid mono-2-ethylhexyl ester-d4 | Isotope-Labeled Compounds
                                                    
                                                        Endogenous Metabolite | Metabolic Disease |  
                                                | Mono-(2-ethylhexyl) phthalate-d4 is a deuterium labeled Mono-(2-ethylhexyl) phthalate (HY-W018392). Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD)  . |  
 
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                                    - HY-W018392R
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                                                | MEHP (Standard); Phthalic acid mono-2-ethylhexyl ester (Standard) | Reference Standards
                                                    
                                                        Endogenous Metabolite | Metabolic Disease |  
                                                | Mono-(2-ethylhexyl) phthalate (Standard) is the analytical standard of Mono-(2-ethylhexyl) phthalate. This product is intended for research and analytical applications. Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD) . |  
 
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                                    - HY-N0723R
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                                                |  | Reference Standards
                                                    
                                                        Others | Metabolic Disease |  
                                                | Neomangiferin (Standard) is the analytical standard of Neomangiferin. This product is intended for research and analytical applications. Neomangiferin is a natural C-glucosyl xanthone isolated from m the dried rhizome of Anemarrhena asphodeloides. Neomangiferin has significant therapeutic effects on high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) in rats . |  
 
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                                    - HY-RS17096
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                                                |  | Small Interfering RNA (siRNA) | Others |  
                                                | Tsc2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tsc2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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                                            Tsc2 Mouse Pre-designed siRNA Set A
                                            
                                                Tsc2 Mouse Pre-designed siRNA Set A
                                             
 
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                                    - HY-100546
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                                                |  | Histone Demethylase | Infection
                                                    
                                                        Metabolic Disease
                                                    
                                                        Cancer |  
                                                | GSK-LSD1, a chemical probe, is a LSD1 inhibitor. GSK-LSD1 reduces food intake and body weight, and improves insulin sensitivity and glycemic control in mouse models of obesity. GSK-LSD1 also ameliorates NAFLD. GSK-LSD1 inhibits SARS-CoV-2-triggered cytokine release in COVID-19 PBMCs. GSK-LSD1 also inhibits cancer growth and metastasis   . |  
 
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                                    - HY-157613
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-5 (Compound 96) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with a Ki value of ≤ 50 nM for the estradiol substrate LCMS. HSD17B13-IN-5 can be used in the research of liver diseases, metabolic disorders, or cardiovascular diseases such as NAFLD or NASH, or drug-induced liver injury (DILI) . |  
 
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                                    - HY-157601
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-4 (Compound 95) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with a Ki value of ≤ 50 nM for the estradiol substrate LCMS. HSD17B13-IN-4 can be used in the research of liver diseases, metabolic disorders, or cardiovascular diseases such as NAFLD or NASH, or drug-induced liver injury (DILI) . |  
 
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                                    - HY-163243
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-29 (Compound 53) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-29 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
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                                    - HY-163249
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-49 (Compound 81) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-49 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
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                                    - HY-161229
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-69 (Compound 11) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-69 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
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                                    - HY-162213
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-86 (Compound 188) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-86 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
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                                    - HY-163251
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-52 (Compound 84) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-52 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
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                                    - HY-163261
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-66 (Compound 146) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-66 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
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                                    - HY-162210
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-65 (Compound 168) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-65 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
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                                    - HY-161230
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-75 (Compound 21) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-75 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
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                                    - HY-162209
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-63 (Compound 160) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-63 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
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                                    - HY-163254
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-57 (Compound 93) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-57 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
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                                    - HY-163263
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-80 (Compound 151) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-80 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
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                                    - HY-163264
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-81 (Compound 154) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-81 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
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                                    - HY-157662
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-33 (Compound 115) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of < 0.1 μM for estradiol. HSD17B13-IN-33 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
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                                    - HY-163252
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-53 (Compound 88) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-53 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
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                                    - HY-163266
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-83 (Compound 150) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-83 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
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                                    - HY-163253
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-56 (Compound 89) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-56 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
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                                    - HY-163250
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-51 (Compound 82) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-51 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
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                                    - HY-161228
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-48 (Compound 12) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-48 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
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                                    - HY-163265
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                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-82 (Compound 156) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-82 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
                                    - HY-163262
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-71 (Compound 149) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-71 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
                                    - HY-162208
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-55 (Compound 167) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-55 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
                                    - HY-163258
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-61 (Compound 132) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-61 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
                                    - HY-162207
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-54 (Compound 158) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-54 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
                                    - HY-161232
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-79 (Compound 32) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-79 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
                                    - HY-163260
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-64 (Compound 143) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-64 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
                                    - HY-162225
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-99 (Compound 6) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of < 0.1 μM for estradiol. HSD17B13-IN-99 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
                                    - HY-163257
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-60 (Compound 126) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-60 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
                                    - HY-163256
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-59 (Compound 177) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-59 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
                                    - HY-161213
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-11 (Compound 2) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 1 μM for leukotriene B3 and ≤ 0.1 μM for estradiol. HSD17B13-IN-11 can be used in the research of liver diseases, metabolic disorders, or cardiovascular diseases such as NAFLD or NASH, or drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
                                    - HY-161216
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-15 (Compound 6) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 1 μM for leukotriene B3 and ≤ 0.1 μM for estradiol. HSD17B13-IN-15 can be used in the research of liver diseases, metabolic disorders, or cardiovascular diseases such as NAFLD or NASH, or drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
                                    - HY-163245
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-32(Compound 67) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-32can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
                                    - HY-161215
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-14 (Compound 4) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 1 μM for leukotriene B3 and ≤ 0.1 μM for estradiol. HSD17B13-IN-14 can be used in the research of liver diseases, metabolic disorders, or cardiovascular diseases such as NAFLD or NASH, or drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
                                    - HY-161214
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-12 (Compound 3) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for both leukotriene B3 and estradiol. HSD17B13-IN-12 can be used in the research of liver diseases, metabolic disorders, or cardiovascular diseases such as NAFLD or NASH, or drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
                                    - HY-153476
- 
                                        
                                            
                                                |  | GCGR | Metabolic Disease |  
                                                | GIP/GLP-1 dual receptor agonist-1 (compound 4) is a GIP/GLP-1 receptor agonist. GIP/GLP-1 dual receptor agonist-1 can be used in the research of metabolic disorders and fatty liver diseases, including nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD) . |  
 
- 
                                        
                                        
                                              
                                    - HY-162278
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-101 is a selective inhibitor of 17 β-hydroxysteroid dehydrogenase (HSD17B13), and its IC50 value for Estradiol is <0.1 μM. HSD17B13-IN-101 can be used in the study of nonalcoholic fatty liver disease (NAFLD) (WO2023146897A1; compound 94) . |  
 
- 
                                        
                                        
                                              
                                    - HY-162219
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-93 (Compound 9) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value for estradiol that is greater than 0.1 μM and less than or equal to 0.5 μM. HSD17B13-IN-93 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
                                    - HY-162217
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-91 (Compound 5) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value for estradiol that is greater than 0.1 μM and less than or equal to 0.5 μM. HSD17B13-IN-91 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
                                    - HY-163253S
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-56-D3 (Compound 169) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-56-D3 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
                                    - HY-151959
- 
                                        
                                            
                                                |  | FXR | Cardiovascular Disease
                                                    
                                                        Metabolic Disease
                                                    
                                                        Inflammation/Immunology |  
                                                | FXR agonist 4 (compound 10a) is an agonist of farnesoid X receptor (FXR) with an EC50 value of 1.05 μM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of non-alcoholic fatty liver disease (NAFLD) . |  
 
- 
                                        
                                        
                                              
                                    - HY-143862
- 
                                        
                                            
                                                |  | PPAR | Metabolic Disease |  
                                                | Pparδ agonist 7 is a potent agonist of Pparδ. The peroxisome proliferator-activated receptor (PPAR) is a member of the intranuclear receptor transcription factor superfamily that plays a key role in the regulation of metabolic homeostasis, inflammation, cell growth and differentiation in vivo. Pparδ agonist 7 has the potential for the research of non-alcoholic fatty liver disease (NAFLD) (extracted from patent WO2019105234A1, compound TM4) . |  
 
- 
                                        
                                        
                                              
                                    - HY-143863
- 
                                        
                                            
                                                |  | PPAR | Metabolic Disease |  
                                                | Pparδ agonist 8 is a potent agonist of Pparδ. The peroxisome proliferator-activated receptor (PPAR) is a member of the intranuclear receptor transcription factor superfamily that plays a key role in the regulation of metabolic homeostasis, inflammation, cell growth and differentiation in vivo. Pparδ agonist 8 has the potential for the research of non-alcoholic fatty liver disease (NAFLD) (extracted from patent WO2021169769A1, compound TM2) . |  
 
- 
                                        
                                        
                                              
                                    - HY-162220
- 
                                        
                                            
                                                |  | Estrogen Receptor/ERR
                                                    
                                                        17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-94 (Compound 12) is an effective inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for Estradiol (HY-B0141). HSD17B13-IN-94 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD, NASH, or drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
                                    - HY-P99614
- 
                                        
                                            
                                                | BFKB8488A;  RG-7992;  RO-7040551 | FGFR | Metabolic Disease |  
                                                | Fazpilodemab (BFKB8488A) is a humanized bispecific IgG1 antibody that selectively targets and activates fibroblast growth factor receptor 1c (FGFR1c) and Klothoβ. Fazpilodemab can be used for the research of type 2 diabetes mellitus (T2DM) or nonalcoholic fatty liver disease (NAFLD) . |  
 
- 
                                        
                                        
                                              
                                    - HY-146398
- 
                                        
                                            
                                                |  | AMPK | Metabolic Disease |  
                                                | AMPK activator 6 (Compound GC) reduces lipid content and activates the AMPK pathway in HepG2 and 3T3-L1 cells. AMPK activator 6 significantly suppresses the increase in triglyceride (TG) , total cholesterol (TC), low-density lipoprotein-C (LDL-C), and other biochemical indices in blood serum. AMPK activator 6 can be used for the research of non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome . |  
 
- 
                                        
                                        
                                              
                                    - HY-12756A
- 
                                        
                                            
                                                |  | Toll-like Receptor (TLR)
                                                    
                                                        Stearoyl-CoA Desaturase (SCD) | Metabolic Disease
                                                    
                                                        Inflammation/Immunology |  
                                                | E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD)   . |  
 
- 
                                        
                                        
                                              
                                    - HY-12756
- 
                                        
                                            
                                                |  | Toll-like Receptor (TLR)
                                                    
                                                        Stearoyl-CoA Desaturase (SCD) | Metabolic Disease
                                                    
                                                        Inflammation/Immunology |  
                                                | E6446 is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD)   . |  
 
- 
                                        
                                        
                                              
                                    - HY-161926
- 
                                        
                                            
                                                |  | PPAR | Metabolic Disease |  
                                                | YGT-31 is a modulator for PPARγ with an IC50 of 1.72 μM, and a Ki of 0.62 μM. YGT-31 reduces blood glucose levels and improves insulin resistance in db/db mice type 2 diabetes models, through inhibition of CDK5-mediated PPARγ-Ser273 phosphorylation. YGT-31 exhibits anti-hepatic steatosis effect in mice non-alcoholic fatty liver disease (NAFLD) model . |  
 
- 
                                        
                                        
                                              
                                    - HY-175235
- 
                                        
                                            
                                                |  | MEK | Metabolic Disease |  
                                                | MEK4 IN-3 (Compound 39) is a selective MEK4 inhibitor with IC50s of 78   and 2920 nM for MEK4 and RSK4, respectively. MEK4 IN-3 reduces toxicity in cells. MEK4 IN-3 can be used for liver failure, particularly nonalcoholic fatty liver disease (NAFLD) research . |  
 
- 
                                        
                                        
                                              
                                    - HY-12756AR
- 
                                        
                                            
                                                |  | Toll-like Receptor (TLR)
                                                    
                                                        Stearoyl-CoA Desaturase (SCD) | Metabolic Disease
                                                    
                                                        Inflammation/Immunology |  
                                                | E6446 (dihydrochloride) (Standard) is the analytical standard of E6446 (dihydrochloride). This product is intended for research and analytical applications. E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD)   . |  
 
- 
                                        
                                        
                                              
                                    - HY-141645
- 
                                        
                                            
                                                | WS070117 | AMPK
                                                    
                                                        TGF-β Receptor
                                                    
                                                        NF-κB
                                                    
                                                        JNK
                                                    
                                                        AP-1 | Cardiovascular Disease
                                                    
                                                        Metabolic Disease
                                                    
                                                        Inflammation/Immunology |  
                                                | IMM-H007 (WS070117) is an orally active and potent AMPK (AMP-activated protein kinase) activator and TGFβ1 (transforming growth factor β1) antagonist. IMM-H007 has protective effects in cardiovascular diseases via activation of AMPK. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 degradation. IMM-H007 resolves hepatic steatosis in HFD-fed hamsters by the regulation of lipid metabolism. IMM-H007 can be used for the research of nonalcoholic fatty liver disease (NAFLD) and inflammatory atherosclerosis   . |  
 
- 
                                        
                                        
                                              
                                    - HY-W592871
- 
                                        
                                            
                                                | 10-HDA;  Queen Bee Acid | mTOR
                                                    
                                                        Apoptosis
                                                    
                                                        ERK
                                                    
                                                        MDM-2/p53
                                                    
                                                        GSK-3
                                                    
                                                        AMPK
                                                    
                                                        Interleukin Related
                                                    
                                                        TNF Receptor
                                                    
                                                        Caspase
                                                    
                                                        NF-κB
                                                    
                                                        Bacterial
                                                    
                                                        Fungal | Cardiovascular Disease
                                                    
                                                        Neurological Disease
                                                    
                                                        Inflammation/Immunology
                                                    
                                                        Cancer |  
                                                | 10-Hydroxy-2-decenoic acid (10-HDA) is an orally active unsaturated medium-chain fatty acid with various physiological activities. 10-Hydroxy-2-decenoic acid induces ROS-mediated apoptosis in A549 cells. 10-Hydroxy-2-decenoic acid inhibits VEGF-induced angiogenesis in human venous endothelial cells. 10-Hydroxy-2-decenoic acid alleviates non-alcoholic fatty liver disease (NAFLD) by activating the AMPK-α signaling pathway. 10-Hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4. 10-Hydroxy-2-decenoic acid is an antibiotic against many bacteria and fungi, such as Neurospora sitophila, molds and Staphylococcus aureus. 10-Hydroxy-2-decenoic acid has longevity-promoting effects in C. elegans. 10-Hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence          . |  
 
- 
                                        
                                        
                                              
                                    - HY-16521
- 
                                        
                                            
                                                |  | Caspase | Inflammation/Immunology |  
                                                | VX-166, a pan caspase inhibitor, can be used for the research of Non- Alcoholic Fatty Liver Disease (NAFLD), nonalcoholic steatohepatitis (NASH), alcoholic steatohepatitis (ASH), and other diseases involving fibrosis, steatosis, or inflammation of the liver . |  
 
- 
                                        
                                        
                                              
                                    - HY-168468
- 
                                        
                                            
                                                |  | PPAR | Metabolic Disease |  
                                                | SKLB102 shows a high affinity with PPARγ. SKLB102 has potent ability to reduce fat deposition and protect liver against non-alcoholic fatty liver disease (NAFLD) through regulating adipocytokine expression and preventing insulin resistance . |  
 
- 
                                        
                                        
                                              
                                    - HY-176493
- 
                                        
                                    
- 
                                        
                                        
                                              
                                    - HY-163241
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-25 (43) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research . |  
 
- 
                                        
                                        
                                              
                                    - HY-168337
- 
                                        
                                            
                                                |  | JNK
                                                    
                                                        Pyruvate Kinase |  |  
                                                | SET-171 is a JNK (c-Jun N-terminal kinase) inhibitor that exhibits significant anticancer activity and lipid metabolism regulation by inhibiting liver pyruvate kinase (PKL) expression. In anticancer studies, SET-171 shows IC50 values of 8.82 μM and 2.97 μM against HepG2 and Huh7 cell lines, respectively, indicating high cytotoxicity. Additionally, in non-alcoholic fatty liver disease (NAFLD)-related studies, SET-171 significantly reduces triacylglycerol (TAG) levels and inhibits the expression of steatosis-related proteins. SET-171 holds promise for research on hepatocellular carcinoma (HCC) and NAFLD . |  
 
- 
                                        
                                        
                                              
                                    - HY-W592871R
- 
                                        
                                            
                                                |  | mTOR | Cardiovascular Disease
                                                    
                                                        Neurological Disease
                                                    
                                                        Inflammation/Immunology
                                                    
                                                        Cancer |  
                                                | 10-Hydroxy-2-decenoic acid (Standard) is an analytical standard for 10-Hydroxy-2-decenoic acid (HY-W592871). This product is intended for research and analytical applications.10-Hydroxy-2-decenoic acid (10-HDA) is an orally active unsaturated medium-chain fatty acid with various physiological activities. 10-Hydroxy-2-decenoic acid induces ROS-mediated apoptosis in A549 cells. 10-Hydroxy-2-decenoic acid inhibits VEGF-induced angiogenesis in human venous endothelial cells. 10-Hydroxy-2-decenoic acid alleviates non-alcoholic fatty liver disease (NAFLD) by activating the AMPK-α signaling pathway. 10-Hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4. 10-Hydroxy-2-decenoic acid is an antibiotic against many bacteria and fungi, such as Neurospora sitophila, molds and Staphylococcus aureus. 10-Hydroxy-2-decenoic acid has longevity-promoting effects in C. elegans. 10-Hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence          . |  
 
- 
                                        
                                        
                                              
                                    - HY-N0592A
- 
                                        
                                            
                                                |  | NF-κB
                                                    
                                                        AMPK | Infection
                                                    
                                                        Metabolic Disease
                                                    
                                                        Inflammation/Immunology
                                                    
                                                        Cancer |  
                                                | Demethyleneberberine chloride is a natural mitochondria-targeted antioxidant. Demethyleneberberine chloride alleviates mice colitis and inhibits the inflammatory responses by inhibiting NF-κB pathway and regulating the balance of Th cells. Demethyleneberberine chloride could serve as a AMPK activator for researching non-alcoholic fatty liver disease (NAFLD)   . |  
 
- 
                                        
                                        
                                              
                                    - HY-N0592
- 
                                        
                                            
                                                |  | NF-κB
                                                    
                                                        AMPK | Infection
                                                    
                                                        Metabolic Disease
                                                    
                                                        Inflammation/Immunology
                                                    
                                                        Cancer |  
                                                | Demethyleneberberine is a natural mitochondria-targeted antioxidant. Demethyleneberberine alleviates mice colitis and inhibits the inflammatory responses by inhibiting NF-κB pathway and regulating the balance of Th cells. Demethyleneberberine could serve as a AMPK activator for treating non-alcoholic fatty liver disease (NAFLD)   . |  
 
- 
                                        
                                        
                                              
                                    - HY-176873
- 
                                        
                                            
                                                |  | Amino acid Transporter | Metabolic Disease |  
                                                | SLC6A19-IN-2 (Example 4) is a potent SLC6A19 inhibitor with an IC50 of 14 nM. SLC6A19-IN-2 can be used for the study of metabolic diseases such as nonalcoholic steatohepatitis (NASH), nonalcoholic fatty liver disease (NAFLD) and phenylketonuria (PKU) . |  
 
- 
                                        
                                        
                                              
                                    - HY-W587771
- 
                                        
                                            
                                                | MECPTP | Drug Metabolite | Metabolic Disease |  
                                                | Mono-2-ethyl-5-carboxypentyl terephthalate (MECPTP) is a major metabolite of Di-2-ethylhexyl terephthalate (DEHTP). Mono-2-ethyl-5-carboxypentyl terephthalate is promising for research of metabolic liver diseases, such as nonalcoholic fatty liver disease (NAFLD) . |  
 
- 
                                        
                                        
                                              
                                    - HY-128696
- 
                                        
                                            
                                                | Amlodipine aspartate | Drug Metabolite
                                                    
                                                        Calcium Channel | Cardiovascular Disease |  
                                                | Amlodipine aspartic acid impurity (Amlodipine aspartate) is the impurity of Amlodipine aspartic acid. Amlodipine aspartic acid is a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine aspartic acid impurity can control blood pressure. Amlodipine aspartic acid impurity corrects gut dysbiosis and enhances taurine and hypotaurine metabolism. Amlodipine aspartic acid impurity can be studied in research for NAFLD and hypertension  . |  
 
- 
                                        
                                        
                                              
                                    - HY-153476A
- 
                                        
                                            
                                                |  | Insulin Receptor
                                                    
                                                        GLP Receptor | Metabolic Disease |  
                                                | GIP/GLP-1 dual receptor agonist-1 (Compound 4) (sodium) is a GIP/GLP-1 receptor agonist. GIP/GLP-1 dual receptor agonist-1 (sodium) can be used in the research of metabolic disorders and fatty liver diseases, including nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD). |  
 
- 
                                        
                                        
                                              
                                    - HY-N0914
- 
                                        
                                    
- 
                                        
                                        
                                              
                                    - HY-167643
- 
                                        
                                            
                                                |  | Drug Metabolite | Metabolic Disease
                                                    
                                                        Inflammation/Immunology |  
                                                | Hydroxy tipelukast (Compound MN-002), the metabolite of Compound MN-001, is an orally active phenoxyalkylcarboxylic acid. Hydroxy tipelukast inhibits liver steatosis, lobular inflammation, hepatic ballooning, and hepatic scarring, and reduces liver hydroxyproline levels. Hydroxy tipelukast is promising for research of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) . |  
 
- 
                                        
                                        
                                              
                                    - HY-19796
- 
                                        
                                            
                                                | Aramchol;  C20-FABAC | Stearoyl-CoA Desaturase (SCD) | Metabolic Disease |  
                                                | Icomidocholic acid (Aramchol) is a lipid molecule synthesized from cholic acid and arachidic acid. Icomidocholic acid is an orally active SCD1 inhibitor and cholesterol solubilizer with antifibrotic effects. Icomidocholic acid can reduce liver fat content, dissolve cholesterol crystals and prevent gallstone formation. Icomidocholic acid can be used in the study of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH)   . |  
 
- 
                                        
                                        
                                              
                                    - HY-162221
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-95 (1) is an inhibitor of 17 β-hydroxysteroid dehydrogenase (HSD17B13), and its IC50 value for estradiol is <0.1 μM. It can be used in the study of nonalcoholic fatty liver disease . |  
 
- 
                                        
                                        
                                              
                                    - HY-162222
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-96 (3) is an inhibitor of 17 β-hydroxysteroid dehydrogenase (HSD17B13), and its IC50 value for estradiol is <0.1 μM. It can be used in the study of nonalcoholic fatty liver disease . |  
 
- 
                                        
                                        
                                              
                                    - HY-N9914
- 
                                        
                                            
                                                |  | p38 MAPK
                                                    
                                                        NF-κB | Metabolic Disease |  
                                                | D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and MCP-1 expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease     . |  
 
- 
                                        
                                        
                                              
                                    - HY-N9921
- 
                                        
                                            
                                                |  | Pyroptosis
                                                    
                                                        NOD-like Receptor (NLR) | Inflammation/Immunology |  
                                                | Antcin A is a potent NLRP3 inhibitor that inhibits the assembly and activation of the NLRP3 inflammasome. Antcin A can inhibit Kupffer cell pyroptosis and has liver protective activity. Antcin A can be used to study inflammation, such as non-alcoholic fatty liver disease . |  
 
- 
                                        
                                        
                                              
                                    - HY-172169
- 
                                        
                                            
                                                |  | PPAR | Inflammation/Immunology |  
                                                | PPARγ-IN-5 (Compound A3) is the inhibitor for PPARγ. PPARγ-IN-5 inhibits lipid accumulation in hepatocytes without significant cytotoxicity in HepG2 cell (400 µM). PPARγ-IN-5 can be used in research of non-alcoholic fatty liver disease . |  
 
- 
                                        
                                        
                                              
                                    - HY-162224
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-98 (5) is an inhibitor of 17 β-hydroxysteroid dehydrogenase (HSD17B13), and its IC50 value for estradiol is <0.1 μM. It can be used in the study of nonalcoholic fatty liver disease . |  
 
- 
                                        
                                        
                                              
                                    - HY-148926
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-1 (compound 2) is a ppotent inhibitor of  hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of < 0.1 μM? estradiol? as substrates. HSD17B13-IN-1? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis) . |  
 
- 
                                        
                                        
                                              
                                    - HY-161226
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-42 (compound 10)? is a ppotent inhibitor of  hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of < 0.1 μM? estradiol? as substrates. HSD17B13-IN-42? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis) . |  
 
- 
                                        
                                        
                                              
                                    - HY-163247
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-35 (compound 76) is a ppotent inhibitor of  hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of < 0.1 μM? estradiol? as substrates. HSD17B13-IN-35? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis) . |  
 
- 
                                        
                                        
                                              
                                    - HY-163242
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-28 (compound? 47) is a ppotent inhibitor of  hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of < 0.1 μM? estradiol? as substrates. HSD17B13-IN-28? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis) . |  
 
- 
                                        
                                        
                                              
                                    - HY-161225
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-40 (compound 6) is a ppotent inhibitor of  hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of < 0.1 μM? estradiol? as substrates. HSD17B13-IN-40? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis) . |  
 
- 
                                        
                                        
                                              
                                    - HY-163244
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-30 (compound 64) is a ppotent inhibitor of  hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of < 0.1 μM? estradiol? as substrates. HSD17B13-IN-30? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis) . |  
 
- 
                                        
                                        
                                              
                                    - HY-157663
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-36 (compound 116) is a ppotent inhibitor of  hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of < 0.1 μM? estradiol? as substrates. HSD17B13-IN-36? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis) . |  
 
- 
                                        
                                        
                                              
                                    - HY-162223
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-97 (compound 4) is a potent hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) inhibitor with an IC50 value of ≤0.1 µM. HSD17B13-IN-97 has the potential for the research of Nonalcoholic fatty liver diseases (NAFLDs), nonalcoholic steatohepatitis (NASH) or or drug induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
                                    - HY-N1399
- 
                                        
                                            
                                                |  | AMPK
                                                    
                                                        PI3K
                                                    
                                                        Autophagy | Metabolic Disease
                                                    
                                                        Inflammation/Immunology |  
                                                | Androsin is an active compound isolated from Picrorhiza Kurroa Royle ex Benth. Androsin activates AMPKα/PI3K/Beclin1/LC3 signaling pathway, inhibits SREBP1c/FASN signaling pathway. Androsin can be used in research of asthma and non-alcoholic fatty liver disease (NAFLD). Androsin is orally active  . |  
 
- 
                                        
                                        
                                              
                                    - HY-157708
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-67 (Compound 677) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of < 0.1 μM for estradiol. HSD17B13-IN-67 can be used for research on liver diseases or metabolic disorders . |  
 
- 
                                        
                                        
                                              
                                    - HY-157722
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-73 (Compound 85) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of < 0.1 μM for estradiol. HSD17B13-IN-73 can be used for research on liver diseases or metabolic disorders . |  
 
- 
                                        
                                        
                                              
                                    - HY-157717
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-70 (Compound 39) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of < 0.1 μM for estradiol. HSD17B13-IN-70 can be used for research on liver diseases or metabolic disorders . |  
 
- 
                                        
                                        
                                              
                                    - HY-157615
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-6(Compound 475) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of 0.01 μM. HSD17B13-IN-6can be used in the research of liver diseases . |  
 
- 
                                        
                                        
                                              
                                    - HY-117110
- 
                                        
                                            
                                                | H-Arg-Pro-OH | Proton Pump | Metabolic Disease |  
                                                | Arginylproline (H-Arg-Pro-OH) is a dipeptide consisted of arginine and proline. Arginylproline reduces intracellular triglyceride (TG) levels stimulated by Oleic acid (HY-N1446), through the peptide transporter 1 (PepT1) pathway . |  
 
- 
                                        
                                        
                                              
                                    - HY-157724
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-76 (Compound 773) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of < 0.1 μM for estradiol. HSD17B13-IN-76 can be used for research on liver diseases or metabolic disorders . |  
 
- 
                                        
                                        
                                              
                                    - HY-157723
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-74 (Compound 760) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of < 0.1 μM for estradiol. HSD17B13-IN-74 can be used for research on liver diseases or metabolic disorders . |  
 
- 
                                        
                                        
                                              
                                    - HY-157674
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-46 (Compound 351) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of < 0.1 μM for estradiol. HSD17B13-IN-46 can be used for research on liver diseases or metabolic disorders . |  
 
- 
                                        
                                        
                                              
                                    - HY-157667
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-44 (Compound 23) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of < 0.1 μM for estradiol. HSD17B13-IN-44 can be used for research on liver diseases or metabolic disorders . |  
 
- 
                                        
                                        
                                              
                                    - HY-157671
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-45 (Compound 195) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of < 0.1 μM for estradiol. HSD17B13-IN-45 can be used for research on liver diseases or metabolic disorders . |  
 
- 
                                        
                                        
                                              
                                    - HY-157676
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-47 (Compound 500) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of < 0.1 μM for estradiol. HSD17B13-IN-47 can be used for research on liver diseases or metabolic disorders . |  
 
- 
                                        
                                        
                                              
                                    - HY-157630
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-10 (Compound 464) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of 0.01 μM. HSD17B13-IN-10 can be used in the research of liver diseases . |  
 
- 
                                        
                                        
                                              
                                    - HY-157720
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-72 (Compound 62) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of < 0.1 μM for estradiol. HSD17B13-IN-72 can be used for research on liver diseases or metabolic disorders . |  
 
- 
                                        
                                        
                                              
                                    - HY-157726
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-77 (Compound 808) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of < 0.1 μM for estradiol. HSD17B13-IN-77 can be used for research on liver diseases or metabolic disorders . |  
 
- 
                                        
                                        
                                              
                                    - HY-157710
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-68 (Compound 16) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of < 0.1 μM for estradiol. HSD17B13-IN-68 can be used for research on liver diseases or metabolic disorders . |  
 
- 
                                        
                                        
                                              
                                    - HY-133707R
- 
                                        
                                    
- 
                                        
                                        
                                              
                                    - HY-161218
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-17 (compound 9) is a ppotent inhibitor of  hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of < 0.1 μM and? < 1 μM estradiol and Leukotriene B3 as substrates, respectively. HSD17B13-IN-17? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis) . |  
 
- 
                                        
                                        
                                              
                                    - HY-161223
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-27 (compound 30) is a ppotent inhibitor of  hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of < 0.1 μM and ?< 1 μM estradiol and Leukotriene B3 as substrates, respectively. HSD17B13-IN-27? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis) . |  
 
- 
                                        
                                        
                                              
                                    - HY-161220
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-19 (compound 16) is a ppotent inhibitor of  hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of < 0.1 μM and? < 1 μM estradiol and Leukotriene B3 as substrates, respectively. HSD17B13-IN-19? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis) . |  
 
- 
                                        
                                        
                                              
                                    - HY-161224
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-31 (compound 32) is a ppotent inhibitor of  hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of < 0.1 μM and? < 1 μM estradiol and Leukotriene B3 as substrates, respectively. HSD17B13-IN-31? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis) . |  
 
- 
                                        
                                        
                                              
                                    - HY-161217
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-16 (compound 8) is a ppotent inhibitor of  hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of < 0.1 μM and? < 1 μM estradiol and Leukotriene B3 as substrates, respectively. HSD17B13-IN-16? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis) . |  
 
- 
                                        
                                        
                                              
                                    - HY-N0914R
- 
                                        
                                    
- 
                                        
                                        
                                              
                                    - HY-N0401A
- 
                                        
                                            
                                                |  | Bacterial
                                                    
                                                        Estrogen Receptor/ERR
                                                    
                                                        FATP | Infection
                                                    
                                                        Metabolic Disease |  
                                                | (Z)-Ligustilide is extracted from  Ligusticum chuanxiong Hort, has antimicrobial and antifungal activity, exhibits an average antifungal score of 5.6 . (Z)-Ligustilide is orally active, it inhibits the expression of FATP5 and DGAT, inhibits fatty acid uptake and esterification in mice and has potential as therapeutics for nonalcoholic fatty liver disease (NAFLD)  . (Z)-Ligustilide is also able to reactivate ERα, has epigenetic regulation, and is used in the study of tamoxifen-resistant breast cancer . |  
 
- 
                                        
                                        
                                              
                                    - HY-161221
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-21 (compound 17) is a ppotent inhibitor of  hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of < 0.1 μM and? < 1 μM estradiol and Leukotriene B3 as substrates, respectively. HSD17B13-IN-21? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis) . |  
 
- 
                                        
                                        
                                              
                                    - HY-161222
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-23 (compound 18) is a ppotent inhibitor of  hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of < 0.1 μM and? < 1 μM estradiol and Leukotriene B3 as substrates, respectively. HSD17B13-IN-23? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis) . |  
 
- 
                                        
                                        
                                              
                                    - HY-128696R
- 
                                        
                                            
                                                | Amlodipine aspartate (Standard) | Drug Metabolite
                                                    
                                                        Reference Standards
                                                    
                                                        Calcium Channel | Cardiovascular Disease |  
                                                | Amlodipine aspartic acid impurity (Amlodipine aspartate) (Standard) is the analytical standard of amlodipine aspartic acid impurity. This product is intended for research and analytical applications. Amlodipine aspartic acid impurity is the impurity of Amlodipine aspartic acid. Amlodipine aspartic acid is a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine aspartic acid impurity can control blood pressure. Amlodipine aspartic acid impurity corrects gut dysbiosis and enhances taurine and hypotaurine metabolism. Amlodipine aspartic acid impurity can be studied in research for NAFLD and hypertension  . |  
 
- 
                                        
                                        
                                              
                                    - HY-161219
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-18 (compound 13) is a ppotent inhibitor of  hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of < 0.1 μM and? < 1 μM estradiol and Leukotriene B3 as substrates, respectively. HSD17B13-IN-18? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis) . |  
 
- 
                                        
                                        
                                              
                                    - HY-135366
- 
                                        
                                            
                                                |  | IKK | Inflammation/Immunology |  
                                                | HPN-01 is a potent and selective IKK inhibitor, with pIC50 values of 6.4, 7.0 and <4.8 for IKK-α, IKK-β and IKK-ε, respectively. HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, and VEGFR-2 . |  
 
- 
                                        
                                        
                                              
                                    - HY-161337
- 
                                        
                                            
                                                |  | Pyruvate Kinase | Metabolic Disease |  
                                                | PKL-IN-1 is a potent inhibitor of pyruvate kinase (PKL) with an IC50 of 0.07 μM. PKL-IN-1 can be used in the study of non-alcoholic fatty liver disease . |  
 
- 
                                        
                                        
                                              
                                    - HY-N2181
- 
                                        
                                            
                                                |  | Cytochrome P450
                                                    
                                                        Apoptosis
                                                    
                                                        Bacterial
                                                    
                                                        Autophagy | Infection
                                                    
                                                        Neurological Disease
                                                    
                                                        Metabolic Disease
                                                    
                                                        Inflammation/Immunology
                                                    
                                                        Cancer |  
                                                | Acetylshikonin is an oral active anti-cancer, anti-inflammatory, antioxidant, anti-fertility, antibacterial, and neuroprotective agent. Acetylshikonin is a inhibitor of acetylcholinase (AChE) (IC50=34.6 μM) and nonselective cytochrome P450. Acetylshikonin can induce Apoptosis and Autophagy in cancer cells. Acetylshikonin regulates blood glucose, liver fat metabolism, and renal fibrosis, and is used in the study of diabetes, diabetic nephropathy (DN), obesity, and nonalcoholic fatty liver disease (NAFLD)         . |  
 
- 
                                        
                                        
                                              
                                    - HY-N1399R
- 
                                        
                                            
                                                |  | Reference Standards
                                                    
                                                        AMPK
                                                    
                                                        PI3K
                                                    
                                                        Autophagy | Metabolic Disease
                                                    
                                                        Inflammation/Immunology |  
                                                | Androsin (Standard) is the analytical standard of Androsin. This product is intended for research and analytical applications. Androsin is an active compound isolated from Picrorhiza Kurroa Royle ex Benth. Androsin activates AMPKα/PI3K/Beclin1/LC3 signaling pathway, inhibits SREBP1c/FASN signaling pathway. Androsin can be used in research of asthma and non-alcoholic fatty liver disease (NAFLD). Androsin is orally active  . |  
 
- 
                                        
                                        
                                              
                                    - HY-174253
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-105 (Compound EX.87) is a selective 17β-hydroxysteroid dehydrogenase 13 (17BHSD13) inhibitor with an IC50 value of 0.036 μM, showing high selectivity over 17BHSD4 (with an IC50 value of 31.5 μM). HSD17B13-IN-105 is promising for research of liver diseases such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH)  . |  
 
- 
                                        
                                        
                                              
                                    - HY-B0679
- 
                                        
                                            
                                                | RU-0211;  SPI-0211 | Chloride Channel
                                                    
                                                        CFTR
                                                    
                                                        Glutathione Peroxidase
                                                    
                                                        NO Synthase
                                                    
                                                        TNF Receptor | Metabolic Disease |  
                                                | Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research   . |  
 
- 
                                        
                                        
                                              
                                    - HY-120657R
- 
                                        
                                    
- 
                                        
                                        
                                              
                                    - HY-135772
- 
                                        
                                            
                                                | 12-Ketolithocholic acid | Endogenous Metabolite | Metabolic Disease |  
                                                | 12-Ketodeoxycholic acid (12-Ketolithocholic acid) is a bile acid, metabolite from kidney. 12-Ketodeoxycholic acid can be a detectable marker for evidence of kidney injury |  
 
- 
                                        
                                        
                                              
                                    - HY-P5762A
- 
                                        
                                            
                                                | PNX-14 TFA | GnRH Receptor | Cardiovascular Disease
                                                    
                                                        Neurological Disease
                                                    
                                                        Metabolic Disease
                                                    
                                                        Inflammation/Immunology |  
                                                | Phoenixin-14 (PNX-14) TFA, a neuropeptide, has anxiolytic, cardioprotective and neuroprotective effect. Phoenixin-14 TFA can regulate pituitary gonadotrophin secretion by upregulating the GnRH receptor mRNA. Phoenixin-14 TFA stimulates insulin secretion. Phoenixin-14 TFA also protects mice from ischemia/reperfusion (IR) injury. PNX-14 TFA prevents oxidative stress by reducing ROS and increasing GSH   . |  
 
- 
                                        
                                        
                                              
                                    - HY-120657
- 
                                        
                                            
                                                |  | Endogenous Metabolite | Cardiovascular Disease
                                                    
                                                        Inflammation/Immunology |  
                                                | 9-PAHSA is an orally available anti-inflammatory lipid that lowers blood sugar and reduces inflammation. 9-PAHSA also improved carotid vascular calcification and attenuates cardiac hypertrophy and dysfunction in db/db mice. 9-PAHSA increases the viability of steatosis primary mouse hepatocytes (PMH). 9-PAHSA can be used in research on diabetes, inflammation, and cardiovascular disease  . |  
 
- 
                                        
                                        
                                              
                                    - HY-135772R
- 
                                        
                                            
                                                | 12-Ketolithocholic acid (Standard) | Reference Standards
                                                    
                                                        Endogenous Metabolite | Metabolic Disease |  
                                                | 12-Ketodeoxycholic acid (Standard) is the analytical standard of 12-Ketodeoxycholic acid. This product is intended for research and analytical applications. 12-Ketodeoxycholic acid (12-Ketolithocholic acid) is a bile acid, metabolite from kidney. 12-Ketodeoxycholic acid can be a detectable marker for evidence of kidney injury[1] |  
 
- 
                                        
                                        
                                              
                                    - HY-163263S1
- 
                                        
                                            
                                                |  | 17β-HSD | Metabolic Disease |  
                                                | HSD17B13-IN-80-d2 (Compound 200) is the the deuterium labeled HSD17B13-IN-80 (HY-163263). HSD17B13-IN-80 is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-80 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
                                    - HY-155539
- 
                                        
                                            
                                                |  | IKZF Family
                                                    
                                                        Zinc Finger Protein | Inflammation/Immunology |  
                                                | Cisd2 agonist 2 (compound 6) is a Cisd2 activator (EC50=191 nM), and Cisd2 levels are associated with non-alcoholic fatty liver disease (NAFLD). Cisd2 agonist 2 has no significant in vivo toxicity in Cisd2hKO-het mice (heterozygous hepatocyte-specific Cisd2 knockout). Cisd2 (CDGSH iron sulfur domain 2) is a zinc finger protein that is mainly localized in the endoplasmic reticulum or mitochondrial membrane. Cisd2 participates in mitochondrial function by forming homodimers containing two redox-active 2Fe-2S clusters  . |  
 
- 
                                        
                                        
                                              
                                    - HY-103211
- 
                                        
                                            
                                                | 
                                                        
                                                            L748337
                                                            
                                                        
                                                        
                                                            
                                                                
                                                                
                                                                
                                                                    1 Publications Verification | Adrenergic Receptor | Cardiovascular Disease
                                                    
                                                        Metabolic Disease
                                                    
                                                        Cancer |  
                                                | L748337 is a potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors. The Ki values of L748337 for β3-, β2- and β1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively . L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6 . L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases   . |  
 
- 
                                        
                                        
                                              
                                    - HY-W587772
- 
                                        
                                            
                                                | MEHHTP | Drug Metabolite | Metabolic Disease |  
                                                | Mono (2-ethyl-5-hydroxyhexyl) terephthalate (MEHHTP), a hydroxyl metabolite of the phthalate alternative Di-2-ethylhexyl terephthalate (DEHTP), is a liver X receptor α (LXRα) agonist with a binding energy of -7.41 kcal/mol. Mono (2-ethyl-5-hydroxyhexyl) terephthalate upregulates LXRα downstream targets such as SREBP-1c and FASN and increases lipogenic enzyme activity in hepatocytes, and elevating triglyceride (TG) levels. Mono (2-ethyl-5-hydroxyhexyl) terephthalate is promising for research of  nonalcoholic fatty liver disease (NAFLD) . |  
 
- 
                                        
                                        
                                              
                                    - HY-114360
- 
                                        
                                            
                                                |  | Endogenous Metabolite
                                                    
                                                        COX
                                                    
                                                        Interleukin Related
                                                    
                                                        Glutathione Peroxidase
                                                    
                                                        TNF Receptor | Metabolic Disease
                                                    
                                                        Inflammation/Immunology |  
                                                | Taurohyodeoxycholic acid is an orally active 6 alpha-hydroxylated bile acid. Taurohyodeoxycholic acid decreases colonic MPO activity, TNF-α, lL-6 serum levels and the expression of COX-2. Taurohyodeoxycholic acid alleviates trinitrobenzene sulfonic acid induced ulcerative colitis via regulating Th1/Th2 and Th17/Treg cells balance. Taurohyodeoxycholic acid ameliorates high-fat diet-induced nonalcoholic fatty liver disease in mice. Taurohyodeoxycholic acid prevents Taurochenodeoxycholic acid (HY-N2027)-induced hepatotoxicity in bile fistula rats. Taurohyodeoxycholic acid can be used for the study of nonalcoholic fatty liver disease (NAFLD), colitis and biliary fistula    . |  
 
- 
                                        
                                        
                                              
                                    - HY-155156
- 
                                        
                                            
                                                |  | Endogenous Metabolite | Cardiovascular Disease |  
                                                | PF-07238025 is a BCKDC kinase (BDK) inhibitor (EC50=19 nM). PF-07238025 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chain amino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07238025 improved cardiometabolic endpoints and improves glucose tolerance in mice . |  
 
- 
                                        
                                        
                                              
                                    - HY-155157
- 
                                        
                                            
                                                |  | Endogenous Metabolite | Cardiovascular Disease |  
                                                | PF-07247685 is a BCKDC kinase (BDK) inhibitor (EC50=2.2 nM). PF-07247685 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chain amino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07247685 improved cardiometabolic endpoints and improves glucose tolerance in mice . |  
 
- 
                                        
                                        
                                              
                                    - HY-130437
- 
                                        
                                            
                                                |  | MDM-2/p53
                                                    
                                                        TGF-β Receptor
                                                    
                                                        Caspase | Infection
                                                    
                                                        Metabolic Disease |  
                                                | p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet [4].
non-alcoholic fatty liver disease   . |  
 
- 
                                        
                                        
                                              
                                    - HY-100443
- 
                                        
                                            
                                                | PX-102 | FXR | Cancer |  
                                                | PX20606 is an orally active agonist for farnesoid X receptor (FXR), with EC50 220 nM (mFXR) and 50 nM (hFXR), measured by Gal4-FXR assay. PX20606 induces the expression of tumor suppressor gene NDRG2, inhibits the tumor growth and metastasis in mouse HCC model. PX20606 exhibits hepatoprotective efficacy . |  
 
- 
                                        
                                        
                                              
                                    - HY-108022A
- 
                                        
                                            
                                                | MSDC-0602K | Insulin Receptor
                                                    
                                                        PPAR | Metabolic Disease |  
                                                | Azemiglitazone potassium (MSDC-0602K), a PPARγ-sparing thiazolidinedione (Ps-TZD), binds to PPARγ with the IC50 of 18.25 μM . Azemiglitazone potassium modulates the mitochondrial pyruvate carrier (MPC). Azemiglitazone potassium can be used for the research of fatty liver including dysfunctional lipid metabolism, inflammation, and insulin resistance . Azemiglitazone potassium, an insulin sensitizer, improves insulinemia and fatty liver disease in mice, alone and in combination with Liraglutide . |  
 
- 
                                        
                                        
                                              
                                    - HY-134988
- 
                                        
                                            
                                                |  | FXR
                                                    
                                                        Phosphatase
                                                    
                                                        Cytochrome P450 | Inflammation/Immunology |  
                                                | EDP-305 is an orally active, potent and selective farnesoid X receptor (FXR) agonist, with EC50 values of 34 nM (chimeric FXR in CHO cells) and 8 nM (full-length FXR in HEK cells). EDP-305 shows a potent and consistent antifibrotic effect. EDP-305 can be used for primary biliary cholangitis (PBC) and non-alcoholic steatohepatitis (NASH) research  . |  
 
- 
                                        
                                        
                                              
 
            
            
            
                
                    
                    
                        
                            
                            - 
                                
                                    - 
                                        HY-L199
                                    
- 
                                        
                                            
                                                |  | 4,042 compounds |  
                                                | Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide and is the primary liver manifestation of metabolic syndrome. The growth of NAFLD has coincided with the obesity epidemic. NAFLD is composed of excess lipid accumulation in the liver, causing steatotoxicity, and shows a wide range of histopathological abnormalities. NAFLD may progress from simple steatosis to Non-alcoholic steatohepatitis (NASH) with or without fibrosis (NASH), and eventually to cirrhosis and hepatocellular carcinoma. To date, very few drugs have been approved for marketing specifically for the treatment of NAFLD, so increased efforts to develop NAFLD drugs are necessary.  MCE designs a unique collection of 4,042 small molecules with definite or potential anti-NAFLD activity, which is an important tool for studying the pathological mechanism of NAFLD and developing drugs for NAFLD.  |  
 
 
 
            
            
            
            
            
                
                    
                        
                            | Cat. No. | Product Name | Type | 
                    
                    
                        
                            
                            - 
                                
                                    - HY-N9914
- 
                                        
                                            
                                                |  | Biochemical Assay Reagents |  
                                                | D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and MCP-1 expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease     . |  
 
 
 
            
            
            
                
                    
                        
                            | Cat. No. | Product Name | Target | Research Area | 
                    
                    
                        
                            
                            - 
                                
                                    - HY-128696
- 
                                        
                                            
                                                | Amlodipine aspartate | Drug Metabolite
                                                        
                                                    
                                                        
                                                        
                                                            Calcium Channel | Cardiovascular Disease |  
                                                | Amlodipine aspartic acid impurity (Amlodipine aspartate) is the impurity of Amlodipine aspartic acid. Amlodipine aspartic acid is a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine aspartic acid impurity can control blood pressure. Amlodipine aspartic acid impurity corrects gut dysbiosis and enhances taurine and hypotaurine metabolism. Amlodipine aspartic acid impurity can be studied in research for NAFLD and hypertension  . |  
 
 
- 
                                
                                    - HY-153476A
- 
                                        
                                            
                                                |  | Insulin Receptor
                                                        
                                                    
                                                        
                                                        
                                                            GLP Receptor | Metabolic Disease |  
                                                | GIP/GLP-1 dual receptor agonist-1 (Compound 4) (sodium) is a GIP/GLP-1 receptor agonist. GIP/GLP-1 dual receptor agonist-1 (sodium) can be used in the research of metabolic disorders and fatty liver diseases, including nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD). |  
 
 
- 
                                
                                    - HY-153476
- 
                                        
                                            
                                                |  | GCGR | Metabolic Disease |  
                                                | GIP/GLP-1 dual receptor agonist-1 (compound 4) is a GIP/GLP-1 receptor agonist. GIP/GLP-1 dual receptor agonist-1 can be used in the research of metabolic disorders and fatty liver diseases, including nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD) . |  
 
 
- 
                                
                                    - HY-117110
- 
                                        
                                            
                                                | H-Arg-Pro-OH | Proton Pump | Metabolic Disease |  
                                                | Arginylproline (H-Arg-Pro-OH) is a dipeptide consisted of arginine and proline. Arginylproline reduces intracellular triglyceride (TG) levels stimulated by Oleic acid (HY-N1446), through the peptide transporter 1 (PepT1) pathway . |  
 
 
- 
                                
                                    - HY-128696R
- 
                                        
                                            
                                                | Amlodipine aspartate (Standard) | Drug Metabolite
                                                        
                                                    
                                                        
                                                        
                                                            Reference Standards
                                                        
                                                    
                                                        
                                                        
                                                            Calcium Channel | Cardiovascular Disease |  
                                                | Amlodipine aspartic acid impurity (Amlodipine aspartate) (Standard) is the analytical standard of amlodipine aspartic acid impurity. This product is intended for research and analytical applications. Amlodipine aspartic acid impurity is the impurity of Amlodipine aspartic acid. Amlodipine aspartic acid is a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine aspartic acid impurity can control blood pressure. Amlodipine aspartic acid impurity corrects gut dysbiosis and enhances taurine and hypotaurine metabolism. Amlodipine aspartic acid impurity can be studied in research for NAFLD and hypertension  . |  
 
 
- 
                                
                                    - HY-P5762A
- 
                                        
                                            
                                                | PNX-14 TFA | GnRH Receptor | Cardiovascular Disease
                                                    
                                                        Neurological Disease
                                                    
                                                        Metabolic Disease
                                                    
                                                        Inflammation/Immunology |  
                                                | Phoenixin-14 (PNX-14) TFA, a neuropeptide, has anxiolytic, cardioprotective and neuroprotective effect. Phoenixin-14 TFA can regulate pituitary gonadotrophin secretion by upregulating the GnRH receptor mRNA. Phoenixin-14 TFA stimulates insulin secretion. Phoenixin-14 TFA also protects mice from ischemia/reperfusion (IR) injury. PNX-14 TFA prevents oxidative stress by reducing ROS and increasing GSH   . |  
 
 
 
            
            
            
            
            
                
                    
                        
                            | Cat. No. | Product Name | Target | Research Area | 
                    
                    
                        
                            
                            - 
                                
                                    - HY-P99614
- 
                                        
                                            
                                                | BFKB8488A;  RG-7992;  RO-7040551 | FGFR | Metabolic Disease |  
                                                | Fazpilodemab (BFKB8488A) is a humanized bispecific IgG1 antibody that selectively targets and activates fibroblast growth factor receptor 1c (FGFR1c) and Klothoβ. Fazpilodemab can be used for the research of type 2 diabetes mellitus (T2DM) or nonalcoholic fatty liver disease (NAFLD) . |  
 
 
 
            
            
            
                
                    
                        
                            | Cat. No. | Product Name | Category | Target | Chemical Structure | 
                    
                    
                        
                            
                            - 
                                
                                    - HY-137996
- 
                                        
                                    
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-W018392
- 
                                        
                                    
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-133707
- 
                                        
                                    
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-N0723
- 
                                        
                                    
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-W592871
- 
                                        
                                            
                                                | 10-HDA;  Queen Bee Acid | Animals
                                                            
                                                        
                                                            
                                                            
                                                                Ketones, Aldehydes, Acids
                                                            
                                                        
                                                            
                                                            
                                                                Source classification 
                                                        
                                                     | mTOR
                                                    
                                                        Apoptosis
                                                    
                                                        ERK
                                                    
                                                        MDM-2/p53
                                                    
                                                        GSK-3
                                                    
                                                        AMPK
                                                    
                                                        Interleukin Related
                                                    
                                                        TNF Receptor
                                                    
                                                        Caspase
                                                    
                                                        NF-κB
                                                    
                                                        Bacterial
                                                    
                                                        Fungal |  
                                                | 10-Hydroxy-2-decenoic acid (10-HDA) is an orally active unsaturated medium-chain fatty acid with various physiological activities. 10-Hydroxy-2-decenoic acid induces ROS-mediated apoptosis in A549 cells. 10-Hydroxy-2-decenoic acid inhibits VEGF-induced angiogenesis in human venous endothelial cells. 10-Hydroxy-2-decenoic acid alleviates non-alcoholic fatty liver disease (NAFLD) by activating the AMPK-α signaling pathway. 10-Hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4. 10-Hydroxy-2-decenoic acid is an antibiotic against many bacteria and fungi, such as Neurospora sitophila, molds and Staphylococcus aureus. 10-Hydroxy-2-decenoic acid has longevity-promoting effects in C. elegans. 10-Hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence          . |  
 
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-N0592A
- 
                                        
                                    
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-W018392R
- 
                                        
                                            
                                                | MEHP (Standard); Phthalic acid mono-2-ethylhexyl ester (Standard) | Ketones, Aldehydes, Acids
                                                            
                                                        
                                                            
                                                            
                                                                Source classification
                                                            
                                                        
                                                            
                                                            
                                                                Endogenous metabolite 
                                                        
                                                     | Reference Standards
                                                    
                                                        Endogenous Metabolite |  
                                                | Mono-(2-ethylhexyl) phthalate (Standard) is the analytical standard of Mono-(2-ethylhexyl) phthalate. This product is intended for research and analytical applications. Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD) . |  
 
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-N0723R
- 
                                        
                                    
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-W592871R
- 
                                        
                                            
                                                |  | Animals
                                                            
                                                        
                                                            
                                                            
                                                                Ketones, Aldehydes, Acids
                                                            
                                                        
                                                            
                                                            
                                                                Source classification 
                                                        
                                                     | mTOR |  
                                                | 10-Hydroxy-2-decenoic acid (Standard) is an analytical standard for 10-Hydroxy-2-decenoic acid (HY-W592871). This product is intended for research and analytical applications.10-Hydroxy-2-decenoic acid (10-HDA) is an orally active unsaturated medium-chain fatty acid with various physiological activities. 10-Hydroxy-2-decenoic acid induces ROS-mediated apoptosis in A549 cells. 10-Hydroxy-2-decenoic acid inhibits VEGF-induced angiogenesis in human venous endothelial cells. 10-Hydroxy-2-decenoic acid alleviates non-alcoholic fatty liver disease (NAFLD) by activating the AMPK-α signaling pathway. 10-Hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4. 10-Hydroxy-2-decenoic acid is an antibiotic against many bacteria and fungi, such as Neurospora sitophila, molds and Staphylococcus aureus. 10-Hydroxy-2-decenoic acid has longevity-promoting effects in C. elegans. 10-Hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence          . |  
 
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-N0592
- 
                                        
                                    
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-N0914
- 
                                        
                                    
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-N9914
- 
                                        
                                    
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-N9921
- 
                                        
                                    
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-N1399
- 
                                        
                                    
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-133707R
- 
                                        
                                    
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-N0914R
- 
                                        
                                    
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-N0401A
- 
                                        
                                    
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-N2181
- 
                                        
                                            
                                                |  | Quinones
                                                            
                                                        
                                                            
                                                            
                                                                Classification of Application Fields
                                                            
                                                        
                                                            
                                                            
                                                                Source classification
                                                            
                                                        
                                                            
                                                            
                                                                Phenols
                                                            
                                                        
                                                            
                                                            
                                                                Polyphenols
                                                            
                                                        
                                                            
                                                            
                                                                Plants
                                                            
                                                        
                                                            
                                                            
                                                                Lithospermum erythrorhizon Sieb. et Zucc.
                                                            
                                                        
                                                            
                                                            
                                                                Naphthalene Quinones
                                                            
                                                        
                                                            
                                                            
                                                                Boraginaceae
                                                            
                                                        
                                                            
                                                            
                                                                Inflammation/Immunology
                                                            
                                                        
                                                            
                                                            
                                                                Disease Research Fields 
                                                        
                                                     | Cytochrome P450
                                                    
                                                        Apoptosis
                                                    
                                                        Bacterial
                                                    
                                                        Autophagy |  
                                                | Acetylshikonin is an oral active anti-cancer, anti-inflammatory, antioxidant, anti-fertility, antibacterial, and neuroprotective agent. Acetylshikonin is a inhibitor of acetylcholinase (AChE) (IC50=34.6 μM) and nonselective cytochrome P450. Acetylshikonin can induce Apoptosis and Autophagy in cancer cells. Acetylshikonin regulates blood glucose, liver fat metabolism, and renal fibrosis, and is used in the study of diabetes, diabetic nephropathy (DN), obesity, and nonalcoholic fatty liver disease (NAFLD)         . |  
 
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-N1399R
- 
                                        
                                    
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-120657R
- 
                                        
                                    
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-135772
- 
                                        
                                    
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-120657
- 
                                        
                                    
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-135772R
- 
                                        
                                    
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-114360
- 
                                        
                                    
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-155156
- 
                                        
                                            
                                                |  | Cardiovascular Disease
                                                            
                                                        
                                                            
                                                            
                                                                Classification of Application Fields
                                                            
                                                        
                                                            
                                                            
                                                                Ketones, Aldehydes, Acids
                                                            
                                                        
                                                            
                                                            
                                                                Source classification
                                                            
                                                        
                                                            
                                                            
                                                                Endogenous metabolite
                                                            
                                                        
                                                            
                                                            
                                                                Disease Research Fields 
                                                        
                                                     | Endogenous Metabolite |  
                                                | PF-07238025 is a BCKDC kinase (BDK) inhibitor (EC50=19 nM). PF-07238025 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chain amino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07238025 improved cardiometabolic endpoints and improves glucose tolerance in mice . |  
 
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-155157
- 
                                        
                                            
                                                |  | Cardiovascular Disease
                                                            
                                                        
                                                            
                                                                Natural Products
                                                            
                                                            
                                                        
                                                            
                                                            
                                                                Classification of Application Fields
                                                            
                                                        
                                                            
                                                            
                                                                Source classification
                                                            
                                                        
                                                            
                                                            
                                                                Endogenous metabolite
                                                            
                                                        
                                                            
                                                            
                                                                Disease Research Fields 
                                                        
                                                     | Endogenous Metabolite |  
                                                | PF-07247685 is a BCKDC kinase (BDK) inhibitor (EC50=2.2 nM). PF-07247685 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chain amino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07247685 improved cardiometabolic endpoints and improves glucose tolerance in mice . |  
 
- 
                                        
                                        
                                              
 
 
            
            
            
            
            
                
                    
                        
                            | Cat. No. | Product Name | Chemical Structure | 
                    
                    
                        
                            
                            - 
                                
                                    - HY-W018392S
- 
                                        
                                            
                                                |  |  
                                                | Mono-(2-ethylhexyl) phthalate-d4 is a deuterium labeled Mono-(2-ethylhexyl) phthalate (HY-W018392). Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD)  . |  
 
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-163263S
- 
                                        
                                            
                                                |  |  
                                                | HSD17B13-IN-80-d3 (179) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research . |  
 
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-163259S
- 
                                        
                                            
                                                |  |  
                                                | HSD17B13-IN-62-d3 (176) is a 17β-Hydroxysteroid dehydrogenases (HSD17B13) inhibitor, with an IC50 of <0.1 μM for Estradiol. Used in NAFLD (Nonalcoholic fatty liver diseases) research . |  
 
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-163253S
- 
                                        
                                            
                                                |  |  
                                                | HSD17B13-IN-56-D3 (Compound 169) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-56-D3 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-163263S1
- 
                                        
                                            
                                                |  |  
                                                | HSD17B13-IN-80-d2 (Compound 200) is the the deuterium labeled HSD17B13-IN-80 (HY-163263). HSD17B13-IN-80 is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-80 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) . |  
 
- 
                                        
                                        
                                              
 
 
            
            
            
            
            
                
                
                    
                        
                            
                                | Cat. No. | Product Name |  | Classification | 
                        
                        
                     
                
         
        
        
        
        
        
        
            
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