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Results for "

N-oxide metabolite

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Metabolite (46) Endogenous Metabolite (11) 5-HT Receptor (2) Antibiotic (1) c-Kit (2) Cannabinoid Receptor (1) Cholinesterase (ChE) (1) CXCR (3) Cytochrome P450 (2) Dopamine Receptor (7) GABA Receptor (1) Histamine Receptor (2) Isotope-Labeled Compounds (9) mAChR (7) Monoamine Oxidase (1) NOD-like Receptor (NLR) (6) Oxidative Phosphorylation (2) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (1) Raf (2) Reactive Oxygen Species (ROS) (7) Reference Standards (8) TGF-beta/Smad (6) VEGFR (2)
By Research Areas:	Cancer (15) Cardiovascular Disease (8) Endocrinology (4) Infection (4) Inflammation/Immunology (13) Metabolic Disease (9) Neurological Disease (28)

By Targets:

Drug Metabolite (46)

Endogenous Metabolite (11)

5-HT Receptor (2)

Antibiotic (1)

c-Kit (2)

Cannabinoid Receptor (1)

Cholinesterase (ChE) (1)

CXCR (3)

Cytochrome P450 (2)

Dopamine Receptor (7)

GABA Receptor (1)

Histamine Receptor (2)

Isotope-Labeled Compounds (9)

mAChR (7)

Monoamine Oxidase (1)

NOD-like Receptor (NLR) (6)

Oxidative Phosphorylation (2)

Platelet-activating Factor Receptor (PAFR) (1)

Potassium Channel (1)

Raf (2)

Reactive Oxygen Species (ROS) (7)

Reference Standards (8)

TGF-beta/Smad (6)

VEGFR (2)

By Research Areas:

Cancer (15)

Cardiovascular Disease (8)

Endocrinology (4)

Infection (4)

Inflammation/Immunology (13)

Metabolic Disease (9)

Neurological Disease (28)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Drug Metabolite Endogenous Metabolite NO Synthase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-G0011

Netupitant metabolite Netupitant N-oxide Netupitant N-oxide	Drug Metabolite	Neurological Disease Endocrinology
Netupitant N-oxide is the metabolite of Netupitant, which is a highly selective NK1 receptor antagonist.

HY-135265

Moclobemide N-Oxide Ro 12-5637	Monoamine Oxidase	Neurological Disease
Moclobemide N-Oxide (Ro 12-5637) is N-oxide metabolite of Moclobemide. Moclobemide N-Oxide retains certain MAO-A (monoamine oxidase) inhibitory activity, but is generally present in low concentrations. Moclobemide N-Oxide can be detected by UV absorption at 240 nm .

HY-147085

Loratadine n-oxide	Histamine Receptor	Inflammation/Immunology
Loratadine n-oxide is a metabolite of Loratadine. Loratadine n-oxide shows antihistamine activity .

HY-G0011S

Netupitant N-oxide-d6	Drug Metabolite	Neurological Disease Endocrinology
Netupitant N-oxide-d₆ is the deuterium labeled Netupitant N-oxide, which is a metabolite of Netupitant.

HY-N16472

Echiumine N-oxide	Endogenous Metabolite	Others
Echiumine N-oxide, a pyrrolizidine alkaloid related N-oxides (PANOs), is a plant secondary metabolite. Echiumine N-oxide can be isolated from Echium plantagineum. Echiumine N-oxide acts as a defensive role in plants, prevent plants from tissue death .

HY-100644

Trimethoprim N-oxide Trimethoprim 1-N-oxide	Drug Metabolite	Infection
Trimethoprim N-oxide (Trimethoprim 1-N-oxide) belongs to human urinary metabolites. Trimethoprim N-oxide is generated by oxidation of nitrogen atoms in the pyrimidine ring. Trimethoprim N-oxide is formed predominantly by CYP1A2 in human liver microsomes .

HY-N6828R

Monocrotaline N-Oxide (Standard)	Reference Standards Others	Metabolic Disease
Monocrotaline N-Oxide (Standard) is the analytical standard of Monocrotaline N-Oxide. This product is intended for research and analytical applications. Monocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo .

HY-W701397

Nicotinamide N-oxide-d4	Isotope-Labeled Compounds CXCR Drug Metabolite Endogenous Metabolite Oxidative Phosphorylation	Inflammation/Immunology
Nicotinamide N-oxide-d₄ is the deuterium labeled Nicotinamide N-oxide (HY-101407). Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.

HY-101407R

Nicotinamide N-oxide (Standard)	Reference Standards CXCR Drug Metabolite Endogenous Metabolite	Inflammation/Immunology Endocrinology
Nicotinamide N-oxide (Standard) is the analytical standard of Nicotinamide N-oxide. This product is intended for research and analytical applications. Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.

HY-142122R

Imipramine N-oxide (Standard)	Reference Standards Drug Metabolite	Neurological Disease
Imipramine N-oxide (Standard) is the analytical standard of Imipramine N-oxide. This product is intended for research and analytical applications. Imipramine N-oxide is the metabolite of Imipramine. Imipramine is a tertiary amine tricyclic antidepressant[1][2].

HY-148377

Abiraterone sulfate N-oxide	Drug Metabolite	Cancer
Abiraterone sulfate N-oxide is a carboxylic acid. Abiraterone sulfate N-oxide also is a major *metabolite* of Abiraterone (HY-70013). Abiraterone sulfate N-oxide can be used for the research of prostate cancer .

HY-W715183

6α-Oxycodol N-oxide	Cannabinoid Receptor	Neurological Disease
6α-Oxycodol N-oxide is structurally categorized as an opioid. 6α-Oxycodol N-oxide is a metabolite of Oxycodone.

HY-N11425

Benzydamine N-Oxide	Others	Others
Benzydamine N-Oxide is a metabolite of Benzydamine. Benzydamine N-Oxide can be used to measure flavin-containing monooxygenase activity .

HY-133794S

Dasatinib N-oxide-d8	Isotope-Labeled Compounds Drug Metabolite	Cancer
Dasatinib N-oxide-d₈ is the deuterium labeled Dasatinib N-oxide. Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor .

HY-W753452

N,N-Dimethyltryptamine N-oxide-d6	Isotope-Labeled Compounds Drug Metabolite	Metabolic Disease
N,N-Dimethyltryptamine N-oxide-d₆ is the deuterium labeled N,N-Dimethyltryptamine N-oxide (HY-W576312). N,N-Dimethyltryptamine N-oxide is a metabolite of N,N-Dimethyltryptamine .

HY-100664

Zopiclone N-oxide RP 29753	Drug Metabolite GABA Receptor	Neurological Disease
Zopiclone N-oxide (RP 29753) is a less active metabolite of Zopiclone. Zopiclone N-oxide is also an impurity of Eszopiclone and is formed by the oxidation of Eszopiclone .

HY-131574

Heliosupine N-oxide	mAChR	Neurological Disease
Heliosupine N-oxide, Heliosupin metabolite, inhibits muscarinic acetylcholine receptor (mAChR) with the IC₅₀ of 350 μM. Heliosupine N-oxide is a pyrrolizidine alkaloid (PA) .

HY-132343S

Zolmitriptan N-Oxide-d6	Isotope-Labeled Compounds	Neurological Disease
Zolmitriptan N-Oxide-d₆ is a deuterium labeled Zolmitriptan N-Oxide. Zolmitriptan N-Oxide is the major metabolite of Zolmitriptan. Zolmitriptan is a 5-HT1B/1D receptor partial agonist .

HY-116084S

Trimethylamine N-oxide-d9 1 Publications Verification	NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Trimethylamine N-oxide-d₉ is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-W709612

Regorafenib N-oxide and N-desmethyl (M5)-d3-1 N-Desmethyl regorafenib N-oxide-d₃-1	Isotope-Labeled Compounds VEGFR Raf c-Kit Drug Metabolite	Cancer
Regorafenib N-oxide and N-desmethyl (M5)-d₃-1 (N-Desmethyl regorafenib N-oxide-d₃-1) is the deuterium labeled Regorafenib N-oxide and N-desmethyl (M5) (HY-108226). Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4 .

HY-133787R

Levofloxacin N-oxide (Standard)	Reference Standards Drug Metabolite	Infection
Levofloxacin N-oxide (Standard) is the analytical standard of Levofloxacin N-oxide. This product is intended for research and analytical applications. Levofloxacin N-oxide is a minor metabolite of Levofloxacin (HY-B0330). Levofloxacin N-oxide does not exhibit significantly genotoxic risks. Levofloxacin is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria .

HY-133798

Sorafenib N-oxide	Cytochrome P450 Drug Metabolite	Cancer
Sorafenib N-oxide is an active metabolite of sorafenib (HY-10201). Sorafenib N-oxide is a linear-mixed inhibitor of microsomal CYP3A4, with a K_i of 15 μM .

HY-116084R

Trimethylamine N-oxide (Standard)	Drug Metabolite NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Trimethylamine N-oxide (Standard) is the analytical standard of Trimethylamine N-oxide. This product is intended for research and analytical applications. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-108226

Regorafenib N-oxide and N-desmethyl (M5) N-Desmethyl regorafenib N-oxide	Drug Metabolite Raf VEGFR c-Kit	Cancer
Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4 .

HY-116084S1

Trimethylamine-N-oxide-13C3	Isotope-Labeled Compounds NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Trimethylamine-N-oxide- ¹³C₃ is the ¹³C-labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-108915R

Trimethylamine N-oxide dihydrate (Standard)	NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Trimethylamine N-oxide (dihydrate) (Standard) is the analytical standard of Trimethylamine N-oxide (dihydrate). This product is intended for research and analytical applications. Trimethylamine N-oxide dihydrate is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide dihydrate induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide dihydrate also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-133010

Tamoxifen N-oxide	Drug Metabolite	Cancer
Tamoxifen N-oxide is a Tamoxifen (HY-13757A) metabolite .

HY-137989A

Voriconazole N-oxide hydrochloride Voriconazole oxynitride hydrochloride	Drug Metabolite	Infection
Voriconazole N-oxide (Voriconazole oxynitride) (hydrochloride) is the main metabolite of Voriconazole (HY-76200) , a widely used triazole antibiotic (fungal). Voriconazole N-oxide (hydrochloride) provides information on the patient's drug metabolism capacity .

HY-W748582

Clozapine N-oxide-d8	Isotope-Labeled Compounds Dopamine Receptor mAChR Drug Metabolite	Neurological Disease
Clozapine N-oxide-d₈ is the deuterium labeled Clozapine N-oxide (HY-17366). Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can't cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC₅₀=11 nM) agonist .

HY-17366R

Clozapine N-oxide (Standard)	Reference Standards mAChR Dopamine Receptor Drug Metabolite	Neurological Disease
Clozapine N-oxide (Standard) is the analytical standard of Clozapine N-oxide. This product is intended for research and analytical applications. Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide cannot cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].

HY-17366AR

Clozapine N-oxide dihydrochloride (Standard)	Reference Standards mAChR Dopamine Receptor Drug Metabolite	Neurological Disease
Clozapine N-oxide (dihydrochloride) (Standard) is the analytical standard of Clozapine N-oxide (dihydrochloride). This product is intended for research and analytical applications. Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].

HY-W576312

N,N-Dimethyltryptamine N-oxide	Drug Metabolite	Metabolic Disease
N,N-Dimethyltryptamine N-oxide is a metabolite of N,N-Dimethyltryptamine .

HY-145531

Mirtazapine N-oxide	5-HT Receptor	Neurological Disease
Mirtazapine N-oxide is a metabolite of Mirtazapine (HY-B0352) .

HY-W722562

Trimethylamine oxide-15N	Reactive Oxygen Species (ROS)	Inflammation/Immunology
Trimethylamine oxide- ¹⁵N is the deuterium labeled Trimethylamine N-oxide (HY-116084). Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-Z2493

Aripiprazole N1-oxide	Dopamine Receptor	Neurological Disease
Aripiprazole N-oxide is a metabolite of the atypical antipsychotic Aripiprazole (HY-14546). Aripiprazole N-oxide is formed from aripiprazole by the cytochrome P450 (CYP) isoforms CYP2D6 and CYP3A4.

HY-133728

Piribedil N-oxide	Dopamine Receptor Drug Metabolite	Neurological Disease
Piribedil N-oxide is a metabolite of the dopamine receptor agonist Piribedil (HY-12707).

HY-N6828

Monocrotaline N-Oxide	Others	Metabolic Disease
Monocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo .

HY-116084

Trimethylamine N-oxide 5+ Cited Publications	Drug Metabolite NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-142122

Imipramine N-oxide	Drug Metabolite	Neurological Disease
Imipramine N-oxide is the metabolite of Imipramine. Imipramine is a tertiary amine tricyclic antidepressant .

HY-101407

Nicotinamide N-oxide	Oxidative Phosphorylation CXCR Drug Metabolite Endogenous Metabolite	Inflammation/Immunology Endocrinology
Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.

HY-108915

Trimethylamine N-oxide dihydrate 5+ Cited Publications	NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Trimethylamine N-oxide dihydrate is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide dihydrate induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide dihydrate also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-133787

Levofloxacin N-oxide	Drug Metabolite	Infection
Levofloxacin N-oxide is a minor metabolite of Levofloxacin (HY-B0330). Levofloxacin N-oxide does not exhibit significantly genotoxic risks. Levofloxacin is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria .

HY-100645

Trimethoprim 3-oxide Trimethoprim 3-N-oxide	Drug Metabolite	Others
Trimethoprim 3-oxide (Trimethoprim 3-N-oxide) is the primary metabolite of trimethoprim .

HY-134137

Donepezil N-oxide	Cholinesterase (ChE) Drug Metabolite	Neurological Disease
Donepezil N-oxide, a metabolite of Donepezil (HY-14566), is human erythrocyte acetylcholinesterase (AChE) inhibitor .

HY-W701635

Meclizine N-oxide	Histamine Receptor	Neurological Disease
Meclizine N-oxide is a metabolite of the histamine H1 receptor antagonist Meclizine (HY-B0349A).

HY-147333

Trimipramine N-oxide	Drug Metabolite	Neurological Disease
Trimipramine N-oxide is an active metabolite of the tricyclic antidepressant trimipramine. Trimipramine N-oxide inhibits the human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT) and the human organic cation transporters (hOCT1 and hOCT2) with IC₅₀s of 11.7, 3.59, 9.4, 9.35 and 27.4 nM, respectively. Trimipramine N-oxide can be used for the research of depression and anxiety .

HY-17366A

Clozapine N-oxide dihydrochloride Maximum Cited Publications 122 Publications Verification	mAChR Dopamine Receptor Drug Metabolite	Neurological Disease
Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride cannot cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC₅₀=11 nM) agonist .

HY-17366

Clozapine N-oxide Maximum Cited Publications 122 Publications Verification	Drug Metabolite mAChR Dopamine Receptor	Neurological Disease
Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can't cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC₅₀=11 nM) agonist .

HY-171000

Propiverine N-oxide	Endogenous Metabolite	Metabolic Disease
Propiverine N-oxide is the main metabolite of hydrochloride propiverine, and it can affect bladder contractions and saliva secretion in small pigs .

HY-172560

6β-Oxycodol N-oxide	Drug Metabolite	Neurological Disease Metabolic Disease
6β-Oxycodol N-oxide is an opioid derivative and a metabolite of Oxycodone, which can be detected in urine .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N11425

Benzydamine N-Oxide	Natural Products Source classification Endogenous metabolite	Others
Benzydamine N-Oxide is a metabolite of Benzydamine. Benzydamine N-Oxide can be used to measure flavin-containing monooxygenase activity .

HY-N6828

Monocrotaline N-Oxide	Alkaloids Pyrrole Alkaloids Classification of Application Fields Leguminosae Source classification Metabolic Disease Plants Crotalaria pallida Ait. Disease Research Fields	Others
Monocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo .

HY-116084

Trimethylamine N-oxide 5+ Cited Publications	Cardiovascular Disease Natural Products Microorganisms Other disease Classification of Application Fields Source classification Disease markers Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Drug Metabolite NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite
Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-101407

Nicotinamide N-oxide	Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Endocrinology	Oxidative Phosphorylation CXCR Drug Metabolite Endogenous Metabolite
Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.

HY-N16472

Echiumine N-oxide	Structural Classification Alkaloids Echium plantagineum L. Other Alkaloids Source classification Plants Boraginaceae	Endogenous Metabolite
Echiumine N-oxide, a pyrrolizidine alkaloid related N-oxides (PANOs), is a plant secondary metabolite. Echiumine N-oxide can be isolated from Echium plantagineum. Echiumine N-oxide acts as a defensive role in plants, prevent plants from tissue death .

HY-N6828R

Monocrotaline N-Oxide (Standard)	Alkaloids Pyrrole Alkaloids Leguminosae Source classification Crotalaria pallida Ait. Plants	Reference Standards Others
Monocrotaline N-Oxide (Standard) is the analytical standard of Monocrotaline N-Oxide. This product is intended for research and analytical applications. Monocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo .

HY-101407R

Nicotinamide N-oxide (Standard)	Alkaloids Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology	Reference Standards CXCR Drug Metabolite Endogenous Metabolite
Nicotinamide N-oxide (Standard) is the analytical standard of Nicotinamide N-oxide. This product is intended for research and analytical applications. Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.

HY-131574

Heliosupine N-oxide	Alkaloids Pyrrole Alkaloids Source classification Cynoglossumofficinale Linn. Plants Boraginaceae	mAChR
Heliosupine N-oxide, Heliosupin metabolite, inhibits muscarinic acetylcholine receptor (mAChR) with the IC₅₀ of 350 μM. Heliosupine N-oxide is a pyrrolizidine alkaloid (PA) .

HY-116084R

Trimethylamine N-oxide (Standard)	Natural Products Microorganisms Other disease Source classification Disease markers Endogenous metabolite Cancer	Drug Metabolite NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite
Trimethylamine N-oxide (Standard) is the analytical standard of Trimethylamine N-oxide. This product is intended for research and analytical applications. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-108915R

Trimethylamine N-oxide dihydrate (Standard)	Natural Products Source classification Endogenous metabolite	NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite
Trimethylamine N-oxide (dihydrate) (Standard) is the analytical standard of Trimethylamine N-oxide (dihydrate). This product is intended for research and analytical applications. Trimethylamine N-oxide dihydrate is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide dihydrate induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide dihydrate also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-108915

Trimethylamine N-oxide dihydrate 5+ Cited Publications	Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite
Trimethylamine N-oxide dihydrate is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide dihydrate induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide dihydrate also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-N16484

Trichodesmine N-oxide	Structural Classification Alkaloids Other Alkaloids Source classification Plants Trichodesma incanum (Bunge) A.DC. Boraginaceae	Others
Trichodesmine N-oxide is the oxidized form of a pyrrolizidine alkaloid (PA) that can be isolated from the sunn hemp (Crotalaria juncea) teas. PAs are secondary metabolites in plants, which may exhibit toxicity and carcinogenicity .

Cat. No.	Product Name	Chemical Structure

HY-116084S

Trimethylamine N-oxide-d9

1 Publications Verification

Trimethylamine N-oxide-d₉ is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-W722562

Trimethylamine oxide-15N

Trimethylamine oxide- ¹⁵N is the deuterium labeled Trimethylamine N-oxide (HY-116084). Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-G0011S

Netupitant N-oxide-d6
Netupitant N-oxide-d₆ is the deuterium labeled Netupitant N-oxide, which is a metabolite of Netupitant.

HY-W701397

Nicotinamide N-oxide-d4
Nicotinamide N-oxide-d₄ is the deuterium labeled Nicotinamide N-oxide (HY-101407). Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.

HY-133794S

Dasatinib N-oxide-d8
Dasatinib N-oxide-d₈ is the deuterium labeled Dasatinib N-oxide. Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor .

HY-W753452

N,N-Dimethyltryptamine N-oxide-d6
N,N-Dimethyltryptamine N-oxide-d₆ is the deuterium labeled N,N-Dimethyltryptamine N-oxide (HY-W576312). N,N-Dimethyltryptamine N-oxide is a metabolite of N,N-Dimethyltryptamine .

HY-132343S

Zolmitriptan N-Oxide-d6
Zolmitriptan N-Oxide-d₆ is a deuterium labeled Zolmitriptan N-Oxide. Zolmitriptan N-Oxide is the major metabolite of Zolmitriptan. Zolmitriptan is a 5-HT1B/1D receptor partial agonist .

HY-W709612

Regorafenib N-oxide and N-desmethyl (M5)-d3-1
Regorafenib N-oxide and N-desmethyl (M5)-d₃-1 (N-Desmethyl regorafenib N-oxide-d₃-1) is the deuterium labeled Regorafenib N-oxide and N-desmethyl (M5) (HY-108226). Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4 .

HY-116084S1

Trimethylamine-N-oxide-13C3

Trimethylamine-N-oxide- ¹³C₃ is the ¹³C-labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-W748582

Clozapine N-oxide-d8

Clozapine N-oxide-d₈ is the deuterium labeled Clozapine N-oxide (HY-17366). Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can't cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC₅₀=11 nM) agonist .

HY-W016099S

3-Methyl-2-quinoxalinecarboxylic acid-d4
3-Methyl-2-quinoxalinecarboxylic acid-d₄ is the deuterium labeled 3-Methyl-2-quinoxalinecarboxylic acid. 3-Methyl-2-quinoxalinecarboxylic acid (MQCA), an important N-oxide reductive metabolite of Quinocetone or Olaquindox, potently inhibits the growth of Chang liver cells through S phase arrest of the cell cycle .

HY-136428S

Desoxycarbadox-d3 1 Publications Verification
Desoxycarbadox-d₃ is the deuterium labeled Desoxycarbadox. Desoxycarbadox is a metabolite of Carbadox (HY-B1340). Carbadox is a quinoxaline-di-N-oxide antibiotic compound.

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