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MF

" in MedChemExpress (MCE) Product Catalog:

By Targets:	15-PGDH (2) ADC Payload (1) Antibiotic (4) Apoptosis (2) ATP Synthase (1) Bacterial (6) Deubiquitinase (3) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (2) Drug-Linker Conjugates for ADC (1) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (1) FABP (1) FGFR (1) FLT3 (2) GABA Receptor (1) GnRH Receptor (1) JAK (2) Mitophagy (2) Opioid Receptor (1) PGE synthase (1) Photosensitizer (1) Prostaglandin Receptor (4) PROTACs (1) Reference Standards (1) Small Interfering RNA (siRNA) (1) Stearoyl-CoA Desaturase (SCD) (1) Thrombopoietin Receptor (1) TNF Receptor (1) Topoisomerase (2)
By Research Areas:	Cancer (17) Infection (6) Inflammation/Immunology (8) Metabolic Disease (4) Neurological Disease (3)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138978

MF-095	Mitophagy Deubiquitinase	Neurological Disease
MF-095 is a USP30 inhibitor. MF-095 promotes mitochondrial autophagy. MF-095 can be used in neurological disease-related research .

HY-112438

MF-094 5+ Cited Publications	Deubiquitinase	Cancer
MF-094 is a potent and selective USP30 inhibitor with an IC₅₀ of 120 nM. MF-094 increases protein ubiquitination and accelerates mitophagy .

HY-115487

MF-766	Prostaglandin Receptor	Inflammation/Immunology Cancer
MF-766 is a highly potent, selective and orally active EP4 antagonist with a K_i of 0.23 nM. MF-766 behaves as a full antagonist with an IC₅₀ of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay. MF-766 can be used for cancer and inflammation diseases research .

HY-15822

MF-438 4 Publications Verification	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an IC₅₀ of 2.3 nM for rSCD1 .

HY-B0902A

Rufloxacin hydrochloride MF-934 hydrochloride	Bacterial Antibiotic	Infection
Rufloxacin hydrochloride (MF-934 hydrochloride) is a fluoroquinolone antibacterial, inhibits B-cell differentiation in human mononuclear cells, inhibits Topo.

HY-13283

MF63 1 Publications Verification	PGE synthase	Inflammation/Immunology
MF63 is a selective and orally active inhibitor of mPGES-1. MF63 reduces the accumulation of PGE₂, relieves pyresis, hyperalgesia, and inflammatory pain by inhibiting mPGES-1 .

HY-111304

MF266-1	Prostaglandin Receptor Thrombopoietin Receptor	Inflammation/Immunology
MF266-1 is a selective E prostanoid receptor 1 (EP1) antagonist with an K_i value of 3.8 nM. MF266-1 also has moderate selectivity for thromboxane A2 receptor (TP). MF266-1 is promising for research of arthritis .

HY-100289

MF 5137	Bacterial	Infection
MF 5137 is a potent antibacterial agent.

HY-124879

MF 961	Bacterial	Infection
MF 961 is a quinolone biocide. The MIC₅₀ values of MF 961 against E. coli, Klebsiella sp., Enterobacter sp., Citrobacter sp., Citrobacter sp., and Shlgella sp. are all in the range of 0-25 mg/L .

HY-118370

MF-592	Prostaglandin Receptor	Inflammation/Immunology
MF-592 is an inhibitor of PGE2 (IC50=3 nM) and exhibits good oral PK properties in rats and dogs.

HY-10794

MF498 1 Publications Verification	Prostaglandin Receptor	Metabolic Disease Inflammation/Immunology Cancer
MF498 is a selective and orally active E prostanoid Receptor 4 (EP4) antagonist with a K_i value of 0.7 nM. MF498 can be used in the research of inflammation, such as rheumatoid and osteoarthritis .

HY-176803

MF-DH-300	15-PGDH	Metabolic Disease
MF-DH-300 is a 15-PGDH inhibitor with an IC₅₀ of 1.6 nM. MF-DH-300 blocks binding of 15-PGDH to PGE2 and increases stem cell proliferation and muscle force, as well as improves mitochondrial function. MF-DH-300 increases survival motor neuron (SMN) protein expression. MF-DH-300 can be used for muscle disorders like spinal muscular atrophy (SMA) research .

HY-B0902AR

Rufloxacin hydrochloride (Standard) MF-934 hydrochloride (Standard)	Reference Standards Bacterial Antibiotic	Infection
Rufloxacin hydrochloride (Standard) is the analytical standard of Rufloxacin hydrochloride. This product is intended for research and analytical applications. Rufloxacin hydrochloride (MF-934 hydrochloride) is a fluoroquinolone antibacterial, inhibits B-cell differentiation in human mononuclear cells, inhibits Topo.

HY-117723

MF-PGDH-008	15-PGDH	Others
MF-PGDH-008 serves as an inhibitor of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.

HY-145990

FABPs ligand 6 1 Publications Verification MF6	FABP	Inflammation/Immunology
FABPs ligand 6 (MF6) is an FABP5 and FABP7 inhibitor with K_D values of 874 nM and 20 nM, respectively. FABPs ligand 6 can be used for multiple sclerosis research .

HY-106138

Avorelin Meterelin; MF 6001	GnRH Receptor	Cancer
Avorelin (Meterelin) is a gonadotropin releasing hormone (GnRH) agonist. Avorelin can be used of the study of prostate cancer .

HY-112438A

rac-MF-094	Deubiquitinase	Cancer
rac-MF-094 is the racemic mixture of MF-094 (HY-112438). MF-094 is a potent and selective USP30 inhibitor with an IC₅₀ of 120 nM. MF-094 increases protein ubiquitination and accelerates mitophagy .

HY-N11645

Ganoderic acid Mf GA-MF	Apoptosis	Cancer
Ganoderic acid Mf is an antitumor triterpenoid. Ganoderic acid Mf causes cell cycle arrest in the G1 phase. Ganoderic acid Mf shows high selectivity between normal and cancer cells and induces cell apoptosis via mitochondria mediated pathway .

HY-175203

Topi MF-6	Topoisomerase ADC Payload	Cancer
Topi MF-6 is a DNA topoisomerase I (Top1) inhibitor. Topi MF-6 has superior cytotoxicity against gastrointestinal cancer cells. Topi MF-6 can be used as an ADC payload .

HY-131997

2'MeO6MF	GABA Receptor	Neurological Disease Inflammation/Immunology
2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABA_A receptors. 2'MeO6MF also can directly activate α2β2/3 and α2β2/3γ2L GABA_A receptors. 2'MeO6MF has anxiolytic and psychomotor stabilizing properties. 2'MeO6MF offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response .

HY-174981

LC-MF-4	PROTACs FGFR ATP Synthase	Cancer
LC-MF-4 is a selective FGFR3 PROTAC degrader with a DC₅₀ of 30.89 nM in KMS-11 cells. LC-MF-4 inhibits the metabolic function of FGFR3-TACC3 fusion positive cancers with reduction of ATP synthesis and inhibition of mitochondrial biogenesis genes. LC-MF-4 has potent antitumor activity in the Ba/F3-FGFR3-TACC3 xenograft mice model. LC-MF-4 can be used for FGFR3-altered cancers like bladder cancer and urothelial carcinoma (UC) research . Pink: FGFR3 ligand (HY-175414); Blue: VHL ligase ligand (HY-125905); Black: linker (HY-Y1224)

HY-169204

Mito-fisetin mF3	Mitophagy	Cancer
Mito-fisetin mF3 is a potent anticancer and anti-aging therapeutic agent that targets mitophagy. .

HY-RS01209

ATP5MF Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ATP5MF Human Pre-designed siRNA Set A contains three designed siRNAs for ATP5MF gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ATP5MF Human Pre-designed siRNA Set A ATP5MF Human Pre-designed siRNA Set A

HY-175216

Maleimide-Ph(3,5-F)-PEG4-Val-Ala-MF-6	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
Maleimide-Ph(3,5-F)-PEG4-Val-Ala-MF-6 is a drug-linker conjugate for ADC. Maleimide-Ph(3,5-F)-PEG4-Val-Ala-MF-6 consists of a topoisomerase 1 inhibitor (Topi MF-6) (HY-175203) and a cleavable linker (Maleimide-Ph(3,5-F)-PEG4-Val-Ala) (HY-175218). Maleimide-Ph(3,5-F)-PEG4-Val-Ala-MF-6 can be used for synthesis of ADCs .

HY-N12322

Dihydrotetrodecamycin	Antibiotic Bacterial	Infection
Dihydrotetrodecamycin is an antibiotic that can be isolated from the fermentation broth of Streptomyces nashvillensis MJ885-mF8. Dihydrotetrodecamycin has MIC values of 50 mg/mL against both Pasteurella piscicida sp. 639 and P. piscicida sp. 6356 .

HY-121133

(-)-Cyclopenol	Endogenous Metabolite	Others
(-)-Cyclopenol is a fungal metabolite isolated from an Australian marine-derived isolate of Aspergillus versicolor (MST-MF495) .

HY-170490

TTQ-SA	Photosensitizer Apoptosis	Cancer
TTQ-SA is a near-infrared (NIR) spiro-AIEgen (aggregation-induced emission luminogen), that converts near-infrared light (NIR) into thermal energy, causing thermal damage and death of tumor cells. TTQ-SA exhibits cellular uptake and targeting ability in cancer cell MF-7. TTQ-SA silences the expression of survivin gene with combination of DNAzyme, enhances the sensitivity of tumor cells to photothermal therapy .

HY-W754718

Azepinomycin	Others	Cancer
Azepinomycin is found in the strain of Streptomyces toyokaensis MF71803. Azepinomycin can inhibit guanine deaminase (IC₅₀ of 4.9 μM) and tumor cell .

HY-P99670

Iscalimab CFZ-533; OM11-62MF	TNF Receptor	Metabolic Disease Inflammation/Immunology
Iscalimab (CFZ-533) is a non-depleting IGg1 monoclonal antibody targeting CD40 (K_D: 0.3 nM). Iscalimab can be used for research of Graves' hyperthyroidism and autoimmune diseases .

HY-P4107

Bilaid C	Opioid Receptor	Neurological Disease
Bilaid C, a tetrapeptide, can be isolated from the Australian estuarine isolate of Penicillium sp. MST-MF667. Bilaid C is also a potent and selective μ-Opioid Receptor (MOPr) agonist (K_i=210 nM, hMOPr) .

HY-P10603

SP1	Antibiotic Bacterial	Infection
SP1 is an α-peptide encoded by the mating pheromone MFα1 gene in Candida albicans, which can induce cell growth arrest at the mating type locus MTLa in Candida albicans. SP1 can be used in the study of the prevention and treatment of Candida albicans infection .

HY-175406

VH032-cyclopropane-F-C4-CHO	E3 Ligase Ligand-Linker Conjugates	Cancer
VH032-cyclopropane-F-C4-CHO is an E3 ubiquitinase ligand-linker conjugate. VH032-cyclopropane-F-C4-CHO can be used to synthesize LC-MF-4 (HY-174981) .

HY-16379A

Pacritinib hydrochloride SB1518 hydrochloride	JAK FLT3	Cancer
Pacritinib hydrochloride is a potent inhibitor of both wild-type JAK2 (IC₅₀=23 nM) and JAK2 ^V617F mutant (IC₅₀=19 nM). Pacritinib hydrochloride also inhibits FLT3 (IC₅₀=22 nM) and its mutant FLT3 ^D835Y (IC₅₀=6 nM). Pacritinib hydrochloride can be used for the research of acute myeloid leukemia (AML) and myelofibrosis (MF) .

HY-16379B

Pacritinib citrate Maximum Cited Publications 17 Publications Verification SB1518 citrate	JAK FLT3	Cancer
Pacritinib (SB1518) citrate is a potent inhibitor of both wild-type JAK2 (IC₅₀=23 nM) and JAK2 ^V617F mutant (IC₅₀=19 nM). Pacritinib citrate also inhibits FLT3 (IC₅₀=22 nM) and its mutant FLT3 ^D835Y (IC₅₀=6 nM). Pacritinib citrate can be used for the research of acute myeloid leukemia (AML) and myelofibrosis (MF) .

HY-16398R

Pipobroman (Standard)	DNA Alkylator/Crosslinker DNA/RNA Synthesis	Cancer
Pipobroman (Standard) is the analytical standard of Pipobroman. This product is intended for research and analytical applications. Pipobroman is a bromide derivative of piperazine and acts as an alkylating agent. Pipobroman plays its role by inhibiting DNA and RNA polymerase or by reducing pyrimidine nucleotide incorporation into DNA. Pipobroman can be used for the cancer research, including polycythemia vera, myeloproliferative neoplasm, and AML et.al .

HY-16398

Pipobroman	DNA Alkylator/Crosslinker DNA/RNA Synthesis	Cancer
Pipobroman is a bromide derivative of piperazine and acts as an alkylating agent. Pipobroman plays its role by inhibiting DNA and RNA polymerase or by reducing pyrimidine nucleotide incorporation into DNA. Pipobroman can be used for the cancer research, including polycythemia vera, myeloproliferative neoplasm, and AML et.al .

Cat. No.	Product Name	Target	Research Area

HY-106138

Avorelin Meterelin; MF 6001	GnRH Receptor	Cancer
Avorelin (Meterelin) is a gonadotropin releasing hormone (GnRH) agonist. Avorelin can be used of the study of prostate cancer .

HY-P4107

Bilaid C	Opioid Receptor	Neurological Disease
Bilaid C, a tetrapeptide, can be isolated from the Australian estuarine isolate of Penicillium sp. MST-MF667. Bilaid C is also a potent and selective μ-Opioid Receptor (MOPr) agonist (K_i=210 nM, hMOPr) .

HY-P10603

SP1	Antibiotic Bacterial	Infection
SP1 is an α-peptide encoded by the mating pheromone MFα1 gene in Candida albicans, which can induce cell growth arrest at the mating type locus MTLa in Candida albicans. SP1 can be used in the study of the prevention and treatment of Candida albicans infection .

Cat. No.	Product Name	Target	Research Area

HY-P99670

Iscalimab CFZ-533; OM11-62MF	TNF Receptor	Metabolic Disease Inflammation/Immunology
Iscalimab (CFZ-533) is a non-depleting IGg1 monoclonal antibody targeting CD40 (K_D: 0.3 nM). Iscalimab can be used for research of Graves' hyperthyroidism and autoimmune diseases .

Ganoderic acid Mf GA-MF	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Apoptosis
Ganoderic acid Mf is an antitumor triterpenoid. Ganoderic acid Mf causes cell cycle arrest in the G1 phase. Ganoderic acid Mf shows high selectivity between normal and cancer cells and induces cell apoptosis via mitochondria mediated pathway .

Dihydrotetrodecamycin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Dihydrotetrodecamycin is an antibiotic that can be isolated from the fermentation broth of Streptomyces nashvillensis MJ885-mF8. Dihydrotetrodecamycin has MIC values of 50 mg/mL against both Pasteurella piscicida sp. 639 and P. piscicida sp. 6356 .

(-)-Cyclopenol	Alkaloids Structural Classification Microorganisms Classification of Application Fields Source classification Marine natural products Other Diseases Disease Research Fields Marine microorganism	Endogenous Metabolite
(-)-Cyclopenol is a fungal metabolite isolated from an Australian marine-derived isolate of Aspergillus versicolor (MST-MF495) .

Species:	Human (2)
Tag:	His (1) Tag Free (1) Myc (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P70348

	Flap endonuclease 1/FEN-1 Protein, Human rHuFlap endonuclease 1/FEN-1; Flap Endonuclease 1; FEN-1; DNase IV; Flap Structure-Specific Endonuclease 1; Maturation Factor 1; MF1; hFEN-1; FEN1; RAD2	Human	E. coli
	Flap endonuclease 1 (FEN-1) is a structure-specific nuclease crucial for DNA replication and repair. In replication, it cleaves 5'-overhanging flaps, guiding DNA polymerase and creating a nick for ligation. FEN-1 is integral to the long patch base excision repair pathway, preventing genomic instability. It exhibits 5'-3' exonuclease and RNase H activities, playing roles in rDNA and mitochondrial DNA replication and repair. Flap endonuclease 1/FEN-1 Protein, Human is the recombinant human-derived Flap endonuclease 1/FEN-1 protein, expressed by E. coli , with tag free.

HY-P700010

	Flap endonuclease 1/FEN-1 Protein, Human (His, Myc) rHuFlap endonuclease 1/FEN-1; Flap Endonuclease 1; FEN-1; DNase IV; Flap Structure-Specific Endonuclease 1; Maturation Factor 1; MF1; hFEN-1; FEN1; RAD2	Human	E. coli
	Flap endonuclease 1 (FEN-1) is a structure-specific nuclease crucial for DNA replication and repair. In replication, it cleaves 5'-overhanging flaps, guiding DNA polymerase and creating a nick for ligation. FEN-1 is integral to the long patch base excision repair pathway, preventing genomic instability. It exhibits 5'-3' exonuclease and RNase H activities, playing roles in rDNA and mitochondrial DNA replication and repair. Flap endonuclease 1/FEN-1 Protein, Human (His, Myc) is the recombinant human-derived Flap endonuclease 1/FEN-1 protein, expressed by E. coli , with N-10*His, C-Myc labeled tag.

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HY-P83953

	CD18 Antibody (YA3650) LAD; MF17; LCAMB; LFA-1; ITGB2	ICC/IF, ELISA	Human, Mouse
	CD18 Antibody (YA3650) is a mouse-derived and non-conjugated IgG2b antibody, targeting to CD18. It can be applicated for ICC/IF, ELISA assays, in the background of human, mouse.

HY-P83954

	CD18 Antibody (YA3651) ITGB2; LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1	WB, FC, ELISA	Human
	CD18 Antibody (YA3651) is a mouse-derived and non-conjugated IgG1 antibody, targeting to CD18. It can be applicated for WB, FC, ELISA assays, in the background of human.

HY-P80669

	FEN1 Antibody (YA765) FEN1; RAD2; Flap endonuclease 1; FEN-1; DNase IV; Flap structure-specific endonuclease 1; Maturation factor 1; MF1; hFEN-1	WB, IP	Human, Mouse, Rat
	FEN1 Antibody (YA765) is a non-conjugated and Mouse origined monoclonal antibody about 43 kDa, targeting to FEN1 (1E7). It can be used for WB,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P85602

	FEN1 Antibody (YA5294) DNase IV; FEN-1; FEN1; FEN1_HUMAN; Flap endonuclease 1; Flap structure specific endonuclease 1; Flap structure-specific endonuclease 1; hFEN-1; hFEN1; Maturation factor 1; MF1; Rad2.	WB, ICC	Human, Mouse, Rat, Monkey, Hamster
	FEN1 Antibody (YA5294) is a mouse-derived and non-conjugated monoclonal antibody, targeting to FEN-1. It can be applicated for WB, ICC assays, in the background of human, mouse, rat, monkey, hamster.

HY-P85603

	FEN1 Antibody (YA5295) DNase IV; FEN-1; FEN1; FEN1_HUMAN; Flap endonuclease 1; Flap structure specific endonuclease 1; Flap structure-specific endonuclease 1; hFEN-1; hFEN1; Maturation factor 1; MF1; Rad2.	WB, IP	Human, Mouse, Rat
	FEN1 Antibody (YA5295) is a mouse-derived and non-conjugated monoclonal antibody, targeting to FEN-1. It can be applicated for WB, IP assays, in the background of human, mouse, rat.

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