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Leishmania donovani

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminoacyl-tRNA Synthetase (1) Antibiotic (1) Apoptosis (1) Autophagy (1) Bacterial (1) Biochemical Assay Reagents (1) Drug Intermediate (1) Opioid Receptor (1) Parasite (18) Reactive Oxygen Species (ROS) (1) α-synuclein (1)
By Research Areas:	Cancer (2) Infection (20) Inflammation/Immunology (1) Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-149093

Antileishmanial agent-14	Parasite	Infection
Antileishmanial agent-14 is a sulfuretin analog with potential activity against the parasite Leishmania donovani promastigotes (IC₅₀=4.1 μM). Antileishmanial agent-14 also inhibits infection by L. donovani* amastigotes* (IC₅₀=11.1 μM) .

HY-163457

Antileishmanial agent-27	Aminoacyl-tRNA Synthetase Parasite	Infection
Antileishmanial agent-27 (compound 7j) is a benzothiazolo-coumarin derivative. Antileishmanial agent-27 is a competitive inhibitor of arginyl-tRNA synthetases (ArgRSs). Antileishmanial agent-27 shows selectivity toward ArgRS of Leishmania donovani (LdArgRS) than its human counterpart (HsArgRS), with IC₅₀ values of 1.2 and 19 μM, respectively. Antileishmanial agent-27 possesses high pharmacokinetic properties .

HY-147535

Antileishmanial agent-7	Parasite	Infection
Antileishmanial agent-7 (compound 23) is a potent antileishmanial agent. Antileishmanial agent-7 shows antileishmanial activity against Leishmania donovani and L-6, with IC₅₀ values of 6.89 and 259 μM, respectively .

HY-155520

Antileishmanial agent-19	Parasite	Infection
Antileishmanial agent-19 (Compound F27) is an antileishmanial agent, with a IC₅₀ of 3.39 μM for L. donovani* promastigotes. Antileishmanial agent-19 inhibits Leishmania* prolyl-tRNA synthetase. Antileishmanial agent-19 inhibits host PI3K/Akt/CREB axis-mediated IL-10 secretion. Antileishmanial agent-19 induces autophagy-mediated apoptosis in L. donovani* promastigotes*. Antileishmanial agent-19 reduces parasite burden in L.d-infected animals .

HY-147534

Antileishmanial agent-6	Parasite	Infection
Antileishmanial agent-6 (compound 8m) is a potent antileishmanial agent. Antileishmanial agent-6 shows antileishmanial and cytotoxic activity against Leishmania donovani and L-6, with IC₅₀ values of 0.54 and 10.2 μM, respectively .

HY-161325

Antileishmanial agent-26	Parasite	Infection
Antileishmanial agent-26 (Compound 69) is a guanidine-containing compound with anti-Leishmania donovani activity. Its IC₅₀ value against Leishmania donovani is 5.67 μM, and its CC₅₀ value against THP-1 is 3.79 μM. Antileishmanial agent-26 can be used in the research of tropical diseases .

HY-147537

Antileishmanial agent-9	Parasite	Infection
Antileishmanial agent-9 (compound 16c) has potent and selective activity against Leishmania donovani (L. donovani) with an IC₅₀ value of 4.01 μM. Antileishmanial agent-9 has relatively low cytotoxicity in L-6 cells (IC₅₀ = 40.1 μM) .

HY-162833

Antileishmanial agent-30	Parasite	Infection
Antileishmanial agent-30 (compound 17k) is a potent inhibitor of leishmania, with the IC₅₀, CC₅₀, and SI of 0.2 μM, >100 μM and >500 for L. donovani .

HY-147536

Antileishmanial agent-8	Parasite	Infection
Antileishmanial agent-8 (compound 18) has potent and selective activity against Leishmania donovani (L. donovani) with an IC₅₀ value of 5.64 μM. Antileishmanial agent-8 has relatively low cytotoxicity in L-6 cells (IC₅₀=73.9 μM) .

HY-N2894

Piperolactam A	Parasite	Infection
Piperolactam A is a natural product that can be isolated from root of Piper betle. Piperolactam A exhibits promising leishmanicidal action against wild type and drug resistant strains of Leishmania donovani .

HY-170963

LASSBio-1985	Parasite	Infection
LASSBio-1985 is an NHLd inhibitor (nucleoside hydrolase from Leishmania donovani), with a Ki of 79 μM and an IC₅₀ of 84.6 μM. LASSBio-1985 exhibits selective toxicity against Leishmania parasites, with no toxicity to mammalian cells, making it a promising candidate for research in the field of anti-infective therapies .

HY-16565

10-Deacetylbaccatin III	Biochemical Assay Reagents Drug Intermediate Parasite	Infection
10-Deacetylbaccatin-III is an intermediate in the preparation process of paclitaxel. 10-Deacetylbaccatin III can be isolated from the dried needles and small branches of the European yew tree (Taxus baccata). 10-Deacetylbaccatin III exhibits antileishmanial activity .

HY-130993

Isatropolone A	Parasite	Infection
Isatropolone A, a natural product containing a 1,5-diketone moiety, is reisolated from Streptomyces Gö66. Isatropolone A shows potent activity against **Leishmania donovani with an IC₅₀** of 0.5 μM .

HY-129819

(Rac)-DNDI-8219	Bacterial	Infection
(Rac)-DNDI-8219 is an antituberculosis compound with potent anti-leishmanial activity. (Rac)-DNDI-8219 demonstrated superior efficacy in the Leishmania donovani mouse model. (Rac)-DNDI-8219 showed promising activity in the Leishmania infantum hamster model. (Rac)-DNDI-8219 candidate compound R-6 provided excellent oral efficacy in the same hamster model .

HY-N10547

6-O-Methylcatalpol	Parasite	Infection
6-O-Methylcatalpol can be isolated from the roots of Scrophularia ningpoensis. 6-O-Methylcatalpol has anti-protozoal activity against Trypanosoma b. rhodesiense and Leishmania donovani (IC₅₀: 32.5 and 8.3 μg/mL) .

HY-101011

Naloxonazine dihydrochloride	Opioid Receptor	Infection Neurological Disease
Naloxonazine dihydrochloride is a specific μ-opioid receptor antagonist with an IC₅₀ of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity .

HY-N0413

Hupehenine	α-synuclein Reactive Oxygen Species (ROS) Apoptosis Autophagy Parasite	Infection Neurological Disease Inflammation/Immunology Cancer
Hupehenine is an orally active isosteroidal alkaloid that can be extracted from F. hupehensis. Hupehenine exhibits activities such as antitussive, expectorant, anticancer, and antiparasitic. In vitro, Hupehenine can also inhibit α-synuclein seeded fibril formation, making it applicable for the research of Parkinson's disease and other related disorders .

HY-147766

Antileishmanial agent-10	Parasite	Infection
Antileishmanial agent-10 (Compound 7h) is an antiprotozoal agent .

HY-147765

Anti-Trypanosoma cruzi agent-3	Parasite	Infection
Anti-Trypanosoma cruzi agent-3 (Compound 7c) is an antiprotozoal agent .

HY-124210

Formycin B	Antibiotic Parasite	Infection Cancer
Formycin B is an antibiotic, which exhibits antiparasitic activity against Leishmania. Formycin B exhibits toxicity to leukocytes, reversibly decreases neutrophils. Formycin B can be used in research about myeloid leukemia .

10-Deacetylbaccatin III	Structural Classification Classification of Application Fields Terpenoids Taxaceae Source classification Diterpenoids Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Cancer	Biochemical Assay Reagents Drug Intermediate Parasite
10-Deacetylbaccatin-III is an intermediate in the preparation process of paclitaxel. 10-Deacetylbaccatin III can be isolated from the dried needles and small branches of the European yew tree (Taxus baccata). 10-Deacetylbaccatin III exhibits antileishmanial activity .

Hupehenine	Alkaloids Structural Classification Liliaceae Classification of Application Fields Fritillaria hupehensis Hsiao et K. C. Hsia Source classification Plants Inflammation/Immunology Disease Research Fields Indole Alkaloids	α-synuclein Reactive Oxygen Species (ROS) Apoptosis Autophagy Parasite
Hupehenine is an orally active isosteroidal alkaloid that can be extracted from F. hupehensis. Hupehenine exhibits activities such as antitussive, expectorant, anticancer, and antiparasitic. In vitro, Hupehenine can also inhibit α-synuclein seeded fibril formation, making it applicable for the research of Parkinson's disease and other related disorders .

Piperolactam A	Structural Classification Alkaloids Piper betle L. Source classification Piperaceae Plants	Parasite
Piperolactam A is a natural product that can be isolated from root of Piper betle. Piperolactam A exhibits promising leishmanicidal action against wild type and drug resistant strains of Leishmania donovani .

Isatropolone A	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Parasite
Isatropolone A, a natural product containing a 1,5-diketone moiety, is reisolated from Streptomyces Gö66. Isatropolone A shows potent activity against **Leishmania donovani with an IC₅₀** of 0.5 μM .

6-O-Methylcatalpol	Structural Classification Scrophularia ningpoensis Hemsl. Polymer products Scrophulariaceae Plants Saccharides Monosaccharides	Parasite
6-O-Methylcatalpol can be isolated from the roots of Scrophularia ningpoensis. 6-O-Methylcatalpol has anti-protozoal activity against Trypanosoma b. rhodesiense and Leishmania donovani (IC₅₀: 32.5 and 8.3 μg/mL) .

Formycin B	Structural Classification Microorganisms Antibiotics Source classification	Antibiotic Parasite
Formycin B is an antibiotic, which exhibits antiparasitic activity against Leishmania. Formycin B exhibits toxicity to leukocytes, reversibly decreases neutrophils. Formycin B can be used in research about myeloid leukemia .

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Leishmania donovani

Inhibitors & Agonists

NaturalProducts

Natural
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