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LIN28 inhibitor

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-123905A
    LIN28 inhibitor LI71 enantiomer

    		Drug Isomer MicroRNA Parasite Infection Cancer
    LIN28 inhibitor LI71 enantiomer is the less active enantiomer of LIN28 inhibitor LI71 (HY-123905). LIN28 inhibitor LI71 is a LIN28 inhibitor that effectively inhibits LIN28:let-7 binding (IC50: 7 μM). LIN28 inhibitor LI71 can abolish LIN28-mediated oligouridylation of let-7 precursor (IC50: 27 μM). LIN28 inhibitor LI71 has potential application value in LIN28-driven cancer research. LIN28 inhibitor LI71 inhibits the interaction of cold shock protein of Plasmodium falciparum (PfCoSP) with DNA and α/β tubulin and has an inhibitory effect on Plasmodium falciparum .
    LIN28 inhibitor LI71 enantiomer
  • HY-123905
    LIN28 inhibitor LI71

    		MicroRNA Parasite Infection Cancer
    LIN28 inhibitor LI71 is a LIN28 inhibitor that effectively inhibits LIN28:let-7 binding (IC50: 7 μM). LIN28 inhibitor LI71 can abolish LIN28-mediated oligouridylation of let-7 precursor (IC50: 27 μM). LIN28 inhibitor LI71 has potential application value in LIN28-driven cancer research. LIN28 inhibitor LI71 inhibits the interaction of cold shock protein of Plasmodium falciparum (PfCoSP) with DNA and α/β tubulin and has an inhibitory effect on Plasmodium falciparum .
    LIN28 inhibitor LI71
  • HY-112659
    Lin28-let-7 antagonist 1

    		MicroRNA Neurological Disease Cancer
    Lin28-let-7 antagonist 1 (compound 1632) is a potent antagonist of Lin28/pre-let-7 interaction. Lin28-let-7 antagonist 1 inhibits Lin28A binding to pre-let-7a-2, with an IC50 of 8 μM. Lin28-let-7 antagonist 1 inhibits proliferation in human cancer cells .
    Lin28-let-7 antagonist 1
  • HY-155237
    LIN28-IN-1

    		MicroRNA Cancer
    LIN28-IN-1 (compound 5) is an inhibitor of the RNA-binding and regulatory protein LIN28 and binds to the LIN28 cold shock domain (CSD). LIN28-IN-1 effectively inhibits the interaction between LIN28 and let-7 miRNA (IC50: 5.4 μM), blocking the negative impact of LIN28 on epigenetic gene regulation. LIN28-IN-1 significantly inhibits the proliferation of JAR cancer cells expressing LIN28 (IC50: 6.4 μM) .
    LIN28-IN-1
  • HY-168437
    LIN28-IN-2

    		DNA/RNA Synthesis Cancer
    LIN28-IN-2 (Compound Ln268) blocks the binding of the zinc finger domain (ZKD) of Lin28 to RNA substrates, and inhibits Lin28a and Lin28b. LIN28-IN-2 inhibits the proliferation of Lin28-positive cancer cell and spheroid growth .
    LIN28-IN-2
  • HY-168346
    TS-002455

    		DNA Methyltransferase DNA/RNA Synthesis Cancer
    TS-002455 (Example 668) is an inhibitor for Lin28a-dep Z11 with an IC50 < 1 μM. TS-002455 is the enantiomer of TS-002266 (HY-169091) .
    TS-002455

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