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LIM Kinase (LIMK)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	LIM Kinase (LIMK) (8) PKA (2) Reverse Transcriptase (1) ROCK (3)
By Research Areas:	Cancer (2) Endocrinology (2) Infection (1) Neurological Disease (2)

8

Inhibitors & Agonists

1

Peptides

2

Recombinant Proteins

3

Antibodies

Targets Recommended: LIM Kinase (LIMK)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

TH470	LIM Kinase (LIMK)	Neurological Disease
TH470 is a highly selective *LIMK1/2* (LIM *kinase1/2) inhibitor (LIMK1 IC₅₀=9.8 nM; LIMK2 IC₅₀*=13 nM), and can be used in orphan disease research .

LIMK-IN-1	LIM Kinase (LIMK) ROCK	Others
LIMK-IN-1 (Compound 14) is an inhibitor of **LIM-Kinase (LIMK), with IC₅₀*s of 0.5 nM and 0.9 nM for LIMK1 and LIMK2, respectively. LIMK*-IN-1 can be used for ocular hypertension and associated glaucoma research .

SR7826 1 Publications Verification	LIM Kinase (LIMK)	Neurological Disease Cancer
SR7826 is a class of bis-aryl urea derived potent, selective and orally active **LIM kinase (LIMK) inhibitor with an IC₅₀ of 43 nM for LIMK1. SR7826 is >100-fold more selective for LIMK1** than ROCK and JNK kinases .

LIMK1 inhibitor BMS-4	LIM Kinase (LIMK)	Cancer
LIMK1 inhibitor BMS-4 is a **LIM Kinase (LIMK)** inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells .

R-10015	LIM Kinase (LIMK) Reverse Transcriptase	Infection
R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of **LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC₅₀** of 38 nM for human LIMK1 .

LX7101 2 Publications Verification	LIM Kinase (LIMK) ROCK PKA	Endocrinology
LX7101 is a potent *LIM-kinase, ROCK* and PKA inhibitor with IC₅₀s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 proves significantly selective for LIMK2 with IC₅₀ values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 has the potential for ocular hypertension and associated glaucoma research .

S3 Fragment	LIM Kinase (LIMK)	Others
S3 Fragment is a biological active peptide. (This peptide contains the unique amino-terminal phosphorylation site of Xenopus ADF/cofilin, the LIM kinase (LIMK) phosphorylation site. LIMK1 is a key regulator of the actin cytoskeleton through its phosphorylation of ADF/cofilin at serine-3 for inactivation. This peptide is a fragment of the S3 peptide containing the serine-3 sequence of ADF/cofilin that has been widely used as an effective competitive inhibitor of LIMK1.)

LX7101 monohydrochloride	LIM Kinase (LIMK) ROCK PKA	Endocrinology
LX7101 monohydrochloride is a potent *LIM-kinase, ROCK* and PKA inhibitor with IC₅₀s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 monohydrochloride proves significantly selective for LIMK2 with IC₅₀ values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 monohydrochloride has the potential for ocular hypertension and associated glaucoma research .

Cat. No.	Product Name	Target	Research Area

S3 Fragment	LIM Kinase (LIMK)	Others
S3 Fragment is a biological active peptide. (This peptide contains the unique amino-terminal phosphorylation site of Xenopus ADF/cofilin, the LIM kinase (LIMK) phosphorylation site. LIMK1 is a key regulator of the actin cytoskeleton through its phosphorylation of ADF/cofilin at serine-3 for inactivation. This peptide is a fragment of the S3 peptide containing the serine-3 sequence of ADF/cofilin that has been widely used as an effective competitive inhibitor of LIMK1.)

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

	LIMK1 Protein, Human (D460N, sf9) LIMK1; LIM domain Kinase 1; LIMK-1	Human	Sf9 insect cells
	The LIMK1 protein is an important serine/threonine protein kinase that controls actin dynamics downstream of Rho GTPases. Activation of ROCK1, PAK1, and PAK4 phosphorylates LIMK1, allowing it to phosphorylate and inhibit actin depolymerizing factors, including cofilin-1/CFL1 and destrin/DSTN. LIMK1 Protein, Human (D460N, sf9) is the recombinant human-derived LIMK1 protein, expressed by sf9 insect cells , with tag free.

	LIMK1 Protein, Human (D460N, sf9, His) LIMK1; LIM domain Kinase 1; LIMK-1	Human	Sf9 insect cells
	The LIMK1 protein is an important serine/threonine protein kinase that controls actin dynamics downstream of Rho GTPases. Activation of ROCK1, PAK1, and PAK4 phosphorylates LIMK1, allowing it to phosphorylate and inhibit actin depolymerizing factors, including cofilin-1/CFL1 and destrin/DSTN. LIMK1 Protein, Human (D460N, sf9, His) is the recombinant human-derived LIMK1 protein, expressed by sf9 insect cells , with N-8*His labeled tag.

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	LIM Kinase 1 Antibody (YA1686) LIMK1; LIMK; LIM domain Kinase 1; LIMK-1	WB	Human, Mouse
	LIM Kinase 1 Antibody (YA1686) is a non-conjugated IgG antibody, targeting LIM Kinase 1, with a predicted molecular weight of 73 kDa (observed band size: 73 kDa). LIM Kinase 1 Antibody (YA1686) can be used for WB experiment in human, mouse background.

	LIMK2 Antibody (YA6637) LIM domain Kinase 2 antibody; LIM Kinase 2 antibody; LIMK 2 antibody; LIMK-2 antibody; LIMk2 antibody; LIMK2_HUMAN antibody	WB, ICC/IF, IHC-P, IP	Human, Mouse, Rat, Monkey

	LIMK-1/2 Antibody (YA5556) LIM domain Kinase 1; LIMK-1;	WB, ICC/IF, ELISA	Human, Mouse, Rat
	LIMK-1/2 Antibody (YA5556) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LIMK-1/2. It can be applicated for WB, ICC/IF, ELISA assays, in the background of human, mouse, rat.

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