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L-leucine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (18) Aminopeptidase (1) Autophagy (1) Biochemical Assay Reagents (6) Drug Intermediate (1) Endogenous Metabolite (36) Fluorescent Dye (1) Isotope-Labeled Compounds (10) mTOR (17) Prolyl Endopeptidase (PREP) (1) Proteasome (6) Reference Standards (5) SOD (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (3) Metabolic Disease (32) Neurological Disease (8)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
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Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: MELK LRRK2

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0486

*L-Leucine* Maximum Cited Publications 9 Publications Verification leucine	mTOR Endogenous Metabolite	Metabolic Disease Cancer
L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486R

L-Leucine (Standard) leucine (Standard)	Reference Standards mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine (Standard) is the analytical standard of L-Leucine. This product is intended for research and analytical applications. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-W002303

L-Leucine benzyl ester p-toluenesulfonate	Amino Acid Derivatives	Others
L-Leucine benzyl ester p-toluenesulfonate is a leucine derivative .

HY-N0486S

L-Leucine-d10	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-d₁₀ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S12

L-Leucine-d2	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-d₂ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S9

L-Leucine-d3	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-d₃ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-137946

L-Leucine 4-methoxy-β-naphthylamide hydrochloride	Aminopeptidase	Others
L-Leucine 4-methoxy-β-naphthylamide hydrochloride is an aminopeptidase M and leucine aminopeptidase substrate .

HY-W419440

H-Lys-Leu-OH L-leucine, L-lysyl-	Biochemical Assay Reagents	Others
H-Lys-Leu-OH (L-Leucine, L-lysyl-) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-N0486S11

L-Leucine-d1	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-d is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S4

L-Leucine-d7	Isotope-Labeled Compounds mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-d₇ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S1

L-Leucine-13C	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine- ¹³C is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S3

L-Leucine-15N	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine- ¹⁵N is the ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S10

L-Leucine-18O2	Isotope-Labeled Compounds mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine- ¹⁸O₂ is the ¹⁸O-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S5

L-Leucine-2-13C	Isotope-Labeled Compounds mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-2- ¹³C is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S2

L-Leucine-13C6	mTOR Endogenous Metabolite	Metabolic Disease
Leucine- ¹³C₆ is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S8

L-Leucine-13C6,15N	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine- ¹³C₆, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S6

L-Leucine-2-13C,15N	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-2- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S7

L-Leucine-1-13C,15N	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-1- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-W557739

L-Leucine-7-amido-4-methylcoumarin	Biochemical Assay Reagents	Others
L-Leucine-7-amido-4-methylcoumarin is a biochemical assay reagent.

HY-N0486S13

L-Leucine-15N,d10	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine- ¹⁵N,d₁₀ is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-137844

L-Leucine-7-amido-4-methylcoumarin hydrochloride Leu-AMC hydrochloride	Fluorescent Dye	Others
L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase). L-Leucine-7-amido-4-methylcoumarin hydrochloride can be used for leucine aminopeptidase inhibition assays in vitro .

HY-79415

4-Methyl-L-leucine L-leucine, 4-methyl- (9CI); L-2-Amino-4,4-dimethylpentanoic acid; L-γ-Methylleucine	Amino Acid Derivatives	Others
4-Methyl-L-leucine is a Glycine (HY-Y0966) derivative .

HY-79404

N-(Tert-Butoxycarbonyl)-L-neopentylglycine L-leucine, N-[(1,1-dimethylethoxy)carbonyl]-4-methyl- (9CI); (S)-2-(tert-Butoxycarbonylamino)-4,4-dimethylpentanoic acid	Amino Acid Derivatives	Others
N-(Tert-Butoxycarbonyl)-L-neopentylglycine is a Glycine (HY-Y0966) derivative .

HY-169826

N-Lithocholyl-L-Leucine	Biochemical Assay Reagents	Others
N-Lithocholyl-L-Leucine is a bile acid conjugate composed of Lithocholic acid (HY-B0172) and L-leucine (HY-N0486). N-Lithocholyl-L-Leucine can be used to form hydrogels .

HY-128434

L-Leucyl-L-alanine	Endogenous Metabolite	Metabolic Disease
L-Leucyl-L-alanine is a simple aliphatic dipeptide composed of L-leucine and L-alanine .

HY-113221

Isovalerylcarnitine	Proteasome Endogenous Metabolite	Metabolic Disease
Isovalerylcarnitine is a product of the catabolism of L-leucine. Isovalerylcarnitine is also a selective and reversible calpain activator that induces apoptosis .

HY-129905

*L-Leucyl-L-Leucine* methyl ester hydrochloride** 5+ Cited Publications LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride	Endogenous Metabolite	Inflammation/Immunology
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress .

HY-113221R

Isovalerylcarnitine (Standard)	Reference Standards Proteasome Endogenous Metabolite	Metabolic Disease
Isovalerylcarnitine (Standard) is the analytical standard of Isovalerylcarnitine. This product is intended for research and analytical applications. Isovalerylcarnitine is a product of the catabolism of L-leucine. Isovalerylcarnitine is also a selective and reversible calpain activator that induces apoptosis .

HY-129905A

*L-Leucyl-L-Leucine* methyl ester hydrobromide** 5+ Cited Publications LLOMe hydrobromide; Leu-Leu methyl ester hydrobromide; H-Leu-Leu-OMe hydrobromide	Endogenous Metabolite	Inflammation/Immunology
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrobromide also can induce endolysosomal pathway stress .

HY-122811

Dansyl-L-leucine Dansyl-L-leucine	Amino Acid Derivatives	Others
Dansyl-L-leucine is a leucine derivative .

HY-W016077

Glycyl-L-leucine	Endogenous Metabolite	Others
Glycyl-l-leucine is a dipeptide that can be a common substrate for glycyl-leucine dipeptidase.

HY-W046352

(Cyclohexanecarbonyl)-L-leucine	Amino Acid Derivatives	Others
(Cyclohexanecarbonyl)-L-leucine is a leucine derivative .

HY-W068839

L-Phenylalanyl-L-leucine	Amino Acid Derivatives	Others
L-Phenylalanyl-L-leucine is a leucine derivative .

HY-W009686

L-Prolyl-L-leucine	Amino Acid Derivatives	Others
L-Prolyl-L-leucine is a leucine derivative .

HY-W016077R

*Glycyl-L-leucine* (Standard)**	Reference Standards Endogenous Metabolite	Others
Glycyl-L-leucine (Standard) is the analytical standard of Glycyl-L-leucine. This product is intended for research and analytical applications. Glycyl-l-leucine is a dipeptide that can be a common substrate for glycyl-leucine dipeptidase.

HY-W142035

N-Benzoyl-L-leucine	Amino Acid Derivatives	Others
N-Benzoyl-L-leucine is a leucine derivative .

HY-Y0555

N-[(Phenylmethoxy)carbonyl]-L-leucine	Amino Acid Derivatives	Others
N-[(Phenylmethoxy)carbonyl]-L-leucine is a leucine derivative .

HY-W101499

L-a-Aspartyl-L-leucine	Biochemical Assay Reagents	Others
L-a-Aspartyl-L-leucine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-59291

Levacetylleucine N-Acetyl-L-leucine	Amino Acid Derivatives	Neurological Disease Metabolic Disease Inflammation/Immunology
Levacetylleucine (N-acetyl-L-leucine), an orally bioavailable and brain-penetrant compound, is an acetylated derivative of amino acid Leucine. Levacetylleucine is the active form of N-acetyl-leucine (NAL). Levacetylleucine attenuates neuronal death and neuroinflammation in the cortical tissue of mice. Levacetylleucine also potentially improves ameliorates lysosomal and metabolic dysfunction. Levacetylleucine improves compensation of postural symptoms after unilateral chemical labyrinthectomy (UL) in rats. Levacetylleucine is promising for research of neurological manifestations of Niemann-Pick disease type C, traumatic brain injury and neurodegeneration prevention .

HY-N14218

Eurystatin A	Prolyl Endopeptidase (PREP)	Neurological Disease
Eurystatin A is a prolyl endopeptidase inhibitor, L-Leucine and L-Ornithine are the direct precursors of the L-Leucine and L-Ornithine moieties of eurystatins A .

HY-W101495

Boc-Leu-OH hydrate N-Boc-L-leucine monohydrate	Amino Acid Derivatives	Others
Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is an amino acid derivative with a Boc protecting group, which can be used to synthesize L-prolyl-L-leucyl-glycinamide peptide, a peptide mimetic with dopamine receptor modulatory activity .

HY-W008642

Leu-Leu-OH L-Leucyl-L-leucine	Amino Acid Derivatives	Metabolic Disease
Leu-Leu-OH (L-Leucyl-L-leucine), a Leu derivative, is a neutral dipeptide that can be used to study the functionality of dileucine motifs .

HY-W037451

Methyl L-leucinate	Amino Acid Derivatives	Others
Methyl L-leucinate, methyl ester of L-leucine, is an alpha-amino acid ester. Methyl L-leucinate is a derivative of methyl ester and L-leucine, a class of compounds containing both amino and carboxyl groups in the molecule .

HY-W040088

L-Alanyl-L-leucine H-Ala-Leu-OH	Endogenous Metabolite	Metabolic Disease
L-Alanyl-L-leucine is an endogenous metabolite.

HY-43459

(4-(Thiazol-2-ylcarbamoyl)piperidine-1-carbonyl)-L-leucine	Amino Acid Derivatives	Others
(4-(Thiazol-2-ylcarbamoyl)piperidine-1-carbonyl)-L-leucine is a leucine derivative .

HY-78008

N-[(1,1-Dimethylethoxy)carbonyl]-L-leucyl-L-leucine	Amino Acid Derivatives	Others
N-[(1,1-Dimethylethoxy)carbonyl]-L-leucyl-L-leucine is a leucine derivative .

HY-Y0378

D-Leucine (R)-leucine	Endogenous Metabolite	Neurological Disease
D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro .

HY-W340583S

*(2-(1H-indol-3-yl)acetyl)-L-leucine-d4*	Isotope-Labeled Compounds	Others
(2-(1H-indol-3-yl)acetyl)-L-leucine-d₄ is deuterium labeled (2-(1H-indol-3-yl)acetyl)-L-leucine .

HY-Y0378S

*D-Leucine-d10* (R)-leucine-d₁₀	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease
D-Leucine-d₁₀ is the deuterium labeled D-Leucine. D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro .

HY-W012708

3-Amino-4-methylpentanoic acid	Endogenous Metabolite	Others
3-Amino-4-methylpentanoic acid is a β amino acid and positional isomer of L-leucine which is naturally produced in humans via the metabolism of L-leucine by the enzyme leucine 2,3-aminomutase. 3-Amino-4-methylpentanoic acid is also a metabolite produced by Torulaspora delbrueckii and can be used in the research of wine fermentation .

Cat. No.	Product Name	Type

HY-137844

L-Leucine-7-amido-4-methylcoumarin hydrochloride Leu-AMC hydrochloride	Fluorescent Dyes/Probes
L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase). L-Leucine-7-amido-4-methylcoumarin hydrochloride can be used for leucine aminopeptidase inhibition assays in vitro .

Cat. No.	Product Name	Type

HY-W002291

p-Fluoro-L-phenylalanine 4-Fluoro-L-phenylalanine	Biochemical Assay Reagents
p-Fluoro-L-phenylalanine (4-Fluoro-L-phenylalanine) is a substrate for tyrosine hydroxylase (TH) that can be used to study the regulation of that enzyme. p-Fluoro-L-phenylalanine binds to the L-leucine specific receptor of Escherichia coli (K_D=0.26 μM) .

HY-137872

L-Leucyl-4-nitroanilide hydrochloride

Enzyme Substrates

L-Leucyl-4-nitroanilide hydrochloride is a commonly used substrate in various biochemical assays to measure the activity of enzymes that cleave peptide bonds, such as proteases. L-Leucine p-nitroanilide hydrochloride has unique chemical properties that allow it to be cleaved by these enzymes to form a yellow product called p-nitroaniline. This makes it a useful tool for detecting and quantifying protease activity in biological samples such as blood or tissue extracts.

HY-W557739

L-Leucine-7-amido-4-methylcoumarin	Enzyme Substrates
L-Leucine-7-amido-4-methylcoumarin is a biochemical assay reagent.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0486

*L-Leucine* Maximum Cited Publications 9 Publications Verification leucine	Structural Classification Source classification Metabolic Disease Amino acids Endogenous metabolite	mTOR Endogenous Metabolite
L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486R

L-Leucine (Standard) leucine (Standard)	Structural Classification Zea mays L. Source classification Endocrine diseases Amino acids Plants Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Gramineae Disease markers Nervous System Disorder Cardiovascular System Disorder	Reference Standards mTOR Endogenous Metabolite
L-Leucine (Standard) is the analytical standard of L-Leucine. This product is intended for research and analytical applications. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-128434

L-Leucyl-L-alanine	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Leucyl-L-alanine is a simple aliphatic dipeptide composed of L-leucine and L-alanine .

HY-113221

Isovalerylcarnitine	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Proteasome Endogenous Metabolite
Isovalerylcarnitine is a product of the catabolism of L-leucine. Isovalerylcarnitine is also a selective and reversible calpain activator that induces apoptosis .

HY-129905

*L-Leucyl-L-Leucine* methyl ester hydrochloride** 5+ Cited Publications LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress .

HY-129905A

*L-Leucyl-L-Leucine* methyl ester hydrobromide** 5+ Cited Publications LLOMe hydrobromide; Leu-Leu methyl ester hydrobromide; H-Leu-Leu-OMe hydrobromide	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrobromide also can induce endolysosomal pathway stress .

HY-W016077

Glycyl-L-leucine	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Glycyl-l-leucine is a dipeptide that can be a common substrate for glycyl-leucine dipeptidase.

HY-59291

Levacetylleucine N-Acetyl-L-leucine	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Amino Acid Derivatives
Levacetylleucine (N-acetyl-L-leucine), an orally bioavailable and brain-penetrant compound, is an acetylated derivative of amino acid Leucine. Levacetylleucine is the active form of N-acetyl-leucine (NAL). Levacetylleucine attenuates neuronal death and neuroinflammation in the cortical tissue of mice. Levacetylleucine also potentially improves ameliorates lysosomal and metabolic dysfunction. Levacetylleucine improves compensation of postural symptoms after unilateral chemical labyrinthectomy (UL) in rats. Levacetylleucine is promising for research of neurological manifestations of Niemann-Pick disease type C, traumatic brain injury and neurodegeneration prevention .

HY-113221R

Isovalerylcarnitine (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Proteasome Endogenous Metabolite
Isovalerylcarnitine (Standard) is the analytical standard of Isovalerylcarnitine. This product is intended for research and analytical applications. Isovalerylcarnitine is a product of the catabolism of L-leucine. Isovalerylcarnitine is also a selective and reversible calpain activator that induces apoptosis .

HY-W016077R

*Glycyl-L-leucine* (Standard)**	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite
Glycyl-L-leucine (Standard) is the analytical standard of Glycyl-L-leucine. This product is intended for research and analytical applications. Glycyl-l-leucine is a dipeptide that can be a common substrate for glycyl-leucine dipeptidase.

HY-N14218

Eurystatin A	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Prolyl Endopeptidase (PREP)
Eurystatin A is a prolyl endopeptidase inhibitor, L-Leucine and L-Ornithine are the direct precursors of the L-Leucine and L-Ornithine moieties of eurystatins A .

HY-W008642

Leu-Leu-OH L-Leucyl-L-leucine	Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Amino Acid Derivatives
Leu-Leu-OH (L-Leucyl-L-leucine), a Leu derivative, is a neutral dipeptide that can be used to study the functionality of dileucine motifs .

HY-W040088

L-Alanyl-L-leucine H-Ala-Leu-OH	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Alanyl-L-leucine is an endogenous metabolite.

HY-Y0378

D-Leucine (R)-leucine	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro .

HY-W012708

3-Amino-4-methylpentanoic acid	Structural Classification Classification of Application Fields Source classification Other Diseases Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
3-Amino-4-methylpentanoic acid is a β amino acid and positional isomer of L-leucine which is naturally produced in humans via the metabolism of L-leucine by the enzyme leucine 2,3-aminomutase. 3-Amino-4-methylpentanoic acid is also a metabolite produced by Torulaspora delbrueckii and can be used in the research of wine fermentation .

HY-145542

Isovalerylcarnitine chloride	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Proteasome Endogenous Metabolite
Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca ²⁺-dependent proteinase (calpain) of human neutrophils .

HY-Y0378R

*D-Leucine* (Standard)** (R)-leucine (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite
D-Leucine (Standard) is the analytical standard of D-Leucine. This product is intended for research and analytical applications. D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro .

HY-145542R

Isovalerylcarnitine chloride (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Proteasome Endogenous Metabolite
Isovalerylcarnitine (chloride) (Standard) is the analytical standard of Isovalerylcarnitine (chloride). This product is intended for research and analytical applications. Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca2+-dependent proteinase (calpain) of human neutrophils .

HY-128434R

L-Leucyl-L-alanine (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite
L-Leucyl-L-alanine (Standard) is the analytical standard of L-Leucyl-L-alanine (HY-128434). This product is intended for research and analytical applications. L-Leucyl-L-alanine is a simple aliphatic dipeptide composed of L-leucine and L-alanine .

HY-W012722

4-Methyl-2-oxopentanoic acid 1 Publications Verification α-Ketoisocaproic acid	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Endogenous metabolite	Endogenous Metabolite Autophagy mTOR SOD
4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid) is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways. 4-Methyl-2-oxopentanoic acid also causes oxidative damage, leading to cognitive deficits, inhibits α-ketoglutarate dehydrogenase activity, acts as an oxidative phosphorylation uncoupler and metabolic inhibitor. 4-Methyl-2-oxopentanoic acid acts as a nutrient signal and stimulates skeletal muscle protein synthesis. 4-Methyl-2-oxopentanoic acid can be used in the study of maple syrup urine disease .

Cat. No.	Product Name	Chemical Structure

HY-N0486S

L-Leucine-d10
L-Leucine-d₁₀ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S12

L-Leucine-d2
L-Leucine-d₂ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S9

L-Leucine-d3
L-Leucine-d₃ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S1

L-Leucine-13C
L-Leucine- ¹³C is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S3

L-Leucine-15N
L-Leucine- ¹⁵N is the ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S2

L-Leucine-13C6
Leucine- ¹³C₆ is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S11

L-Leucine-d1
L-Leucine-d is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S4

L-Leucine-d7
L-Leucine-d₇ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S10

L-Leucine-18O2
L-Leucine- ¹⁸O₂ is the ¹⁸O-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S5

L-Leucine-2-13C
L-Leucine-2- ¹³C is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S8

L-Leucine-13C6,15N
L-Leucine- ¹³C₆, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S6

L-Leucine-2-13C,15N
L-Leucine-2- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S7

L-Leucine-1-13C,15N
L-Leucine-1- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S13

L-Leucine-15N,d10
L-Leucine- ¹⁵N,d₁₀ is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-W340583S

*(2-(1H-indol-3-yl)acetyl)-L-leucine-d4*
(2-(1H-indol-3-yl)acetyl)-L-leucine-d₄ is deuterium labeled (2-(1H-indol-3-yl)acetyl)-L-leucine .

HY-Y0378S

*D-Leucine-d10*
D-Leucine-d₁₀ is the deuterium labeled D-Leucine. D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro .

HY-W654243

Isovalerylcarnitine-d9-1 chloride
Isovalerylcarnitine-d₉-1 (chloride) is deuterium labeled Isovalerylcarnitine (chloride). Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca ²⁺-dependent proteinase (calpain) of human neutrophils .

HY-145542S

Isovalerylcarnitine-d9 chloride
Isovalerylcarnitine-d₉ (chloride) is the deuterium labeled Isovalerylcarnitine (chloride) . Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca2+-dependent proteinase (calpain) of human neutrophils .

HY-W269700S

Ile-(Leu-13C6,15N)-OH TFA
Ile-(Leu-13C6,15N)-OH (TFA) is ¹³C- and ¹⁵N-labeled L-Isoleucyl-L-leucine (HY-W269700). L-Isoleucyl-L-leucine has a role as a metabolite and can be used to inhibit movement-induced muscle damage and muscle defective condition.

HY-W008642S

(Leu-13C6,15N)-Leu-OH TFA
(Leu-13C6,15N)-Leu-OH TFA is a C13 and N15 labeled Leu-Leu-OH TFA. Leu-Leu-OH, a Leu derivative, is a dipeptide .

HY-W700927

*N-Formyl-L-leucine-d3*
N-Formyl-L-leucine-d₃ (N-Formyl-S-leucine-d₃) is deuterium labeled N-Formyl-L-leucine. N-Formyl-L-leucine is a leucine derivative .

HY-W012722BS

4-Methyl-2-oxopentanoic acid-d7 sodium

4-Methyl-2-oxopentanoic acid-d₇ (α-Ketoisocaproic acid-d₇) sodium is the deuterium labeled 4-Methyl-2-oxopentanoic acid (HY-W012722).4-Methyl-2-oxopentanoic acid is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways .

Cat. No.	Product Name		Classification

HY-N0486

*L-Leucine* 5+ Cited Publications leucine		Others
L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

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