Isovalerylcarnitine-d₉-1 chloride

Cat. No.: HY-W654243: Data Sheet Handling Instructions
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Isovalerylcarnitine-d₉-1 (chloride) is deuterium labeled Isovalerylcarnitine (chloride). Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca²⁺-dependent proteinase (calpain) of human neutrophils.

For research use only. We do not sell to patients.

Isovalerylcarnitine-d<sub>9</sub>-1 chloride Chemical Structure

Isovalerylcarnitine-d₉-1 chloride Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Other Forms of Isovalerylcarnitine-d₉-1 chloride:

Isovalerylcarnitine chloride In-stock

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

290.83

Formula

C₁₂H₁₅D₉ClNO₄

Unlabeled CAS

139144-12-0

SMILES

O=C(O[C@H](CC(O)=O)C[N+](C)(C)C)C([2H])(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])[2H].[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (343.84 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4384 mL	17.1922 mL	34.3843 mL
5 mM	0.6877 mL	3.4384 mL	6.8769 mL
10 mM	0.3438 mL	1.7192 mL	3.4384 mL

View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

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Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Pontremoli S, et al. Isovalerylcarnitine is a specific activator of calpain of human neutrophils. Biochem Biophys Res Commun. 1987 Nov 13;148(3):1189-95. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4384 mL	17.1922 mL	34.3843 mL	85.9609 mL
	5 mM	0.6877 mL	3.4384 mL	6.8769 mL	17.1922 mL
	10 mM	0.3438 mL	1.7192 mL	3.4384 mL	8.5961 mL
	15 mM	0.2292 mL	1.1461 mL	2.2923 mL	5.7307 mL
	20 mM	0.1719 mL	0.8596 mL	1.7192 mL	4.2980 mL
	25 mM	0.1375 mL	0.6877 mL	1.3754 mL	3.4384 mL
	30 mM	0.1146 mL	0.5731 mL	1.1461 mL	2.8654 mL
	40 mM	0.0860 mL	0.4298 mL	0.8596 mL	2.1490 mL
	50 mM	0.0688 mL	0.3438 mL	0.6877 mL	1.7192 mL
	60 mM	0.0573 mL	0.2865 mL	0.5731 mL	1.4327 mL
	80 mM	0.0430 mL	0.2149 mL	0.4298 mL	1.0745 mL
	100 mM	0.0344 mL	0.1719 mL	0.3438 mL	0.8596 mL