HI | MedChemExpress (MCE) Life Science Reagents

By Targets:	Apoptosis (2) FLT3 (1) Fluorescent Dye (1) Histamine Receptor (1) HIV (3) Indoleamine 2,3-Dioxygenase (IDO) (1) Interleukin Related (1) Isotope-Labeled Compounds (2) Lipase (1) Microtubule/Tubulin (1) nAChR (2) Reverse Transcriptase (2) Small Interfering RNA (siRNA) (2) Somatostatin Receptor (1) TOPK (1)
By Research Areas:	Cancer (3) Infection (2) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (2)
Oligonucleotides:	Human Pre-designed siRNA Sets (2) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-106901A

Asoxime dichloride HI-6	nAChR	Neurological Disease
Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride involves in modulating immunity response. Asoxime dichloride (HI-6) can be used as an antigen and improves vaccination efficacy in the nervous system .

HY-101550

HI-TOPK-032 3 Publications Verification	TOPK	Cancer
HI-TOPK-032 is a potent and specific TOPK inhibitor.

HY-153523

Hi 76-0079 NNC0076-0079; 76-0079	Lipase	Metabolic Disease
Hi 76-0079 (NNC0076-0079; 76-0079) is a lipase inhibitor that specifically targets hormone-sensitive lipase (HSL). Hi 76-0079 inhibits PNPB Hydrolysis in cell lysates of HEK293A cells overexpressing Lipe with an IC₅₀ value of 0.1 μM. Hi 76-0079 synergizes with the ATGL inhibitor Atglistatin (HY-15859) to block lipolysis in vitro. Hi 76-0079 can be used for the study of lipid metabolism .

HY-106901AS

Asoxime-d4 dichloride HI-6-d₄	Isotope-Labeled Compounds nAChR	Neurological Disease
Asoxime-d₄ (dichloride) is the deuterium labeled Asoxime dichloride. Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride involves in modulating immunity response. Asoxime dichloride (HI-6) can be used as an antigen and improves vaccination efficacy in the nervous system .

HY-105386

HI-280	HIV Reverse Transcriptase	Infection
HI-280 is a human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitor. HI-280 can be used for the research of infection .

HY-121611

HI-236	HIV	Inflammation/Immunology
HI-236 is a potent non-nucleoside inhibitor of HIV-1 reverse transcriptase.? HI-236 inhibits HIV activity (wild type HTLV_IIB IC₅₀p24 < 0.001 μM) .

HY-146261

HI5	Microtubule/Tubulin Indoleamine 2,3-Dioxygenase (IDO) Apoptosis	Cancer
HI5 is a potent tublin and IDO inhibitor, with an IC₅₀ value of 70 nM in HeLa cells. HI5 inhibit IDO expression and decrease kynurenine production, leading to stimulating T cells activation and proliferation. HI5 can inhibit tubulin polymerization and cell migration, cause G2/M phase arrest, and induce apoptosis via the mitochondrial dependent apoptosis pathway and cause reactive oxidative stress generation in HeLa cells. HI5 can be used for researching anticancer .

HY-126900

HI-253	HIV Reverse Transcriptase	Others
HI-253 is a non-nucleoside inhibitor of HIV-1 reverse transcriptase that has demonstrated greater activity than multiple anti-HIV compounds against both resistant and sensitive HIV-1 strains.

HY-175473

HI042	FLT3 Apoptosis	Cancer
HI042 is a FMS-like Tyrosine Kinase 3 (FLT3) inhibitor. HI042 shows IC₅₀ values of 0.62 μM for MOLM-13, 0.33 μM for MV4-11, and 0.89 μM for OCI-AML3 cells. HI042 selectively reduces the viability of FLT3-internal tandem duplication (FLT3-\|TD) mutations-positive cell lines, induces apoptosis, disrupts cell cycle progression, and diminishes the clonogenic potential. HI042 can be used for the research of acute myeloid leukemia (AML) .

HY-150669S

HI-P224-d6 hydrochloride	Isotope-Labeled Compounds	Others
HI-P224-d₆ (hydrochloride) is the deuterium labeled HI-P224 hydrochloride .

HY-119832

Setastine EGIS-2062 free acid; EGYT-2062 free acid	Histamine Receptor	Inflammation/Immunology
Setastine (EGIS-2062 (free acid); EGYT-2062 (free acid) is an orally effective, non-sedative and long acting anti-allergic agent. Setastine possesses potent histamine Hi-receptor blocking properties and can be used for allergies and rhinitis research ^[1]<.

HY-164040

Zavolosotine	Somatostatin Receptor	Metabolic Disease
Zavolosotine (Compound 1) is an orally active agonist for somatostatin receptor type 5 (SST5) with EC₅₀ <1 nM. Zavolosotine inhibits insulin and glucagon secretion, increases levels of glucagon in blood in rat model .

HY-P99140

Anti-Mouse IL-1R Antibody (JAMA-147)	Interleukin Related	Infection Metabolic Disease Inflammation/Immunology
Anti-Mouse IL-1R Antibody (JAMA-147) is an anti-mouse IL-1R IgG2b antibody inhibitor derived from host Armenian Hamster. Anti-Mouse IL-1R Antibody (JAMA-147) diminishes Spp1hi-TAM-mediated T cell suppression. Anti-Mouse IL-1R Antibody (JAMA-147) can be used for the researches of inflammation, metabolic disease and infection, such as diabetes .

HY-RS00519

AKAP4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AKAP4 Human Pre-designed siRNA Set A contains three designed siRNAs for AKAP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AKAP4 Human Pre-designed siRNA Set A AKAP4 Human Pre-designed siRNA Set A

HY-D0219

Thymol blue Thymolsulphonephthalein	Fluorescent Dye	Others
Thymol blue is a reversible pH indicator that responds to the pH of the solution through structural changes of protonation and deprotonation. Thymol blue is red (HI ^- form) under acidic conditions and blue (I ^2- form) under alkaline conditions. Quantitative detection is achieved through the absorption peak shift (435 nm/596 nm) of the UV-visible spectrum. Thymol blue selectively responds to pH changes, changing from red to yellow at pH 1.2-2.8 and from yellow to blue at pH 8.0-9.6. Thymol blue can be fixed in a silica gel matrix through sol-gel technology to form a solid-state sensor for in-situ pH measurement in the marine environment and acid-base monitoring in the biomedical field[1][2].

HY-RS00066

ABCC8 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ABCC8 Human Pre-designed siRNA Set A contains three designed siRNAs for ABCC8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ABCC8 Human Pre-designed siRNA Set A ABCC8 Human Pre-designed siRNA Set A

Cat. No.	Product Name	Type

HY-D0219

Thymol blue Thymolsulphonephthalein	Fluorescent Dyes/Probes
Thymol blue is a reversible pH indicator that responds to the pH of the solution through structural changes of protonation and deprotonation. Thymol blue is red (HI ^- form) under acidic conditions and blue (I ^2- form) under alkaline conditions. Quantitative detection is achieved through the absorption peak shift (435 nm/596 nm) of the UV-visible spectrum. Thymol blue selectively responds to pH changes, changing from red to yellow at pH 1.2-2.8 and from yellow to blue at pH 8.0-9.6. Thymol blue can be fixed in a silica gel matrix through sol-gel technology to form a solid-state sensor for in-situ pH measurement in the marine environment and acid-base monitoring in the biomedical field[1][2].

Thymol blue

Thymolsulphonephthalein

Fluorescent Dyes/Probes

Thymol blue is a reversible pH indicator that responds to the pH of the solution through structural changes of protonation and deprotonation. Thymol blue is red (HI ^- form) under acidic conditions and blue (I ^2- form) under alkaline conditions. Quantitative detection is achieved through the absorption peak shift (435 nm/596 nm) of the UV-visible spectrum. Thymol blue selectively responds to pH changes, changing from red to yellow at pH 1.2-2.8 and from yellow to blue at pH 8.0-9.6. Thymol blue can be fixed in a silica gel matrix through sol-gel technology to form a solid-state sensor for in-situ pH measurement in the marine environment and acid-base monitoring in the biomedical field[1][2].

Cat. No.	Product Name	Target	Research Area

HY-P99140

Anti-Mouse IL-1R Antibody (JAMA-147)	Interleukin Related	Infection Metabolic Disease Inflammation/Immunology
Anti-Mouse IL-1R Antibody (JAMA-147) is an anti-mouse IL-1R IgG2b antibody inhibitor derived from host Armenian Hamster. Anti-Mouse IL-1R Antibody (JAMA-147) diminishes Spp1hi-TAM-mediated T cell suppression. Anti-Mouse IL-1R Antibody (JAMA-147) can be used for the researches of inflammation, metabolic disease and infection, such as diabetes .

Cat. No.	Product Name	Chemical Structure

HY-106901AS

Asoxime-d4 dichloride
Asoxime-d₄ (dichloride) is the deuterium labeled Asoxime dichloride. Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride involves in modulating immunity response. Asoxime dichloride (HI-6) can be used as an antigen and improves vaccination efficacy in the nervous system .

HY-150669S

HI-P224-d6 hydrochloride
HI-P224-d₆ (hydrochloride) is the deuterium labeled HI-P224 hydrochloride .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82189

	SESN2 Antibody (YA1934) HI95; SES2; SEST2	WB, ICC/IF, IP	Human, Mouse, Rat
	SESN2 Antibody (YA1934) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SESN2.

HY-P80874

	PRMT1 Antibody (YA686) ANM 1; ANM1; ANM1_HUMAN; complete cds; HCP 1; HCP1; Heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2; Heterogeneous nuclear ribonucleoproteins methyltransferase like 2; Heterogeneous nuclear ribonucleoproteins methyltransferase like2; HI	WB	Human
	PRMT1 Antibody (YA686) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PRMT1.

HY-P86301

	SESN2 Antibody (YA5993) Sestrin-2; HI95;	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	SESN2 Antibody (YA5993) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SESN2.

HY-P83624

	AMBP Antibody (YA3369) A1M; alpha 1 microglobulin bikunin; Alpha 1 microglycoprotein; AMBP; Bikunin; EDC1; HI30	WB, IHC-P	Human
	AMBP Antibody (YA3369) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AMBP.

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Cat. No.	Product Name		Classification

HY-RS00519

AKAP4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
AKAP4 Human Pre-designed siRNA Set A contains three designed siRNAs for AKAP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00066

ABCC8 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ABCC8 Human Pre-designed siRNA Set A contains three designed siRNAs for ABCC8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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HI

Inhibitors & Agonists

Fluorescent Dye

Inhibitory Antibodies

Isotope-Labeled Compounds

Antibodies

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