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Ganglioside GM1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (3) Endogenous Metabolite (3) Isotope-Labeled Compounds (3) Trk Receptor (1)
By Research Areas:	Cancer (1) Infection (1) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (4)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N10546

**Ganglioside GM1**	Others	Neurological Disease
Ganglioside GM1 is a member of the ganglioside family that can be used for neurological disease research. Ganglioside GM1 is a functional tissue receptor for the Cholera Toxin1 .

HY-146876S

*C18:0 GM1* Ganglioside-d5 ammonium**	Isotope-Labeled Compounds	Others
C18:0 GM1 Ganglioside-d₅ (ammonium) is deuterium labeled C18:0 GM1 Ganglioside (ammonium).

HY-171936

Ganglioside GM1 ammonium GM1 (d18:1/C18:0) ammonium; C18 Ganglioside GM1 (d18:1/18:0) ammonium	Endogenous Metabolite	Neurological Disease
Ganglioside GM1 (ammonium) is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue. Ganglioside GM1 (ammonium) is one of the most abundant gangliosides in the brain which provides neuroprotection. Ganglioside GM1 (ammonium) exhibits anti-inflammatory property. Ganglioside GM1 (ammonium) has a well-balanced amphiphilic behavior. Ganglioside GM1 (ammonium) can reduce the fluidity of the plasma membrane that implies a retention and enrichment of the ganglioside in specific membrane domains that are called lipid rafts. Ganglioside GM1 (ammonium) can modify the process of differentiation, amplifies responses to neurotrophic factors, protects against excitatory amino acid-related neurotoxicity. Ganglioside GM1 (ammonium) can alleviate acute nerve cell damage through blocking cytotoxicity and potentiating neurotophic factors. Ganglioside GM1 (ammonium) can be studied in neurodegenerative diseases such as Alzheimer’s disease ^{[1] ^{^{[2] ^{^{[3] ^.}}}}}

HY-N10546A

Ganglioside GM1 (bovine) ammonium	Endogenous Metabolite	Neurological Disease
Ganglioside GM1 (bovine) ammonium is a member of the ganglioside family that can be used for neurological disease research. Ganglioside GM1 (bovine) ammonium is a functional tissue receptor for the Cholera Toxin1 .

HY-P10529

Ganglioside GM1-binding peptides p3	Trk Receptor	Infection
Ganglioside GM1-binding peptides p3 is a synthetic peptide that can specifically bind to the pentasaccharide part of *GM1* ganglioside. The dynamic transformation of Ganglioside GM1-binding peptides p3 may play an important role in the function of *GM1* as a multiple receptor, such as in the classical pathway of cholera toxin infection. Ganglioside GM1-binding peptides p3 can be used to study the interaction between *GM1* and its ligands .

HY-W714151

Ganglioside ga1 Gg4cer; AsialoGanglioside GM1; Asialo GM1, Gangliotetraosylceramide; Asialo Ganglioside GM1a [...]; Ganglio-n-tetraosylceramide; Asialo GM1 Ganglioside; AsialoGanglioside gt1b	Biochemical Assay Reagents	Metabolic Disease
Ganglioside ga1 (Gg4cer; Asialoganglioside gm1; Asialo gm1, Gangliotetraosylceramide; Asialo ganglioside gm1a [...]; Ganglio-n-tetraosylceramide; Asialo gm1 ganglioside; Asialoganglioside gt1b) is an ester product.

HY-N10511

GM1a Ganglioside oligosaccharide	Others	Inflammation/Immunology
GM1a Ganglioside oligosaccharide is a semisynthetic form of ganglioside GM1. Ganglioside GM1 is the natural receptor for cholera toxin and plays an important role not only in general growth regulation but also in the coupling of hormone-induced responses .

HY-171941A

*C24:1 Ganglioside* GM1 (d18:1/24:1) ammonium** C24:1-GM1 ammonium	Endogenous Metabolite	Neurological Disease
C24:1 Ganglioside GM1 (d18:1/24:1) (ammonium) is a monosialylated ganglioside that contains nervonic acid.

HY-165650S

*C16 Ganglioside* GM1-d9 (d18:1/16:0) ammonium** C16-GM1-d₉ ammonium; N-Hexadecaoyl-d₉ (13,13,14,14,15,15,16,16,16)-moosialogaglioside GM1 ammonium	Isotope-Labeled Compounds	Others
C16 Ganglioside GM1-d₉ (d₁₈:1/16:0) (C16 GM1-d₉) ammonium salt is deuterium labeled C16 Ganglioside GM1 (d18:1/16:0) (ammonium) .

HY-152000S

*C18 Ganglioside* GM1-d3 ammonium**	Isotope-Labeled Compounds	Others
C18 Ganglioside GM1-d₃ (ammonium) is deuterium labeled C18 Ganglioside GM1 (ammonium) .

HY-E70073

Ganglioside sialidase (AuSialidase M2) Sialidase isoenzyme M2; AuSialidase M2	Biochemical Assay Reagents	Others
Ganglioside sialidase (AuSialidase M2) from Arthrobacter ureafaciens. Ganglioside sialidase is a highly specific N-acetylneuraminidase. Ganglioside sialidase can hydrolyze the internal sialic acid of GM1 under optimal condition with sodium cholate .

HY-P3394

Cholera toxin B subunit, from vibrio cholerae CTB, from vibrio cholerae	Biochemical Assay Reagents	Others
Cholera toxin B subunit, from vibrio cholerae (CTB, from vibrio cholerae) is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. Cholera toxin B subunit, from vibrio cholerae attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. Cholera toxin B subunit, from vibrio cholerae has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Cholera toxin B subunit, from vibrio cholerae has been widely used as a marker of membrane lipid rafts .

Cat. No.	Product Name	Type

HY-P3394

Cholera toxin B subunit, from vibrio cholerae CTB, from vibrio cholerae	Native Proteins
Cholera toxin B subunit, from vibrio cholerae (CTB, from vibrio cholerae) is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. Cholera toxin B subunit, from vibrio cholerae attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. Cholera toxin B subunit, from vibrio cholerae has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Cholera toxin B subunit, from vibrio cholerae has been widely used as a marker of membrane lipid rafts .

Cholera toxin B subunit, from vibrio cholerae

CTB, from vibrio cholerae

Native Proteins

Cholera toxin B subunit, from vibrio cholerae (CTB, from vibrio cholerae) is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. Cholera toxin B subunit, from vibrio cholerae attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. Cholera toxin B subunit, from vibrio cholerae has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Cholera toxin B subunit, from vibrio cholerae has been widely used as a marker of membrane lipid rafts .

Cat. No.	Product Name	Target	Research Area

HY-P10529

Ganglioside GM1-binding peptides p3	Trk Receptor	Infection
Ganglioside GM1-binding peptides p3 is a synthetic peptide that can specifically bind to the pentasaccharide part of *GM1* ganglioside. The dynamic transformation of Ganglioside GM1-binding peptides p3 may play an important role in the function of *GM1* as a multiple receptor, such as in the classical pathway of cholera toxin infection. Ganglioside GM1-binding peptides p3 can be used to study the interaction between *GM1* and its ligands .

Cat. No.	Product Name	Target	Research Area

HY-P990902

Atigotatug BMS-986012	Inhibitory Antibodies	Inflammation/Immunology
HY-P990902 is an Fucosyl ganglioside GM1 (fuc-GM1)-targeting IgG1κ type humanized antibody. Atigotatug can induce immune-mediated tumor cell death, such as small cell lung cancer . The recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001)

HY-P990902A

Atigotatug (FUT8-KO) BMS-986012 (FUT8-KO)	Inhibitory Antibodies	Cancer
Atigotatug (FUT8-KO) is an anti-fuc-GM1 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out, and fucose deficiency enhances the ADCC effect of the antibody. Atigotatug (HY-P990902) is a Fucosyl ganglioside GM1 (fuc-GM1)-targeting IgG1κ type humanized antibody. Atigotatug can induce immune-mediated tumor cell death, such as small cell lung cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure