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Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent thymidylate synthase (TS) inhibitor with a Ki of 0.44 nM. Plevitrexed is taken up via the α-folatereceptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical . Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Idetrexed (ONX 0801) trisodium is a thymidylate synthase (TS) inhibitor with a Ki of 1.2 nM. Idetrexed trisodium can be specifically transported into α-folatereceptor (α-FR)-overexpressing tumors, such as ovarian cancer .
FRα-IN-1 (Compound 4) is a tumor-targeting agent. FRα-IN-1 shows selective anticancer activity towards folatereceptors (FRα and FRβ) expression cells .
PLLA10000-PEG2000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA10000-PEG2000-FOL can be used in drug delivery research .
PLLA20000-PEG2000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA20000-PEG2000-FOL can be used in drug delivery research .
PLLA20000-PEG5000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA20000-PEG5000-FOL can be used in drug delivery research .
PLLA5000-PEG2000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA5000-PEG2000-FOL can be used in drug delivery research .
PLLA10000-PEG5000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA10000-PEG5000-FOL can be used in drug delivery research .
PLLA5000-PEG5000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA5000-PEG5000-FOL can be used in drug delivery research .
FRα-targeting peptide C7 is a selective peptide ligand for folatereceptor α (FRα) that has specific binding to FRα expressing cells and in vivo tumor targeting ability. FRα-targeting peptide C7 can be used in the research of tumor diagnosis and treatment .
FRα-targeting peptide C7 TFA is a selective peptide ligand for folatereceptor α (FRα) that has specific binding to FRα expressing cells and in vivo tumor targeting ability. FRα-targeting peptide C7 TFA can be used in the research of tumor diagnosis and treatment .
Farletuzumab ecteribulin (MORAb-202) is an antibody-drug conjugate (ADC), consisting of the humanized anti-human folatereceptor alpha (FRA) antibody Farletuzumab (HY-P99153) conjugated via reduced interchain disulfide bonds to Mal-PEG2-Val-Cit-PAB-eribulin. Farletuzumab ecteribulin has a agent-to-antibody ratio of 4.0. Farletuzumab ecteribulin is highly cytotoxic to FRA-positive cells in vitro. Farletuzumab ecteribulin has potent antitumor activity.
DSPE-PEG-Folate (MW 3400) is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .
DSPE-PEG-Folate (MW 1000) is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .
DSPE-PEG-Folate (MW 5000) is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .
DSPE-PEG-Folate, MW 3350 is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .
Folate-FITC (EC-17) is a folatereceptor alpha (FRα) targeting contrast agent with fluorescent properties in the visible light spectrum. The Folate-FITC maximum excitation and emission wavelengths are 490 nm and 520 nm, respectively .
DSPE-PEG-Folate, MW 2000 is a PEG derivative containing folic acid. DSPE-PEG-Folate, MW 2000 has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate, MW 2000 form micelles/lipid bilayer and can be used to targeted drug delivery system research.
DSPE-PEG-Folate, MW 5000 is a PEG derivative containing folic acid. DSPE-PEG-Folate, MW 5000 has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate, MW 5000 form micelles/lipid bilayer and can be used to targeted drug delivery system research .
mPEG-FA (MW 1000) (mPEG-Folate (MW 1000)) is a polyethylene glycol derivative of Folic acid (HY-16637). Folic acid has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
mPEG-FA (MW 5000) (mPEG-Folate (MW 5000)) is a polyethylene glycol derivative of Folic acid (HY-16637). Folic acid has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
mPEG-FA (MW 2000) (mPEG-Folate (MW 2000)) is a polyethylene glycol derivative of Folic acid (HY-16637). Folic acid has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
EC1454 is a peptide compound with anticancer activity that targets folatereceptor-expressing cancers. EC1454 is a folate-tubulysin conjugate that can be used to prepare drug delivery conjugates for targeted therapy .
BOC-NH-PEG-FA (MW 3400) (BOC-NH-PEG-Folate (MW 3400)) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG-FA (MW 5000) (BOC-NH-PEG-Folate (MW 5000)) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG-FA (MW 2000) (BOC-NH-PEG-Folate (MW 2000)) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG-FA (MW 1000) (BOC-NH-PEG-Folate (MW 1000)) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG-FA (MW 400) (BOC-NH-PEG-Folate (MW 400)) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG-FA (MW 10000) (BOC-NH-PEG-Folate (MW 10000)) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG-FA (MW 600) (BOC-NH-PEG-Folate (MW 600)) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
mPEG-amine (MW 350) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
mPEG-amine (MW 750) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
mPEG-amine (MW 3400) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
mPEG-amine (MW 550) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
mPEG-amine (MW 4000) can be used to synthesize folate-conjugated polymer micelles for encapsulating anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
Mirvetuximab (M9346A) is an anti-FOLR1 (folatereceptor 1) monoclonal antibody. Mirvetuximab is the antibody moiety of folatereceptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research .
Mirvetuximab (M9346A) (powder) is an anti-FOLR1 (folatereceptor 1) monoclonal antibody. Mirvetuximab (powder) is the antibody moiety of folatereceptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research .
8-Arm-PEG-FA (MW 10000) (8-Arm-PEG-folate (MW 10000)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG-FA (MW 5000) (4-Arm-PEG-folate (MW 5000)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
8-Arm-PEG-FA (MW 400) (8-Arm-PEG-folate (MW 400)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG-FA (MW 10000) (4-Arm-PEG-folate (MW 10000)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
8-Arm-PEG-FA (MW 2000) (8-Arm-PEG-folate (MW 2000)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG-FA (MW 400) (4-Arm-PEG-folate (MW 400)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG-FA (MW 600) (4-Arm-PEG-folate (MW 600)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
8-Arm-PEG-FA (MW 5000) (8-Arm-PEG-folate (MW 5000)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
8-Arm-PEG-FA (MW 600) (8-Arm-PEG-folate (MW 600)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG-FA (MW 2000) (4-Arm-PEG-folate (MW 2000)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
8-Arm-PEG-FA (MW 3400) (8-Arm-PEG-folate (MW 3400)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
8-Arm-PEG-FA (MW 1000) (8-Arm-PEG-folate (MW 1000)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG-FA (MW 1000) (4-Arm-PEG-folate (MW 1000)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG-FA (MW 3400) (4-Arm-PEG-folate (MW 3400)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
Desacetylvinblastine hydrazide (Deacetylvinblastine hydrazide; DAVLBH) is an active component of EC145, a folate-targeted drug conjugate. Desacetylvinblastine hydrazide interferes with the formation of the mitotic spindle, and thus inhibits cell division and leads to cell death. Desacetylvinblastine hydrazide exhibits antitumor activity against folatereceptor (FR)-positive tumor .
FA-PEG-COOH (MW 3400) (Folate-PEG-COOH (MW 3400)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG-COOH (MW 10000) (Folate-PEG-COOH (MW 10000)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG-COOH (MW 1000) (Folate-PEG-COOH (MW 1000)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG-COOH (MW 400) (Folate-PEG-COOH (MW 400)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG-COOH (MW 2000) (Folate-PEG-COOH (MW 2000)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG-COOH (MW 600) (Folate-PEG-COOH (MW 600)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG-COOH (MW 5000) (Folate-PEG-COOH (MW 5000)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
6-Arm-PEG-FA (MW 3400) (6-Arm-PEG-Folate (MW 3400)) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG-FA (MW 5000) (6-Arm-PEG-Folate (MW 5000)) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG-FA (MW 1000) (6-Arm-PEG-Folate (MW 1000)) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG-FA (MW 600) (6-Arm-PEG-Folate (MW 600)) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG-FA (MW 2000) (6-Arm-PEG-Folate (MW 2000)) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG-FA (MW 400) (6-Arm-PEG-Folate (MW 400)) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG-FA (MW 10000) (6-Arm-PEG-Folate (MW 10000)) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
PEG-bis-amine (MW 8000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
PEG-bis-amine (MW 1000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
EC0489, a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folatereceptor (FR). Refractory or metastatic Tumor . Small molecule-agent conjugate (SMDC) .
Mirvetuximab soravtansine (IMGN853) solution is an anti-folatereceptor α (FRα) antibody drug-conjugate (ADC) consisting of the cytotoxic maytansinoid, DM4, covalently linked to the humanized monoclonal antibody M9346A, and the drug-linker conjugate for ADC is sulfo-SPDB-DM4 (HY-101141). Mirvetuximab soravtansine selectively binds to folatereceptor 1 (FOLR1). Mirvetuximab soravtansine has an anti-proliferative effect via growth arrest and augmented DNA damage .
Cy3-PEG-FA (MW 2000) is a fluorescent folate-PEG derivative with excitation/emission wavelengths of ~550 nm/~570 nm. Cy3-PEG-FA (MW 2000) can be readily traced by its intense red fluorescent signal. Cy3-PEG-FA (MW 2000) can be used for cell imaging, folatereceptor targeting and detection.
Idetrexed (ONX 0801) is a thymidylate synthase (TS) inhibitor with a Ki of 1.2 nM. Idetrexed can be specifically transported into α-folatereceptor (α-FR)-overexpressing tumors, such as ovarian cancer .
EC-17 disodium salt is a folatereceptor alpha (FRα) targeting contrast agent with fluorescent properties in the visible light spectrum. The EC-17 maximum excitation and emission wavelengths are 490 nm and 520 nm, respectively .
TLR7 agonist 3 (compound 2) is a TLR7 agonist. TLR7 agonist 3 (compound 5) can be coupled to folatereceptor binding ligands to target myeloid-derived suppressor cells and exert anticancer activity .
Farletuzumab (MORAb-003) is a potent folatereceptor-alpha (FRα) inhibitor. Farletuzumab is a humanized monoclonal antibody with high affinity for FRα. Farletuzumab possesses growth-inhibitory functions on cells overexpressing FRα. Farletuzumab can be used in research of cancer .
RB-PEG-FA (MW 3400) (Rhodamine B-PEG-FA (MW 3400)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG-FA (MW 3400) can be used for cell imaging, folatereceptor targeting and detection (Ex/Em = 546/610 nm) .
RB-PEG-FA (MW 2000) (Rhodamine B-PEG-FA (MW 2000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG-FA (MW 2000) can be used for cell imaging, folatereceptor targeting and detection (Ex/Em = 546/610 nm) .
RB-PEG-FA (MW 10000) (Rhodamine B-PEG-FA (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG-FA (MW 10000) can be used for cell imaging, folatereceptor targeting and detection (Ex/Em = 546/610 nm) .
RB-PEG-FA (MW 5000) (Rhodamine B-PEG-FA (MW 5000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG-FA (MW 5000) can be used for cell imaging, folatereceptor targeting and detection (Ex/Em = 546/610 nm) .
RB-PEG-FA (MW 600) (Rhodamine B-PEG-FA (MW 600)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG-FA (MW 600) can be used for cell imaging, folatereceptor targeting and detection (Ex/Em = 546/610 nm) .
RB-PEG-FA (MW 1000) (Rhodamine B-PEG-FA (MW 1000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG-FA (MW 1000) can be used for cell imaging, folatereceptor targeting and detection (Ex/Em = 546/610 nm) .
RB-PEG-FA (MW 400) (Rhodamine B-PEG-FA (MW 400)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG-FA (MW 400) can be used for cell imaging, folatereceptor targeting and detection (Ex/Em = 546/610 nm) .
S0456 is a raw material that plays a crucial role in the construction of the folatereceptor-targeted near-infrared dye OTL 38 (HY-139579). S0456 is connected to the modified folic acid to form OTL 38, endowing OTL 38 with good optical properties, high affinity, and specificity. S0456 can be used in the research of tumor optical imaging agents .
SC239 is a cleavable 2-aminophenyl hemiasterlin agent-linker. SC239 can be as the agent-linker for ADC . SC239 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
AG2034 is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 28 nM against human GARFT, and it binds with high affinity to the folatereceptor (Kd of 0.0042 nM). Additionally, AG2034 is a substrate for rat liver folylpolyglutamate synthetase, with a Km of 6.4 µM. AG2034 inhibits the growth of L1210 and CCRF-CEM cells, with IC50 values of 4 nM and 2.9 nM, respectively, and it has demonstrated antitumor activity in xenograft models such as 6C3HED .
Ricorfotide vedotin (CBP-1008) is a dual-ligand peptide-drug conjugate (PDC) conjugated to MMAE (HY-15162), targeting Folatereceptor α (FRα) and TRPV6. Ricorfotide vedotin binds to FRα with high affinity and TRPV6 with low affinity. Ricorfotide vedotin has antitumor activity, and can be used in advanced solid tumor research (eg: colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma and follicular dendritic cell sarcoma) .
FGT-4 is a folatereceptor β (FR-β) targeting chimeric molecule. FGT-4 is a TLR7 agonist. FGT-4 facilitates the secretion of iNOS and proinflammatory cytokine IL-6 associated with M1 macrophages and enhances the proliferation of cytotoxic CD8 + T cells. FGT-4 has anti-tumor activity in the 4T1 breast cancer mouse model. FGT-4 can be used for the study of cancer immunity. (Pink: target protein TLR7/8 agonist 1 ligand (HY-103698); black: linker (HY-172936); blue: FR-β ligand (HY-172935)) .
S0456 is a raw material that plays a crucial role in the construction of the folatereceptor-targeted near-infrared dye OTL 38 (HY-139579). S0456 is connected to the modified folic acid to form OTL 38, endowing OTL 38 with good optical properties, high affinity, and specificity. S0456 can be used in the research of tumor optical imaging agents .
Cy3-PEG-FA (MW 2000) is a fluorescent folate-PEG derivative with excitation/emission wavelengths of ~550 nm/~570 nm. Cy3-PEG-FA (MW 2000) can be readily traced by its intense red fluorescent signal. Cy3-PEG-FA (MW 2000) can be used for cell imaging, folatereceptor targeting and detection.
RB-PEG-FA (MW 3400) (Rhodamine B-PEG-FA (MW 3400)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG-FA (MW 3400) can be used for cell imaging, folatereceptor targeting and detection (Ex/Em = 546/610 nm) .
RB-PEG-FA (MW 2000) (Rhodamine B-PEG-FA (MW 2000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG-FA (MW 2000) can be used for cell imaging, folatereceptor targeting and detection (Ex/Em = 546/610 nm) .
RB-PEG-FA (MW 10000) (Rhodamine B-PEG-FA (MW 10000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG-FA (MW 10000) can be used for cell imaging, folatereceptor targeting and detection (Ex/Em = 546/610 nm) .
RB-PEG-FA (MW 5000) (Rhodamine B-PEG-FA (MW 5000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG-FA (MW 5000) can be used for cell imaging, folatereceptor targeting and detection (Ex/Em = 546/610 nm) .
RB-PEG-FA (MW 600) (Rhodamine B-PEG-FA (MW 600)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG-FA (MW 600) can be used for cell imaging, folatereceptor targeting and detection (Ex/Em = 546/610 nm) .
RB-PEG-FA (MW 1000) (Rhodamine B-PEG-FA (MW 1000)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG-FA (MW 1000) can be used for cell imaging, folatereceptor targeting and detection (Ex/Em = 546/610 nm) .
RB-PEG-FA (MW 400) (Rhodamine B-PEG-FA (MW 400)) is a fluorescent dye composed of Rhodamine B (HY-Y0016), PEG and Folic acid (FA) (HY-16637). RB-PEG-FA (MW 400) can be used for cell imaging, folatereceptor targeting and detection (Ex/Em = 546/610 nm) .
DSPE-PEG-Folate, MW 3350 is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .
PLLA10000-PEG2000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA10000-PEG2000-FOL can be used in drug delivery research .
PLLA20000-PEG2000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA20000-PEG2000-FOL can be used in drug delivery research .
PLLA20000-PEG5000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA20000-PEG5000-FOL can be used in drug delivery research .
PLLA5000-PEG2000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA5000-PEG2000-FOL can be used in drug delivery research .
PLLA10000-PEG5000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA10000-PEG5000-FOL can be used in drug delivery research .
PLLA5000-PEG5000-FOL is a polylactic acid derivative. Polylactic acid derivatives have strong binding affinity to folatereceptors and clear biodegradability. PLLA5000-PEG5000-FOL can be used in drug delivery research .
DSPE-PEG-Folate (MW 3400) is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .
DSPE-PEG-Folate (MW 1000) is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .
DSPE-PEG-Folate (MW 5000) is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .
DSPE-PEG-Folate, MW 2000 is a PEG derivative containing folic acid. DSPE-PEG-Folate, MW 2000 has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate, MW 2000 form micelles/lipid bilayer and can be used to targeted drug delivery system research.
DSPE-PEG-Folate, MW 5000 is a PEG derivative containing folic acid. DSPE-PEG-Folate, MW 5000 has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate, MW 5000 form micelles/lipid bilayer and can be used to targeted drug delivery system research .
mPEG-FA (MW 1000) (mPEG-Folate (MW 1000)) is a polyethylene glycol derivative of Folic acid (HY-16637). Folic acid has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
mPEG-FA (MW 5000) (mPEG-Folate (MW 5000)) is a polyethylene glycol derivative of Folic acid (HY-16637). Folic acid has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
mPEG-FA (MW 2000) (mPEG-Folate (MW 2000)) is a polyethylene glycol derivative of Folic acid (HY-16637). Folic acid has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG-FA (MW 3400) (BOC-NH-PEG-Folate (MW 3400)) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG-FA (MW 5000) (BOC-NH-PEG-Folate (MW 5000)) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG-FA (MW 2000) (BOC-NH-PEG-Folate (MW 2000)) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG-FA (MW 1000) (BOC-NH-PEG-Folate (MW 1000)) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG-FA (MW 400) (BOC-NH-PEG-Folate (MW 400)) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG-FA (MW 10000) (BOC-NH-PEG-Folate (MW 10000)) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
BOC-NH-PEG-FA (MW 600) (BOC-NH-PEG-Folate (MW 600)) is a PEG derivative modified with Folic acid (HY-16637). Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
mPEG-amine (MW 350) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
mPEG-amine (MW 750) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
mPEG-amine (MW 3400) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
mPEG-amine (MW 550) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
mPEG-amine (MW 4000) can be used to synthesize folate-conjugated polymer micelles for encapsulating anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
8-Arm-PEG-FA (MW 10000) (8-Arm-PEG-folate (MW 10000)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG-FA (MW 5000) (4-Arm-PEG-folate (MW 5000)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
8-Arm-PEG-FA (MW 400) (8-Arm-PEG-folate (MW 400)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG-FA (MW 10000) (4-Arm-PEG-folate (MW 10000)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG-FA (MW 400) (4-Arm-PEG-folate (MW 400)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG-FA (MW 600) (4-Arm-PEG-folate (MW 600)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
8-Arm-PEG-FA (MW 5000) (8-Arm-PEG-folate (MW 5000)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG-FA (MW 2000) (4-Arm-PEG-folate (MW 2000)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG-FA (MW 1000) (4-Arm-PEG-folate (MW 1000)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
4-Arm-PEG-FA (MW 3400) (4-Arm-PEG-folate (MW 3400)) is a PEG derivative with one Folic acid (HY-16637) molecule attached to each end of the PEG chain. Folic acid has a high affinity for folatereceptors and can be used for targeted drug delivery to cell membrane receptors .
FA-PEG-COOH (MW 3400) (Folate-PEG-COOH (MW 3400)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG-COOH (MW 10000) (Folate-PEG-COOH (MW 10000)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG-COOH (MW 1000) (Folate-PEG-COOH (MW 1000)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG-COOH (MW 400) (Folate-PEG-COOH (MW 400)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG-COOH (MW 2000) (Folate-PEG-COOH (MW 2000)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG-COOH (MW 600) (Folate-PEG-COOH (MW 600)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
FA-PEG-COOH (MW 5000) (Folate-PEG-COOH (MW 5000)) is a Folic acid (HY-16637)-modified PEG derivative containing a carboxyl group (-COOH). The carboxyl group can easily form a stable amide bond with an amino group, or an ester bond with a hydroxyl group. Folic acid (-FA) has a high affinity for the folatereceptor and can be used to target cell membrane receptors for drug delivery .
6-Arm-PEG-FA (MW 3400) (6-Arm-PEG-Folate (MW 3400)) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG-FA (MW 5000) (6-Arm-PEG-Folate (MW 5000)) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG-FA (MW 1000) (6-Arm-PEG-Folate (MW 1000)) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG-FA (MW 600) (6-Arm-PEG-Folate (MW 600)) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG-FA (MW 2000) (6-Arm-PEG-Folate (MW 2000)) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG-FA (MW 400) (6-Arm-PEG-Folate (MW 400)) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
6-Arm-PEG-FA (MW 10000) (6-Arm-PEG-Folate (MW 10000)) is a PEG derivative modified with Folic acid (HY-16637). Polyethylene glycol can increase solubility and stability and reduce the immunogenicity of peptides and proteins. It can also inhibit the nonspecific binding of charged molecules to modified surfaces. Folic acid (-FA) has a high affinity for folatereceptors and can be used for cell membrane receptors for targeted drug delivery .
PEG-bis-amine (MW 8000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
PEG-bis-amine (MW 1000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
FRα-targeting peptide C7 TFA is a selective peptide ligand for folatereceptor α (FRα) that has specific binding to FRα expressing cells and in vivo tumor targeting ability. FRα-targeting peptide C7 TFA can be used in the research of tumor diagnosis and treatment .
FRα-targeting peptide C7 is a selective peptide ligand for folatereceptor α (FRα) that has specific binding to FRα expressing cells and in vivo tumor targeting ability. FRα-targeting peptide C7 can be used in the research of tumor diagnosis and treatment .
Ricorfotide vedotin (CBP-1008) is a dual-ligand peptide-drug conjugate (PDC) conjugated to MMAE (HY-15162), targeting Folatereceptor α (FRα) and TRPV6. Ricorfotide vedotin binds to FRα with high affinity and TRPV6 with low affinity. Ricorfotide vedotin has antitumor activity, and can be used in advanced solid tumor research (eg: colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma and follicular dendritic cell sarcoma) .
Farletuzumab ecteribulin (MORAb-202) is an antibody-drug conjugate (ADC), consisting of the humanized anti-human folatereceptor alpha (FRA) antibody Farletuzumab (HY-P99153) conjugated via reduced interchain disulfide bonds to Mal-PEG2-Val-Cit-PAB-eribulin. Farletuzumab ecteribulin has a agent-to-antibody ratio of 4.0. Farletuzumab ecteribulin is highly cytotoxic to FRA-positive cells in vitro. Farletuzumab ecteribulin has potent antitumor activity.
Mirvetuximab (M9346A) is an anti-FOLR1 (folatereceptor 1) monoclonal antibody. Mirvetuximab is the antibody moiety of folatereceptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research .
Farletuzumab (MORAb-003) is a potent folatereceptor-alpha (FRα) inhibitor. Farletuzumab is a humanized monoclonal antibody with high affinity for FRα. Farletuzumab possesses growth-inhibitory functions on cells overexpressing FRα. Farletuzumab can be used in research of cancer .
Mirvetuximab (M9346A) (powder) is an anti-FOLR1 (folatereceptor 1) monoclonal antibody. Mirvetuximab (powder) is the antibody moiety of folatereceptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research .
The FOLR1 protein is an important mediator of folate uptake, binding to folate and promoting the delivery of 5-methyltetrahydrofolate into cells. Studies show high affinity at neutral pH. FOLR1 Protein, Human (HEK293, His) is the recombinant human-derived FOLR1 protein, expressed by HEK293 , with C-His labeled tag.
FOLR1 Protein, binding to folate and reduced folic acid derivatives, facilitates their delivery into cells. It maintains high affinity under neutral pH but undergoes a conformational change upon endocytosis, reducing affinity and releasing folates in slightly acidic pH. Crucial for embryonic development, cell proliferation, and renal folate reabsorption. FOLR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FOLR1 protein, expressed by HEK293 , with C-6*His labeled tag.
FOLR3 protein is crucial in folate metabolism, binding to folate and aiding 5-methyltetrahydrofolate delivery into cells. Notably, the Isoform Short of FOLR3 lacks folate-binding capabilities, indicating diverse functional roles among FOLR3 isoforms. This highlights nuanced regulation in cellular folate transport processes. FOLR3 Protein, Human (HEK293, His) is the recombinant human-derived FOLR3 protein, expressed by HEK293 , with C-His labeled tag.
FOLR2 Protein binds folate, enabling the transport of 5-methyltetrahydrofolate into cells with high affinity under neutral pH. Upon endocytosis, exposure to slightly acidic pH induces a conformational change, substantially reducing FOLR2's folate affinity and releasing it from the receptor. FOLR2 Protein, Human (HEK293, His) is the recombinant human-derived FOLR2 protein, expressed by HEK293 , with C-His labeled tag.
The FOLR1 protein is a member of the folate receptor family. Folate receptors are cell surface proteins that bind folate (vitamin B9) and transport it into cells. FOLR1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived FOLR1 protein, expressed by HEK293 , with C-hFc labeled tag.
The FOLR1 protein is a member of the folate receptor family. Folate receptors are cell surface proteins that bind folate (vitamin B9) and transport it into cells. FOLR1 Protein, Rat (HEK293, His) is the recombinant rat-derived FOLR1 protein, expressed by HEK293 , with C-His labeled tag.
The FOLR1 protein is an important mediator of folate uptake, binding to folate and promoting the delivery of 5-methyltetrahydrofolate into cells. Studies show high affinity at neutral pH. FOLR1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FOLR1 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.
FOLR1 Protein, binding to folate and reduced folic acid derivatives, facilitates their delivery into cells. It maintains high affinity under neutral pH but undergoes a conformational change upon endocytosis, reducing affinity and releasing folates in slightly acidic pH. Crucial for embryonic development, cell proliferation, and renal folate reabsorption. FOLR1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived FOLR1 protein, expressed by HEK293, with C-hFc labeled tag.
The FOLR1 protein is an important mediator of folate uptake, binding to folate and promoting the delivery of 5-methyltetrahydrofolate into cells. Studies show high affinity at neutral pH. FOLR1 Protein, Human (HEK293, Fc) is the recombinant human-derived FOLR1 protein, expressed by HEK293, with C-hFc labeled tag.
FOLR1 is a folic acid receptor that binds to folic acid and reductive folic acid derivatives and promotes the entry of 5-methyltetrahydrofolate and folate analogs into the cell interior. FOLR1 enhances the stability and nuclear translocation of β-catenin through the EGFR/AKT/GSK3β axis, thereby promoting the proliferation and migration of laryngeal squamous cell carcinoma (LSCC). FOLR1 is highly expressed in a variety of tumors and is a potential prognostic and therapeutic target for many cancers. FOLR1 Protein, Canine (HEK293, Fc) is the recombinant canine-derived FOLR1 protein, expressed by HEK293 , with C-hFc labeled tag.
FOLR1 is a folic acid receptor that binds to folic acid and reductive folic acid derivatives and promotes the entry of 5-methyltetrahydrofolate and folate analogs into the cell interior. FOLR1 enhances the stability and nuclear translocation of β-catenin through the EGFR/AKT/GSK3β axis, thereby promoting the proliferation and migration of laryngeal squamous cell carcinoma (LSCC). FOLR1 is highly expressed in a variety of tumors and is a potential prognostic and therapeutic target for many cancers. FOLR1 Protein, Canine (HEK293, His) is the recombinant canine-derived FOLR1 protein, expressed by HEK293 , with C-His labeled tag.
The FOLR4 protein serves as a receptor for IZUMO1 on the egg membrane and plays a crucial role in species-specific gamete recognition and fertilization. The interaction between IZUMO1 and FOLR4 (IZUMO1R/JUNO) is an important adhesion event that is required for fertilization but not sufficient for cell fusion. FOLR4 Protein, Human (HEK293, His) is the recombinant human-derived FOLR4 protein, expressed by HEK293 , with C-His labeled tag.
FOLR4 is a receptor on the egg membrane that interacts with IZUMO1 and is essential for species-specific gamete recognition and fertilization. Although it is essential for fertilization, it is not sufficient by itself to achieve cell fusion. FOLR4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FOLR4 protein, expressed by HEK293 , with C-His labeled tag.
Folate Binding Protein Antibody (YA1099) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1099), targeting Folate Binding Protein. Folate Binding Protein Antibody (YA1099) can be used for IHC-P experiment in human background.
Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent thymidylate synthase (TS) inhibitor with a Ki of 0.44 nM. Plevitrexed is taken up via the α-folatereceptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical . Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
SC239 is a cleavable 2-aminophenyl hemiasterlin agent-linker. SC239 can be as the agent-linker for ADC . SC239 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Idetrexed (ONX 0801) trisodium is a thymidylate synthase (TS) inhibitor with a Ki of 1.2 nM. Idetrexed trisodium can be specifically transported into α-folatereceptor (α-FR)-overexpressing tumors, such as ovarian cancer .
Idetrexed (ONX 0801) is a thymidylate synthase (TS) inhibitor with a Ki of 1.2 nM. Idetrexed can be specifically transported into α-folatereceptor (α-FR)-overexpressing tumors, such as ovarian cancer .
DSPE-PEG-Folate, MW 3350 is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research .
DSPE-PEG-Folate, MW 2000 is a PEG derivative containing folic acid. DSPE-PEG-Folate, MW 2000 has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate, MW 2000 form micelles/lipid bilayer and can be used to targeted drug delivery system research.
DSPE-PEG-Folate, MW 5000 is a PEG derivative containing folic acid. DSPE-PEG-Folate, MW 5000 has a targeting effect and bind to folatereceptors in cancer cells. DSPE-PEG-Folate, MW 5000 form micelles/lipid bilayer and can be used to targeted drug delivery system research .
mPEG-amine (MW 750) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
mPEG-amine (MW 550) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
PEG-bis-amine (MW 8000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
mPEG-amine (MW 350) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
mPEG-amine (MW 3400) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
mPEG-amine (MW 4000) can be used to synthesize folate-conjugated polymer micelles for encapsulating anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
PEG-bis-amine (MW 1000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folatereceptors (FR).
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