2. Cell Cycle/DNA Damage
  3. Antifolate
  4. Antifolate agent 1

Antifolate agent 1 (Compound 1) is an antifolate agent with one-carbon bridge. Antifolate agent 1 lacks RFC transport and has no affinity for FRα and FRβ and no GARFTase inhibitory activity. Antifolate agent 1 can be used as a negative control for the development of folate receptor-targeting antifolates.

For research use only. We do not sell to patients.

Antifolate agent 1

Antifolate agent 1 Chemical Structure

CAS No. : 518063-75-7

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Antifolate agent 1 Related Antibodies

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Description

Antifolate agent 1 (Compound 1) is an antifolate agent with one-carbon bridge. Antifolate agent 1 lacks RFC transport and has no affinity for FRα and FRβ and no GARFTase inhibitory activity. Antifolate agent 1 can be used as a negative control for the development of folate receptor-targeting antifolates[1].

Cellular Effect
Cell Line Type Value Description References
IGROV-1 IC50
> 1000 nM
Compound: 1
Antiproliferative activity against human RFC and FRalpha expressing human IGROV1 cells
Antiproliferative activity against human RFC and FRalpha expressing human IGROV1 cells
[PMID: 18680275]
IGROV-1 IC50
> 1000 nM
Compound: 1
Antiproliferative activity against human RFC and FRalpha expressing human IGROV1 cells in presence of folic acid
Antiproliferative activity against human RFC and FRalpha expressing human IGROV1 cells in presence of folic acid
[PMID: 18680275]
KB IC50
> 1000 nM
Compound: 1
Antiproliferative activity against human RFC and FRalpha expressing human KB cells
Antiproliferative activity against human RFC and FRalpha expressing human KB cells
[PMID: 18680275]
KB IC50
> 1000 nM
Compound: 1
Antiproliferative activity against human RFC and FRalpha expressing human KB cells in presence of folic acid
Antiproliferative activity against human RFC and FRalpha expressing human KB cells in presence of folic acid
[PMID: 18680275]
KB IC50
> 1000 nM
Compound: 1
Inhibition of GARFTase in human KB cells assessed as inhibition of [14C]glycine incorporation into [14C]formylGAR in presence of azaserine
Inhibition of GARFTase in human KB cells assessed as inhibition of [14C]glycine incorporation into [14C]formylGAR in presence of azaserine
[PMID: 18680275]
R2 IC50
> 1000 nM
Compound: 1
Antiproliferative activity against human RFC expressing Chinese hamster R2 cells
Antiproliferative activity against human RFC expressing Chinese hamster R2 cells
[PMID: 18680275]
Molecular Weight

413.38

Formula

C19H19N5O6
CAS No.
SMILES

O=C1C2=C(NC(N)=N1)NC(CC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antifolate agent 1 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antifolate agent 1518063-75-7Antifolate agent1Antifolate agent-1AntifolateOne-carbon bridgeRFCFRαFRβGARFTaseNegative controlInhibitorinhibitorinhibit

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