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Elongation factor 2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (1) Bacterial (1) CaMK (1) Fungal (2) HIV (1) PKA (1) PKC (1) Src (1) Virus Protease (1)
By Research Areas:	Cancer (1) Infection (2)

3

Inhibitors & Agonists

1

Natural
Products

2

Recombinant Proteins

8

Antibodies

Targets Recommended: ELOVL

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

NH125 2 Publications Verification	CaMK Autophagy Bacterial Fungal Virus Protease	Cancer
NH125 is a potent and selective inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K/CaMKIII), also can induce eEF2 phosphorylation, with an IC₅₀ of 60 nM for eEF-2K .

Sordarin	Fungal	Infection
Sordarin (Compound 1) is an antifungal agent targeting Elongation factor 2 (EF2) with a tetracyclic diterpene core including a norbornene system. Sordarin can be isolated from the fungus Sordaria araneosa. Sordarin has potent antifungal activity against Saccharomyces cerevisiae and Candida albicans. Sordarin prevents the translocation of the ribosome along mRNA during elongation of the emerging polypeptide chain, inhibiting protein synthesis in fungi by stabilizing the ribosome/EF2 complex .

TX-1918	HIV Src PKA PKC	Infection
TX-1918 is an inhibitor for eukaryotic elongation factor 2 kinase (eEF2-K) and Src kinase with IC₅₀ of 0.44 and 4.4 μM, respectively. TX-1918 exhibits cytotoxicity in cell HepG2 and HCT116, with IC₅₀ of 2.07 and 230 μM, respectively. TX-1918 inhibits the C-terminal domain of HIV-1 CA (CA CTD)(IC₅₀ =3.81 μM), and inhibits the viral replication (IC₅₀ =15.16 μM) .

Cat. No.	Product Name	Category	Target	Chemical Structure

Sordarin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Fungal
Sordarin (Compound 1) is an antifungal agent targeting Elongation factor 2 (EF2) with a tetracyclic diterpene core including a norbornene system. Sordarin can be isolated from the fungus Sordaria araneosa. Sordarin has potent antifungal activity against Saccharomyces cerevisiae and Candida albicans. Sordarin prevents the translocation of the ribosome along mRNA during elongation of the emerging polypeptide chain, inhibiting protein synthesis in fungi by stabilizing the ribosome/EF2 complex .

Species:	Human (2)
Tag:	His (1) GST (1)
Source:	Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

	EEF2K Protein, Human (GST) EEF2K; Eukaryotic Elongation factor 2 kinase; eEF-2 kinase; eEF-2K; Calcium/calmodulin-dependent eukaryotic Elongation factor 2 kinase	Human	E. coli
	EEF2K, a threonine kinase, critically regulates protein synthesis by modulating peptide chain elongation. Activation by upstream kinases like AMPK or TRPM7 leads to phosphorylation of EEF2, inhibiting its binding to ribosomes and decelerating protein synthesis. EEF2K's intricate control underscores its pivotal role in modulating cellular processes related to protein translation. EEF2K Protein, Human (GST) is the recombinant human-derived EEF2K protein, expressed by E. coli , with N-GST labeled tag.

	EEF2 Protein, Human (sf9, His) Elongation factor 2; EEF2; EF2; EF-2	Human	Sf9 insect cells
	EEF2 Protein, Human (sf9, His) is the recombinant human-derived EEF2 protein, expressed by Sf9 insect cells, with N-6*His tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

	Elongation factor 2 Antibody (YA962) EEF2; EF2; Elongation factor 2; EF-2	WB, ICC/IF, ChIP	Human
	Elongation factor 2 Antibody (YA962) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Elongation factor 2.

	Elongation factor 2 Antibody (YA964) EEF2; EF2; Elongation factor 2; EF-2	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Elongation factor 2 Antibody (YA964) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Elongation factor 2.

	Elongation factor 2 Antibody (YA963) EEF2; EF2; Elongation factor 2; EF-2	WB, ICC/IF	Human, Mouse, Monkey, Rat
	Elongation factor 2 Antibody (YA963) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Elongation factor 2.

	Elongation factor 2 Antibody (YA5120) EEF2; EF2; Elongation factor 2; EF-2	WB	Human, Mouse, Rat
	Elongation factor 2 Antibody (YA5120) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Elongation factor 2.

	Elongation factor 2 Antibody (YA5227) EEF2; Eef2; EF-2; EF2; EF2_HUMAN; Elongation factor 2; Eukaryotic translation Elongation factor 2; Polypeptidyl tRNA translocase; SCA26.	WB, IHC-P, ICC/IF, ELISA	Human
	Elongation factor 2 Antibody (YA5227) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Elongation factor 2.

	Elongation factor 2 Antibody (YA3783) EF2; EEF-2; EEF2	WB, IHC-P, ICC/IF, ELISA	Human
	Elongation factor 2 Antibody (YA3783) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Elongation factor 2.

	*Phospho-Elongation* Factor 2 (Thr56/Thr58) Antibody (YA2581)** EEF2; EF2; Elongation factor 2; EF-2	WB	Human
	Phospho-Elongation Factor 2 (Thr56/Thr58) Antibody (YA2581) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Elongation Factor 2 (Thr56/Thr58).

	EEF2K Antibody (YA6551) C86191 antibody; Calcium/calmodulin dependent eukaryotic Elongation factor 2 antibody; Calcium/calmodulin dependent eukaryotic Elongation factor 2 kinase antibody; Calcium/calmodulin-dependent eukaryotic Elongation factor 2 kinase antibody; Calmodulin dependent protein kinase III antibody; cb365 antibody; EC 2.7.11.20 antibody; eEF 2 kinase antibody; eEF 2K antibody; eEF-2 kinase antibody; C86191 antibody; Calcium/calmodulin dependent eukaryotic Elongation factor 2 antibody; Calcium/calmodulin dependent eukaryotic Elongation factor 2 kinase antibody; Calcium/calmodulin-dependent eukaryotic Elongation factor 2 kinase antibody; Calmodulin dependent protein kinase III antibody; cb365 antibody; EC 2.7.11.20 antibody; eEF 2 kinase antibody; eEF 2K antibody; eEF-2 kinase antibody; eEF-2K antibody; Eef2k antibody; EEF2K protein antibody; EF2K_HUMAN antibody; Elongation factor 2 kinase antibody; Eukaryotic Elongation factor 2 kinase antibody; fa04b08 antibody; HSU93850 antibody; kinase eEF2K antibody; MGC45041 antibody; SMEF2K antibody; wu:fa04b08 antibody; zgc:100973 antibody;	WB, ICC/IF, FC	Human, Mouse, Rat
	EEF2K Antibody (YA6551) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EEF2K.

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