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Efficient synthesis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetolactate Synthase (ALS) (1) Amino Acid Derivatives (1) Aminoacyl-tRNA Synthetase (1) Antibiotic (1) Apoptosis (10) Autophagy (8) Bacterial (4) Bcl-2 Family (1) Biochemical Assay Reagents (25) Calcium Channel (1) Caspase (1) Drug Intermediate (4) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (10) Fungal (1) Histone Demethylase (1) HMG-CoA Reductase (HMGCR) (8) Isotope-Labeled Compounds (3) Mitochondrial Metabolism (3) Mitophagy (8) NOD-like Receptor (NLR) (1) Nucleoside Antimetabolite/Analog (1) Parasite (1) Photosystem II (1) PSMA (1) Radionuclide-Drug Conjugates (RDCs) (1) Reactive Oxygen Species (ROS) (1) Reference Standards (2) Sodium Channel (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (6) Infection (8) Inflammation/Immunology (1) Metabolic Disease (11) Neurological Disease (7)
Click Chemistry:	PROTAC Synthesis (1) Azide (1)
Oligonucleotides:	Adenosine (1) Nucleoside Analogs (2) Inosine (1) Polymers (1) pH Modifiers (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: DNA/RNA Synthesis

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y0302

Diammonium phosphate	Biochemical Assay Reagents	Others
Diammonium phosphate is a neutral and efficient catalyst in 1,8‐Dioxo‐octahydroxanthene derivatives synthesis. Diammonium phosphate can be used as an excipient, such as diuretic, buffer, effervescent .

HY-W001095

N-Methoxy-N-methylacetamide	Biochemical Assay Reagents Drug Intermediate	Others
N-Methoxy-N-methylacetamide can efficiently acetylate polycarbonyl compounds. As an important intermediate, N-Methoxy-N-methylacetamide can be used for the synthesis of other active compounds .

HY-145396

PLGA-PEG-NH2	Biochemical Assay Reagents	Cancer
PLGA-PEG-NH2 is a material to synthesis nanomicelles. PLGA-PEG-NH2 nanomicelle is an efficient delivery system of Irinotecan for targeted colorectal cancer and hepatocellular carcinoma .

HY-75200

N-(Benzyloxycarbonyloxy)succinimide	Biochemical Assay Reagents	Others
N-(Benzyloxycarbonyloxy)succinimide is an efficient amino-protecting reagent in organic synthesis, playing an important role in the field of organic synthesis. N-(Benzyloxycarbonyloxy)succinimide is also a neutral ionophore, which significantly improves the performance of erbium ion (Er ³⁺) sensors and provides a practical tool for the rapid detection of erbium ions in the environment and water quality .

HY-W127637

Tetraamylammonium chloride Tetrapentylammonium chloride	Biochemical Assay Reagents	Others
Tetraamylammonium chloride is an organic compound containing ammonium and chloride ions. It is commonly used as a phase transfer catalyst in organic synthesis, especially in the production of pharmaceuticals and agrochemicals. Tetraamylammonium Chloride has a strong base that facilitates the transfer of reactants between immiscible solvents, resulting in more efficient chemical reactions. In addition, it can also be used as an intermediate in the synthesis of other quaternary ammonium compounds.

HY-W127681

Tetrabutylammonium dichlorobromide Tetra-n-butylammonium dichlorobromide	Biochemical Assay Reagents	Others
Tetrabutylammonium dichlorobromide is an organic compound containing ammonium, chloride, and bromide ions. It is commonly used as a phase transfer catalyst in organic synthesis, especially in the production of pharmaceuticals and agrochemicals. Tetrabutylammonium Dichlorobromide has a strong base that facilitates the transfer of reactants between immiscible solvents, resulting in more efficient chemical reactions. In addition, it can also be used as an intermediate in the synthesis of other quaternary ammonium compounds.

HY-W664016

Difluoroheptylazidosulfinate sodium	Biochemical Assay Reagents Endogenous Metabolite
Difluoroheptylazidosulfinate sodium is a compound with efficient C–H activation catalysis, which can effectively promote the formation of CC bonds in organic synthesis, thereby expanding the diverse molecular structures.

HY-Y0302S

Diammonium phosphate-15N2	Biochemical Assay Reagents	Others
Diammonium phosphate- ¹⁵N₂ is ¹⁵N₂ labeled Diammonium phosphate (HY-Y0302). Diammonium phosphate is a neutral and efficient catalyst in 1,8-Dioxo-octahydroxanthene derivatives synthesis, which can be used as an excipient, such as diuretic, buffer, effervescent .

HY-W127654

(Ferrocenylmethyl)trimethylammonium bromide	Biochemical Assay Reagents	Others
(Ferrocenylmethyl)trimethylammonium bromide is an organic compound containing ammonium and bromide ions. It is commonly used as a phase transfer catalyst in organic synthesis, especially in the production of pharmaceuticals and agrochemicals. (Ferrocenylmethyl)trimethylammonium Bromide has a strong base that facilitates the transfer of reactants between immiscible solvents for more efficient chemical reactions. In addition, it can also be used as an intermediate in the synthesis of other organic compounds.

HY-W543065

CPhos Pd G2	Biochemical Assay Reagents Endogenous Metabolite
CPhos Pd G2 is a highly efficient palladium catalyst with excellent cross-coupling reaction activity. CPhos Pd G2 is widely used in compound synthesis and material science, especially for the construction of complex organic molecules and the synthesis of bioactive compounds. CPhos Pd G2 is also favored for improving reaction selectivity and reducing the formation of by-products.

HY-N9542

Dimethyl Citric acid 1 Publications Verification	Others	Others
Dimethylurea/citric acid is a highly efficient deep eutectic solvent (DES). Dimethylurea/citric acid can be used as a catalyst and a green reaction medium for the synthesis of bis(indolyl)methanes, quinolines and aryl-4, 5-diphenyl-1H-imidazoles.

HY-19877

GSK932121	Parasite	Infection
GSK932121 is an antimalarial drug with activity that inhibits the electron transport chain of P. falciparum. GSK932121 acts selectively on this pathogen at the level of cytochrome bc1 (complex III). The synthesis method of GSK932121 is highly efficient, and the final structure can be obtained in only 5 steps. The synthesis of GSK932121 can be prepared atK_ilog scale to support clinical studies .

HY-W002864

6-Bromonicotinic acid	Drug Intermediate	Others
6-Bromonicotinic acid is a brominated derivative of Niacin (HY-B0143), can be used as a drug intermediate for the synthesis of Anabaseine (HY-115766) derivatives.

HY-W018454

Benzyltrimethylammonium tribromide	Biochemical Assay Reagents	Others
Benzyl trimethyl ammonium tribromide is an organic ammonium tribromide. Benzyl trimethyl ammonium tribromide provides controlled bromide ions, enabling efficient cyclization and oxidation while minimizing side reactions caused by excess bromine. Benzyl trimethyl ammonium tribromide can be used in the synthesis of 2-aminobenzothiazole compounds .

HY-W001095S

N-Methoxy-N-methylacetamide-d3	Isotope-Labeled Compounds Biochemical Assay Reagents Drug Intermediate	Others
N-Methoxy-N-methylacetamide-d₃ is deuterium labeled N-Methoxy-N-methylacetamide (HY-W001095). N-Methoxy-N-methylacetamide can efficiently acetylate polycarbonyl compounds. As an important intermediate, N-Methoxy-N-methylacetamide can be used for the synthesis of other active compounds .

HY-159103

LeuRS-IN-2	Aminoacyl-tRNA Synthetase	Infection
LeuRS-IN-2 (Compound 9) is a Wolbachia leucyl-tRNA synthetase (LeuRS) inhibitor in the presence of adenosine monophosphate (AMP) with an EC₅₀ value of 6 nM, efficiently arresting the growth of pathogenic host. LeuRS-IN-2 forms adenosine-based adducts inhibiting protein synthesis, which is promising for research of new antimicrobials with disrupting microbiota .

HY-B0144AS1

Pitavastatin-d5 sodium NK-104-d₅ sodium	Apoptosis HMG-CoA Reductase (HMGCR) Mitophagy Autophagy	Metabolic Disease Cancer
Pitavastatin-d₅ (sodium) is the deuterium labeled Pitavastatin sodium. Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity.

HY-E70067

GlcNAc 1-P uridyltransferase (PmGlmU)	Biochemical Assay Reagents	Others
GlcNAc 1-P uridyltransferase (PmGlmU) catalyzes high efficient synthesis of UDP-GlcNAc from GlcNAc-1-P and UTP. GlcNAc 1-P uridyltransferase (PmGlmU) is used to break down the pyrophosphate formed in the PmGlmU reaction to inorganic phosphate to shift the equilibrium of the coupled enzymatic reactions towards the formation of UDP-GlcNA .

HY-159901

LSD1-IN-37	Histone Demethylase	Cancer
LSD1-IN-37 (Compound 5g) is a lysine-specific demethylase 1 (LSD1) inhibitor constructed using an efficient synthesis strategy incorporating hexafluoroisopropyl groups. This metal-free method exhibits excellent reaction stability and adaptability. LSD1-IN-37 demonstrated outstanding LSD1 inhibitory activity and holds potential for further research .

HY-W854275

(H2IPr)(Cl)2Ru=CH(o-iPrOC6H4)	Biochemical Assay Reagents Endogenous Metabolite
(H2IPr)(Cl)2Ru=CH(o-iPrOC6H4) is a highly efficient catalyst that can effectively promote the metathesis reaction of olefins. The compound exhibits excellent selectivity in the field of transition metal catalysts, is suitable for the synthesis of biologically active compounds, and shows potential application value in compound development.

HY-W074081

(CAAC-Cy)Rh(COD)Cl	Biochemical Assay Reagents Endogenous Metabolite
(CAAC-Cy)Rh(COD)Cl is a rhodium-based catalyst with significant hydrogenation activity. (CAAC-Cy)Rh(COD)Cl is widely used in organic synthesis to catalyze different types of reactions. (CAAC-Cy)Rh(COD)Cl is highly efficient in promoting hydrogenation reactions. (CAAC-Cy)Rh(COD)Cl can effectively catalyze the conversion of certain unsaturated compounds.

HY-W674002

1-Adamantylphosphaethyne 1-(2-Phosphaethynyl)adamantane	Apoptosis
1-Adamantylphosphaethyne (1-(2-Phosphaethynyl)adamantane) is a compound with potential biological activity and can be used as a catalyst in organic synthesis. 1-Adamantylphosphaethyne has shown the ability to induce cell apoptosis in compound development, which helps in anti-tumor inhibition. 1-Adamantylphosphaethyne can also be used as an efficient reaction intermediate to promote the progress of various chemical reactions.

HY-W013156

2′,3′,5′-Triacetylinosine 2′,3′,5′-Tri-O-acetylinosine	Biochemical Assay Reagents	Cancer
2′,3′,5′-Triacetylinosine (2′,3′,5′-Tri-O-acetylinosine) has been shown to inhibit the growth of cancer cells, and is also an efficient method for bond cleavage and radiation protection. 2',3',5'-Tri-O-acetylinosine has been shown to bind to pyridinium ions, and it has been used in the synthesis of tetrapeptides with hydroxyl groups or alkylation.

HY-16485

Telavancin hydrochloride 1 Publications Verification TD-6424 hydrochloride	Antibiotic Bacterial	Infection
Telavancin hydrochloride is the hydrochloride form of Telavancin (HY-112959). Telavancin hydrochloride is a semisynthetic derivative of vancomycin, and exhibits antibacterial efficacy through inhibition of cell wall synthesis and disruption of cell membrane barrier function. Telavancin hydrochloride is efficient against antibiotic resistant S. aureus strains MRSA, VISA, and hVISA. Telavancin hydrochloride attenuates gram positive bacteria induced complicated skin and skin structure infections (cSSSI) .

HY-W042557

Tetrabutylammonium trifluoromethanesulfonate	Biochemical Assay Reagents	Others
Tetrabutylammonium trifluoromethanesulfonate, commonly known as TBAOTf. TBAOTf is widely used as a strong acid catalyst and phase transfer agent in organic synthesis, especially for reactions involving nucleophilic substitution, elimination, and rearrangement, in addition, it is also used as an electrolyte additive for rechargeable batteries and a stabilizer of supercritical fluids Due to its high stability, solubility and selectivity, TBAOTf is considered to be a highly efficient and multifunctional reagent in various applications.

HY-W075744

SK-J002-1n	Biochemical Assay Reagents Endogenous Metabolite
SK-J002-1n is a highly efficient catalyst with excellent cross-coupling reaction activity. SK-J002-1n is widely used in organic synthesis to construct complex molecular structures. The chiral properties of SK-J002-1n make it play an important role in the pharmaceutical industry and provide support for the synthesis of chiral compounds. SK-J002-1n can significantly improve the conversion efficiency and is an important component of transition metal catalysts.

HY-116765

MAO-B-IN-35	Endogenous Metabolite	Neurological Disease
MAO-B-IN-35 is a potent, selective, reversible monoamine oxidase B (MAO-B) inhibitor with high inhibitory activity. MAO-B-IN-35 can exhibit high selectivity and potency at a small molecule scale. MAO-B-IN-35 is designed and synthesized so that it can be efficiently obtained during standard synthesis procedures and has superior physical and chemical properties .

HY-W072147

Fmoc-Ser-OMe Fmoc-L-Ser-OMe	Amino Acid Derivatives	Others
Fmoc-Ser-OMe (Fmoc-L-Ser-OMe) is a hydroxylated L-amino acid protected with a 9-fluorenylmethyloxycarbonyl (Fmoc) group. Fmoc-Ser-OMe involves in chlorophyll–amino acid conjugates synthesis, and acts as a chromo/fluorophores modified protein and emits visible to near-infrared lights efficiently. Fmoc-Ser-OMe glycosylates and produces small mucin-related Olinked glycopeptides, as an alcohol acceptor .

HY-W051391

1,4,7-Trimethyl-1,4,7-triazonane Me3TACN	Biochemical Assay Reagents	Others
1,4,7-Trimethyl-1,4,7-triazonane, also known as TMT or trimethylenetris(aziridine), is a cyclic organic compound. TMT is commonly used as a crosslinking agent and a precursor for polymer and resin synthesis. In addition, it is used as a stabilizer in the production of polyurethane foam and as a curing agent for epoxy resins. Due to its high reactivity and stability, TMT is considered to be a versatile and efficient reagent in various applications.

HY-B0144A

Pitavastatin Maximum Cited Publications 11 Publications Verification NK-104	HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects .

HY-W021005

Silver bis(trifluoromethanesulfonyl)imide Silver triflimide	Biochemical Assay Reagents	Others
Silver bis(trifluoromethanesulfonyl)imide is a kind of silver salt and is widely used as an organic synthesis catalyst. Silver bis(trifluoromethanesulfonyl)imide is used for the C-3 regioselective alkylation of indole derivatives with α,β -enones through conjugated addition reactions. Silver bis(trifluoromethanesulfonyl)imide can also be used as a highly efficient and stable solid-state dye sensitization and P-type dopant for perovskite solar cells .

HY-B0144B

Pitavastatin sodium NK-104 sodium	HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Pitavastatin (NK-104) sodium is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin sodium inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells. Pitavastatin sodium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin sodium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects .

HY-W583317

sSPhos Pd G2	Biochemical Assay Reagents Endogenous Metabolite
sSPhos Pd G2 is a palladium catalyst with excellent cross-coupling reaction activity. sSPhos Pd G2 exhibits efficient catalytic ability in the synthesis of organic molecules and compounds. sSPhos Pd G2 can effectively promote the formation of CC bonds, optimize reaction conditions and increase yields. sSPhos Pd G2 is also used in a variety of transformation reactions, helping researchers develop new materials and compounds.

HY-79647

Fmoc-OSu N-(Fmoc-oxy)succinimide	Biochemical Assay Reagents	Others
Fmoc-OSu (N-(Fmoc-oxy)succinimide) is an acylating agent that targets amino groups (-NH2). It can selectively protect the amino groups of amino acids by covalently binding with primary or secondary amines through nucleophilic substitution reactions. Fmoc-OSu forms a stable amide bond with the amino group to avoid side reactions of the amino group in peptide synthesis. It can also be used as a fluorescent labeling reagent to react with glycosylamines for efficient labeling of N-sugar chains. Fmoc-OSu can be used as an Fmoc protection strategy in peptide synthesis, and as a fluorescent labeling and analysis method for N-sugar chains .

HY-W008658

[1,4-Bis(diphenylphosphino)butane](norbornadiene)rhodium tetrafluoroborate	Biochemical Assay Reagents Endogenous Metabolite
[1,4-Bis(diphenylphosphino)butane](norbornadiene)rhodium tetrafluoroborate is a highly efficient and selective transition metal catalyst that can catalyze a variety of reactions, including cross-coupling reactions and hydrogenation reactions. This compound is widely used in organic synthesis and helps to promote the development of new compounds and materials. Through its catalytic activity, [1,4-Bis(diphenylphosphino)butane](norbornadiene)rhodium tetrafluoroborate offers the potential to optimize reaction conditions and improve yields.

HY-B0144S

Pitavastatin-d4 hemicalcium NK-104-d₄ hemicalcium; Pitavastatin-d₄ hemicalcium	Isotope-Labeled Compounds HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Metabolic Disease Cancer
Pitavastatin-d₄ (hemicalcium) is deuterium labeled Pitavastatin (Calcium). Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity[1][2][3].

HY-B1876

Nicosulfuron	Acetolactate Synthase (ALS) Photosystem II Fungal	Others
Nicosulfuron is efficient, harmless, antifungal and selective herbicide belonging to the sulfonylurea family. Nicosulfuron is also a photosynthetic system inhibitor and inhibits acetolactate synthase (ALS) enzyme activity. Nicosulfuron degradation by Plectosphaerella cucumerina AR1 is glucose concentration dependent in planktonic lifestyle. Nicosulfuron enhances the glycolysis pathway and tricarboxylic acid cycle to improve the adaptability of sweet maize. Nicosulfuron reduces the synthesis of branched-chain amino acids (BCAAs), which is proming for maize cultivation .

HY-B0144AR

Pitavastatin (Standard)	HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Pitavastatin (Standard) is the analytical standard of Pitavastatin. This product is intended for research and analytical applications. Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects .

HY-B0144

Pitavastatin Calcium Maximum Cited Publications 11 Publications Verification NK-104 hemicalcium; Pitavastatin hemicalcium	HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin Calcium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects .

HY-116284

Methyl β-D-glucopyranoside Methyl β-D-glucoside	Drug Intermediate	Others
Methyl β-D-glucopyranoside (Methyl β-D-glucoside) is a model glycosyl acceptor for enzymatic glycosylation reactions. Methyl β-D-glucopyranoside participates in glycoside synthesis and can react with acyl donors such as caffeic acid esters under the catalysis of specific enzymes (such as Lipozyme TL IM) to achieve acylation modification. Methyl β-D-glucopyranoside can generate biologically active derivatives (such as 6-O-caffeoyl glucoside). Methyl β-D-glucopyranoside can be used in organic synthesis and biocatalysis research, especially the efficient enzymatic preparation of medicinal glycosides (such as Robustaside B (HY-N2720), 6-O-caffeoyl salidroside) .

HY-W582827

RuPhos Pd G1 methyl t-butyl ether adduct (MTBE)	Biochemical Assay Reagents Endogenous Metabolite
RuPhos Pd G1 methyl t-butyl ether adduct (MTBE) is a highly efficient catalyst with excellent cross-coupling activity. RuPhos Pd G1 methyl t-butyl ether adduct (MTBE) is widely used in organic synthesis and can be used to promote various reactions to build complex molecular structures. RuPhos Pd G1 methyl t-butyl ether adduct (MTBE) has good adaptability to temperature and reaction conditions, which enables it to exhibit excellent catalytic performance in different reaction systems.

HY-B0987

Ascorbyl palmitate 3 Publications Verification L-Ascorbic acid 6-hexadecanoate; 6-O-Palmitoyl-L-ascorbic acid	Reactive Oxygen Species (ROS) Endogenous Metabolite Calcium Channel Sodium Channel Apoptosis NOD-like Receptor (NLR) Bcl-2 Family Caspase	Inflammation/Immunology
Ascorbyl palmitate is an orally active ester formed from ascorbic acid and palmitic acid, used as an antioxidant and food additive. Ascorbyl palmitate in preventing fat and oil oxidation is more efficient than Butylated hydroxyanisole (HY-B1066) and Butylated hydroxytoluene (HY-Y0172). Ascorbyl palmitate mitigates inhibition of collagen synthesis by select calcium and sodium channel blockers. Ascorbyl palmitate induces Apoptosis in human umbilical vein endothelial cells (HUVECs). Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of NLRP3 inflammasome .

HY-W002530

(1S,2R)-1-Aminoindan-2-ol	Biochemical Assay Reagents	Infection
(1S,2R)-1-Aminoindan-2-ol is a chiral resolving agent. (1S,2R)-1-Aminoindan-2-ol efficiently resolves various racemic 2-arylalkanoic acids and precisely controls the stereostructure of the products in asymmetric syntheses. (1S,2R)-1-Aminoindan-2-ol can be used in the synthesis of HIV protease inhibitors .

HY-B0144AS3

Pitavastatin-d4-1 sodium NK-104-d₄-1 sodium	Isotope-Labeled Compounds HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease
Pitavastatin-d₄-1 (NK-104-d₄-1) sodium is the deuterium labeled Pitavastatin sodium (HY-B0144B). Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects .

HY-B0144R

Pitavastatin Calcium (Standard) NK-104 hemicalcium (Standard); Pitavastatin hemicalcium (Standard)	Reference Standards HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Pitavastatin (Calcium) (Standard) is the analytical standard of Pitavastatin (Calcium). This product is intended for research and analytical applications. Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin Calcium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects .

HY-P10744

BQ7859	Radionuclide-Drug Conjugates (RDCs) PSMA	Cancer
BQ7859 is a probe targeting PSMA that contains a NOTA chelator and demonstrates excellent imaging performance. BQ7859 can be labeled with various radionuclides, such as 68Ga, 18F, 55Co, and 111In. In a mouse prostate cancer xenograft model, BQ7859 (labeled with 111In) efficiently accumulates in tumor regions in a PSMA-dependent manner and provides high-contrast tumor imaging. BQ7859 shows potential for research in prostate cancer imaging, particularly in positron emission tomography (PET) and single-photon emission computed tomography (SPECT) . BQ7859 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-W039442

2′-Deoxy-2′-fluoroadenosine 1 Publications Verification	Nucleoside Antimetabolite/Analog	Infection Cancer
2′-Deoxy-2′-fluoroadenosine is a fluorinated deoxyadenosine with antitumor and antiviral activity, able to interfere with viral or cancer cell replication by being incorporated into DNA. 2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde). 2′-Deoxy-2′-fluoroadenosine shows excellent in vivo activity against tumors expressing E. coli PNP .

HY-W012572A

D-Histidine hydrochloride hydrate	Mitochondrial Metabolism Bacterial	Infection Metabolic Disease
D-Histidine hydrochloride hydrate is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine hydrochloride hydrate works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine hydrochloride hydrate downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine hydrochloride hydrate is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu ²⁺) .

HY-W012572

D-Histidine	Mitochondrial Metabolism Bacterial	Infection Metabolic Disease
D-Histidine is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu ²⁺) .

HY-130652

Pomalidomide 4'-PEG3-azide	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1?degrader based on Rucaparib by using the PROTAC approach . Pomalidomide 4'-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name

HY-L039

Reprogramming Compound Library

2,717 compounds

Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since Yamanaka reprogrammed somatic cells to become induced pluripotent stem cells (iPSCs) using four transcription factors, OCT4, SOX2, KLF4, and c-MYC in 2006. Despite the development of efficient reprogramming methods, most methods are inappropriate for clinical applications because they carry the risk of integrating exogenous genetic factors or use oncogenes. Alternative approaches, such as those based on miRNA, non-viral genes, non-integrative vectors, and small molecules, have been studied as possible solutions to the problems. Among these alternatives, small molecules are attractive options for clinical applications. Reprogramming using small molecules is inexpensive and easy to control in a concentration- and time-dependent manner. It offers a high level of cell permeability, ease of synthesis and standardization, and it is appropriate for mass-producing cells.

MCE Reprogramming Compound Library contains a unique collection of 2,717 compounds that act on reprogramming signaling pathways. These compounds are potential stimulators for reprogramming. This library is a useful tool for researching reprogramming and regenerative medicine.

Cat. No.	Product Name	Type

HY-W001095

N-Methoxy-N-methylacetamide	Biochemical Assay Reagents
N-Methoxy-N-methylacetamide can efficiently acetylate polycarbonyl compounds. As an important intermediate, N-Methoxy-N-methylacetamide can be used for the synthesis of other active compounds .

HY-145396

PLGA-PEG-NH2	Drug Delivery
PLGA-PEG-NH2 is a material to synthesis nanomicelles. PLGA-PEG-NH2 nanomicelle is an efficient delivery system of Irinotecan for targeted colorectal cancer and hepatocellular carcinoma .

HY-75200

N-(Benzyloxycarbonyloxy)succinimide

Biochemical Assay Reagents

N-(Benzyloxycarbonyloxy)succinimide is an efficient amino-protecting reagent in organic synthesis, playing an important role in the field of organic synthesis. N-(Benzyloxycarbonyloxy)succinimide is also a neutral ionophore, which significantly improves the performance of erbium ion (Er ³⁺) sensors and provides a practical tool for the rapid detection of erbium ions in the environment and water quality .

HY-W127637

Tetraamylammonium chloride

Tetrapentylammonium chloride

Biochemical Assay Reagents

Tetraamylammonium chloride is an organic compound containing ammonium and chloride ions. It is commonly used as a phase transfer catalyst in organic synthesis, especially in the production of pharmaceuticals and agrochemicals. Tetraamylammonium Chloride has a strong base that facilitates the transfer of reactants between immiscible solvents, resulting in more efficient chemical reactions. In addition, it can also be used as an intermediate in the synthesis of other quaternary ammonium compounds.

HY-W127681

Tetrabutylammonium dichlorobromide

Tetra-n-butylammonium dichlorobromide

Cell Assay Reagents

Tetrabutylammonium dichlorobromide is an organic compound containing ammonium, chloride, and bromide ions. It is commonly used as a phase transfer catalyst in organic synthesis, especially in the production of pharmaceuticals and agrochemicals. Tetrabutylammonium Dichlorobromide has a strong base that facilitates the transfer of reactants between immiscible solvents, resulting in more efficient chemical reactions. In addition, it can also be used as an intermediate in the synthesis of other quaternary ammonium compounds.

HY-W002864

6-Bromonicotinic acid	Biochemical Assay Reagents
6-Bromonicotinic acid is a brominated derivative of Niacin (HY-B0143), can be used as a drug intermediate for the synthesis of Anabaseine (HY-115766) derivatives.

HY-W018454

Benzyltrimethylammonium tribromide	Biochemical Assay Reagents
Benzyl trimethyl ammonium tribromide is an organic ammonium tribromide. Benzyl trimethyl ammonium tribromide provides controlled bromide ions, enabling efficient cyclization and oxidation while minimizing side reactions caused by excess bromine. Benzyl trimethyl ammonium tribromide can be used in the synthesis of 2-aminobenzothiazole compounds .

HY-W042557

Tetrabutylammonium trifluoromethanesulfonate

Biochemical Assay Reagents

Tetrabutylammonium trifluoromethanesulfonate, commonly known as TBAOTf. TBAOTf is widely used as a strong acid catalyst and phase transfer agent in organic synthesis, especially for reactions involving nucleophilic substitution, elimination, and rearrangement, in addition, it is also used as an electrolyte additive for rechargeable batteries and a stabilizer of supercritical fluids Due to its high stability, solubility and selectivity, TBAOTf is considered to be a highly efficient and multifunctional reagent in various applications.

HY-W051391

1,4,7-Trimethyl-1,4,7-triazonane

Me3TACN

Biochemical Assay Reagents

1,4,7-Trimethyl-1,4,7-triazonane, also known as TMT or trimethylenetris(aziridine), is a cyclic organic compound. TMT is commonly used as a crosslinking agent and a precursor for polymer and resin synthesis. In addition, it is used as a stabilizer in the production of polyurethane foam and as a curing agent for epoxy resins. Due to its high reactivity and stability, TMT is considered to be a versatile and efficient reagent in various applications.

HY-W127654

(Ferrocenylmethyl)trimethylammonium bromide

Cell Assay Reagents

(Ferrocenylmethyl)trimethylammonium bromide is an organic compound containing ammonium and bromide ions. It is commonly used as a phase transfer catalyst in organic synthesis, especially in the production of pharmaceuticals and agrochemicals. (Ferrocenylmethyl)trimethylammonium Bromide has a strong base that facilitates the transfer of reactants between immiscible solvents for more efficient chemical reactions. In addition, it can also be used as an intermediate in the synthesis of other organic compounds.

HY-W021005

Silver bis(trifluoromethanesulfonyl)imide

Silver triflimide

Biochemical Assay Reagents

Silver bis(trifluoromethanesulfonyl)imide is a kind of silver salt and is widely used as an organic synthesis catalyst. Silver bis(trifluoromethanesulfonyl)imide is used for the C-3 regioselective alkylation of indole derivatives with α,β -enones through conjugated addition reactions. Silver bis(trifluoromethanesulfonyl)imide can also be used as a highly efficient and stable solid-state dye sensitization and P-type dopant for perovskite solar cells .

HY-79647

Fmoc-OSu

N-(Fmoc-oxy)succinimide

Biochemical Assay Reagents

Fmoc-OSu (N-(Fmoc-oxy)succinimide) is an acylating agent that targets amino groups (-NH2). It can selectively protect the amino groups of amino acids by covalently binding with primary or secondary amines through nucleophilic substitution reactions. Fmoc-OSu forms a stable amide bond with the amino group to avoid side reactions of the amino group in peptide synthesis. It can also be used as a fluorescent labeling reagent to react with glycosylamines for efficient labeling of N-sugar chains. Fmoc-OSu can be used as an Fmoc protection strategy in peptide synthesis, and as a fluorescent labeling and analysis method for N-sugar chains .

HY-W002530

(1S,2R)-1-Aminoindan-2-ol	Biochemical Assay Reagents
(1S,2R)-1-Aminoindan-2-ol is a chiral resolving agent. (1S,2R)-1-Aminoindan-2-ol efficiently resolves various racemic 2-arylalkanoic acids and precisely controls the stereostructure of the products in asymmetric syntheses. (1S,2R)-1-Aminoindan-2-ol can be used in the synthesis of HIV protease inhibitors .

Cat. No.	Product Name	Target	Research Area

HY-W072147

Fmoc-Ser-OMe Fmoc-L-Ser-OMe	Amino Acid Derivatives	Others
Fmoc-Ser-OMe (Fmoc-L-Ser-OMe) is a hydroxylated L-amino acid protected with a 9-fluorenylmethyloxycarbonyl (Fmoc) group. Fmoc-Ser-OMe involves in chlorophyll–amino acid conjugates synthesis, and acts as a chromo/fluorophores modified protein and emits visible to near-infrared lights efficiently. Fmoc-Ser-OMe glycosylates and produces small mucin-related Olinked glycopeptides, as an alcohol acceptor .

HY-W012572A

D-Histidine hydrochloride hydrate	Mitochondrial Metabolism Bacterial	Infection Metabolic Disease
D-Histidine hydrochloride hydrate is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine hydrochloride hydrate works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine hydrochloride hydrate downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine hydrochloride hydrate is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu ²⁺) .

HY-P10744

BQ7859	Radionuclide-Drug Conjugates (RDCs) PSMA	Cancer
BQ7859 is a probe targeting PSMA that contains a NOTA chelator and demonstrates excellent imaging performance. BQ7859 can be labeled with various radionuclides, such as 68Ga, 18F, 55Co, and 111In. In a mouse prostate cancer xenograft model, BQ7859 (labeled with 111In) efficiently accumulates in tumor regions in a PSMA-dependent manner and provides high-contrast tumor imaging. BQ7859 shows potential for research in prostate cancer imaging, particularly in positron emission tomography (PET) and single-photon emission computed tomography (SPECT) . BQ7859 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9542

Dimethyl Citric acid 1 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Plants Actinidiaceae Disease Research Fields Actinidia arguta (Sieb. & Zucc) Planch. ex Miq.	Others
Dimethylurea/citric acid is a highly efficient deep eutectic solvent (DES). Dimethylurea/citric acid can be used as a catalyst and a green reaction medium for the synthesis of bis(indolyl)methanes, quinolines and aryl-4, 5-diphenyl-1H-imidazoles.

HY-B0987

Ascorbyl palmitate 3 Publications Verification L-Ascorbic acid 6-hexadecanoate; 6-O-Palmitoyl-L-ascorbic acid	Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Reactive Oxygen Species (ROS) Endogenous Metabolite Calcium Channel Sodium Channel Apoptosis NOD-like Receptor (NLR) Bcl-2 Family Caspase
Ascorbyl palmitate is an orally active ester formed from ascorbic acid and palmitic acid, used as an antioxidant and food additive. Ascorbyl palmitate in preventing fat and oil oxidation is more efficient than Butylated hydroxyanisole (HY-B1066) and Butylated hydroxytoluene (HY-Y0172). Ascorbyl palmitate mitigates inhibition of collagen synthesis by select calcium and sodium channel blockers. Ascorbyl palmitate induces Apoptosis in human umbilical vein endothelial cells (HUVECs). Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of NLRP3 inflammasome .

HY-W012572

D-Histidine	Microorganisms Source classification	Mitochondrial Metabolism Bacterial
D-Histidine is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu ²⁺) .

HY-W012572R

D-Histidine (Standard)	Microorganisms Source classification	Reference Standards Mitochondrial Metabolism Bacterial
D-Histidine (Standard) is the analytical standard of D-Histidine (HY-W012572). This product is intended for research and analytical applications. D-Histidine is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu ²⁺) .

Cat. No.	Product Name	Chemical Structure

HY-B0144AS1

Pitavastatin-d5 sodium
Pitavastatin-d₅ (sodium) is the deuterium labeled Pitavastatin sodium. Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity.

HY-B0144AS3

Pitavastatin-d4-1 sodium

Pitavastatin-d₄-1 (NK-104-d₄-1) sodium is the deuterium labeled Pitavastatin sodium (HY-B0144B). Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects .

HY-Y0302S

Diammonium phosphate-15N2
Diammonium phosphate- ¹⁵N₂ is ¹⁵N₂ labeled Diammonium phosphate (HY-Y0302). Diammonium phosphate is a neutral and efficient catalyst in 1,8-Dioxo-octahydroxanthene derivatives synthesis, which can be used as an excipient, such as diuretic, buffer, effervescent .

HY-W001095S

N-Methoxy-N-methylacetamide-d3
N-Methoxy-N-methylacetamide-d₃ is deuterium labeled N-Methoxy-N-methylacetamide (HY-W001095). N-Methoxy-N-methylacetamide can efficiently acetylate polycarbonyl compounds. As an important intermediate, N-Methoxy-N-methylacetamide can be used for the synthesis of other active compounds .

HY-B0144S

Pitavastatin-d4 hemicalcium

Pitavastatin-d₄ (hemicalcium) is deuterium labeled Pitavastatin (Calcium). Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity[1][2][3].

Cat. No.	Product Name		Classification

HY-130652

Pomalidomide 4'-PEG3-azide		Azide PROTAC Synthesis
Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1?degrader based on Rucaparib by using the PROTAC approach . Pomalidomide 4'-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-Y0302

Diammonium phosphate		pH Modifiers
Diammonium phosphate is a neutral and efficient catalyst in 1,8‐Dioxo‐octahydroxanthene derivatives synthesis. Diammonium phosphate can be used as an excipient, such as diuretic, buffer, effervescent .

HY-145396

PLGA-PEG-NH2		Polymers
PLGA-PEG-NH2 is a material to synthesis nanomicelles. PLGA-PEG-NH2 nanomicelle is an efficient delivery system of Irinotecan for targeted colorectal cancer and hepatocellular carcinoma .

HY-W013156

2′,3′,5′-Triacetylinosine 2′,3′,5′-Tri-O-acetylinosine		Nucleoside Analogs Inosine
2′,3′,5′-Triacetylinosine (2′,3′,5′-Tri-O-acetylinosine) has been shown to inhibit the growth of cancer cells, and is also an efficient method for bond cleavage and radiation protection. 2',3',5'-Tri-O-acetylinosine has been shown to bind to pyridinium ions, and it has been used in the synthesis of tetrapeptides with hydroxyl groups or alkylation.

HY-W039442

2′-Deoxy-2′-fluoroadenosine 1 Publications Verification		Nucleoside Analogs Adenosine
2′-Deoxy-2′-fluoroadenosine is a fluorinated deoxyadenosine with antitumor and antiviral activity, able to interfere with viral or cancer cell replication by being incorporated into DNA. 2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde). 2′-Deoxy-2′-fluoroadenosine shows excellent in vivo activity against tumors expressing E. coli PNP .

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