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Ectonucleotidases inhibitor

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-125286
    AB-680
    10+ Cited Publications

    		 CD73 Cancer
    AB-680 is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity .
    AB-680
  • HY-125286A
    AB-680 ammonium

    		CD73 Cancer
    AB-680 ammonium is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity .
    AB-680 ammonium
  • HY-172528
    Enpp-1/3-IN-1

    		Phosphodiesterase (PDE) CD73 Phosphatase Cancer
    Enpp-1/3-IN-1 (Compound 5j) is an ENPP1/ENPP3 inhibitor, with IC50s of 0.59 μM (h-ENPP1) and 0.62 μM (h-ENPP3) respectively. Enpp-1/3-IN-1 also inhibits e5′NT (CD73) and TNAP with IC50s of 0.89 μM (h-e5′NT), 5.12 μM (r-e5′NT) and 1.68 μM (h-TNAP), respectively. Enpp-1/3-IN-1 can be used for cancer research .
    Enpp-1/3-IN-1
  • HY-171805
    PSB-0963

    		CD73 Cancer
    PSB-0963 is a selective and competitive ecto-5'-nucleotidase (eN/CD73) inhibitor with a Ki of 150 nM for rat ecto-5'-nucleotidase. PSB-0963 shows high selectivity over other ectonucleotidases (NTPDases 1-3) and P2Y receptors. PSB-0963 can be used for the study of cancer .
    PSB-0963
  • HY-172527
    CD73-IN-20

    		CD73 Phosphodiesterase (PDE) Phosphatase Cancer
    CD73-IN-20 (Compound 5c) is an e5′NT (CD73) inhibitor (IC50: 0.37 μM). CD73-IN-20 also inhibits other ectonucleotidases, with IC50s of 1.12 μM (h-ENPP1), 1.37 μM (h-ENPP3), 1.66 μM (r-e5′NT), 1.48 μM (h-TNAP), respectively. CD73-IN-20 can be used for cancer research .
    CD73-IN-20

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