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Results for "

EGR1

" in MedChemExpress (MCE) Product Catalog:

15

Inhibitors & Agonists

1

Recombinant Proteins

1

Isotope-Labeled Compounds

4

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-RS04215
    EGR1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    EGR1 Human Pre-designed siRNA Set A contains three designed siRNAs for EGR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    EGR1 Human Pre-designed siRNA Set A
    EGR1 Human Pre-designed siRNA Set A
  • HY-170415
    EGR-1-IN-3

    		Interleukin Related Inflammation/Immunology
    EGR-1 IN-3 (Compound 36) is an early growth response 1 (EGR-1)-DNA binding disruptor. EGR-1-IN-3 inhibits TNFα-induced binding of EGR-1 to DNA and expression of genes associated with inflammation (such as TSLP, IL-31, IL-6 and CCL2). EGR-1-IN-3 can be used in the study of inflammatory diseases [1].
    EGR-1-IN-3
  • HY-163731
    EGR-1-IN-1

    		DNA Methyltransferase Inflammation/Immunology
    EGR-1-IN-1 (IT25) is an inhibitor targeting EGR-1, with IC50 of 1.86 μM. EGR-1-IN-1 can be used in the research of inflammatory skin diseases [1].
    EGR-1-IN-1
  • HY-169118
    EGR-1-IN-2

    		TNF Receptor Inflammation/Immunology
    EGR-1-IN-2 (compound 2) is an EGR-1 inhibitor with anti-inflammatory activity. EGR-1-IN-2 inhibits the formation of EGR-1-DNA complexes induced by TNF-α in HaCaT cells [1].
    EGR-1-IN-2
  • HY-125980
    LX-3
    1 Publications Verification

    		 p38 MAPK Cancer
    LX-3 is a selective activator of the p38 MAPK signaling pathway and activates EGFP reporter genes that are silenced by DNA methylation, such as TNF, EGR1, LY6K, and ISG20 [1].
    LX-3
  • HY-157549A
    Brivoligide sodium

    AYX1 sodium

    		 Nucleoside Antimetabolite/Analog Neurological Disease
    Brivoligide (AYX1) sodium is a double-stranded, unprotected, 23 base-pair oligonucleotide. Brivoligide sodium can reduce acute post-surgical pain. Brivoligide sodium mimics the DNA sequence normally bound by EGR1 on chromosomes [1].
    Brivoligide sodium
  • HY-RS16606
    Egr1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Egr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Egr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Egr1 Mouse Pre-designed siRNA Set A
    Egr1 Mouse Pre-designed siRNA Set A
  • HY-RS23040
    Egr1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Egr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Egr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Egr1 Rat Pre-designed siRNA Set A
    Egr1 Rat Pre-designed siRNA Set A
  • HY-157549
    Brivoligide

    AYX1

    		 Nucleoside Antimetabolite/Analog Neurological Disease
    Brivoligide (AYX1) is a double-stranded, unprotected, 23 base-pair oligonucleotide. Brivoligide can reduce acute post-surgical pain. Brivoligide mimics the DNA sequence normally bound by EGR1 on chromosomes [1].
    Brivoligide
  • HY-131721
    14,15-EET-SI

    		Drug Derivative Mitosis Others
    14,15-EET-SI is a sulfonimide (SI) analog metabolized from 14,15-EET, which is also an effective mitogen. 14,15-EET-SI can stimulate the incorporation of [3H] thymidine, activate pp60c-src and initiate the tyrosine kinase cascade, mediating their mitotic effects. Additionally, 14,15-EET-SI can increase cell proliferation as well as the expression of c-fos and egr-1 mRNA [1].
    14,15-EET-SI
  • HY-146411
    microRNA-21-IN-1

    		MicroRNA Apoptosis Cancer
    microRNA-21-IN-1 (compound A7) is an efficient microRNA inhibitor. microRNA-21-IN-1 has antiproliferative activity against Hela and HCT-116 cells with IC50s of 5.5 μM and 2.8 μM respectively, as well as promotes apoptosis of Hela cells. microRNA-21-IN-1 upregulates the expression of microRNA-21 downstream functional targets (PTEN, EGR1 and SLIT2). microRNA-21-IN-1 can be used for researching anticancer [1].
    microRNA-21-IN-1
  • HY-116818
    Crebinostat

    		HDAC Neurological Disease
    Crebinostat is a potent histone deacetylase (HDAC) inhibitor with IC50 values of 0.7 nM, 1.0 nM, 2.0 nM and 9.3 nM for HDAC1, HDAC2, HDAC3 and HDAC6, respectively. Crebinostat potently induces acetylation of both histone H3 and histone H4 as well as enhances the expression of the cAMP response element-binding protein (CREB) target gene Egr1. Crebinostat increases the density of synapsin-1 punctae along dendrites in cultured neurons. Crebinostat can modulate chromatin-mediated neuroplasticity and exhibits enhanced memory in mice [1].
    Crebinostat
  • HY-121246
    Fluorofenidone
    1 Publications Verification

    AKF-PD

    		 NF-κB ERK TGF-beta/Smad Inflammation/Immunology
    Fluorofenidone (AKF-PD) is an orally active compound with anti-fibrotic, antioxidant, and anti-inflammatory pharmacological effects. Fluorofenidone downregulates the expression of ACSL4, upregulates GPX4 expression and inhibits the NF-κB signaling pathway to alleviate inflammation and fibrosis. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Fluorofenidone demonstrates protective effects against chronic lung injury in mice. Fluorofenidone can be used for the study of chronic obstructive pulmonary disease (COPD) and pulmonary interstitial fibrosis (PIF) [1] .
    Fluorofenidone
  • HY-121246R
    Fluorofenidone (Standard)

    		Reference Standards NF-κB ERK TGF-beta/Smad Inflammation/Immunology
    Fluorofenidone (Standard) is the analytical standard of Fluorofenidone. This product is intended for research and analytical applications. Fluorofenidone (AKF-PD) is an orally active compound with anti-fibrotic, antioxidant, and anti-inflammatory pharmacological effects. Fluorofenidone downregulates the expression of ACSL4, upregulates GPX4 expression and inhibits the NF-κB signaling pathway to alleviate inflammation and fibrosis. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Fluorofenidone demonstrates protective effects against chronic lung injury in mice. Fluorofenidone can be used for the study of chronic obstructive pulmonary disease (COPD) and pulmonary interstitial fibrosis (PIF) [1] .
    Fluorofenidone (Standard)
  • HY-121246S
    Fluorofenidone-d3

    AKF-PD-d3

    		 Isotope-Labeled Compounds NF-κB ERK TGF-beta/Smad Inflammation/Immunology
    Fluorofenidone-d3 (AKF-PD-d3) is deuterium labeled Fluorofenidone. Fluorofenidone (AKF-PD) is an orally active compound with anti-fibrotic, antioxidant, and anti-inflammatory pharmacological effects. Fluorofenidone downregulates the expression of ACSL4, upregulates GPX4 expression and inhibits the NF-κB signaling pathway to alleviate inflammation and fibrosis. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Fluorofenidone demonstrates protective effects against chronic lung injury in mice. Fluorofenidone can be used for the study of chronic obstructive pulmonary disease (COPD) and pulmonary interstitial fibrosis (PIF) [1] .
    Fluorofenidone-d3

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