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Results for "

EF2

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

1

Natural
Products

1

Recombinant Proteins

8

Antibodies

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-128478
    Sordarin

    		Fungal Infection
    Sordarin (Compound 1) is an antifungal agent targeting Elongation factor 2 (EF2) with a tetracyclic diterpene core including a norbornene system. Sordarin can be isolated from the fungus Sordaria araneosa. Sordarin has potent antifungal activity against Saccharomyces cerevisiae and Candida albicans. Sordarin prevents the translocation of the ribosome along mRNA during elongation of the emerging polypeptide chain, inhibiting protein synthesis in fungi by stabilizing the ribosome/EF2 complex .
    Sordarin
  • HY-169349
    Androgen receptor antagonist 12

    		Androgen Receptor Cancer
    Androgen receptor antagonist 12 (Compound EF2) is an orally active Androgen receptor (AR) antagonist (IC50: 0.30 μM). Androgen receptor antagonist 12 inhibits transcriptional activity of variant AR mutants and and the proliferation of AR-positive PCa cell lines. Androgen receptor antagonist 12 blocks AR nuclear translocation. Androgen receptor antagonist 12 inhibits tumor growth in a C4-2B xenograft mouse model. Androgen receptor antagonist 12 can be used for prostate cancer (PCa) research .
    Androgen receptor antagonist 12
  • HY-175164
    SVC112

    		Apoptosis c-Myc Cancer
    SVC112 is a translation elongation inhibitor that prevents the cyclic dissociation of EF2 from the ribosome, thereby inhibiting the elongation step of translation. SVC112 shows activity in growth inhibition among cancer cell lines of various origins (acute myeloid leukemia (AML), multiple myeloma (Myeloma), colorectal cancer (CRC), and head and neck squamous cell carcinoma (HNSCC)). SVC112 preferentially impedes ribosomal processing of mRNAs, and decreaseds CSC-related proteins including Myc and Sox2. SVC112 induces apoptosis in hematologic cancer cell lines, while phosphorylation of c-Myc correlates with sensitivity to SVC112 in colorectal cancer cell lines. SVC112 inactivates HNSCC stem cells in vitro and prevents the regrowth of HNSCC tumor xenografts in mice. SVC112 can be used for the study of HNSCC [2].
    SVC112
  • HY-RS20725
    Eef2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Eef2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Eef2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Eef2 Mouse Pre-designed siRNA Set A
    Eef2 Mouse Pre-designed siRNA Set A
  • HY-RS27237
    Eef2 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Eef2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Eef2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Eef2 Rat Pre-designed siRNA Set A
    Eef2 Rat Pre-designed siRNA Set A
  • HY-RS04180
    EEF2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    EEF2 Human Pre-designed siRNA Set A contains three designed siRNAs for EEF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    EEF2 Human Pre-designed siRNA Set A
    EEF2 Human Pre-designed siRNA Set A
  • HY-RS19149
    Npr3 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Npr3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npr3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Npr3 Mouse Pre-designed siRNA Set A
    Npr3 Mouse Pre-designed siRNA Set A

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