Dihydropyrimidine Dehydrogenase (DPD)

By Targets:	Dihydropyrimidine Dehydrogenase (DPD) (1) Biochemical Assay Reagents (2) DNA/RNA Synthesis (3) Endogenous Metabolite (5) Isotope-Labeled Compounds (2) Nucleoside Antimetabolite/Analog (1)
By Research Areas:	Cancer (7) Infection (1) Metabolic Disease (5)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Nucleosides and their Analogs (1) T (1)

Targets Recommended: Dihydropyrimidine Dehydrogenase (DPD) Succinate Dehydrogenase Glutamate Dehydrogenase (GLDH) Malate Dehydrogenase (MDH) Lactate Dehydrogenase Dihydroorotate Dehydrogenase Isocitrate Dehydrogenase (IDH) Methylenetetrahydrofolate Dehydrogenase (MTHFD) Phosphoglycerate Dehydrogenase (PHGDH) Aldehyde Dehydrogenase (ALDH) IMPDH PDHK 15-PGDH 17β-HSD 11β-HSD

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124062

TAS-114 3 Publications Verification	DNA/RNA Synthesis	Cancer
TAS-114 is an orally active dual dUTPase/dihydropyrimidine dehydrogenase (DPD) inhibitor, can improving the therapeutic efficacy of fluoropyrimidine .

HY-W012926

Dihydrouracil 5,6-Dihydrouracil	Endogenous Metabolite	Metabolic Disease
Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient .

HY-17469

Gimeracil 2 Publications Verification Gimestat	DNA/RNA Synthesis Dihydropyrimidine Dehydrogenase (DPD)	Cancer
Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD) .

HY-W010450

Thymine	Endogenous Metabolite	Metabolic Disease Cancer
Thymine, one of the four bases of DNA, is a substrate for rat liver dihydropyrimidine dehydrogenase (DPD), with a K_m value of 2.2 μM, K_i of 24 μM (using 5-FU as the DPD substrate), and a specific activity of 0.68 nmol/min/mg .

HY-10533

Eniluracil 5-Ethynyluracil; GW776C85	Biochemical Assay Reagents	Cancer
Eniluracil (5-Ethynyluracil) is an orally active **dihydropyrimidine dehydrogenase** (DPD) inhibitor. Eniluracil irreversibly inhibits *DPD*, increases the oral bioavailability of 5-fluorouracil to 100%, and facilitates the uniform absorption and toxicity of 5-fluorouracil. Eniluracil can be used in cancer research of combination with fluoropyrimidines (including 5-fluorouracil) . Eniluracil is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W012926S1

Dihydrouracil-d4 5,6-Dihydrouracil-d₄	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Dihydrouracil-d₄ is the deuterium labeled Dihydrouracil . Dihydrouracil (HY-W012926), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient .

HY-W012926R

Dihydrouracil (Standard) 5,6-Dihydrouracil (Standard)	Endogenous Metabolite	Metabolic Disease
Dihydrouracil (Standard) is the analytical standard of Dihydrouracil. This product is intended for research and analytical applications. Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient[1][2].

HY-W012926S

Dihydrouracil-13C4,15N2 5,6-Dihydrouracil-¹³C₄,¹⁵N₂	Endogenous Metabolite	Metabolic Disease
Dihydrouracil- ¹³C₄, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Dihydrouracil . Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient .

HY-17469S

Gimeracil-13C3,15N Gimestat-¹³C₃,¹⁵N	Isotope-Labeled Compounds	Cancer
Gimeracil- ¹³C₃, ¹⁵N (Gimestat- ¹³C₃, ¹⁵N) is ¹³C and ¹⁵N labeled Gimeracil. Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD) .

HY-W014109

(E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione (E)-5-(2-Bromovinyl)uracil; BVU	DNA/RNA Synthesis	Infection
(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil (HY-90006) in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time.

HY-10533R

Eniluracil (Standard) 5-Ethynyluracil (Standard); GW776C85 (Standard)	Biochemical Assay Reagents	Cancer
Eniluracil (Standard) is the analytical standard of Eniluracil. This product is intended for research and analytical applications. Eniluracil (5-Ethynyluracil) is an orally active dihydropyrimidine dehydrogenase (DPD) inhibitor. Eniluracil irreversibly inhibits DPD, increases the oral bioavailability of 5-fluorouracil to 100%, and facilitates the uniform absorption and toxicity of 5-fluorouracil. Eniluracil can be used in cancer research of combination with fluoropyrimidines (including 5-fluorouracil) . Eniluracil is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-134160

5,6-Dihydro-5-Fluorouracil 5-DHFU; 5-FluoroDihydropyrimidine-2,4-dione; 5-Fluorodihydrouracil	Nucleoside Antimetabolite/Analog	Cancer
5,6-Dihydro-5-Fluorouracil (5-DHFU; 5-Fluorodihydropyrimidine-2,4-dione) is the active metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil (HY-90006), which is formed from 5-fluorouracil by dihydropyrimidine dehydrogenase (DPD). 5,6-Dihydro-5-Fluorouracil is cytotoxic to HaCaT keratinocytes (IC50=13.5 μM). Intravenous administration of 5,6-Dihydro-5-Fluorouracil (90 mg/kg/wk) in combination with 5-fluorouracil and the DPD inhibitor eniluracil (HY-10533) slows tumor growth in a rat colon cancer model.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W012926

Dihydrouracil 5,6-Dihydrouracil	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient .

HY-W012926R

Dihydrouracil (Standard) 5,6-Dihydrouracil (Standard)	Structural Classification Natural Products Microorganisms Source classification Disease markers Endocrine diseases Endogenous metabolite	Endogenous Metabolite
Dihydrouracil (Standard) is the analytical standard of Dihydrouracil. This product is intended for research and analytical applications. Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient[1][2].

Cat. No.	Product Name	Chemical Structure

HY-W012926S1

Dihydrouracil-d4
Dihydrouracil-d₄ is the deuterium labeled Dihydrouracil . Dihydrouracil (HY-W012926), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient .

HY-W012926S

Dihydrouracil-13C4,15N2
Dihydrouracil- ¹³C₄, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Dihydrouracil . Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient .

HY-17469S

Gimeracil-13C3,15N
Gimeracil- ¹³C₃, ¹⁵N (Gimestat- ¹³C₃, ¹⁵N) is ¹³C and ¹⁵N labeled Gimeracil. Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD) .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82255

	DPD Antibody (YA2000) DPYD; Dihydropyrimidine Dehydrogenase [NADP(+)]; DHPDHase; DPD; Dihydrothymine Dehydrogenase; Dihydrouracil Dehydrogenase	WB, IHC-P, ICC/IF, FC	Human
	DPD Antibody (YA2000) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2000), targeting DPD, with a predicted molecular weight of 111 kDa (observed band size: 111 kDa). DPD Antibody (YA2000) can be used for WB, IHC-P, ICC/IF, FC experiment in human background.

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Cat. No.	Product Name		Classification

HY-10533

Eniluracil 5-Ethynyluracil; GW776C85		Alkynes
Eniluracil (5-Ethynyluracil) is an orally active **dihydropyrimidine dehydrogenase** (DPD) inhibitor. Eniluracil irreversibly inhibits *DPD*, increases the oral bioavailability of 5-fluorouracil to 100%, and facilitates the uniform absorption and toxicity of 5-fluorouracil. Eniluracil can be used in cancer research of combination with fluoropyrimidines (including 5-fluorouracil) . Eniluracil is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-W010450

Thymine		Nucleosides and their Analogs T
Thymine, one of the four bases of DNA, is a substrate for rat liver dihydropyrimidine dehydrogenase (DPD), with a K_m value of 2.2 μM, K_i of 24 μM (using 5-FU as the DPD substrate), and a specific activity of 0.68 nmol/min/mg .

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Dihydropyrimidine Dehydrogenase (DPD)

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