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DNH 28

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-175037
    DNH28

    		NF-κB p38 MAPK Bcl-2 Family Caspase Apoptosis Cancer
    DNH28 is a potent NF-κB and MAPK inhibitor with an IC50 of 0.93 μM against HepG2 cells. DNH28 promotes apoptosis by down-regulating the expression of Bcl-2, up-regulating the expression of BAX and C-caspase-3. DNH28 blocks the cell cycle and inhibits migration. DNH28 can be used for the study of hepatocellular carcinoma (HCC) .
    DNH28
  • HY-175000
    L14-8

    		Ferroptosis Polo-like Kinase (PLK) MDM-2/p53 Endocrinology Cancer
    L14-8 is a potent ferroptosis inducer. L14-8 promotes PLK1 degradation via ubiquitination, increasing TP53 phosphorylation to enhance SAT1 transcription, thereby triggering ferroptosis and cancer cell death. DNH28 can be used for the study of advanced prostate cancer .
    L14-8

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