DAPK1

By Targets:	Anaplastic lymphoma kinase (ALK) (1) Antibiotic (2) Apoptosis (3) ATF6 (2) Autophagy (2) Bacterial (2) DAPK (8) DYRK (1) Heme Oxygenase (HO) (1) IPK Superfamily (1) Isocitrate Dehydrogenase (IDH) (1) Keap1-Nrf2 (1) NF-κB (2) NO Synthase (2) Nuclear Hormone Receptor 4A/NR4A (1) PDGFR (1) PERK (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (2) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-169109

DAPK1-IN-1	DAPK	Neurological Disease
DAPK1-IN-1 (compound 10) is a death-associated protein kinase 1 (DAPK1) inhibitor with a K_d value of 0.63 μM. DAPK1-IN-1 can be used in Alzheimer’s disease research ^[1].

HY-15513

*TC-DAPK* 6** Maximum Cited Publications 11 Publications Verification	DAPK	Cancer
TC-DAPK 6 is a potent, ATP-competitive, and highly selective *DAPK* inhibitor (IC₅₀=69 and 225 nM against *DAPK1* and *DAPK3*, respectively, with 10 μM ATP).

HY-15847

HS38 3 Publications Verification	DAPK	Cardiovascular Disease
HS38 is a potent, selective, and ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) and zipper-interacting protein kinase (ZIPK, also called DAPK3), with K_ds of 300 nM and 280 nM, respectively. HS38 is also a PIM3 inhibitor with an IC₅₀ of 200 nM. HS38 can be used for the research of smooth muscle related disorders ^[1].

HY-123581

Quinocetone	Antibiotic Bacterial ATF6 DAPK Autophagy NF-κB NO Synthase Apoptosis Reactive Oxygen Species (ROS) Keap1-Nrf2 Heme Oxygenase (HO)	Infection Inflammation/Immunology
Quinocetone is an orally active animal feed additive used to increase the meat production of livestock and poultry. Quinocetone exhibits antibacterial activity against a variety of pathogenic microorganisms. Quinocetone exhibits tissue-specific (liver, lymphocyte) toxicity. Quinocetone induces autophagy in cells through the *ATF6/DAPK1* pathway. Quinocetone activates the NF-κB and iNOS pathways, leading to cell apoptosis, hepatocyte vacuolar degeneration and fibrosis. Quinocetone can inhibit *Nrf2/HO-1* and induce the generation of reactive oxygen species (ROS), leading to oxidative stress and DNA damage ^[1] .

HY-123581R

Quinocetone (Standard)	Reference Standards Antibiotic Bacterial ATF6 DAPK Autophagy NF-κB NO Synthase Apoptosis Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology
Quinocetone (Standard) is the analytical standard of Quinocetone (HY-123581). This product is used for research and analytical purposes. Quinocetone is an orally active animal feed additive used to increase the meat production of livestock and poultry. Quinocetone exhibits antibacterial activity against a variety of pathogenic microorganisms. Quinocetone exhibits tissue-specific (liver, lymphocyte) toxicity. Quinocetone induces autophagy in cells through the *ATF6/DAPK1* pathway. Quinocetone activates the NF-κB and iNOS pathways, leading to cell apoptosis, hepatocyte vacuolar degeneration and fibrosis. Quinocetone can inhibit *Nrf2/HO-1* and induce the generation of reactive oxygen species (ROS), leading to oxidative stress and DNA damage.

HY-RS16812

Dapk1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dapk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dapk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dapk1 Mouse Pre-designed siRNA Set A Dapk1 Mouse Pre-designed siRNA Set A

HY-RS23252

Dapk1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dapk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dapk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dapk1 Rat Pre-designed siRNA Set A Dapk1 Rat Pre-designed siRNA Set A

HY-RS03527

DAPK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DAPK1 Human Pre-designed siRNA Set A contains three designed siRNAs for DAPK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DAPK1 Human Pre-designed siRNA Set A DAPK1 Human Pre-designed siRNA Set A

HY-P5277

TAT-GluN2BCTM	DAPK	Neurological Disease
TAT-GluN2BCTM is a membrane-permeable *DAPK1*-targeting peptide. TAT-GluN2BCTM targets active DAPK1 to lysosomes for degradation. TAT-GluN2BCTM protects neurons from oxidative stress and NMDAR-mediated excitotoxicity by knocking down DAPK1. TAT-GluN2BCTM can be used in the study of neuroprotection ^[1].

HY-175477

UNC9750	DAPK DYRK PDGFR IPK Superfamily	Cancer
UNC9750 is an inositol phosphate multikinase (IPMK) inhibitor with IC₅₀ values of 31.6 and 374 nM for IPMK and IP6K2, respectively.. UNC9750 inhibits cellular accumulation of InsP₅, the direct product of IPMK kinase activity, while having no effect on either InsP6 or InsP₇ levels. UNC9750 has ≥ 75% inhibition of four kinases (DAPK1, *DYRK1B, PDGFR, and KDR*). UNC9750 can be used for the study of glioblastoma ^[1].

HY-131909

CJ-2360	Anaplastic lymphoma kinase (ALK)	Cancer
CJ-2360 is a potent and orally active ALK inhibitor with IC₅₀s of 2.2, 4.0, 8.8, 6.3, and 8.9 nM against wild-type ALK and F1197M, G1269A, L1196M, and S1206Y ALK mutants, respectively. CJ-2360 displays potent inhibitory activity against two clinically reported ALK mutants (C1156Y and L1196M) and a few other kinases (LTK, MERTK, CLK1, DAPK1, and DAPK2) among the 468 kinases evaluated ^[1].

HY-112056

DIM-C-pPhCO2Me 1 Publications Verification	Nuclear Hormone Receptor 4A/NR4A Apoptosis DAPK Isocitrate Dehydrogenase (IDH) PERK	Cancer
DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhCO2Me induces Apoptosis. DIM-C-pPhCO2Me decreases *PAX3-FOXO1A, N-Myc, Rassf4, MyoD1, Grem1, and DAPK1* proteins. DIM-C-pPhCO2Me decreases expression of TXNDC5 and *IDH1, induces markers of ER stress (CHOP, ATF4* and p-PERK). DIM-C-pPhCO2Me inhibits renal cell carcinoma, breast cancer. DIM-C-pPhCO2Me can also be used in rhabdomyosarcoma research ^[1] .

Cat. No.	Product Name	Target	Research Area

HY-P5277

TAT-GluN2BCTM	DAPK	Neurological Disease
TAT-GluN2BCTM is a membrane-permeable *DAPK1*-targeting peptide. TAT-GluN2BCTM targets active DAPK1 to lysosomes for degradation. TAT-GluN2BCTM protects neurons from oxidative stress and NMDAR-mediated excitotoxicity by knocking down DAPK1. TAT-GluN2BCTM can be used in the study of neuroprotection ^[1].

Recombinant Proteins Recommended:

Death-Associated Protein Kinase 1 (DAPK1)

Species:	Human (2)
Tag:	His (1) GST (2)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P76858

	DAPK1 Protein, Human (sf9, His-GST) Death-associated protein kinase 1; DAP kinase 1; DAPK	Human	Sf9 insect cells
	The DAPK1 protein is a calcium/calmodulin-dependent kinase involved in multiple cellular pathways, regulating cell survival, apoptosis, and autophagy. The DAPK1 protein also acts as a signal amplifier for NMDA receptors, causing brain damage in stroke. DAPK1 Protein, Human (sf9, His-GST) is the recombinant human-derived DAPK1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P702657

	DAPK1 Protein, Human (289a.a, sf9, GST) Death-associated protein kinase 1; DAP kinase 1; DAPK	Human	Sf9 insect cells
	The DAPK1 protein is a calcium/calmodulin-dependent kinase involved in multiple cellular pathways, regulating cell survival, apoptosis, and autophagy. The DAPK1 protein also acts as a signal amplifier for NMDA receptors, causing brain damage in stroke. DAPK1 Protein, Human (289a.a, sf9, GST) is the recombinant human-derived DAPK1, expressed by Sf9 insect cells, with GST labeled tag. The total length of DAPK1 Protein, Human (289a.a, sf9, GST) is 289 a.a..

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HY-P83053

	DAP Kinase 1 Antibody (YA2798) DAK1; DAP K1; DAP kinase 1; DAPK 1; DAPK; DAPK1; DAPK1_HUMAN; Death Associated Protein Kinase 1; Death-associated protein kinase 1	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	DAP Kinase 1 Antibody (YA2798) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DAP Kinase 1.

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Cat. No.	Product Name		Classification

HY-RS16812

Dapk1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Dapk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dapk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23252

Dapk1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Dapk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dapk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS03527

DAPK1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
DAPK1 Human Pre-designed siRNA Set A contains three designed siRNAs for DAPK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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