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Pathways Recommended:	Vitamin D Related/Nuclear Receptor

Results for "

D-( )-Malic acid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (1) DNA/RNA Synthesis (1) Dopamine Receptor (1) Endogenous Metabolite (8) Estrogen Receptor/ERR (1) Insecticide (1) Isotope-Labeled Compounds (2) Liposome (1) PTHR (2) Reference Standards (3)
By Research Areas:	Cancer (2) Endocrinology (2) Infection (2) Inflammation/Immunology (1) Metabolic Disease (4) Neurological Disease (1)
Oligonucleotides:	Liposomal Film-forming Agents (1) Emulsifiers (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Amino acid Transporter Amino Acid Derivatives Amino Acid Decarboxylase Hydroxycarboxylic Acid Receptor (HCAR) Amino Acid Oxidase Free Fatty Acid Receptor Fatty Acid Synthase (FASN) Apical Sodium-Dependent Bile Acid Transporter G protein-coupled Bile Acid Receptor 1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-20558

*D-(+)-Malic* acid** 1 Publications Verification D-Malic acid	Endogenous Metabolite	Metabolic Disease
D-(+)-Malic acid (D-Malic acid), an active enantiomer of Malic acid, is a competitive inhibitor of L(--)malic acid transport .

HY-20558R

*D-(+)-Malic* acid (Standard)** D-Malic acid (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
D-(+)-Malic acid (Standard) is the analytical standard of D-(+)-Malic acid. This product is intended for research and analytical applications. D-(+)-Malic acid (D-Malic acid), an active enantiomer of Malic acid, is a competitive inhibitor of L(--)malic acid transport .

HY-Y1069S

*(S)-Malic* acid-d3** 1 Publications Verification (S)-Hydroxybutanedioic acid-d₃; (S)-E 296-d₃; L-Malic acid-d₃	Endogenous Metabolite	Metabolic Disease
(S)-Malic acid-d₃ is the deuterium labeled (S)-Malic acid. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive .

HY-Y1311S

Malic acid-d3 Hydroxybutanedioic acid-d₃; E 296-d₃	Endogenous Metabolite	Others
Malic acid-d₃ is the deuterium labeled Malic acid. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods .

HY-Y0367S

Maleic Acid-d2 Maleic-2,3-d2 acid	Bacterial Endogenous Metabolite	Infection
Maleic Acid-d₂ is the deuterium labeled Maleic Acid . Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes .

HY-59354S

Maleic hydrazide-d2	DNA/RNA Synthesis	Cancer
Maleic hydrazide-d₂ is the deuterium labeled Maleic hydrazide . Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins .

HY-W673589

Hexacosane, 2-Methyl- 2-Me-C26	Insecticide	Infection
2-Methylhexacosane is a saturated hydrocarbon and an insect pheromone. It has been found in the cuticle of M. dasystomus females, but not males, where it contributes to the mating behavior of males, as well as in D. melanogaster females where it modulates aggression of males towards females. 2-methylhexacosane has also been found in yellow jacket (V. vulgaris) trail extracts.

HY-116047S

Anisylacetone-d5 p-Methoxybenzylacetone-d₅	Isotope-Labeled Compounds Others	Others
Anisylacetone-d₅ (p-Methoxybenzylacetone-d₅) is deuterium labeled Anisylacetone. Anisylacetone (p-Methoxybenzylacetone) is a male fruit fly attractant .

HY-N15531

Icariside D1	Estrogen Receptor/ERR	Inflammation/Immunology Cancer
Icariside D1 (Compound 9) is a flavonoid glycoside compound with antioxidant and anti-inflammatory activities, which is found in plants such as Epimedium. Icariside D1 is also a regulator of estrogen receptors. Icariside D1 is promising for research of osteoporosis, male infertility and female reproductive dysfunction and cancers .

HY-119069

FAUC 3019	Dopamine Receptor	Neurological Disease
FAUC 3019 is a partial agonist of dopamine D(4) receptors and has the activity of promoting penile erection. FAUC 3019 has a strong stimulatory effect on penile erection in male rats at low concentrations. The biological activity of FAUC 3019 makes it a promising compound candidate .

HY-32351B

3-epi-Calcifediol 3-epi-25-hydroxy Cholecalciferol	PTHR	Endocrinology
3-epi-25-hydroxy Vitamin D3 is the C-3 epimer of 25-hydroxy vitamin D3.1 Dietary administration of 3-epi-25-hydroxy vitamin D3 (0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats.

HY-117081

C30(ω-hydroxy) Ceramide (d18:1/30:0)	Endogenous Metabolite	Others
C30(ω-hydroxy) Ceramide (d18:1/30:0), a sphingolipid, is an epidermis-specifically vital component of the water barrier in mammalian skin. C30(ω-hydroxy) Ceramide (d18:1/30:0) is expressed in epidermal keratinocytes and male germ cells during their differentiation and maturation. C30(ω-hydroxy) Ceramide (d18:1/30:0) deficiency in the epiderm of Elovl4 deletion or mutation mice .

HY-32351BR

3-epi-Calcifediol (Standard) 3-epi-25-hydroxy Cholecalciferol (Standard)	PTHR Reference Standards	Endocrinology
3-epi-Calcifediol (Standard) is the analytical standard of 3-epi-Calcifediol. This product is intended for research and analytical applications. 3-epi-25-hydroxy Vitamin D3 is the C-3 epimer of 25-hydroxy vitamin D3.1 Dietary administration of 3-epi-25-hydroxy vitamin D3 (0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats.

HY-N6996S

Methyl Eugenol-13C,d3	Isotope-Labeled Compounds	Others
Methyl Eugenol- ¹³C,d₃ is the ¹³C- and deuterium labeled Methyl Eugenol. Methyl Eugenol, a phenylpropanoid chemical in leaves, fruits, stems, and/or roots, may be released when that corresponding part of a plant is damaged as a result of feeding by an herbivore. Methyl Eugenol is used for male annihilation of the oriental fruit fly .

HY-D0889R

Glycylglycine (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Glycylglycine (Standard) is the analytical standard of Glycylglycine (HY-D0889). This product is intended for research and analytical applications. Glycylglycine is a non-selective glycylglycine dipeptidase substrate and iNOS inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) .

HY-N0322B

Cholesterol (Excipient, GMP Like)	Liposome Endogenous Metabolite	Others
Cholesterol (Excipient, GMP Like) is the GMP Like class Cholesterol (HY-N0322), and can be used as pharmaceutical excipients. Cholesterol is a component of the cell membrane and a precursor of some hormones, vitamin D and bile acid, with oral activity. In Vitro: Cholesterol (200 μg/mL; 40 h) increases the production of newly synthesized β-amyloid protein and enhances the secretion of Aβ_1-40 in HEK cells transfected with APP . In Vivo: Cholesterol (0.5% cholesterol in diet; oral; once daily; 7 days) increases plasma cholesterol in the hamster model, while the cholesterol absorption inhibitor SCH 48461 (10 mg/kg; oral gavage; once daily; 7 days) inhibits cholesterol absorption and reduces plasma cholesterol . Cholesterol (1% cholesterol + 0.5% bile acid in diet; oral; once daily; 7 days) increases plasma cholesterol levels in the male CD rat model, while SCH 48461 (2 mg/kg; oral; once daily; 7 days) reduces hepatic cholesterol ester accumulation . Cholesterol (0.25% cholesterol + 22% saturated fat diet; oral; once daily; 3 weeks) increases VLDL+LDL cholesterol levels in the rhesus monkey model, while SCH 48461 (0.2 mg/kg; oral; once daily; 3 weeks) maintains baseline levels and inhibits cholesterol absorption .

Cat. No.	Product Name	Target	Research Area

HY-D0889R

Glycylglycine (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Glycylglycine (Standard) is the analytical standard of Glycylglycine (HY-D0889). This product is intended for research and analytical applications. Glycylglycine is a non-selective glycylglycine dipeptidase substrate and iNOS inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-20558

*D-(+)-Malic* acid** 1 Publications Verification D-Malic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Malus pumila Mill. Source classification Rosaceae Metabolic Disease Plants Disease Research Fields	Endogenous Metabolite
D-(+)-Malic acid (D-Malic acid), an active enantiomer of Malic acid, is a competitive inhibitor of L(--)malic acid transport .

HY-20558R

*D-(+)-Malic* acid (Standard)** D-Malic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Malus pumila Mill. Source classification Rosaceae Plants	Reference Standards Endogenous Metabolite
D-(+)-Malic acid (Standard) is the analytical standard of D-(+)-Malic acid. This product is intended for research and analytical applications. D-(+)-Malic acid (D-Malic acid), an active enantiomer of Malic acid, is a competitive inhibitor of L(--)malic acid transport .

HY-D0889R

Glycylglycine (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite
Glycylglycine (Standard) is the analytical standard of Glycylglycine (HY-D0889). This product is intended for research and analytical applications. Glycylglycine is a non-selective glycylglycine dipeptidase substrate and iNOS inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) .

HY-N15531

Icariside D1	Structural Classification Source classification Piperaceae Piper crocatum Ruiz & Pav. Plants Saccharides Monosaccharides	Estrogen Receptor/ERR
Icariside D1 (Compound 9) is a flavonoid glycoside compound with antioxidant and anti-inflammatory activities, which is found in plants such as Epimedium. Icariside D1 is also a regulator of estrogen receptors. Icariside D1 is promising for research of osteoporosis, male infertility and female reproductive dysfunction and cancers .

HY-117081

C30(ω-hydroxy) Ceramide (d18:1/30:0)	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
C30(ω-hydroxy) Ceramide (d18:1/30:0), a sphingolipid, is an epidermis-specifically vital component of the water barrier in mammalian skin. C30(ω-hydroxy) Ceramide (d18:1/30:0) is expressed in epidermal keratinocytes and male germ cells during their differentiation and maturation. C30(ω-hydroxy) Ceramide (d18:1/30:0) deficiency in the epiderm of Elovl4 deletion or mutation mice .

Cat. No.	Product Name	Chemical Structure

HY-Y1069S

*(S)-Malic* acid-d3** 1 Publications Verification
(S)-Malic acid-d₃ is the deuterium labeled (S)-Malic acid. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive .

HY-Y1311S

Malic acid-d3
Malic acid-d₃ is the deuterium labeled Malic acid. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods .

HY-Y0367S

Maleic Acid-d2
Maleic Acid-d₂ is the deuterium labeled Maleic Acid . Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes .

HY-59354S

Maleic hydrazide-d2
Maleic hydrazide-d₂ is the deuterium labeled Maleic hydrazide . Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins .

HY-116047S

Anisylacetone-d5
Anisylacetone-d₅ (p-Methoxybenzylacetone-d₅) is deuterium labeled Anisylacetone. Anisylacetone (p-Methoxybenzylacetone) is a male fruit fly attractant .

HY-N6996S

Methyl Eugenol-13C,d3
Methyl Eugenol- ¹³C,d₃ is the ¹³C- and deuterium labeled Methyl Eugenol. Methyl Eugenol, a phenylpropanoid chemical in leaves, fruits, stems, and/or roots, may be released when that corresponding part of a plant is damaged as a result of feeding by an herbivore. Methyl Eugenol is used for male annihilation of the oriental fruit fly .

Cat. No.	Product Name		Classification

HY-N0322B

Cholesterol (Excipient, GMP Like)		Emulsifiers Liposomal Film-forming Agents
Cholesterol (Excipient, GMP Like) is the GMP Like class Cholesterol (HY-N0322), and can be used as pharmaceutical excipients. Cholesterol is a component of the cell membrane and a precursor of some hormones, vitamin D and bile acid, with oral activity. In Vitro: Cholesterol (200 μg/mL; 40 h) increases the production of newly synthesized β-amyloid protein and enhances the secretion of Aβ_1-40 in HEK cells transfected with APP . In Vivo: Cholesterol (0.5% cholesterol in diet; oral; once daily; 7 days) increases plasma cholesterol in the hamster model, while the cholesterol absorption inhibitor SCH 48461 (10 mg/kg; oral gavage; once daily; 7 days) inhibits cholesterol absorption and reduces plasma cholesterol . Cholesterol (1% cholesterol + 0.5% bile acid in diet; oral; once daily; 7 days) increases plasma cholesterol levels in the male CD rat model, while SCH 48461 (2 mg/kg; oral; once daily; 7 days) reduces hepatic cholesterol ester accumulation . Cholesterol (0.25% cholesterol + 22% saturated fat diet; oral; once daily; 3 weeks) increases VLDL+LDL cholesterol levels in the rhesus monkey model, while SCH 48461 (0.2 mg/kg; oral; once daily; 3 weeks) maintains baseline levels and inhibits cholesterol absorption .

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D-( )-Malic acid

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products