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Results for "

Col1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Amino Acid Derivatives (1) Ceramidase (1) DNA/RNA Synthesis (1) ERK (1) FXR (1) HDAC (1) MMP (1) Phosphatase (1) Prostaglandin Receptor (1) Small Interfering RNA (siRNA) (6) TGF-beta/Smad (2)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Endocrinology (1) Inflammation/Immunology (6) Metabolic Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (2) siRNAs (6)

Inhibitors & Agonists

Biochemical Assay Reagents

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-158225

Methacrylated Type I collagen Col1MA	MMP	Others
Methacrylated Type I collagen (Col1MA) is a methacrylated tissue engineering scaffold material that retains the basic properties of natural collagen ^[1]. Methacrylated Type I collagen needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity. Application: cell culture, biological 3D printing, tissue engineering, etc.

HY-Y1123

2-Aminoacetamide hydrochloride Glycinamide hydrochloride	Amino Acid Derivatives Phosphatase	Endocrinology
2-Aminoacetamide hydrochloride (Glycinamide hydrochloride) is a derivative of Glycine (HY-Y0966). 2-Aminoacetamide hydrochloride forms cell-absorbable nanocomplexes with proteins (such as bovine serum albumin) through strong electrostatic interactions, promoting cellular uptake of related proteins. 2-Aminoacetamide hydrochloride synergizes with BMP2 to upregulate the expression of osteogenic marker genes (such as *Col1a1, Alp, Runx2) and proteins (such as COL1, BSP), enhancing collagen synthesis. 2-Aminoacetamide hydrochloride synergizes with BMP2 to promote osteoblast differentiation in vitro* and bone regeneration in vivo ^[1].

HY-RS26651

Col1a2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Col1a2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Col1a2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Col1a2 Rat Pre-designed siRNA Set A Col1a2 Rat Pre-designed siRNA Set A

HY-RS16961

Col1a1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Col1a1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Col1a1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Col1a1 Mouse Pre-designed siRNA Set A Col1a1 Mouse Pre-designed siRNA Set A

HY-RS02970

COL1A1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
COL1A1 Human Pre-designed siRNA Set A contains three designed siRNAs for COL1A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

COL1A1 Human Pre-designed siRNA Set A COL1A1 Human Pre-designed siRNA Set A

HY-RS23404

Col1a1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Col1a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Col1a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Col1a1 Rat Pre-designed siRNA Set A Col1a1 Rat Pre-designed siRNA Set A

HY-RS02971

COL1A2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
COL1A2 Human Pre-designed siRNA Set A contains three designed siRNAs for COL1A2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

COL1A2 Human Pre-designed siRNA Set A COL1A2 Human Pre-designed siRNA Set A

HY-RS20147

Col1a2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Col1a2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Col1a2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Col1a2 Mouse Pre-designed siRNA Set A Col1a2 Mouse Pre-designed siRNA Set A

HY-138868

17-Phenyl trinor prostaglandin E2 ethyl amide 17-Phenyl trinor PGE2 ethyl amide	Prostaglandin Receptor	Metabolic Disease
17-Phenyl trinor prostaglandin E2 ethyl amide (17-Phenyl trinor PGE2 ethyl amide) is a EP1 receptor agonist. 17-Phenyl trinor prostaglandin E2 ethyl amide aggravates renal dysfunction and glomerulosclerosis ^[1].

HY-154979

Anti-hepatic fibrosis agent 2	DNA/RNA Synthesis	Inflammation/Immunology
Anti-hepatic fibrosis agent 2 (Compound 6k) is an orally active *COL1A1* inhibitor. Anti-hepatic fibrosis agent 2 is an anti-fibrogenic agent targeting ewing sarcoma breakpoint region 1 (EWSR1) ^[1].

HY-151932

FXR agonist 3	FXR	Inflammation/Immunology
FXR agonist 3 is an anti-NASH agent, acting by activating FXR. FXR agonist 3 inhibits *COL1A1, TGF-β1, α-SMA* and *TIMP1* expression with anti-fibrogenic activity. FXR agonist 3 significantly reduces liver steatosis and inflammation, improves liver fibrosis level ^[1].

HY-155328

GK444	HDAC	Inflammation/Immunology
GK444 (Compound 15a) is a *HDAC1/2* inhibitor (IC₅₀: 100 and 92 nM for HDAC1/2 respectively). GK444 inhibits Caco-2 cells with IC₅₀ of 4.1 μM. GK444 also reduces TGF-β1 induced COL1A1 mRNA levels in primary normal human lung fibroblasts. GK444 inhibits Bleomycin (HY-108345)-induced lung fibrosis in mice ^[1].

HY-146434

TGFβ-IN-2 1 Publications Verification	TGF-beta/Smad	Inflammation/Immunology
TGFβ-IN-2 is an orally active TGF-β inhibitor. TGFβ-IN-2 suppresses the TGF-β-induced protein expression of COL1A1, α-SMA, and p-Smad3 in vitro. TGFβ-IN-2 demonstrates excellent anti-fibrotic efficacy in Bleomycin (HY-108345)-induced pulmonary fibrosis model. TGFβ-IN-2 can be used for the study of pulmonary fibrosis ^[1].

HY-176737

TGF-β1/Smad-IN-1	TGF-beta/Smad	Inflammation/Immunology
TGF-β1/Smad-IN-1 (compound C9) is a potent *TGF-β1/Smad* inhibitor. TGF-β1/Smad-IN-1 inhibits the expression of fibrosis markers (α-SMA and COL1A1) induced by TGF-β1. TGF-β1/Smad-IN-1 shows antifibrotic effects. TGF-β1/Smad-IN-1 has the potential for the research of hepatic fibrosis ^[1].

HY-172258

5-HT2B antagonist-2	5-HT Receptor	Cancer
5-HT2B antagonist-2 (Compound 19c) is a 5HT_2B receptor antagonist with an IC₅₀ of 1.09 nM. 5-HT2B antagonist-2 can downregulate the expression of fibrosis-related genes α-SMA, Timp1, Col1a1, and Col3a1, and significantly reduce the deposition of fibrosis, thereby reducing the fibrotic area and inhibiting the fibrotic process in CCl4-induced liver fibrosis mouse models. 5-HT2B antagonist-2 can be used in the study of immune inflammatory-related diseases, particularly in the research of pulmonary fibrosis diseases ^[1].

HY-175496

Acid Ceramidase-IN-3	Ceramidase	Inflammation/Immunology
Acid Ceramidase-IN-3 is a acid ceramidase (aCDase) inhibitor. Acid Ceramidase-IN-3 inhibits the enzymatic activity of aCDase with a pIC ₅₀ of 8.5 in enzymatic assays and 6.8 in A375 melanoma cellular assays. Acid Ceramidase-IN-3 promotes HSC inactivation, as measured by a dose-dependent reduction in COL1A1 and ACTA2. Acid Ceramidase-IN-3 inhibits aCDase activity in HSCs, promotes HSC inactivation and suppresses YAP/TAZ nuclear localization. Acid Ceramidase-IN-3 increases Dynein/Kinesin (NDE1, NDEL1. KIF3B, KIF15) while decreases several proteins involved with signaling pathway (SARM1, RGAP1, PDGF-D,PDGFR-B). Acid Ceramidase-IN-3 can be used for the study of fibrotic diseases ^[1].

HY-120006A

(rel)-AR234960 1 Publications Verification	ERK	Cardiovascular Disease
(rel)-AR234960 is a selective and competitive agonist of the G protein-coupled receptor MAS. (rel)-AR234960 binds to the MAS receptor to activate the downstream *ERK1/2* signaling pathway, inducing the expression of connective tissue growth factor (CTGF) and its downstream collagen subtype genes (such as COL1A1, COL3A1). (rel)-AR234960 promotes collagen synthesis in cardiac fibroblasts through the *MAS-ERK1/2-CTGF* pathway and aggravates extracellular matrix remodeling. (rel)-AR234960's in vitro effect can be blocked by the MAS inverse agonist AR244555 and MEK1 inhibitor. (rel)-AR234960 regulates the expression of cardiac fibrosis-related genes and can be used in the study of heart failure ^[1] .

Cat. No.	Product Name	Type

HY-158225

Methacrylated Type I collagen Col1MA	3D Bioprinting
Methacrylated Type I collagen (Col1MA) is a methacrylated tissue engineering scaffold material that retains the basic properties of natural collagen ^[1]. Methacrylated Type I collagen needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity. Application: cell culture, biological 3D printing, tissue engineering, etc.

Methacrylated Type I collagen

Col1MA

3D Bioprinting

Methacrylated Type I collagen (Col1MA) is a methacrylated tissue engineering scaffold material that retains the basic properties of natural collagen ^[1]. Methacrylated Type I collagen needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity.
Application: cell culture, biological 3D printing, tissue engineering, etc.

HY-Y1123

2-Aminoacetamide hydrochloride Glycinamide hydrochloride	Biochemical Assay Reagents
2-Aminoacetamide hydrochloride (Glycinamide hydrochloride) is a derivative of Glycine (HY-Y0966). 2-Aminoacetamide hydrochloride forms cell-absorbable nanocomplexes with proteins (such as bovine serum albumin) through strong electrostatic interactions, promoting cellular uptake of related proteins. 2-Aminoacetamide hydrochloride synergizes with BMP2 to upregulate the expression of osteogenic marker genes (such as *Col1a1, Alp, Runx2) and proteins (such as COL1, BSP), enhancing collagen synthesis. 2-Aminoacetamide hydrochloride synergizes with BMP2 to promote osteoblast differentiation in vitro* and bone regeneration in vivo ^[1].

2-Aminoacetamide hydrochloride

Glycinamide hydrochloride

Biochemical Assay Reagents

2-Aminoacetamide hydrochloride (Glycinamide hydrochloride) is a derivative of Glycine (HY-Y0966). 2-Aminoacetamide hydrochloride forms cell-absorbable nanocomplexes with proteins (such as bovine serum albumin) through strong electrostatic interactions, promoting cellular uptake of related proteins. 2-Aminoacetamide hydrochloride synergizes with BMP2 to upregulate the expression of osteogenic marker genes (such as Col1a1, Alp, Runx2) and proteins (such as COL1, BSP), enhancing collagen synthesis. 2-Aminoacetamide hydrochloride synergizes with BMP2 to promote osteoblast differentiation in vitro and bone regeneration in vivo ^[1].

Species:	Human (2)
Tag:	His (2)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P704237

	COL1A1 Protein, Human (HEK293, His) Col1A1; LCollagen alpha-1(I) chain; LAlpha-1 type I Collagen	Human	HEK293
	The procollagen alpha 1/COL1A1 protein is an important type I collagen component and forms a trimeric structure with alpha 2(I) and two alpha 1(I) chains. It interacts with MRC2, associates with MFAP4 in a Ca2+-dependent manner, and interacts with TRAM2. COL1A1 Protein, Human (HEK293, His) is the recombinant human-derived COL1A1 protein, expressed by HEK293, with N-His labeled tag.

HY-P704238

	*Pro-COL1A1 Protein, Human (HEK293, His)* Col1A1; LCollagen alpha-1(I) chain; LAlpha-1 type I Collagen	Human	HEK293
	The procollagen alpha 1/COL1A1 protein is an important type I collagen component and forms a trimeric structure with alpha 2(I) and two alpha 1(I) chains. It interacts with MRC2, associates with MFAP4 in a Ca2+-dependent manner, and interacts with TRAM2. Pro-COL1A1 Protein, Human (HEK293, His) is the recombinant human-derived Pro-COL1A1 protein, expressed by HEK293, with N-His labeled tag.

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HY-P81227

	Collagen I Antibody 2 Publications Verification Collagen type I; Alpha 1 type I Collagen; Alpha 2 type I Collagen; Col1A1; Col1A2; Collagen I alpha 1 polypeptide; Collagen I alpha 2 polypeptide; Collagen Of Skin Tendon And Bone; Collagen Type 1; Collagen type I alpha 1; Collagen type I alpha 2; OI4; Osteogenesis Imperfecta Type IV; Pro alpha 1(I) Collagen; Type I proCollagen; CO1A1_HUMAN.	WB, IHC-P	Human, Mouse, Rat, Rabbit
	Collagen I Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Collagen I.

HY-P85909

	Collagen I Antibody (YA5601) Alpha 1 Collagen type I; Alpha 1 type I Collagen; Alpha 1 type I proCollagen; Alpha 1; I; Collagen; Alpha 1; I; proCollagen; Alpha-1 type I Collagen; CO1A1_HUMAN; Col1A1; Collagen alpha 1; I; chain; Collagen alpha-1; I; chain; Collagen I alpha 1 polypeptide; Collagen of skin tendon and bone alpha 1 chain; Collagen type I alpha 1	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
	Collagen I Antibody (YA5601) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Collagen I.

HY-P86101

	Collagen I Antibody (YA5793) Alpha 1 Collagen type I; Alpha 1 type I Collagen; Alpha 1 type I proCollagen; Alpha 1; I; Collagen; Alpha 1; I; proCollagen; Alpha-1 type I Collagen; CO1A1_HUMAN; Col1A1; Collagen alpha 1; I; chain; Collagen alpha-1; I; chain; Collagen I alpha 1 polypeptide; Collagen of skin tendon and bone alpha 1 chain; Collagen type I alpha 1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Collagen I Antibody (YA5793) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Collagen I.

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Col1a2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Col1a2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Col1a2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Col1a1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Col1a1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Col1a1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

COL1A1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
COL1A1 Human Pre-designed siRNA Set A contains three designed siRNAs for COL1A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Col1a1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Col1a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Col1a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

COL1A2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
COL1A2 Human Pre-designed siRNA Set A contains three designed siRNAs for COL1A2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Col1a2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Col1a2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Col1a2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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