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Isoforms Recommended:	Cathepsin C

Results for "

Cathepsin C

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cathepsin (10) ADC Linker (1) Apoptosis (1) Biochemical Assay Reagents (1) Carbonic Anhydrase (1) Drug-Linker Conjugates for ADC (1) Elastase (1) SARS-CoV (1) Ser/Thr Protease (1) STING (1)
By Research Areas:	Cancer (5) Inflammation/Immunology (7) Metabolic Disease (2)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Click Chemistry

Targets Recommended: Cathepsin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-146584

Cathepsin C-IN-5	Cathepsin	Inflammation/Immunology
Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC₅₀s of 59.9 nM, 4.26 µM, >5 µM, >5 µM, >5 µM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood. Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases). Cathepsin C-IN-5 shows anti-inflammatory activity .

HY-P3798

Eglin c (41-49)	Ser/Thr Protease	Others
Eglin c (41-49) is a peptide fragment related to eglin c. Eglin c (41-49) shows inhibitory effects to cathepsin G and α-chymotrypsin with K_i values of 42 and 20 μM, respectively .

HY-112318A

GSK-2793660	Cathepsin	Inflammation/Immunology
GSK-2793660 is an orally active and irreversible inhibitor of Cathepsin C (CTSC). GSK-2793660 can be used for the research of bronchiectasis .

HY-W011063

Gly-Phe-β-naphthylamide	Cathepsin	Metabolic Disease
Gly-Phe-β-naphthylamide is the substrate of Cathepsin C. Gly-Phe-β-naphthylamide can be used to study intralysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C .

HY-P2922

Cathepsin C	Biochemical Assay Reagents	Others
Cathepsin C is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-146581

Cathepsin C-IN-4	Cathepsin	Inflammation/Immunology
Cathepsin C-IN-4 (compound SF27) is a potent Cathepsin C (Cat C) inhibitor, with an IC₅₀ of 65.6 nM. Cathepsin C-IN-4 also inhibits THP-1 and U937 cell, with IC₅₀ values of 203.4 and 177.6 nM, respectively .

HY-146580

Cathepsin C-IN-3	Cathepsin	Inflammation/Immunology
Cathepsin C-IN-3 (compound SF11) is a potent Cathepsin C (Cat C) inhibitor, with an IC₅₀ of 61.79 nM. Cathepsin C-IN-3 also inhibits THP-1 and U937 cell, with IC₅₀ values of 101.5 and 86.5 nM, respectively .

HY-155611

Cathepsin C-IN-6	Cathepsin	Inflammation/Immunology
Cathepsin C-IN-6 (compound 2) is a E-64c-hydrazideas based inhibitor of cathepsin C with anti-inflammatory activity. Cathepsin C-IN-6 inhibts activation of neutrophil elastase，exhibits potential efficacy in inflammatory diseases with high neutrophil load (e.g.，chronic obstructive pulmonary disease) .

HY-112318

GSK-2793660 free base	Cathepsin	Inflammation/Immunology
GSK-2793660 (free base) is an oral, irreversible inhibitor of Cathepsin C (CTSC). GSK-2793660 (free base) can be used for the research of bronchiectasis .

HY-168591

CTSC-IN-1	Cathepsin	Cancer
CTSC-IN-1 (B22) is a CTSC inhibitor. CTSC-IN-1 inhibits CTSC activity by binding to S2 pocket and S1 site. CTSC-IN-1 can be used in the study inflammatory bowel disease .

HY-P5086

H-Gly-Arg-NH2	Cathepsin	Others
H-Gly-Arg-NH2 is a substrate for the determination of bovine spleen cathepsin C activity .

HY-100227

E 64c 2 Publications Verification	Cathepsin SARS-CoV	Metabolic Disease
E 64c is a derivative of naturally occurring epoxide inhibitor of cysteine proteases, a Calcium-activated neutral protease (CANP) inhibitor and a very weak irreversible cathepsin C inhibitor. E 64c exhibits entry-blocking effect for MERS-CoV.

HY-132973

MC-Val-Cit-PAB-NH-C2-NH-Boc	ADC Linker	Cancer
MC-Val-Cit-PAB-NH-C2-NH-Boc is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-159128

hCAIX-IN-21	Carbonic Anhydrase	Cancer
hCAIX-IN-21 (compound 16c) is a potent hCAIX inhibitor with K_I values of 5.2, 3.5, 12.6, 13600 nM for hCAIX, hCA II, hCA XII, hCA I, respectively. hCAIX-IN-21 inhibits cathepsin B enzyme activity .

HY-126988

SP-Chymostatin B α-MAPI	Elastase	Others
SP-Chymostatin B (α-MAPI) is a strong inhibitor of many proteases, including chymotrypsin, papain, chymotrypsin-like serine proteinases, chymases, and lysosomal cysteine proteinases such as cathepsins A,B,C, H, and L. SP-Chymostatin B weakly inhibits human leucocyte elastase .

HY-162874

diABZI-V/C-DBCO	STING	Inflammation/Immunology Cancer
diABZI-V/C-DBCO (Compound 3) is a potent STING agonist. diABZI-V/C-DBCO can release diABZI-amine upon activation by cathepsin B to activate STING, leading to the production of interferons and other immune-stimulatory molecules, thereby enhancing the immune system's response to tumors. The EC₅₀ values for diABZI-V/C-DBCO and diABZI-amine in activating STING in THP1-Dual cells are 1.47 and 0.144 nM, respectively, and in primary mouse splenocytes, the EC₅₀ values are 7.7 and 0.17 μM, respectively. diABZI-V/C-DBCO can be used in cancer immunotherapy research .

HY-171509

Mal-N(Me)-C6-N(Me)-PNU-159682	Drug-Linker Conjugates for ADC Apoptosis	Cancer
Mal-N(Me)-C6-N(Me)-PNU-159682 (Compound 27), an agent-linker conjugate for ADC, consists the ADC linker Mal-N(Me)-C6-N(Me) and a potent ADC cytotoxin PNU-159682. Mal-N(Me)-C6-N(Me)-PNU-159682 (Compound 27) selectively delivers the payload to CD46-expressing cells, where the linker is cleaved by cathepsin B to release PNU-159682, inducing DNA damage and apoptosis. Mal-N(Me)-C6-N(Me)-PNU-159682 shows durable tumor regression in xenograft (PDX) models of non-small cell lung cancer (NSCLC) and colorectal cancer (CRC) .

Cat. No.	Product Name	Target	Research Area

HY-P3798

Eglin c (41-49)	Ser/Thr Protease	Others
Eglin c (41-49) is a peptide fragment related to eglin c. Eglin c (41-49) shows inhibitory effects to cathepsin G and α-chymotrypsin with K_i values of 42 and 20 μM, respectively .

HY-P5086

H-Gly-Arg-NH2	Cathepsin	Others
H-Gly-Arg-NH2 is a substrate for the determination of bovine spleen cathepsin C activity .

Recombinant Proteins Recommended:

Cathepsin C

Species:	Human (7) Mouse (3)
Tag:	His (9) Myc (1)
Source:	HEK293 (9) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P704009

	Cathepsin C/DPPI Protein, Human (HEK293, C-His) Cathepsin C; Cathepsin CEC 3.4.14.1; Cathepsin J; CPPIHMS; CTSC; dipeptidyl peptidase 1; Dipeptidyl peptidase I; Dipeptidyl transferase; dipeptidyl-peptidase I; DPP1; DPPI; DPP-I; JP; JPD; PALS; PLS	Human	HEK293

HY-P701247

	Cathepsin C/DPPI Protein, Mouse (Inactive, His-Myc) Cathepsin C; Cathepsin CEC 3.4.14.1; Cathepsin J; CPPIHMS; CTSC; dipeptidyl peptidase 1; Dipeptidyl peptidase I; Dipeptidyl transferase; dipeptidyl-peptidase I; DPP1; DPPI; DPP-I; JP; JPD; PALS; PLS	Mouse	E. coli
	The cathepsin C/DPPI protein is a thiol protease that acts as a dipeptidyl peptidase with multiple substrate specificities, excluding proline at the P1 position and arginine at the P2 position. It has both exopeptidase and endopeptidase functions and can activate serine proteases such as elastase, cathepsin G, and granzymes A and B. Cathepsin C/DPPI Protein, Mouse (Inactive, His-Myc) is the recombinant mouse-derived Cathepsin C/DPPI protein, expressed by E. coli , with N-10*His, C-Myc labeled tag. The accession of Cathepsin C/DPPI Protein, Mouse (Inactive, His-Myc) is P97821 (D25-W134).

HY-P704018

	Cathepsin C/DPPI Protein, Mouse (Active, HEK293, His) Cathepsin C; Cathepsin CEC 3.4.14.1; Cathepsin J; CPPIHMS; CTSC; dipeptidyl peptidase 1; Dipeptidyl peptidase I; Dipeptidyl transferase; dipeptidyl-peptidase I; DPP1; DPPI; DPP-I; JP; JPD; PALS; PLS	Mouse	HEK293

HY-P704017

	Cathepsin C/DPPI Protein, Mouse (HEK293, His) Cathepsin C; Cathepsin CEC 3.4.14.1; Cathepsin J; CPPIHMS; CTSC; dipeptidyl peptidase 1; Dipeptidyl peptidase I; Dipeptidyl transferase; dipeptidyl-peptidase I; DPP1; DPPI; DPP-I; JP; JPD; PALS; PLS	Mouse	HEK293

HY-P7758A

	Cathepsin Z/CTSZ Protein, Human (HEK293, C-His) rHuCathepsin X, His; Cathepsin Z; Cathepsin P; Cathepsin X; CTSZ	Human	HEK293
	Cathepsin Z/CTSZ Protein exhibits dual carboxy-monopeptidase and carboxy-dipeptidase activities, as evidenced by research. Additionally, it displays functional versatility by generating kinin potentiating peptides. Cathepsin Z/CTSZ Protein, Human (HEK293, C-His) is the recombinant human-derived Cathepsin Z/CTSZ protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P7993A

	Cathepsin B Protein, Human (HEK293, C-His) APPS, Cathepsin B1	Human	HEK293
	Cathepsin B Protein, Human (HEK293, His) functions in intracellular protein catabolism and in certain situations may also be involved in other physiological processes, such as processing of antigens in the immune response, hormone activation and bone turnover.

HY-P7748A

	Cathepsin D Protein, Human (HEK293, C-His) rHuCathepsin D, His; Cathepsin D; CTSD; CPSD	Human	HEK293
	Cathepsin D protein is an acidic protease that actively participates in intracellular protein breakdown. Studies have shown that it is critical in the processing of amyloid precursor protein (APP), with ADAM30-mediated cleavage and activation leading to APP degradation. Cathepsin D Protein, Human (HEK293, C-His) is the recombinant human-derived Cathepsin D protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P7745A

	Cathepsin A Protein, Human (HEK293, His) Lysosomal protective protein; CTSA; Carboxypeptidase C; Carboxypeptidase L; Cathepsin A	Human	HEK293
	Cathepsin A protein is an important protective factor for β-galactosidase and neuraminidase, maintaining their stability and optimizing enzyme activity. Its carboxypeptidase activity expands its functional repertoire and can deamid tachykinins and participate in a variety of biochemical processes. Cathepsin A Protein, Human (HEK293, His) is the recombinant human-derived Cathepsin A, expressed by HEK293 , with C-6*His labeled tag.

HY-P7745

	Cathepsin A Protein, Human (HEK293, His, solution) rHuCathepsin A, His; Lysosomal protective protein; CTSA; Carboxypeptidase C; Carboxypeptidase L; Cathepsin A	Human	HEK293
	Cathepsin A Protein, Human (HEK293, His, solution) is a 58-60 kDa human cathepsin A protein with a His-flag. Cathepsin A is a multicatalytic enzyme with carboxypeptidase activities.

HY-P7754A

	Cathepsin L1 Protein, Human (HEK293, C-His) rHuCathepsin L1, His; Cathepsin L1; Major Excreted Protein; MEP; CTSL1; CTSL	Human	HEK293
	Cathepsin L1 protein is a thiol protease that plays a key role in lysosomal protein degradation, affecting cellular functions such as turnover, antigen processing, and bone remodeling. It dissolves cross-linked TG/thyroglobulin, releasing the thyroid hormone thyroxine (T4) in the thyroid follicular cavity. Cathepsin L1 Protein, Human (HEK293, C-His) is the recombinant human-derived Cathepsin L1 protein, expressed by HEK293 , with C-6*His labeled tag.

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Cat. No.	Product Name		Classification

HY-159128

hCAIX-IN-21		Azide
hCAIX-IN-21 (compound 16c) is a potent hCAIX inhibitor with K_I values of 5.2, 3.5, 12.6, 13600 nM for hCAIX, hCA II, hCA XII, hCA I, respectively. hCAIX-IN-21 inhibits cathepsin B enzyme activity .

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