Carboxylesterase (CES)

By Targets:	Carboxylesterase (CES) (7) Antibiotic (2) Apoptosis (1) Biochemical Assay Reagents (1) GABA Receptor (1) SARS-CoV (1) Wnt (1)
By Research Areas:	Cancer (3) Metabolic Disease (1) Neurological Disease (3)

Targets Recommended: Carboxylesterase (CES)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N10686

Tanshinone IIA anhydride	Carboxylesterase (CES)	Cancer
Tanshinone IIA anhydride is a potent and irreversible human **carboxylesterase (CE) inhibitor with K_i** values of 1.9 nM and 1.4 nM for human CE1 and the human intestinal CE (hiCE), respectively .

HY-W341421

3-Indoxyl butyrate	Biochemical Assay Reagents	Others
3-Indoxyl butyrate is a chromogenic substrate for CES (carboxylesterase), producing a blue precipitate upon cleavage.

HY-147331

Oseltamivir acid methyl ester	Antibiotic Carboxylesterase (CES)	Neurological Disease
Oseltamivir acid methyl ester is a precursor form of the neuraminidase inhibitor and antiviral oseltamivir acid. Oseltamivir acid methyl ester is converted to oseltamivir acid by carboxylesterase 1 (CES1) .

HY-120602

WWL229	Carboxylesterase (CES)	Metabolic Disease
WWL229 is a selective inhibitor of carboxylesterase 3 (Ces3) with an IC₅₀ of 1.94 µM. WWL229 promotes lipid storage in cultured adipocytes and prevents basal lipolysis .

HY-23148

1-Methylisatin N-Methylisatin	Carboxylesterase (CES)	Others
1-Methylisatin is a potent and selective CE (carboxylesterases) inhibitor, with K_is of 38.2 and 5.38 μM for hiCE and hCE1, respectively. 1-Methylisatin interacts with Hb (human adult hemoglobin) by hydrophobic binding and electrostatic attraction. 1-Methylisatin can be used in the study of regulation of agent metabolism in vivo .

HY-N1951

Miltirone 1 Publications Verification Rosmariquinone	GABA Receptor Apoptosis Carboxylesterase (CES) SARS-CoV	Neurological Disease Cancer
Miltirone is an orally active natural compound found in the root of Salvia miltiorrhiza. Miltirone is a central benzodiazepine receptor partial agonist, with an IC₅₀ of 0.3 μM. Miltirone induces ROS - and-p53 dependent apoptosis. Miltirone inhibits *carboxylesterase* 2 (CES2; K_i = 0.04 μM) and SARS-CoV main protease (Mpro) .

HY-162502

WZU-13	Carboxylesterase (CES) Wnt	Cancer
WZU-13 is an inhibitor for Carboxylesterase (CES). WZU-13 inhibits 77% CES activity at a dose of 100 μM .

HY-147331A

Oseltamivir acid methyl ester hydrochloride	Antibiotic Carboxylesterase (CES)	Neurological Disease
Oseltamivir acid methyl ester hydrochloride is a precursor form of the neuraminidase inhibitor and antiviral oseltamivir acid. Oseltamivir acid methyl ester hydrochloride is converted to oseltamivir acid by carboxylesterase 1 (CES1) .

Cat. No.	Product Name	Type

HY-W341421

3-Indoxyl butyrate	Cell Assay Reagents
3-Indoxyl butyrate is a chromogenic substrate for CES (carboxylesterase), producing a blue precipitate upon cleavage.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10686

Tanshinone IIA anhydride	Structural Classification Flavonoids Labiatae Samanea saman (Jacq.) Merr. Source classification Plants Other Flavonoids	Carboxylesterase (CES)
Tanshinone IIA anhydride is a potent and irreversible human **carboxylesterase (CE) inhibitor with K_i** values of 1.9 nM and 1.4 nM for human CE1 and the human intestinal CE (hiCE), respectively .

HY-N1951

Miltirone 1 Publications Verification Rosmariquinone	Structural Classification Terpenoids Labiatae Samanea saman (Jacq.) Merr. Source classification Diterpenoids Plants	GABA Receptor Apoptosis Carboxylesterase (CES) SARS-CoV
Miltirone is an orally active natural compound found in the root of Salvia miltiorrhiza. Miltirone is a central benzodiazepine receptor partial agonist, with an IC₅₀ of 0.3 μM. Miltirone induces ROS - and-p53 dependent apoptosis. Miltirone inhibits *carboxylesterase* 2 (CES2; K_i = 0.04 μM) and SARS-CoV main protease (Mpro) .

Species:	Human (4) Mouse (4)
Tag:	His (8)
Source:	HEK293 (7) P. pastoris (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P76193

	CES2/carboxylesterase 2 Protein, Mouse (HEK293, His) Cocaine esterase; Carboxylesterase 2; CE-2; CES2; ICE	Mouse	HEK293
	CES2, a hydrolase, demonstrates notable activity with palmitoylcarnitine and other substrates like p-nitrophenylacetate and alpha-naphthylacetate. Its versatile enzymatic capabilities extend to the hydrolysis of retinyl esters. CES2/carboxylesterase 2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CES2/carboxylesterase 2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P76192

	CES2/carboxylesterase 2 Protein, Human (HEK293,C-His) Cocaine esterase; Carboxylesterase 2; CE-2; CES2; ICE	Human	HEK293
	The CES2 protein plays a crucial role in detoxifying xenobiotics and activating ester and amide prodrugs. It has high catalytic efficiency, especially in the hydrolysis of substances such as cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. CES2/carboxylesterase 2 Protein, Human (HEK293,C-His) is the recombinant human-derived CES2/carboxylesterase 2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P76192A

	CES2/carboxylesterase 2 Protein, Human (HEK293,C-His,Solution) Cocaine esterase; Carboxylesterase 2; CE-2; CES2; ICE	Human	HEK293
	The CES2 protein plays a crucial role in detoxifying xenobiotics and activating ester and amide prodrugs. It has high catalytic efficiency, especially in the hydrolysis of substances such as cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. CES2/carboxylesterase 2 Protein, Human (HEK293,C-His,Solution) is the recombinant human-derived CES2/carboxylesterase 2 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P7731

	Carboxylesterase 5 Protein, Mouse (HEK293, His) rMuCarboxylesterase 5, His; Pyrethroid hydrolase Ces2e; Carboxylesterase 2E; CES5	Mouse	HEK293
	Carboxylesterase 5 Protein, Mouse (HEK293, His) is a mouse Carboxylesterase 5 protein with a His-flag. Carboxylesterase 5 is encoded byCarboxylesterase 5 (CES5) and can catalyses hydrolytic and transesterification reactions.

HY-P7730

	Carboxylesterase 1 Protein, Human (HEK293, His) rHuCarboxylesterase 1, His; CES1; Carboxylesterase 1; Cocaine Carboxylesterase; Serine Esterase 1; Triacylglycerol Hydrolase	Human	HEK293
	Carboxylesterase 1 Protein, Human (HEK293, His) is an approximately 60.0 kDa human carboxylesterase 1 protein with a His-flag. Human Carboxylesterase 1 is the key liver microsomal enzyme that takes part in detoxification and metabolism.

HY-P71802

	Carboxylesterase 1C Protein, Mouse (P.pastoris, His) Carboxylesterase 1C; Ces N; Ces1c; Ee 1; Ee 4; Ee1; Es N; Es1; Es4; EsN; EST1C_MOUSE; Esterase 1; Liver Carboxylesterase N; Lung surfactant convertase; PES-N; PESN	Mouse	P. pastoris
	The carboxylesterase 1C protein is essential for xenobiotic detoxification and ester/amide prodrug activation, as well as participating in extracellular metabolism. Its multifunctional effects include processing of pulmonary surfactant. Carboxylesterase 1C Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Carboxylesterase 1C protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P70088

	CES3/CES1D Protein, Mouse (HEK293, His) rMuCarboxylesterase 1D/CES3, His; CES3; Carboxylesterase 3; Carboxylesterase 3 (brain); EC 3.1.1; EC 3.1.1.1; ES31FLJ21736; Esterase 31; Liver Carboxylesterase 31 homolog	Mouse	HEK293
	CES3/CES1D Protein, a major lipase in white adipose tissue, plays a crucial role in xenobiotic and natural substrate metabolism. It hydrolyzes triacylglycerols and monoacylglycerols, showing a preference for the latter, with susceptibility increasing as the acyl chain length decreases. Additionally, CES3/CES1D catalyzes the synthesis of fatty acid ethyl esters and hydrolyzes retinyl esters. CES3/CES1D Protein, Mouse (HEK293, His) is the recombinant mouse-derived CES3/CES1D protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P703886

	Carboxylesterase 1 Protein, Human (549a.a, HEK293, His) carrHuCarboxylesterase 1, His; CES1; Carboxylesterase 1; Cocaine Carboxylesterase; Serine Esterase 1; Triacylglycerol Hydrolase	Human	HEK293

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HY-P82583

	Liver Carboxylesterase 1 Antibody (YA2328) ACAT; CE 1; CEH; CES1; CES2; CESDD1; Egasyn; ES-HTEL; ES-x; Es22; Esterase 22; hCE 1; HMSE; HMSE1; REH; SES1; TGH; Triacylglycerol hydrolase	WB, IP, FC	Human, Mouse, Rat
	Liver Carboxylesterase 1 Antibody (YA2328) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2328), targeting Liver Carboxylesterase 1, with a predicted molecular weight of 63 kDa (observed band size: 55 kDa). Liver Carboxylesterase 1 Antibody (YA2328) can be used for WB, IP, FC experiment in human, mouse, rat background.

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Carboxylesterase (CES)

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