Search Result

Results for "

Camptothecin Derivative

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Derivative (8) ADC Payload (13) Apoptosis (2) Bcl-2 Family (2) Cytochrome P450 (1) Drug Intermediate (4) Drug-Linker Conjugates for ADC (2) IAP (1) Isotope-Labeled Compounds (1) Reference Standards (2) Survivin (3) Topoisomerase (15)
By Research Areas:	Cancer (32)
Click Chemistry:	ADC Synthesis (1) DBCO (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Drug Derivative

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153185

Decyclohexanamine-Exatecan	ADC Payload Topoisomerase	Cancer
Decyclohexanamine-Exatecan (compound a) is a Camptothecin derivative, with a structure containing Exatecan (HY-13631), which can be used as a ADC cytotoxin .

HY-148185

T01-1 KL610023	ADC Payload	Cancer
T01-1 is an anticancer agent (camptothecin derivative) with good anti-proliferative activity .

HY-N2108

7-Ethylcamptothecin	Drug Derivative Drug Intermediate	Cancer
7-Ethylcamptothecin is a derivative of Camptothecin (HY-16560) and a key intermediate in the synthesis of SN-38 (HY-13704). 7-Ethylcamptothecin can be used in tumor-related research .

HY-177267

Camptothecin derivative-3	Drug Derivative ADC Payload	Cancer
Camptothecin derivative-3 (Compound 11) is a derivative of Camptothecin (HY-16560) and can serve as a payload for ADCs. Camptothecin derivative-3 has certain cytotoxicity, with IC₅₀ values of 2 nM and 0.9 nM against HSC-2 and Namalwa/luc cells, respectively. Camptothecin derivative-3 can be used in tumor-related research .

HY-160438A

PBX-7011 mesylate	Others	Cancer
PBX-7011 mesylate is an active Camptothecin (HY-16560) derivative. PBX-7011 can bind to the DDX5 protein in cells, thereby inducing cell death through DDX5 protein degradation .

HY-160438

PBX-7011	Survivin	Cancer
PBX-7011 is an active camptothecin (HY-16560) derivative. PBX-7011 can bind to the DDX5 protein in cells, thereby inducing cell death through DDX5 protein degradation .

HY-146025

Antitumor agent-F10	Drug Derivative	Cancer
Antitumor agent-F10 (Compound F10) is a camptothecin derivative. Antitumor agent-F10 is an orally–bioavailable and potent antitumor agent. Antitumor agent-F10 displays lower acute toxicity than SN-38 does and the solubility of F10 reached 9.86 μg/mL .

HY-164861

Camptothecin analog-2	Drug Derivative	Cancer
Camptothecin analog-2 (Compound 7b-2) is a camptothecin derivative. Camptothecin analog-2 can be used in the study of cancer .

HY-159162

7-(2-Aminoethyl)camptothecin 7CPT	Drug Intermediate	Others
7-(2-Aminoethyl)camptothecin (7CPT) is a derivative of camptothecin that can be used to prepare TFO-CPT conjugates .

HY-172253

(5R)-Dimethylbenzene-camptothecin	Apoptosis	Cancer
(5R)-Dimethylbenzene-camptothecin (Compound 6a) is a camptothecin derivative. (5R)-Dimethylbenzene-camptothecin is cytotoxic to tumor cells and can induce apoptosis and cell cycle arrest. (5R)-Dimethylbenzene-camptothecin has anti-tumor activity .

HY-159162A

7-(2-Aminoethyl)camptothecin TFA 7CPT TFA	Drug Derivative	Others
7-(2-Aminoethyl)camptothecin TFA (7CPT TFA) is the TFA salt form of Camptothecin (HY-16560) derivative 7-(2-Aminoethyl)camptothecin (HY-159162). 7-(2-Aminoethyl)camptothecin TFA can be used for synthesis of conjugate with triple helix-forming oligonucleotides (TFOs) and camptothecin (CPT). The TFO-CPT conjugate is used for DNA cleavage .

HY-N2063

12-Ethyl-9-hydroxycamptothecin	Topoisomerase	Others
12-Ethyl-9-hydroxycamptothecin is a derivative of Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC₅₀ of 679 nM .

HY-13566A

Belotecan hydrochloride 2 Publications Verification CKD-602	Topoisomerase	Cancer
Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative.

HY-156723

9-Chloromethyl-10-hydroxy-11-F-Camptothecin	Topoisomerase	Cancer
9-Chloromethyl-10-hydroxy-11-F-Camptothecin is a novel camptothecin derivatives. 9-Chloromethyl-10-hydroxy-11-F-Camptothecin is a DNA topoisomerase I (Topo I) inhibitor, can be used in anticancer research .

HY-176777

7-Methylol-9-methoxy-10-F-camptothecin	Drug Derivative ADC Payload	Cancer
7-Methylol-9-methoxy-10-F-camptothecin (Compound D6-1) is a derivative of Camptothecin (HY-16560). 7-Methylol-9-methoxy-10-F-camptothecin can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) .

HY-W897655

20-O-Acetylcamptothecin O-AcetylCamptothecin	Topoisomerase	Others
20-O-Acetylcamptothecin (O-Acetylcamptothecin) is a derivative of Camptothecin (HY-16560) and an inhibitor of Topoisomerase I .

HY-164378

Hydrotecan	ADC Payload	Cancer
Hydrotecan is a Camptothecin (HY-16560) derivative that can be used as an ADC cytotoxin. Hydrotecan can be used to synthesize ADC molecules .

HY-13566AS

Belotecan-d7 hydrochloride	Topoisomerase	Cancer
Belotecan-d₇ (hydrochloride) is the deuterium labeled Belotecan hydrochloride. Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative .

HY-107133

Simmitecan hydrochloride	Topoisomerase Cytochrome P450	Cancer
Simmitecan hydrochloride, a 9-substituted lipophilic Camptothecin (HY-16560) derivative, is a potent topoisomerase I inhibitor. Simmitecan hydrochloride is an anticancer agent .

HY-161082

Topoisomerase I inhibitor 12	Topoisomerase	Cancer
Topoisomerase I inhibitor 12 (compound 12), a Camptothecin (HY-16560)-based derivative, is a potent Topoisomerase I inhibitor. Topoisomerase I inhibitor 12 shows anticancer activity .

HY-153892

Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide is the drug-linker conjugate for ADC, containing ADC linker Gly-Mal-GGFG and ADC cytotoxin Deruxtecan 2-hydroxypropanamide .

HY-13744

Rubitecan RFS 2000; 9-NitroCamptothecin	Topoisomerase	Cancer
Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells .

HY-N12418

(20S)-18,19-Dehydrocamptothecin	Others	Cancer
(20S)-18,19-Dehydrocamptothecin is a natural product that can be isolated from Nothapodytes Foetida .

HY-160438B

PBX-7011 TFA	Bcl-2 Family Survivin	Cancer
PBX-7011 TFA is a derivative of camptothecin (HY-16560), which inhibits expressions of the cancer related survival genes DDX5, Survivin, Mcl-1 and XIAP in cells FaDu, degrades DDX5 proteins and exhibits anticancer activity .

HY-178262A

thioxo-Dxd	ADC Payload	Cancer
thioxo-Dxd is a Camptothecin (HY-16560) derivative. thioxo-Dxd can be connected to monoclonal antibodies via linkers to form antibody-drug conjugate (ADC) molecules. thioxo-Dxd can be used for research on tumors with high HER2 or TROP2 expression .

HY-125331

DRF-1042	Topoisomerase ADC Payload	Cancer
DRF-1042 is an orally active derivative of Camptothecin. DRF-1042 acts to inhibit DNA topoisomerase I. DRF-1042 shows good anticancer activity against a panel of human cancer cell lines including multi-agent resistance (MDR) phenotype .

HY-178262

(R)-thioxo-Dxd	ADC Payload	Cancer
(R)-thioxo-Dxd is a Camptothecin (HY-16560) derivative. (R)-thioxo-Dxd can be connected to monoclonal antibodies via linkers to form antibody-drug conjugate (ADC) molecules. (R)-thioxo-Dxd can be used for research on tumors with high HER2 or TROP2 expression .

HY-N0446

10-Methoxycamptothecin	ADC Payload	Cancer
10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines .

HY-179204

7-MAD-MDCPT-AC-(s-cyclopropane)	ADC Payload	Cancer
7-MAD-MDCPT-AC-(s-cyclopropane) is a derivative of camptothecin. 7-MAD-MDCPT-AC-(s-cyclopropane) can be connected to monoclonal antibodies via linkers to form antibody-drug conjugate (ADC) molecules. 7-MAD-MDCPT-AC-(s-cyclopropane) can be used for cancer research .

HY-120574

TH1338	ADC Payload Topoisomerase	Cancer
TH1338 (compound 3b), an orally active camptothecin derivative and a potent chemotherapeutic agent for cancer, demonstrates excellent cytotoxic potency against human tumor cell lines in vitro. TH1338 (compound 3b) possesses significant brain penetration, favorable efflux pump properties, and hematological toxicity profile .

HY-W740221

7-Ethylcamptothecin-d3-1	Isotope-Labeled Compounds Drug Derivative Drug Intermediate	Cancer
7-Ethylcamptothecin-d₃-1 is the deuterium labeled 7-Ethylcamptothecin (HY-N2108). 7-Ethylcamptothecin is a derivative of Camptothecin (HY-16560) and a key intermediate in the synthesis of SN-38 (HY-13704). 7-Ethylcamptothecin can be used in tumor-related research .

HY-160453

MC-Gly-Gly-Phe-Gly-NH-CH2-O-cyclopropane-CH2COOH	Others	Others
MC-Gly-Gly-Phe-Gly-NH-CH2-O-cyclopropane-CH2COOH is a camptothecin derivative. MC-Gly-Gly-Phe-Gly-NH-CH2-O-cyclopropane-CH2COOH can be used for antibody drug conjugate (ADC) .

HY-N2108R

7-Ethylcamptothecin (Standard)	Reference Standards Drug Derivative Drug Intermediate	Cancer
7-Ethylcamptothecin (Standard) is the analytical standard of 7-Ethylcamptothecin (HY-N2108). This product is intended for research and analytical applications. 7-Ethylcamptothecin is a derivative of Camptothecin (HY-16560) and a key intermediate in the synthesis of SN-38 (HY-13704). 7-Ethylcamptothecin can be used in tumor-related research .

HY-161970

XSJ05	Topoisomerase Apoptosis	Cancer
XSJ05 is a camptothecin (CPT) derivative that can inhibit topoisomerase I (Topo I) to exert anti-cancer activity. XSJ05 can trigger DNA double-strand breaks, leading to DNA damage. XSJ05 can inhibit the growth of colorectal cancer (CRC), arrest the cell cycle in G2/M phase, and induce apoptosis .

HY-178226

PBX-7016	ADC Payload Topoisomerase Survivin Bcl-2 Family IAP	Cancer
PBX-7016 is a Camptothecin (HY-16560) derivative. PBX-7016 can selectively inhibit Topoisomerase 1. PBX-7016 can specifically bind and degrade the cancer protein DDX5, thereby down-regulating the expression of anti-apoptotic proteins such as Survivin, Mcl-1, and XIAP, and promoting the apoptosis of cancer cells. PBX-7016 can be used to synthesis of ADCs .

HY-N0446R

10-Methoxycamptothecin (Standard)	ADC Payload Reference Standards	Cancer
10-Methoxycamptothecin (Standard) is the analytical standard of 10-Methoxycamptothecin. This product is intended for research and analytical applications. 10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines .

HY-158230

SN-398	Topoisomerase	Cancer
SN-398 is a derivative of Camptothecin (HY-158230), which is an antitumor drug. Acting by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex prevents DNA rewiring to induce Topo I mediated DNA breaks. In Hela cell tests, SN-398 shows stronger antitumor activity than SN-38 (HY-13704) (IC₅₀=1.562 μM). SN-398 can be used to study the anti-proliferation and growth inhibition of Topo I in cancer cells .

HY-147363

DIBAC-GGFG-NH2CH2-Dxd	Drug-Linker Conjugates for ADC	Others
DIBAC-GGFG-NH2CH2-Dxd (compound LP4), a Camptothecin (HY-16560) derivative, is a linker-payload of protein-agent conjugates . Dxd (HY-13631D) can be used as a payload for the antibody-coupling drug ADC (DS-8201a).DIBAC-GGFG-NH2CH2-Dxd is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2108

7-Ethylcamptothecin	Alkaloids other families Classification of Application Fields Source classification Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants Disease Research Fields Cancer	Drug Derivative Drug Intermediate
7-Ethylcamptothecin is a derivative of Camptothecin (HY-16560) and a key intermediate in the synthesis of SN-38 (HY-13704). 7-Ethylcamptothecin can be used in tumor-related research .

HY-N2063

12-Ethyl-9-hydroxycamptothecin	Alkaloids Monophenols other families Pyrrole Alkaloids Classification of Application Fields Source classification Other Diseases Phenols Quinoline Alkaloids Plants Disease Research Fields	Topoisomerase
12-Ethyl-9-hydroxycamptothecin is a derivative of Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC₅₀ of 679 nM .

HY-W897655

20-O-Acetylcamptothecin O-AcetylCamptothecin	Alkaloids Source classification Camptotheca acuminata Decne. Nyssaceae Plants Isoquinoline Alkaloids	Topoisomerase
20-O-Acetylcamptothecin (O-Acetylcamptothecin) is a derivative of Camptothecin (HY-16560) and an inhibitor of Topoisomerase I .

HY-13744

Rubitecan RFS 2000; 9-NitroCamptothecin	Alkaloids Classification of Application Fields Source classification Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants Disease Research Fields Cancer	Topoisomerase
Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells .

HY-N0446

10-Methoxycamptothecin	Alkaloids Classification of Application Fields Source classification Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Disease Research Fields Cancer	ADC Payload
10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines .

HY-N12418

(20S)-18,19-Dehydrocamptothecin	Alkaloids Other Alkaloids Source classification Plants Icacinaceae	Others
(20S)-18,19-Dehydrocamptothecin is a natural product that can be isolated from Nothapodytes Foetida .

HY-N2108R

7-Ethylcamptothecin (Standard)	Alkaloids other families Source classification Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants	Reference Standards Drug Derivative Drug Intermediate
7-Ethylcamptothecin (Standard) is the analytical standard of 7-Ethylcamptothecin (HY-N2108). This product is intended for research and analytical applications. 7-Ethylcamptothecin is a derivative of Camptothecin (HY-16560) and a key intermediate in the synthesis of SN-38 (HY-13704). 7-Ethylcamptothecin can be used in tumor-related research .

HY-N0446R

10-Methoxycamptothecin (Standard)	Alkaloids Source classification Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants	ADC Payload Reference Standards
10-Methoxycamptothecin (Standard) is the analytical standard of 10-Methoxycamptothecin. This product is intended for research and analytical applications. 10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines .

Cat. No.	Product Name	Chemical Structure

HY-13566AS

Belotecan-d7 hydrochloride
Belotecan-d₇ (hydrochloride) is the deuterium labeled Belotecan hydrochloride. Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative .

HY-W740221

7-Ethylcamptothecin-d3-1
7-Ethylcamptothecin-d₃-1 is the deuterium labeled 7-Ethylcamptothecin (HY-N2108). 7-Ethylcamptothecin is a derivative of Camptothecin (HY-16560) and a key intermediate in the synthesis of SN-38 (HY-13704). 7-Ethylcamptothecin can be used in tumor-related research .

Cat. No.	Product Name		Classification

HY-147363

DIBAC-GGFG-NH2CH2-Dxd		DBCO ADC Synthesis
DIBAC-GGFG-NH2CH2-Dxd (compound LP4), a Camptothecin (HY-16560) derivative, is a linker-payload of protein-agent conjugates . Dxd (HY-13631D) can be used as a payload for the antibody-coupling drug ADC (DS-8201a).DIBAC-GGFG-NH2CH2-Dxd is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Camptothecin Derivative

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Natural
Products