2. Antibody-drug Conjugate/ADC Related
  3. ADC Payload
  4. Hydrotecan

Hydrotecan is a Camptothecin (HY-16560) derivative that can be used as an ADC cytotoxin. Hydrotecan can be used to synthesize ADC molecules.

For research use only. We do not sell to patients.

Hydrotecan

Hydrotecan Chemical Structure

CAS No. : 2694026-68-9

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Based on 1 publication(s) in Google Scholar

Hydrotecan Related Antibodies

Top Publications Citing Use of Products

View All ADC Payload Isoform Specific Products:

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Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

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Description

Hydrotecan is a Camptothecin (HY-16560) derivative that can be used as an ADC cytotoxin. Hydrotecan can be used to synthesize ADC molecules[1].

Molecular Weight

452.47

Formula

C25H25FN2O5
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

CC[C@@]1(C2=C(COC1=O)C(N3C(C(C(C3)=CC4=C5CCCCO)=NC4=CC(F)=C5C)=C2)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (221.01 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2101 mL 11.0505 mL 22.1009 mL
5 mM 0.4420 mL 2.2101 mL 4.4202 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.33%

SDS (252 KB)

COA (253 KB) HNMR (234 KB) RP-HPLC (226 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2101 mL 11.0505 mL 22.1009 mL 55.2523 mL
5 mM 0.4420 mL 2.2101 mL 4.4202 mL 11.0505 mL
10 mM 0.2210 mL 1.1050 mL 2.2101 mL 5.5252 mL
15 mM 0.1473 mL 0.7367 mL 1.4734 mL 3.6835 mL
20 mM 0.1105 mL 0.5525 mL 1.1050 mL 2.7626 mL
25 mM 0.0884 mL 0.4420 mL 0.8840 mL 2.2101 mL
30 mM 0.0737 mL 0.3683 mL 0.7367 mL 1.8417 mL
40 mM 0.0553 mL 0.2763 mL 0.5525 mL 1.3813 mL
50 mM 0.0442 mL 0.2210 mL 0.4420 mL 1.1050 mL
60 mM 0.0368 mL 0.1842 mL 0.3683 mL 0.9209 mL
80 mM 0.0276 mL 0.1381 mL 0.2763 mL 0.6907 mL
100 mM 0.0221 mL 0.1105 mL 0.2210 mL 0.5525 mL
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Hydrotecan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydrotecan2694026-68-9ADC PayloadADC CytotoxinInhibitorinhibitorinhibit

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